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Tongue Carcinoma

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1921. Oprah Winfrey for President? Does anyone remember all the pseudoscience and quackery she’s promoted?

this blog longer than seven years, because that’s the last time I wrote about Ms. Tinkham. Basically, Ms. Tinkham was diagnosed with breast cancer. Unfortunately, she was also inspired by Oprah and her promotion of The Secret to . It , though. It was of , whom you might remember as the man responsible for the “pH Miracle Living” quackery, where acid was The One True Cause of All Disease, particularly but also and , and who is now in . Tinkham was fortunate in that she did fairly well for three years (...) program said, “We don’t take positions on the opinions of our guests. Rather, we offer a platform for guests to share their first-person stories in an effort to inform the audience and put a human face on topics relevant to them.” When McCarthy’s views have been discussed on the air, statements from the Centers for Disease Control and Prevention and the American Academy of Pediatrics saying that there’s no scientific evidence of a vaccine-autism link have been read. Overall, Oprah had a malign

2018 Respectful Insolence

1922. Stephen Colbert sells out to Gwyneth Paltrow and Goop

. Dochniak (MJD) Johnny efficiently asks, Why? MJD says, Here’s a snippet from the book that speaks volumes: Furthermore, in a blog post from Respectful Insolence (2011) titled, “Steve Jobs, neuroendocrine tumors, and alternative medicine” author Dr. David Gorski (a.k.a. Orac) writes, “If there’s one thing we’re learning increasingly about cancer, it’s that biology is king and queen, and that our ability to fight biology is depressingly limited. In retrospect, we can now tell that Jobs clearly had (...) a tumor that was unusually aggressive for an insulinoma. Such tumors are usually pretty indolent and progress only slowly. Indeed, I’ve seen patients and known a friend of a friend who survived many years with metastatic neuroendocrine tumors with reasonable quality of life. Jobs was unfortunate in that he appears to have had an unusually aggressive form of the disease that probably would have killed him no matter what. That’s not to say that we shouldn’t take into account his delay in treatment

2018 Respectful Insolence

1923. Surgical simulation: skills transfer to the operating room: a systematic review

and Waxman 2006). The numbers of animals needed as well as cultural, financial and ethical issues limit their use. Cadaveric models The limited supply of cadavers in Australia, coupled with concerns regarding disease transmission from human tissues and fluids, and ethical and cultural issues, limit this mode of training. Ex vivo animal tissue models Using anatomic sections or tissues from euthanased animals (ex vivo) is another form of simulation in surgical skills training. Dedicated ‘wet rooms’ within

2012 Publication 80

1924. Management of suspected viral encephalitis in children (Full text)

cerebrovascular accidents Neoplastic Paraneoplastic encephalitis Primary brain tumour Metastases Metabolic encephalopathy Hepatic encephalopathy Renal encephalopathy Hypoglycaemia Toxins (alcohol, drugs) Hashimoto's disease Septic encephalopathy Mitochondrial diseases Other Antibody-mediated encephalitis: VGKC complex or NMDA receptor Drug reactions Encephalitis lethargica Haemophagocytic Lymphohistiocytosis (HLH) syndrome (usually children) Epilepsy Functional disorder In this table some of the important (...) | | | • Airways, Breathing, Circulation • Mini-mental state, cognitive function, behaviour (when possible) • Evidence of prior seizures (tongue biting, injury) • Subtle motor seizures (mouth, digit, eyelid twitching) • Meningism • Focal neurological signs • Papilloedema • Flaccid paralysis (anterior horn cell involvement) • Rash (purpuric – meningococcus; vesicular – hand foot and mouth disease; varicella zoster; rickettsial disease) • Injection sites of drug abuse • Bites from animals (rabies) or insects

