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Tongue Carcinoma

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1901. To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Suffer

, or cola) comprising usually more than 5 cups or glasses per day. Subject has a positive drug of abuse screening result. Subject has severe, unstable disease states (e.g. myocardial infarction, congestive heart failure, diabetes, cirrhosis, cancer, epilepsy, or stroke), pain syndromes, (e.g. fibromyalgia) or any medical or surgical condition that places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study or who (...) , 2017 Last Update Posted : April 7, 2017 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief Summary: To characterize the performance of the nasal dilator strip in lowering nasal resistance during sleep, promoting nasal route breathing and reducing the signs and symptoms of sleep disordered breathing in a group of chronic nocturnal nasal congestion sufferers who report trouble with their sleep. Condition or disease

2017 Clinical Trials

1902. A Controlled Comparison of Two DBS Targets for Upper Extremity Action Tremor

) of the total FTM-score, tremor of the upper limb(s) (same items as above) and of the items scoring tremor in the face, tongue, voice, trunk, lower limb(s). Change of patient evaluated scores at 1 year of stimulation (QUEST and VAS Global Burden Disease Burden (Tremor-burden) [ Time Frame: 1 year (+/- 4 weeks) after surgery ] Change from baseline to 1-yr of Quality of Life in Essential Tremor (QUEST) scale, and Visual Analogue Scale of Global Disease Burden as assessed by the patient. Frequency of serious (...) : South-Eastern Norway Regional Health Authority Information provided by (Responsible Party): Inger Marie Skogseid, Oslo University Hospital Study Details Study Description Go to Brief Summary: Action tremor of the arms can be an invalidizing symptom of diseases such as Essential Tremor, Dystonic Tremor, Parkinson's disease and Multiple Sclerosis. In this study we compare the efficacy and safety of two different brain targets for deep brain stimulation (DBS) that both are known to reduce action tremor

2017 Clinical Trials

1903. Human Immunome Program

Go to Brief Summary: The Human Immunome Program is a large-scale, open-source effort seeking to fill a major gap in our knowledge of the immune system. The power of the immune system to fight disease lies in its ability recognize and adapt to an astonishing range of threats from viruses, parasites and bacteria to cancer cells. Underlying this ability is a vast but specific set of genes and molecular structures known as the human immunome, or the "parts list" of the immune system. This study aims (...) of cancer including skin cancer. History of autoimmune disorders including but not limited to: Ulcerative colitis, Crohn's, Inflammatory Bowel Disease, Rheumatoid Arthritis, Scleroderma, Systemic lupus Erythematosus, Mixed Connective Tissue Disease, Graves, Autoimmune Thyroiditis, Hashimoto's Thyroiditis, Psoriasis, Multiple Sclerosis, Guillain-Barre Syndrome, Chronic Inflammatory demyelinating polyneuropathy, Myasthenia Gravis, Vasculitis, Alopecia areata, autoimmune hemolytic anemia, autoimmune

2017 Clinical Trials

1904. Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage

% (>48 mmol/mol) at screening. Subjects with LDLc, >7.5 mmol/l. TG level >10mmol/l. History of heart failure defined as NYHA class II ‐ IV or those with known LV dysfunction (EF<40%) regardless of symptomatic status History of malignancy within the past 5 years, other than non-melanoma skin cancer. Current life-threatening condition other than vascular disease (e.g. very severe chronic airways disease, HIV positive, life‐threatening arrhythmias) that may prevent a subject from completing the study (...) to patients with persistently raised blood pressure (hypertension). Half the patients will receive the beetroot juice containing inorganic nitrate and half will receive beetroot juice from which the inorganic nitrate has been removed. The volunteers will take the juice every day for 4 months. Condition or disease Intervention/treatment Phase Hypertension Dietary Supplement: Beetroot juice Phase 2 Detailed Description: In hypertension persistent raised blood pressure (BP) is associated with endothelial

2017 Clinical Trials

1905. EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation

or disease Intervention/treatment Phase Stomatitis Drug: EC-18 Drug: Placebo Phase 2 Detailed Description: This is a Phase 2, randomized, double-blind, placebo-controlled, 2-stage trial in subjects with squamous cell cancers of the mouth, oropharynx, hypopharynx and nasopharynx planned to receive standard fractionated IMRT-delivered radiotherapy with concomitant chemotherapy (cisplatin). Informed consent will be obtained from each subject prior to enrollment. The trial will be performed in 2 stages (...) : Enzychem Lifesciences Corporation Information provided by (Responsible Party): Enzychem Lifesciences Corporation Study Details Study Description Go to Brief Summary: This is a Phase 2, randomized, double-blind, placebo-controlled, 2-stage trial in subjects with squamous cell cancers of the mouth, oropharynx, hypopharynx and nasopharynx planned to receive standard fractionated IMRT-delivered radiotherapy with concomitant chemotherapy (cisplatin). Informed consent will be obtained from each subject prior

