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Tongue Carcinoma

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1941. To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Suffer

, or cola) comprising usually more than 5 cups or glasses per day. Subject has a positive drug of abuse screening result. Subject has severe, unstable disease states (e.g. myocardial infarction, congestive heart failure, diabetes, cirrhosis, cancer, epilepsy, or stroke), pain syndromes, (e.g. fibromyalgia) or any medical or surgical condition that places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study or who (...) , 2017 Last Update Posted : April 7, 2017 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief Summary: To characterize the performance of the nasal dilator strip in lowering nasal resistance during sleep, promoting nasal route breathing and reducing the signs and symptoms of sleep disordered breathing in a group of chronic nocturnal nasal congestion sufferers who report trouble with their sleep. Condition or disease

2017 Clinical Trials

1942. Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHN

such as hypertension, diabetes, coronary heart disease and psychiatric history The treatment for the first course of treatment (no head and neck radiotherapy, no chemotherapy within 3 months). Exclusion Criteria: There is a distant shift primary lesions or lymph nodes were radiotherapy had received epidermal growth factor targeted therapy primary tumor had received chemotherapy or immunotherapy had other malignancies (except for cured basal cell carcinoma or cervical cancer) pregnant women or lactating women (...) with cisplatin chemoradiotherapy in the treatment of locally advanced head and neck squamous cell carcinoma. Condition or disease Intervention/treatment Phase Locally Advanced Head and Neck Squamous Cell Carcinoma Drug: Lobaplatin Drug: Cisplatin Phase 2 Detailed Description: TPF program is currently the local advanced head and neck squamous cell carcinoma commonly used inducing chemotherapy, cisplatin is the preferred drug for the same period chemotherapy, however, due to heavier gastrointestinal reactions

2017 Clinical Trials

1943. Human Immunome Program

Go to Brief Summary: The Human Immunome Program is a large-scale, open-source effort seeking to fill a major gap in our knowledge of the immune system. The power of the immune system to fight disease lies in its ability recognize and adapt to an astonishing range of threats from viruses, parasites and bacteria to cancer cells. Underlying this ability is a vast but specific set of genes and molecular structures known as the human immunome, or the "parts list" of the immune system. This study aims (...) of cancer including skin cancer. History of autoimmune disorders including but not limited to: Ulcerative colitis, Crohn's, Inflammatory Bowel Disease, Rheumatoid Arthritis, Scleroderma, Systemic lupus Erythematosus, Mixed Connective Tissue Disease, Graves, Autoimmune Thyroiditis, Hashimoto's Thyroiditis, Psoriasis, Multiple Sclerosis, Guillain-Barre Syndrome, Chronic Inflammatory demyelinating polyneuropathy, Myasthenia Gravis, Vasculitis, Alopecia areata, autoimmune hemolytic anemia, autoimmune

2017 Clinical Trials

1944. The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

or petechia in the tongue, etc. In fact, Qi stagnation and blood stasis are common pathological conditions that would occur on human body for several times in the long period of human's life. Besides, QS&BSS is associated with over 50 kinds of diseases including Coronary Heart Disease, hypertension, cerebral infarction, gastritis, arthritis, dysmenorrhea, chronic pelvic infection, skin disease, and cancer. Xue-Fu-Zhu-Yu Capsule, one of Chinese herbal medicine drugs, could perform the function of promoting (...) , randomized and placebo-controlled trial. The study aims to evaluate the effectiveness and safety of Xue-Fu-Zhu-Yu Capsule (XFZYC) for Qi Stagnation and Blood Stasis syndrome (QS&BSS). QS&BSS is one of the common Zhengs in Traditional Chinese Medicine, which manifests as various symptoms and signs, such as distending pain or tingling sensation in a fixed position, irritability or depression, dim complexion, lumps in body, blood spot under the skin, unsmooth or string-like pulse, purplish tongue

2017 Clinical Trials

1945. CIRSE Registry for LifePearl Microspheres

in treatment it is being applied to assess observed treatment outcomes in terms of safety and efficacy as well as trying to determine any predictive response factors Condition or disease Intervention/treatment Colorectal Carcinoma Neoplasm Metastasis Device: LifePearl Microspheres loaded with Irinotecan Detailed Description: CIREL will capture a broad spectrum of real clinical data on the delivery of transcatheter arterial chemoembolisation (TACE) using LifePearl Microspheres loaded with Irinotecan (LP-IRI (...) by the investigator and central CT/MRI image analysis. Time from observation until disease progression in the liver or death [ Time Frame: 4 years ] Hepatic progression-free survival (liver-specific PFS) will be assessed by the investigator and central CT/MRI image analysis. Proportion of patients with reduction in tumor burden, as assessed by RECIST (v.1.1) [ Time Frame: 4 years ] Objective Tumour Response Rate will be assessed by the investigator and central CT/MRI image analysis. Number of patients with tumour