2012 British Infection Association PubMed abstract

1925. Guidelines on Equipment to Manage a Difficult Airway During Anaesthesia Background Paper

. It has a role as a ventilation/oxygenation bridge and secondary rescue device. 81 The Combitube™ has demonstrated superiority over other supraglottic ventilation devices in resuscitation in relation to ease of ventilation and insertion. 82,83 The device has advantages in patients with massive bleeding, regurgitation and limited mouth opening. 84 It also minimises the risk of aspiration. 55 Complications are rare 85,86 but include piriform sinus perforation, oesophageal laceration and tongue (...) -Mac). The E-Mac has better illumination than the A-Mac. 96 In unexpectedly difficult laryngoscopy the E-Mac provided a better glottic view than the A- Mac. 97 Laryngoscopes with a high proximal flange, such as the A-Mac, might cause more trauma to the maxillary incisors. 98 Macintosh modified the laryngoscope blade to allow the tip to “fit into the angle made by the epiglottis and the base of the tongue”. 99 Tension by the tip of the Macintosh blade on the hyoepiglottic ligament in the vallecula

2012 Australian and New Zealand College of Anaesthetists

1926. Surgical simulation for training: skills transfer to the operating room (update)

and Waxman 2006). The numbers of animals needed as well as cultural, financial and ethical issues limit their use. Cadaveric models The limited supply of cadavers in Australia, coupled with concerns regarding disease transmission from human tissues and fluids, and ethical and cultural issues, limit this mode of training. Ex vivo animal tissue models Using anatomic sections or tissues from euthanased animals (ex vivo) is another form of simulation in surgical skills training. Dedicated ‘wet rooms’ within

2012 Publication 80

1927. ACR-ASNR-SPR Practice Guideline for the Performance of Magnetic Resonance Imaging (MRI) of the Head and Neck

better signal-to- noise ratios [35]. 2. Paranasal sinuses and nasal cavity Computed tomography is the imaging modality of choice for inflammatory disorders of the paranasal sinuses and nasal cavity, with MRI reserved for evaluating complications of inflammatory and neoplastic sinus disease [36- 38], including orbital, skull base, and intracranial extension [25,28,39-41]. For all suspected neoplasms, and to distinguish tumors from mucosal thickening and secretions, MRI with contrast enhancement (...) Clin N Am 2004;14:679-694. 41. Smoker WR. Chapter 27: Oral cavity: anatomy and pathology. In: Som PM, Curtin HD, eds. Head and Neck Imaging. 4th ed. Philadelphia, Pa: Mosby; 2003:1377-1364. 42. Hudgins PA. Sinonasal imaging. Neuroimaging Clin N Am 1996;6:319-331. 43. Kubal WS. Sinonasal imaging: malignant disease. Semin Ultrasound CT MR 1999;20:402-425. 44. Hermans R, De Vuysere S, Marchal G. Squamous cell carcinoma of the sinonasal cavities. Semin Ultrasound CT MR 1999;20:150-161. 45. Eisen MD

2012 American Society of Neuroradiology

1928. 2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN Key Data Elements and Definitions for Peripheral Atherosclerotic Vascular Disease

2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN Key Data Elements and Definitions for Peripheral Atherosclerotic Vascular Disease and Jack A. Ziffer Kerry J. Stewart, Diane Treat-Jacobson, Gilbert R. Upchurch, Jr, Christopher J. White Jeffrey W. Olin, Judith G. Regensteiner, Robert H. Rosenwasser, Peter Sheehan, A. Kern, David J. Malenka, Edward T. Martin, Emile R. Mohler III, Timothy Murphy, Chaturvedi, Michael D. Dake, Jerome L. Fleg, Alan T. Hirsch, Michael R. Jaff, John Mark A. Creager, Michael (...) Belkin, Edward I. Bluth, Donald E. Casey, Jr, Seemant Standards for Peripheral Atherosclerotic Vascular Disease) Force on Clinical Data Standards (Writing Committee to Develop Clinical Data American College of Cardiology Foundation/American Heart Association Task Definitions for Peripheral Atherosclerotic Vascular Disease : A Report of the 2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN Key Data Elements and ISSN: 1524-4539 Copyright © 2011 American Heart Association. All rights reserved. Print ISSN: 0009

2012 Society for Cardiovascular Angiography and Interventions

1929. Infections Associated with Personal Service Establishments: Piercing and Tattooing

draft and Michele Wiens for providing research assistance. May 2012 National Collaborating Centre for Environmental Health 8 Appendix Methods The Ebsco database collection was used to search scientific literature using the following keyword terms, either alone or in combination: piercing, tattooing, permanent makeup, body modification, body art, branding, scarification, ear stapling, and tongue splitting. Word variants were considered along with outcomes for practices, such as infection and disease (...) -use of tattooing ink between clients. • Use of tap water to dilute ink or rinse needles between colour changes has been implicated in outbreaks of mycobacterium infections during tattooing. • The majority of identified studies consists of case reports, which provide limited information on disease transmission risks for specific services. Introduction Personal Service Establishments (PSEs) are a growing industry that encompasses services such as piercing, tattooing, and body modification

2012 National Collaborating Centre for Environmental Health

1930. Oral health care in care homes -best practice model

for denture Care 24 rEFErENCES 26 2 APPENdICES 31 Appendix 1 – Statistics 31 Appendix 2 – Summary of CDS Questionnaire Regarding 32 Domiciliary Dental Care Appendix 3 – Sample Care Plan 34 Appendix 4 – Sample Audit Tool for Residential 36 and Nursing Homes Appendix 5 – Resources 41 Appendix 6 – Glossary of Terms 45 Appendix 7 – Membership of GAIN Sub-Group 47 Appendix 8 – Acknowledgement of Contribution 48 3 INTrOduCTION The necessity for prevention of dental disease in older adults* in care facilities (...) basic approach to maintaining optimum oral health applies; good daily oral hygiene and mouth care, limited use of sugary foods and drinks, and regular dental check-ups. By using this approach the potential for unwanted consequences like dental pain, dental decay, gum disease, and infection are minimised and other interrelated aspects like nutrition, quality of life and self-esteem are optimised. Although there is no published research in Northern Ireland describing the state of oral health

2012 Regulation and Quality Improvement Authority

1931. Guidelines for preventive activities in general practice (8th edition)

-Guérin BMD Bone mineral density BMI Body mass index BNP B-type natriuretic peptide BP Blood pressure BRCA1 Breast cancer susceptibility gene 1 BRCA2 Breast cancer susceptibility gene 2 CA Cancer antigen CA125 Cancer antigen 125 CF Cystic fibrosis CHD Coronary heart disease CKD Chronic kidney disease COPD Chronic obstructive pulmonary disease CRC Colorectal cancer CRP High sensitivity C-Reactive Protein CT Computerised tomography CVD Cardiovascular disease DBP Diastolic blood pressure DNA (...) 34 6.1 Immunisation 34 6.2 STIs 37 7. Prevention of chronic disease 40 7.1 Smoking 42 7.2 Overweight 43 7.3 Nutrition 45 7.4 Early detection of problem drinking 47 7.5 Physical activity 49x Guidelines for preventive activities in general practice 8th edition 8. Prevention of vascular and metabolic disease 50 8.1 Assessment of absolute cardiovascular risk 50 8.2 BP 51 8.3 Cholesterol and other lipids 53 8.4 T ype 2 diabetes 55 8.5 Stroke 57 8.6 Kidney disease 58 9. Early detection of cancers 60

2012 Clinical Practice Guidelines Portal

1932. Position paper on hereditary angioedema

swelling of the gastrointestinal tract may result in abdominal pain, vomiting and hypotension. The most serious manifestation is laryngeal swelling, which was reported in older cohort studies to result in fatal asphyxiation in up to a third of patients 2 . Attacks may be preceded by a prodrome of tingling, or a non-itchy rash (erythema marginatum 3 ) anywhere on the body. Affected patients also have higher than expected rates of autoimmune disease 4, 5 . 1.2 Historical facts The first description (...) of HAE has been attributed to Robert Graves, who in 1843 described a patient with “a tumor rising on the forehead in the space of half an hour” and then later “sometimes the lips, inside of the mouth, palate, and uvula are attacked giving rise to a very considerable inconvenience” 6 . The superceded term angioneurotic edema (a synonym for angioedema) is derived from Heinrich Quincke’s original explanation that swelling arose from increased vascular permeability that could affect not only the face