2017 Clinical Trials

1906. POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

syndrome, multiple sclerosis, schizophrenia, depression, etc.; Had severe head and face disease, trauma history or history of surgery; The serious body disease and tobacco, wine and other substance abuse history; The presence of malignant tumor with shorter survival disease. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please (...) tongue is chinese; The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; The Geriatric Depression Scale (GDS) grade 1 or 2; The important function without serious heart, brain, liver, kidney, lung and other organs; The ASA class I or II; The people signed informed consent. Exclusion Criteria: The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's

2017 Clinical Trials

1907. The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

or petechia in the tongue, etc. In fact, Qi stagnation and blood stasis are common pathological conditions that would occur on human body for several times in the long period of human's life. Besides, QS&BSS is associated with over 50 kinds of diseases including Coronary Heart Disease, hypertension, cerebral infarction, gastritis, arthritis, dysmenorrhea, chronic pelvic infection, skin disease, and cancer. Xue-Fu-Zhu-Yu Capsule, one of Chinese herbal medicine drugs, could perform the function of promoting (...) , randomized and placebo-controlled trial. The study aims to evaluate the effectiveness and safety of Xue-Fu-Zhu-Yu Capsule (XFZYC) for Qi Stagnation and Blood Stasis syndrome (QS&BSS). QS&BSS is one of the common Zhengs in Traditional Chinese Medicine, which manifests as various symptoms and signs, such as distending pain or tingling sensation in a fixed position, irritability or depression, dim complexion, lumps in body, blood spot under the skin, unsmooth or string-like pulse, purplish tongue

2017 Clinical Trials

1908. Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain

to, the risks described as precautions, warnings, and contraindications in the current version of the investigator's brochure for Buprenorphine Sublingual Spray), to be an unsuitable candidate to receive the study drug. Is receiving systemic chemotherapy, has an active malignancy of any type, or has been diagnosed with cancer within 5 years before Screening (excluding squamous or basal cell carcinoma of the skin). Is currently receiving anticoagulants (eg, heparin or warfarin). Low-dose aspirin (...) , cold sores, viral lesions, local irritation, or in the investigator's opinion has significant periodontal disease of the oral cavity. In addition, recent (within 1 year) piercing of the tongue or anywhere in the oral cavity. Has a surgical or medical condition of the GI or renal system that, in the investigator's opinion, might significantly alter the absorption, distribution, or excretion of any drug substance. Is considered by the investigator, for any reason (including, but not limited

2017 Clinical Trials

1909. Lingual Muscle Training in Late-Onset Pompe Disease (LOPD)

internet connection Access to use of electronic device that allows for FaceTime, Jabber, or WebEx use Exclusion Criteria: Neurodegenerative conditions (e.g. stroke, dementia) or other serious neurologic condition that would prevent meaningful study participation as determined at the discretion of the principle investigator Any current or past history of seizures. Infantile onset Pompe disease Head and neck cancer or radiation treatment to head/neck Inability to tolerate IOPI device tongue bulb (...) provided by (Responsible Party): Duke University Study Details Study Description Go to Brief Summary: This study is being done to test the effects of Lingual Muscle Therapy (LMT) in patients with Late-Onset Pompe Disease (LOPD) who have tongue weakness. The results of this study will help design future research studies about LMT in LOPD. Condition or disease Intervention/treatment Phase Glycogen Storage Disease Other: Lingual Muscle Training Not Applicable Study Design Go to Layout table for study

2017 Clinical Trials

1910. Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making

review for all biopsy results will be performed and incorporated into the final analyses. Condition or disease Intervention/treatment Palatal Neoplasms Lip Neoplasm Gingival Neoplasms Leukoplakia, Oral Tongue Neoplasms Oropharyngeal Neoplasms Oral Ulcer Device: OncAlert Detailed Description: Overview The OncAlert Oral Cancer RAPID Test (OncAlert RAPID) is a qualitative point-of-care lateral flow assay to aid in the decision to biopsy in patients with clinical features associated with oral potentially (...) malignant disorders and or oral/oropharyngeal cancer (i.e. head and neck squamous cell carcinoma). Proposed Intended Use Statement The device measures soluble CD44 and total protein in saliva samples collected in saline. The test is an adjunct to the biopsy decision process, and not intended as a screening or stand-alone diagnostic assay. To be used in adults 23 years and older. Not intended for use in pregnant women. STUDY OBJECTIVES The principal objectives of this study are to: Validate the OncAlert

2017 Clinical Trials

1911. Transcutaneous Electrical Acupoint Stimulation (TEAS) for Chronic Constipation

on quality of life measurements in this population, which supports investigation into other acupuncture-based self-care interventions. Given these findings, the investigators hypothesize that home patient-administered TEAS can provide measurable improvements in both symptom severity and health related quality of life. Condition or disease Intervention/treatment Phase Constipation - Functional Device: Verum TEAS Device: Sham TEAS Not Applicable Detailed Description: This study will be a double blinded (...) randomized controlled trial. Respondents will be screened by phone and qualified subjects will be sent home for 2 weeks to complete a bowel movement logbook, then return into the CEWM office where they will submit validated surveys (specifically, the PAC-SYM and PAC-QOL) and have a photo taken of their tongue. A baseline non-invasive heart rate variability (HRV) measurement will be taken at this time as well. Study personnel will instruct each subject on TEAS pad placement and how to use the device

2017 Clinical Trials

1912. Trial of Orencia in Patients With Myasthenia Gravis

the presence at screening of any severe, progressive or uncontrolled renal, hepatic, hematologic, gastrointestinal, pulmonary, cardiac, neurologic or cerebral disease, whether or not related to MG that, in the opinion of the Investigator, might place the subject at unacceptable risk for participation in the study. Female subject has a history of breast cancer screening that is suspicious for malignancy and in whom the possibility of malignancy cannot be reasonably excluded by additional clinical (...) , laboratory or other diagnostic evaluations Subject has a history of cancer in the last 5 years, other than non-melanoma skin cell cancers cured by local resection or carcinoma in situ Subject currently abuses drugs or alcohol Subject has evidence of active or latent bacterial or viral infections, including positive infectious disease laboratory test result (Hepatitis B, Hepatitis C or HIV) Subject has history of herpes zoster or cytomegalovirus (CMV) infection that resolved less than 2 months prior

2017 Clinical Trials

1913. Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions. Condition or disease Congenital Fibrosis of Extraocular Muscles Duane Retraction Syndrome Duane Radial Ray Syndrome Mobius Syndrome Brown Syndrome Marcus Gunn Syndrome Strabismus Congenital Horizontal Gaze Palsy Horizontal Gaze Palsy With Progressive Scoliosis Facial Palsy Facial Paresis, Hereditary, Congenital Third Nerve Palsy Fourth Nerve Palsy Sixth Nerve Palsy Synkinesis Ocular Motility (...) Disorders Levator-Medial Rectus Synkinesis Athabaskan Brainstem Dysgenesis Tongue Paralysis Ninth Nerve Disorder Fifth Nerve Palsy Seventh Nerve Palsy Eleventh Nerve Disorder Twelfth Nerve Disorder Vagus Nerve Paralysis Moebius Sequence Detailed Description: If left untreated or unrecognized, strabismus or misalignment of the eyes, can impair the development of normal vision and is recognized to be an inherited trait in some families. The Engle Lab has investigated the genetics of complex and common

2017 Clinical Trials

1914. Function of Jiangzhong Hou Gu® Mi Xi™ in Patients With Spleen Qi Deficiency and Peptic Ulcer Diseases

any agents or other intervention for treating his/her gastrointestinal disorder Patients with any malignant tumor Patients who have severe mental disorders so that could not control his/her action and coordinate the treatment in this trial. Patients who are unwilling to provider personal information and enter this trial Patients who cannot understand and sign informed consent Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your (...) Function of Jiangzhong Hou Gu® Mi Xiâ„¢ in Patients With Spleen Qi Deficiency and Peptic Ulcer Diseases Efficacy and Safety of Hou Gu Mi Xi in Patients With Peptic Ulcer Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

1915. Systemic Fungal Infections in ICU Patients

): Shaimaa Selim, Assiut University Study Details Study Description Go to Brief Summary: This study aims to : Diagnosis of Systemic fungal infections in ICU patients. Detection the most common fungal species in ICU. Detection of in vitro antifungal sensitivity pattern Condition or disease Intervention/treatment Fungal Infection Diagnostic Test: - Microscopic examination and culture of collected specimens Detailed Description: Systemic fungal infections are a significant and growing public health problem (...) surgery), the use of broad-spectrum antibiotics, parenteral nutrition, hemodialysis, mechanical ventilation, the presence of central vascular catheters, and therapy with immunosuppressive agents,Prolonged treatment with corticosteroids before ICU admission, liver cirrhosis with prolonged ICU stay (.7 days), solid organ cancer, HIV infection and lung transplantation are also considered as risk factors ,It can also occur following trauma or invasion of wounds covered with contaminated dressings, e.g

