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Tongue Carcinoma

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1841. Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S

2008 Clinical Trials

1842. Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma. Full Text available with Trip Pro

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma. Recent proteomic studies identified Hsp27 as a highly over-expressed protein in oral squamous cell carcinoma (OSCC). Clinical studies that attempted to evaluate the prognostic values of Hsp27 yielded inconsistent results, which may be due to inclusion of OSCC cases from multiple anatomic sites. In this study, to determine the utility of Hsp27 for prognosis, we focused on oral tongue SCC (OTSCC), one (...) of the most aggressive forms of OSCC.Archival clinical samples of 15 normal oral tongue mucosa, 31 dysplastic lesions, 80 primary OTSCC, and 32 lymph node metastases were examined for Hsp27 expression by immunohistochemistry (IHC). Statistical analyses were carried out to assess the prognostic value of Hsp27 expression for patients with this disease.Dysregulation of Hsp27 expression was observed in dysplastic lesions, primary OTSCC, and lymph node metastases, and appears to be associated with disease

2009 BMC Cancer

1843. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Full Text available with Trip Pro

Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. There are controversies on the benefits of elective neck dissection (END) for oral tongue carcinoma.This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral tongue carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters

2009 Head & neck Controlled trial quality: uncertain

1844. Transoral resection for squamous cell carcinoma of the base of the tongue. Full Text available with Trip Pro

Transoral resection for squamous cell carcinoma of the base of the tongue. To review the oncologic and functional outcomes of patients with squamous cell carcinoma of the base of the tongue who underwent transoral tumor resection and neck dissection with or without postoperative adjuvant therapy.Retrospective medical record review.Tertiary referral center.All patients undergoing transoral resection of squamous cell carcinoma on the base of the tongue as part of their primary treatment from (...) metastasis.Transoral resection of squamous cell carcinoma of the base of the tongue with postoperative adjuvant therapy provided excellent local and regional control and minimized morbidity. Transoral resection is a reasonable treatment option for patients with oropharyngeal squamous cell carcinoma, resulting in very low overall loss of organ function in properly selected patients.

2009 Archives of Otolaryngology Head and Neck Surgery

1845. Expression of C-Myc mRNA in squamous cell carcinoma of the tongue. (Abstract)

Expression of C-Myc mRNA in squamous cell carcinoma of the tongue. The aim of this study was to evaluate clinical significance of C-myc mRNA in patients with tongue cancer.C-myc mRNA expression was studied by RT-PCR in peripheral blood of 25 tongue cancer patients and 24 controls. C-myc protein expression was studied by immunohistochemistry.In tongue cancer patients, pretherapeutic C-myc mRNA expression was significantly higher as compared to controls. In tumor tissues, a trend of low (...) was noted in 72% of the tumors and an inverse correlation was noted between C-myc protein expression and disease stage. In early stage disease, an inverse correlation was noted while in advanced stage disease, a positive correlation was noted.In tongue cancer, downregulation of C-myc mRNA associated with advancement of the disease and worse prognosis.

2007 Journal of Surgical Oncology

1846. Preliminary study of indirect CT lymphography-guided sentinel lymph node biopsy in a tongue VX2 carcinoma model. (Abstract)

Preliminary study of indirect CT lymphography-guided sentinel lymph node biopsy in a tongue VX2 carcinoma model. The feasibility of using indirect CT lymphography (CT-LG) to guide sentinel lymph node (SLN) biopsy in a rabbit model of tongue VX2 carcinoma with cervical lymph node metastasis was studied. Tongue VX2 carcinoma with cervical lymph node metastasis was induced in 19 rabbits by injecting VX2 carcinoma suspension into the tongue submucosa. SLN biopsy was performed under the guidance (...) of indirect CT-LG. SLN identification was performed by indirect CT-LG combined with blue dye injection in 2 rabbits. Tongue SLNs were identified preoperatively by indirect CT-LG and blue-stained SLNs were visualized intraoperatively. Only one SLN was enhanced in each side of the neck, lateral to the larynx-tracheal region. CT attenuation values of the enhanced SLNs were 782.4+/-46.6, 443.1+/-68.5, 180.3+/-20.6 and 80.5+/-10.7 HU at 1, 5, 15 and 20 min after contrast injection. Overall, ipsilateral SLN

2009 International Journal of Oral and Maxillofacial Surgery

1847. Metabolic Tumor Volumes by [(18)F]-Fluorodeoxyglucose PET/CT Correlate with Occult Metastasis in Oral Squamous Cell Carcinoma of the Tongue. (Abstract)

Metabolic Tumor Volumes by [(18)F]-Fluorodeoxyglucose PET/CT Correlate with Occult Metastasis in Oral Squamous Cell Carcinoma of the Tongue. To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue.Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (...) and SUV(max) showed only trends toward significance (P=0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P=0.04).MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.

2009 Annals of Surgical Oncology

1848. Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base. (Abstract)

Extended lateral pharyngotomy for selected squamous cell carcinomas of the lateral tongue base. In a retrospective review of an inception cohort of 26 patients with an isolated, previously untreated, moderately to well-differentiated invasive squamous cell carcinoma of the lateral tongue base, consecutively managed with an extended lateral pharyngotomy approach at a single tertiary referral care center, the authors review the key surgical points, highlight the potential technical pitfalls (...) classified as T1, T2, and T3-T4a, respectively.Such results suggest that extended lateral pharyngotomy should be integrated among the various conservative treatment options available to patients with selected carcinomas of the lateral tongue base.

2009 Rhinology and Laryngology

1849. Cardiac metastasis after squamous cell carcinoma of the base of tongue. (Abstract)

Cardiac metastasis after squamous cell carcinoma of the base of tongue. Metastases to the heart are rare. We report a case of squamous cell carcinoma of the base of tongue secondarily complicated with cardiac metastasis 6 months after surgical treatment resulted in successful local control.The lesion was found using computerized axial tomography in a patient with minimal cardiologic symptoms.The patient died shortly due to complications of his metastatic disease. No curative treatment

2009 American Journal of Otolaryngology

1850. Carcinoma of the tongue. (Abstract)

Carcinoma of the tongue. