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Tongue Carcinoma

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1921. Efficacy and Safety of Hou Gu Mi Xi in Patients With Spleen Qi Deficiency and Non-organic Gastrointestinal Disorders

or more Sign the informed consent Exclusion Criteria: Patients who have organic pathologic changes, including peptic ulcer, gastrointestinal erosions, gastroesophageal reflux disease, acute gastrointestinal hemorrhage or perforation, structural changes in gastrointestinal structure, gastrointestinal vascular diseases, ileus, and benign tumor Pregnancy or breast-feeding women Allergic to sample or sample composition impaired liver function, including one of following condition: a) total bilirubin > 2 (...) intervention for treating his/her gastrointestinal disorder patients with any malignant tumor patients who have severe mental disorders so that could not control his/her action and coordinate the treatment in this trial. patients who are unwilling to provider personal information and enter this trial patients who cannot understand and sign informed consent Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study

2017 Clinical Trials

1922. [Trial of device that is not approved or cleared by the U.S. FDA]

-snoring product in the past (by self-report) [These individuals may be included in the study if recruitment timeline dictates it] Exclusion Criteria (Snorer): Scored higher than a 9 on the Modified Snore Scale Score (MSSS>9) Scored higher than a 6 on the OSA 50 screener (OSA50>6) The presence of physical or mental limitations that would limit the ability to use the anti-snoring solutions. Any unstable medical condition like congestive heart failure, neuromuscular disease, renal failure, or cancer (...) , Netherlands). The Silent Night app also records snoring through the night and provides feedback to the user via a "snore score." Condition or disease Intervention/treatment Phase Snoring Device: Nasal Dilator Device: Mandibular Advancement Device: Positional Therapy Not Applicable Detailed Description: Silent Night is a solution for primary snorers to guide them to the proper anti-snoring solution. It consists of a mobile application, which had an intake questionnaire, guides users to one of three anti

2017 Clinical Trials

1923. Phage II Trial of Stathmin as Predictive Biomarker for TPF Induction Chemotherapy in OSCC

aminotransferase )/ASAT(aspartate transaminase ) <2.5 times the upper limit of normal (ULN), bilirubin <1.5 times ULN. Serum creatinine <1.5 times ULN. Written informed consent Exclusion Criteria: Distant metastatic disease and other cancers. Previous surgical procedure of the primary tumors or lymph nodes (except diagnostic biopsy). Previous radiotherapy or chemotherapy. Other previous malignancies within 5 years. Sever systematic diseases such as severe pulmonary or cardiac diseases. Legal incapacity (...) surgery and radiotherapy/chemoradiotherapy. Condition or disease Intervention/treatment Phase Neoplasm Neck Drug: docetaxel, cisplatin and 5-fluorouracil Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomized Phase II Trial of Low Stathmin Expression as a Predictive

2017 Clinical Trials

1924. A Study to Assess the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of ASP6981 in Subjects With Schizophrenia

clinically significant. Subject has any history or evidence of any clinically significant cardiovascular, gastro-intestinal endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric (other than schizophrenia or schizoaffective disorder), renal and/or other major disease or malignancy. Subject has a history of being diagnosed with moderate or severe tardive dyskinesia, bipolar disorder, major depressive disorder, personality disorders (...) as measured by cognitive function and neurophysiological biomarkers. The secondary purpose of this study is to evaluate the pharmacokinetics of ASP6981 in participants with schizophrenia. Condition or disease Intervention/treatment Phase Schizophrenia Drug: ASP6981 Drug: Placebo Phase 1 Detailed Description: This study will evaluate ASP6981 in stable participants with schizophrenia on stable doses of up to 2 second generation antipsychotic drugs for at least 2 months prior to screening. Participants

2017 Clinical Trials

1925. Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation

discoloration or tongue edema. Other Names: Palifermin Kepivance K Outcome Measures Go to Primary Outcome Measures : Percentage of patients with leukemia free survival [ Time Frame: Up to 1 year after transplant ] Leukemia Free Survival (LFS) at 1 year is the percentage of patients alive and without evidence of hematologic malignancy at 1 year after transplant. Secondary Outcome Measures : Average overall survival [ Time Frame: Up to 1 year after transplant ] Overall Survival (OS) at 1 year (...) Criteria: Patients with the following hematologic malignancies: Acute myelogenous leukemia (AML): High-risk AML including: Antecedent hematological disease (e.g., myelodysplasia (MDS)) Treatment-related leukemia Complete Remission (CR1) with poor-risk cytogenetics or molecular markers (e.g. Flt 3 mutation, 11q23, del 5, del 7, complex cytogenetics) Second complete remission (CR2) or third complete remission (CR3) Induction failure or 1st relapse with ≤ 10% blasts in the marrow Acute lymphoblastic

2017 Clinical Trials

1926. Prevalence of Oral Manifestations of Iron Deficiency Anemia in a Sample of Egyptian Population

of existing local factors for example traumatic ulcer on the tongue because of sharp tooth against tongue, angular cheilitis because of poor denture design and older age patients. Inflammatory diseases, malignancy, or recent surgery were excluded. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) as a hospital-based cross-sectional study on a sample of Egyptian patients in hematology department (no previous data recorded). Condition or disease Iron Deficiency Anemia Detailed Description: Study will be held in at the Hematology department at El Qasr Al-Einy Cairo University Hospital data collection started from February 2018 till end of April 2018 primary completion. Clinical examination performed for oral mucosa, the number and type of lesions will be recorded. Patients' age, sex, duration

2017 Clinical Trials

1927. Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin. Full Text available with Trip Pro

Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin. The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS).Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom (...) imaging system equipped with an endoscope.ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3). Detection of sentinel lymph nodes was attempted after injecting ICG:MSA in the mouse tongue cancer model (n = 3). During the operation, lymph nodes were easily identified and resected using ICFIS without the aid of other magnifiers. In the rabbit tongue cancer model (n = 3), the ICFIS equipped with 30-degree endoscopy

2017 Laryngoscope

1928. Real-time continuous image-guided surgery: Preclinical investigation in glossectomy. (Abstract)

of otolaryngology residents, fellows, medical students, and staff under a reproducible setting by using realistic tongue phantoms. Evaluators were grouped into a senior and a junior group based on surgical experience, and guided and unguided tumor resections were performed. National Aeronautics and Space Administration Task Load Index (NASA-TLX) scores and a Likert scale were used to measure workloads and impressions of the system, respectively. Efficacy was studied by comparing surgical accuracy, time

2017 Laryngoscope

1929. Management of the thyroid gland during laryngectomy. Full Text available with Trip Pro

Management of the thyroid gland during laryngectomy. This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement.A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total (...) gland involvement in laryngeal carcinoma. Most cases of gland involvement occurred by direct extension. Thyroidectomy during laryngectomy should be considered for advanced stage tumours with cartilage invasion.

2017 Journal of Laryngology & Otology

1930. Newly Described Entities in Salivary Gland Pathology. (Abstract)

low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion. Cribriform adenocarcinoma (CASG) is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma by location (ie, most often arising on the tongue), by prominent nuclear clearing, differing alterations of the PRKD gene family, and clinical behavior with frequent metastases at the time of presentation of the primary tumor. Early nodal (...) Newly Described Entities in Salivary Gland Pathology. Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secretory carcinoma is a distinctive

2017 American Journal of Surgical Pathology

1931. Using a pedicle pectoralis major musculocutaneous flap in head and neck reconstruction after modified radical mastectomy: A case report. Full Text available with Trip Pro

modified radical mastectomy (MRM) more than 20 years earlier.She had squamous cell carcinoma of the tongue and had undergone partial glossection and left modified radial neck dissection. Four months later, a left submandibular mass was noted with progressive enlargement and the biopsy revealed recurrent carcinoma.Left marginal mandibulectomy with radical neck dissection was performed and the neck area was reconstructed by a left pedicle PMMC flap harvested from the left chest wall which had (...) Using a pedicle pectoralis major musculocutaneous flap in head and neck reconstruction after modified radical mastectomy: A case report. A pedicle pectoralis major musculocutaneous (PMMC) flap is one of the strategies for head and neck reconstruction. Seldom studies reported the case in which the skin area of previous modified radical mastectomy (MRM) had been used as a PMMC flap in head and neck reconstruction.An 84-year-old female who had suffered from left breast cancer and undergone a left

2017 Medicine

1932. Radiographic Predictors of Difficult Laryngoscopy in Acromegaly Patients. (Abstract)

in acromegaly patients.Data on demographics, preoperative serum levels of pituitary hormones, and radiographic indices were collected from 90 acromegaly patients that underwent transsphenoidal removal for pituitary tumor from January 2010 to December 2016. Difficult laryngoscopy was defined as Cormack-Lehane grade ≥III.Difficult laryngoscopy occurred in 21 (23%) patients. In univariate analysis, age and radiographic indices indicating tongue size, such as tongue area (TA) on ostiomeatal unit computed (...) and radiographic predictors indicating large tongue size (large TA, long alveolar line of the mandible to the hyoid bone and mandible to the hyoid bone) were associated with an increased rate of difficult laryngoscopy in acromegaly patients. Preoperative radiographic measurements of tongue size can be helpful for safe airway management in such patients.

2017 Journal of neurosurgical anesthesiology

1933. Teriparatide therapy for severe, refractory osteoradionecrosis of the jaw. (Abstract)

risk of osteosarcoma seen in rat models. Hence, we first report here two patients with tongue cancer with late-emerging ORN who were successfully treated with TPTD for 4-6 months with serum calcium and vitamin D supplementation. In contrast to the usual progress of ORN, the bone defect regenerated well and bone turnover markers including serum C-terminal telopeptide of type 1 collagen and osteocalcin were restored with TPTD therapy. Our experience might suggest that TPTD therapy with careful

2017 Osteoporosis International

1934. Clavicle fracture with osteomyelitis after neck dissection and post-operative radiotherapy: case report. (Abstract)

with accessory nerve preservation and post-operative radiotherapy for submandibular lymph node metastases of tongue cancer. Four weeks after the radiotherapy, a clavicle fracture, with osteomyelitis and abscess formation in the pectoralis major muscle, occurred. Unlike in simple stress fracture, long-term antibiotic administration and drainage surgery were required to suppress the inflammation.As seen in the present patient, clavicle stress fractures may occur even after neck dissection in which (...) Clavicle fracture with osteomyelitis after neck dissection and post-operative radiotherapy: case report. Non-traumatic bone fractures in cancer patients are usually pathological fractures due to bone metastases. In head and neck cancer patients, clavicle stress fractures may occur as a result of atrophy of the trapezius muscle after neck dissection in which the accessory nerve becomes structurally or functionally damaged.A 71-year-old man underwent modified radical neck dissection

2017 Journal of Laryngology & Otology

1935. Vertical platysma myocutaneous flap reconstruction for oral defects using three different incision designs: experience with 68 cases. (Abstract)

Vertical platysma myocutaneous flap reconstruction for oral defects using three different incision designs: experience with 68 cases. This study evaluated the effects of three different incision designs for the vertical platysma myocutaneous flap (VPMF): apron, MacFee, and T-shaped. This flap was used for the reconstruction of intraoral defects following cancer ablation in selected patients. Sixty-eight cases of VPMF reconstruction were assessed: the apron incision was used in 28, MacFee (...) with the apron incision and one case with the MacFee incision. The MacFee incision had the best aesthetic effect, and the postoperative neck scar was more obvious for the T-shaped incision. It is recommended that VPMF with the MacFee or apron incision be used for the reconstruction of larger buccal mucosa and floor of the mouth defects, while VPMF with the T-shaped incision should be used for smaller intraoral defects, especially tongue defects of the lateral surface.Copyright © 2017 International

2017 International Journal of Oral and Maxillofacial Surgery

1936. Low-grade myofibroblastic sarcoma of the orbit: A case report and literature review. Full Text available with Trip Pro

Low-grade myofibroblastic sarcoma of the orbit: A case report and literature review. Low-grade myofibroblastic sarcoma (LGMS) is a malignant lesion composed of myofibroblasts. It is an uncommon tumor of unknown etiology that mainly develops in the bone or soft tissue and is most often reported in the head and neck, particularly in the tongue and oral cavity.A 2-year-old girl, previously well and with no significant medical history or family history of other diseases, presented with a 2-week (...) , there was no recurrence of the postoperative CT. The patient and her family were satisfied with the result of the surgery.Based on clinical characteristics and postoperative CT, we considered the mass may be a benign tumor. We completely resected along the capsule without an extensive surgical margin. However, postoperative histopathology diagnose LGMS, which shows a strong potential for local recurrence and vascular invasion. So we should close observation of the patient's symptoms and sign. If the tumor has invaded

2017 Medicine

1937. Ewing sarcoma of the oral cavity. A review Full Text available with Trip Pro

Ewing sarcoma of the oral cavity. A review A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity.A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operators were used: Ewing AND Sarcoma AND [tongue, jaw, maxilla, cheek, condyle OR temporomandibular (...) , floor AND mouth, gum OR gingiva, palate OR palatal, lip, uvula, head AND neck].Seventy-one cases of ES of the oral cavity were documented from 53 articles. The main differences versus ES of other locations were a younger age at manifestation, a shorter time from symptoms onset to diagnosis, and swelling as the most frequent clinical manifestation versus swelling and pain in the rest of disease locations. The way in which ES manifests in the oral cavity is varied and comprises dental displacement

2017 Journal of clinical and experimental dentistry

1938. Soft Tissue Schwannomas of the Hard Palate and the Mandibular Mentum Full Text available with Trip Pro

Soft Tissue Schwannomas of the Hard Palate and the Mandibular Mentum Schwannomas are benign, slow growing, encapsulated tumours that originate from the Schwann cells. Intraoral schwannomas are rare, and most of these tumours involve the tongue. They are rarely located in the hard palate or in the facial soft tissue. Herein, we present the clinical and histological features as well as the prognoses of two male patients with schwannoma, one of which was localized to the hard palate and the other

2017 Case reports in dentistry

1939. Ectopic Thyroid in Stomach; a Case Report Full Text available with Trip Pro

Ectopic Thyroid in Stomach; a Case Report An ectopic thyroid is a form of thyroid dysgenesis in which an entire or parts of the thyroid gland may be located in another part of the body than what is the usual place. The most frequent location is the base of tongue. Although most cases are asymptomatic, symptoms related to tumor size and its relationship with surrounding tissues, hormonal dysfunction and seldom malignancy may also occur. Any disease affecting the thyroid gland may involve (...) the ectopic thyroid, including malignancy.

2017 Iranian Journal of Pathology

1940. Mortality following single-fraction stereotactic body radiation therapy for central pulmonary oligometastasis Full Text available with Trip Pro

Mortality following single-fraction stereotactic body radiation therapy for central pulmonary oligometastasis The case of a 56-year-old male who developed bronchopulmonary hemorrhage after a course of stereotactic body radiation therapy (SBRT) for centrally located squamous cell lung carcinoma is presented. The patient was previously treated with concurrent chemoradiation for stage IVA squamous cell carcinoma of the base of tongue. He showed no evidence of disease for 4 years until he developed (...) a solitary metastasis of squamous cell carcinoma in the right hilum. He underwent a single fraction of 26 Gy with heterogeneity correction. He showed no evidence of disease for 13 months until he developed a sudden grade 4 bronchopulmonary hemorrhage. He underwent an urgent right pneumonectomy and later died of a post-operative complication. Pathologic analysis of the specimen revealed no evidence of tumor. Single-fraction SBRT of 26 Gy was sufficient to achieve complete response of his large central

2017 Journal of radiosurgery and SBRT

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