2017 Clinical Trials

1916. Macintosh Laryngoscope Assisted Fiberoptic Intubation

Inclusion Criteria: Adult patients with Modified Mallampati (NT-MMT) airway score III,VI American Society of Anaesthesiologists (ASA) physical class I-III Scheduled for elective cancer surgery under general anesthesia Exclusion Criteria: Modified Mallampati I,II Airway scored patients. History of upper airway surgery. Patients with serious deformities of the mandible, maxilla, tongue, pharynx or larynx. Patients with a history of significant cardiac and pulmonary diseases, Obesity with BMI >40, Epilepsy (...) Summary: During fiberoptic endotracheal intubation, the perfect airway exposure produced by the classic curved Macintosh laryngoscope in place of head tilt -chin lift-jaw thrust maneuver may increase the accuracy and produce rapid direct vocal cord access in a short time under Inhalation anesthesia to maintain the respiratory drive for grade III&VI Modified Mallampati . Condition or disease Intervention/treatment Phase Difficult Intubation Device: fiberoptic, airway Device: fiberoptic, Machintosh

2017 Clinical Trials

1917. Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation

Cancer Center: melphalan stem cell transplantation 17-404 hematopoietic cell transplantation HCT Additional relevant MeSH terms: Layout table for MeSH terms Multiple Myeloma Neoplasms, Plasma Cell Neoplasms by Histologic Type Neoplasms Hemostatic Disorders Vascular Diseases Cardiovascular Diseases Paraproteinemias Blood Protein Disorders Hematologic Diseases Hemorrhagic Disorders Lymphoproliferative Disorders Immunoproliferative Disorders Immune System Diseases (...) for details. ClinicalTrials.gov Identifier: NCT03276481 Recruitment Status : Recruiting First Posted : September 8, 2017 Last Update Posted : November 26, 2018 See Sponsor: Memorial Sloan Kettering Cancer Center Information provided by (Responsible Party): Memorial Sloan Kettering Cancer Center Study Details Study Description Go to Brief Summary: The purpose of this study is to study taste disturbances on patients with myeloma who received high dose melphalan. Condition or disease Intervention/treatment

2017 Clinical Trials

1918. Assessment of Pharmacokinetics and Safety of Diazepam Buccal Soluble Film in Pediatric Patients

during and in-between experiencing seizures. Condition or disease Intervention/treatment Phase Epilepsy Drug: Diazepam Buccal Soluble Film Phase 2 Detailed Description: This is a Multicenter , Open Label Crossover study to assess the Pharmacokinetics and Safety of Diazepam Buccal Soluble Film (DBSF) in Pediatric patients with Epilepsy. The Primary objective of the study is to assess the pharmacokinetics of DBSF in pediatric patients with epilepsy in interictal State (Period A) and ictal/peri-ictal (...) Treatment Periods and the Follow-up Visit, and must be willing to comply with all required study procedures and adhere to all protocol requirements. Subject and/or subject's parent(s) or legally authorized representative must be able to comprehend and be informed of the nature of the study, as assessed by the Investigator. Exclusion Criteria: Potential subjects meeting any of the following criteria will be excluded: Subjects with a progressive neurological disorder such as a brain tumor, demyelinating

2017 Clinical Trials

1919. Physiological Flow of Liquids Used in Dysphagia Management

management. Condition or disease Intervention/treatment Amyotrophic Lateral Sclerosis Parkinson Disease Dysphagia Diagnostic Test: Videofluoroscopic Swallowing Examination Other: Tongue Strength Measurement Detailed Description: This research study will measure swallowing function in individuals with Amyotrophic Lateral Sclerosis or Parkinson's disease. The aims of this study are to (1) identify parameters of swallowing physiology that are associated with impaired swallowing safety and efficiency, and (2 (...) isometric tongue presses). Participants will also be asked to swallow their saliva with the bulb placed in their mouth, three (3) times. Tongue pressure measurement will be completed twice in the data collection session - once at the beginning, and once at the end (following the videofluoroscopy). Parkinson's Disease We will be recruiting individuals with a diagnosis of Parkinson's disease, who experience speech or swallowing problems, to attend one data collection session. All participants will undergo

2017 Clinical Trials

1920. Efficacy and Safety of Hou Gu Mi Xi in Patients With Spleen Qi Deficiency and Non-organic Gastrointestinal Disorders

or more Sign the informed consent Exclusion Criteria: Patients who have organic pathologic changes, including peptic ulcer, gastrointestinal erosions, gastroesophageal reflux disease, acute gastrointestinal hemorrhage or perforation, structural changes in gastrointestinal structure, gastrointestinal vascular diseases, ileus, and benign tumor Pregnancy or breast-feeding women Allergic to sample or sample composition impaired liver function, including one of following condition: a) total bilirubin > 2 (...) intervention for treating his/her gastrointestinal disorder patients with any malignant tumor patients who have severe mental disorders so that could not control his/her action and coordinate the treatment in this trial. patients who are unwilling to provider personal information and enter this trial patients who cannot understand and sign informed consent Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study

2017 Clinical Trials

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