2017 Clinical Trials

1946. A Controlled Comparison of Two DBS Targets for Upper Extremity Action Tremor

) of the total FTM-score, tremor of the upper limb(s) (same items as above) and of the items scoring tremor in the face, tongue, voice, trunk, lower limb(s). Change of patient evaluated scores at 1 year of stimulation (QUEST and VAS Global Burden Disease Burden (Tremor-burden) [ Time Frame: 1 year (+/- 4 weeks) after surgery ] Change from baseline to 1-yr of Quality of Life in Essential Tremor (QUEST) scale, and Visual Analogue Scale of Global Disease Burden as assessed by the patient. Frequency of serious (...) : South-Eastern Norway Regional Health Authority Information provided by (Responsible Party): Inger Marie Skogseid, Oslo University Hospital Study Details Study Description Go to Brief Summary: Action tremor of the arms can be an invalidizing symptom of diseases such as Essential Tremor, Dystonic Tremor, Parkinson's disease and Multiple Sclerosis. In this study we compare the efficacy and safety of two different brain targets for deep brain stimulation (DBS) that both are known to reduce action tremor

2017 Clinical Trials

1947. Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy

and written consent to participation in the study. Exclusion Criteria: secondary hypertension (other than primary hyperaldosteronism), myocardial infarction, stroke within 6 months before the study, congestive heart failure with New York Heart Association (NYHA) grade III-IV, chronic kidney disease (GFR < 30 ml/min), active addiction to alcohol or psychoactive substances, active cancer disease. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study (...) Krasinska, Poznan University of Medical Sciences Study Details Study Description Go to Brief Summary: Obstructive sleep apnea syndrome (OSA) is the most frequent sleep disorder characterized by excessive decrease in muscle tone of the soft palate, the tongue and the posterior pharyngeal wall. It leads to airway collapse. In cases of decreased airway passage hypoventilation (hypopnea) occurs while periodic lack of airflow is called apnea. An obstructive sleep apnea syndrome is recognized

2017 Clinical Trials

1948. Physiological Flow of Liquids Used in Dysphagia Management

management. Condition or disease Intervention/treatment Amyotrophic Lateral Sclerosis Parkinson Disease Dysphagia Diagnostic Test: Videofluoroscopic Swallowing Examination Other: Tongue Strength Measurement Detailed Description: This research study will measure swallowing function in individuals with Amyotrophic Lateral Sclerosis or Parkinson's disease. The aims of this study are to (1) identify parameters of swallowing physiology that are associated with impaired swallowing safety and efficiency, and (2 (...) isometric tongue presses). Participants will also be asked to swallow their saliva with the bulb placed in their mouth, three (3) times. Tongue pressure measurement will be completed twice in the data collection session - once at the beginning, and once at the end (following the videofluoroscopy). Parkinson's Disease We will be recruiting individuals with a diagnosis of Parkinson's disease, who experience speech or swallowing problems, to attend one data collection session. All participants will undergo

2017 Clinical Trials

1949. POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

syndrome, multiple sclerosis, schizophrenia, depression, etc.; Had severe head and face disease, trauma history or history of surgery; The serious body disease and tobacco, wine and other substance abuse history; The presence of malignant tumor with shorter survival disease. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please (...) tongue is chinese; The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; The Geriatric Depression Scale (GDS) grade 1 or 2; The important function without serious heart, brain, liver, kidney, lung and other organs; The ASA class I or II; The people signed informed consent. Exclusion Criteria: The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's

2017 Clinical Trials

1950. Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage

% (>48 mmol/mol) at screening. Subjects with LDLc, >7.5 mmol/l. TG level >10mmol/l. History of heart failure defined as NYHA class II ‐ IV or those with known LV dysfunction (EF<40%) regardless of symptomatic status History of malignancy within the past 5 years, other than non-melanoma skin cancer. Current life-threatening condition other than vascular disease (e.g. very severe chronic airways disease, HIV positive, life‐threatening arrhythmias) that may prevent a subject from completing the study (...) to patients with persistently raised blood pressure (hypertension). Half the patients will receive the beetroot juice containing inorganic nitrate and half will receive beetroot juice from which the inorganic nitrate has been removed. The volunteers will take the juice every day for 4 months. Condition or disease Intervention/treatment Phase Hypertension Dietary Supplement: Beetroot juice Phase 2 Detailed Description: In hypertension persistent raised blood pressure (BP) is associated with endothelial