2012 Clinical Practice Guidelines Portal

1933. Management of suspected viral encephalitis in adults

haemorrhagic leukoencephalopathy (AHLE) Acute necrotising encephalitis (ANE) in children Bickerstaff's encephalitis Toxic/Metabolic Reye's syndrome Systemic infection Septic encephalopathy Shigellosis Non-infectious causes Vascular Vasculitis Systemic lupus erythematosis Behçet's disease Subarachnoid & subdural haemorrhage Ischaemic cerebrovascular accidents Neoplastic Paraneoplastic encephalitis Primary brain tumour Metastases Metabolic encephalopathy Hepatic encephalopathy Renal encephalopathy (...) and Disease Initiative, Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK Author Footnotes t Tel.: +44151 228 4811; fax: +44 151 228 032. R. Kneen Footnotes t Tel.: +44151 228 4811; fax: +44 151 228 032. Affiliations Department of Neurology, Littlewood's Neuroscience Unit, Alder Hey Children's NHS Foundation Trust, Eaton Road, West Derby, Liverpool L12 2AP, UK Author Footnotes p Tel.: +44 151 706 2000. N.J. Beeching

2012 British Infection Association

1934. Function of Jiangzhong Hou Gu® Mi Xi™ in Patients With Spleen Qi Deficiency and Peptic Ulcer Diseases

any agents or other intervention for treating his/her gastrointestinal disorder Patients with any malignant tumor Patients who have severe mental disorders so that could not control his/her action and coordinate the treatment in this trial. Patients who are unwilling to provider personal information and enter this trial Patients who cannot understand and sign informed consent Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your (...) Function of Jiangzhong Hou Gu® Mi Xiâ„¢ in Patients With Spleen Qi Deficiency and Peptic Ulcer Diseases Efficacy and Safety of Hou Gu Mi Xi in Patients With Peptic Ulcer Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

1935. Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation

discoloration or tongue edema. Other Names: Palifermin Kepivance K Outcome Measures Go to Primary Outcome Measures : Percentage of patients with leukemia free survival [ Time Frame: Up to 1 year after transplant ] Leukemia Free Survival (LFS) at 1 year is the percentage of patients alive and without evidence of hematologic malignancy at 1 year after transplant. Secondary Outcome Measures : Average overall survival [ Time Frame: Up to 1 year after transplant ] Overall Survival (OS) at 1 year (...) Criteria: Patients with the following hematologic malignancies: Acute myelogenous leukemia (AML): High-risk AML including: Antecedent hematological disease (e.g., myelodysplasia (MDS)) Treatment-related leukemia Complete Remission (CR1) with poor-risk cytogenetics or molecular markers (e.g. Flt 3 mutation, 11q23, del 5, del 7, complex cytogenetics) Second complete remission (CR2) or third complete remission (CR3) Induction failure or 1st relapse with ≤ 10% blasts in the marrow Acute lymphoblastic

2017 Clinical Trials

1936. [Trial of device that is not approved or cleared by the U.S. FDA]

-snoring product in the past (by self-report) [These individuals may be included in the study if recruitment timeline dictates it] Exclusion Criteria (Snorer): Scored higher than a 9 on the Modified Snore Scale Score (MSSS>9) Scored higher than a 6 on the OSA 50 screener (OSA50>6) The presence of physical or mental limitations that would limit the ability to use the anti-snoring solutions. Any unstable medical condition like congestive heart failure, neuromuscular disease, renal failure, or cancer (...) , Netherlands). The Silent Night app also records snoring through the night and provides feedback to the user via a "snore score." Condition or disease Intervention/treatment Phase Snoring Device: Nasal Dilator Device: Mandibular Advancement Device: Positional Therapy Not Applicable Detailed Description: Silent Night is a solution for primary snorers to guide them to the proper anti-snoring solution. It consists of a mobile application, which had an intake questionnaire, guides users to one of three anti

2017 Clinical Trials

1937. Macintosh Laryngoscope Assisted Fiberoptic Intubation

Inclusion Criteria: Adult patients with Modified Mallampati (NT-MMT) airway score III,VI American Society of Anaesthesiologists (ASA) physical class I-III Scheduled for elective cancer surgery under general anesthesia Exclusion Criteria: Modified Mallampati I,II Airway scored patients. History of upper airway surgery. Patients with serious deformities of the mandible, maxilla, tongue, pharynx or larynx. Patients with a history of significant cardiac and pulmonary diseases, Obesity with BMI >40, Epilepsy (...) Summary: During fiberoptic endotracheal intubation, the perfect airway exposure produced by the classic curved Macintosh laryngoscope in place of head tilt -chin lift-jaw thrust maneuver may increase the accuracy and produce rapid direct vocal cord access in a short time under Inhalation anesthesia to maintain the respiratory drive for grade III&VI Modified Mallampati . Condition or disease Intervention/treatment Phase Difficult Intubation Device: fiberoptic, airway Device: fiberoptic, Machintosh

2017 Clinical Trials

1938. Phage II Trial of Stathmin as Predictive Biomarker for TPF Induction Chemotherapy in OSCC

aminotransferase )/ASAT(aspartate transaminase ) <2.5 times the upper limit of normal (ULN), bilirubin <1.5 times ULN. Serum creatinine <1.5 times ULN. Written informed consent Exclusion Criteria: Distant metastatic disease and other cancers. Previous surgical procedure of the primary tumors or lymph nodes (except diagnostic biopsy). Previous radiotherapy or chemotherapy. Other previous malignancies within 5 years. Sever systematic diseases such as severe pulmonary or cardiac diseases. Legal incapacity (...) surgery and radiotherapy/chemoradiotherapy. Condition or disease Intervention/treatment Phase Neoplasm Neck Drug: docetaxel, cisplatin and 5-fluorouracil Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomized Phase II Trial of Low Stathmin Expression as a Predictive

2017 Clinical Trials

1939. Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature (Full text)

cavity; in addiction in biopsy specimen of the dorsum of the tongue revealed the presence of erythroplakia with high grade dysplasia.Verruciform xanthoma of the oral cavity associated with chronic graft-versus-host disease is a rare condition with a usually benign clinical course but malignant transformation has been described in association with oral potential malignant disorder (e.g. chronic graft versus host disease, erythroplakia). Very rare cases showed association with oral chronic graft versus (...) on the hard palate, yellowish and verrucous nodules on left buccal mucosa. In addiction an area of white striae in a reticular pattern with erythema and ulceration was present on the dorsum of the tongue. This lesion was consistent with a known history of oral chronic graft versus host disease. Moreover, we observed a suspected area of oral erythroplakia yet on the dorsum of the tongue. In biopsy specimen of hard palate histopathological examination revealed a diagnosis of verrucous xanthoma of the oral

2017 BMC research notes PubMed abstract

1940. The Effects of Palate Features and Glossectomy Surgery on /s/ Production (Full text)

The Effects of Palate Features and Glossectomy Surgery on /s/ Production The aims of this article were to determine the effects of hard palate morphology and glossectomy surgery on tongue position and shape during /s/ for patients with small tumors. The first expectation was that laminal /s/ would be more prevalent in patients, than apical, due to reduced tongue tip control after surgery. The second was that patients would hold the tongue more anteriorly than controls to compensate for reduced (...) tongue mass.Three-dimensional tongue volumes were calculated from magnetic resonance imaging for the whole tongue and the portion anterior to the first molar during the /s/ in /əsuk/ for 21 controls and 14 patients. These volumes were used to calculate tongue anteriority and cross-sectional shape. Dental casts were used to measure palate perimeter, height, and width of the hard palate.Palate height correlated with tongue height in controls (p < .05), but not patients. In patients, tongue anteriority

2017 Journal of speech, language, and hearing research : JSLHR PubMed abstract

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