2017 Clinical Trials

1951. Efficacy of a Novel MAD in OSA

Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age between 18 and 65 years old VPSG within the last three months Diagnosis of mild-to-moderate OSAS (AHI 5-30/h) At least 4 teeth present in the lower and upper arch Ability to protrude the mandible for at least 6 mm Informed Consent Exclusion Criteria: Significant ENT disease Tonsillar hypertrophy Uvulopalatopharyngoplasty (UPPP) Palatoschisis Neoplastic lesions Other neurological disorders Trigeminal neuralgia Myofacial pain dysfunction (...) Details Study Description Go to Brief Summary: Oral appliances (OA) have emerged as an alternative to continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment. The most commonly used OA reduces upper airway collapse by advancing the mandible (mandibular advancement devices, MAD). There is a strong evidence base demonstrating that MADs improve OSA in the majority of patients, including some with more severe disease. However, MADs are not efficacious for all

2017 Clinical Trials

1952. EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation

or disease Intervention/treatment Phase Stomatitis Drug: EC-18 Drug: Placebo Phase 2 Detailed Description: This is a Phase 2, randomized, double-blind, placebo-controlled, 2-stage trial in subjects with squamous cell cancers of the mouth, oropharynx, hypopharynx and nasopharynx planned to receive standard fractionated IMRT-delivered radiotherapy with concomitant chemotherapy (cisplatin). Informed consent will be obtained from each subject prior to enrollment. The trial will be performed in 2 stages (...) : Enzychem Lifesciences Corporation Information provided by (Responsible Party): Enzychem Lifesciences Corporation Study Details Study Description Go to Brief Summary: This is a Phase 2, randomized, double-blind, placebo-controlled, 2-stage trial in subjects with squamous cell cancers of the mouth, oropharynx, hypopharynx and nasopharynx planned to receive standard fractionated IMRT-delivered radiotherapy with concomitant chemotherapy (cisplatin). Informed consent will be obtained from each subject prior

2017 Clinical Trials

1953. Assessment of Pharmacokinetics and Safety of Diazepam Buccal Soluble Film in Pediatric Patients

during and in-between experiencing seizures. Condition or disease Intervention/treatment Phase Epilepsy Drug: Diazepam Buccal Soluble Film Phase 2 Detailed Description: This is a Multicenter , Open Label Crossover study to assess the Pharmacokinetics and Safety of Diazepam Buccal Soluble Film (DBSF) in Pediatric patients with Epilepsy. The Primary objective of the study is to assess the pharmacokinetics of DBSF in pediatric patients with epilepsy in interictal State (Period A) and ictal/peri-ictal (...) Treatment Periods and the Follow-up Visit, and must be willing to comply with all required study procedures and adhere to all protocol requirements. Subject and/or subject's parent(s) or legally authorized representative must be able to comprehend and be informed of the nature of the study, as assessed by the Investigator. Exclusion Criteria: Potential subjects meeting any of the following criteria will be excluded: Subjects with a progressive neurological disorder such as a brain tumor, demyelinating

2017 Clinical Trials

1954. Lingual Muscle Training in Late-Onset Pompe Disease (LOPD)

internet connection Access to use of electronic device that allows for FaceTime, Jabber, or WebEx use Exclusion Criteria: Neurodegenerative conditions (e.g. stroke, dementia) or other serious neurologic condition that would prevent meaningful study participation as determined at the discretion of the principle investigator Any current or past history of seizures. Infantile onset Pompe disease Head and neck cancer or radiation treatment to head/neck Inability to tolerate IOPI device tongue bulb (...) provided by (Responsible Party): Duke University Study Details Study Description Go to Brief Summary: This study is being done to test the effects of Lingual Muscle Therapy (LMT) in patients with Late-Onset Pompe Disease (LOPD) who have tongue weakness. The results of this study will help design future research studies about LMT in LOPD. Condition or disease Intervention/treatment Phase Glycogen Storage Disease Other: Lingual Muscle Training Not Applicable Study Design Go to Layout table for study

2017 Clinical Trials

1955. Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain

to, the risks described as precautions, warnings, and contraindications in the current version of the investigator's brochure for Buprenorphine Sublingual Spray), to be an unsuitable candidate to receive the study drug. Is receiving systemic chemotherapy, has an active malignancy of any type, or has been diagnosed with cancer within 5 years before Screening (excluding squamous or basal cell carcinoma of the skin). Is currently receiving anticoagulants (eg, heparin or warfarin). Low-dose aspirin (...) , cold sores, viral lesions, local irritation, or in the investigator's opinion has significant periodontal disease of the oral cavity. In addition, recent (within 1 year) piercing of the tongue or anywhere in the oral cavity. Has a surgical or medical condition of the GI or renal system that, in the investigator's opinion, might significantly alter the absorption, distribution, or excretion of any drug substance. Is considered by the investigator, for any reason (including, but not limited

2017 Clinical Trials

1956. Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making

review for all biopsy results will be performed and incorporated into the final analyses. Condition or disease Intervention/treatment Palatal Neoplasms Lip Neoplasm Gingival Neoplasms Leukoplakia, Oral Tongue Neoplasms Oropharyngeal Neoplasms Oral Ulcer Device: OncAlert Detailed Description: Overview The OncAlert Oral Cancer RAPID Test (OncAlert RAPID) is a qualitative point-of-care lateral flow assay to aid in the decision to biopsy in patients with clinical features associated with oral potentially (...) malignant disorders and or oral/oropharyngeal cancer (i.e. head and neck squamous cell carcinoma). Proposed Intended Use Statement The device measures soluble CD44 and total protein in saliva samples collected in saline. The test is an adjunct to the biopsy decision process, and not intended as a screening or stand-alone diagnostic assay. To be used in adults 23 years and older. Not intended for use in pregnant women. STUDY OBJECTIVES The principal objectives of this study are to: Validate the OncAlert

2017 Clinical Trials

1957. Using a pedicle pectoralis major musculocutaneous flap in head and neck reconstruction after modified radical mastectomy: A case report. Full Text available with Trip Pro

modified radical mastectomy (MRM) more than 20 years earlier.She had squamous cell carcinoma of the tongue and had undergone partial glossection and left modified radial neck dissection. Four months later, a left submandibular mass was noted with progressive enlargement and the biopsy revealed recurrent carcinoma.Left marginal mandibulectomy with radical neck dissection was performed and the neck area was reconstructed by a left pedicle PMMC flap harvested from the left chest wall which had (...) Using a pedicle pectoralis major musculocutaneous flap in head and neck reconstruction after modified radical mastectomy: A case report. A pedicle pectoralis major musculocutaneous (PMMC) flap is one of the strategies for head and neck reconstruction. Seldom studies reported the case in which the skin area of previous modified radical mastectomy (MRM) had been used as a PMMC flap in head and neck reconstruction.An 84-year-old female who had suffered from left breast cancer and undergone a left

2017 Medicine

1958. Newly Described Entities in Salivary Gland Pathology. (Abstract)

low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion. Cribriform adenocarcinoma (CASG) is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma by location (ie, most often arising on the tongue), by prominent nuclear clearing, differing alterations of the PRKD gene family, and clinical behavior with frequent metastases at the time of presentation of the primary tumor. Early nodal (...) Newly Described Entities in Salivary Gland Pathology. Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secretory carcinoma is a distinctive

2017 American Journal of Surgical Pathology

1959. Management of the thyroid gland during laryngectomy. Full Text available with Trip Pro

Management of the thyroid gland during laryngectomy. This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement.A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total (...) gland involvement in laryngeal carcinoma. Most cases of gland involvement occurred by direct extension. Thyroidectomy during laryngectomy should be considered for advanced stage tumours with cartilage invasion.

2017 Journal of Laryngology & Otology

1960. Real-time continuous image-guided surgery: Preclinical investigation in glossectomy. (Abstract)

of otolaryngology residents, fellows, medical students, and staff under a reproducible setting by using realistic tongue phantoms. Evaluators were grouped into a senior and a junior group based on surgical experience, and guided and unguided tumor resections were performed. National Aeronautics and Space Administration Task Load Index (NASA-TLX) scores and a Likert scale were used to measure workloads and impressions of the system, respectively. Efficacy was studied by comparing surgical accuracy, time

2017 Laryngoscope

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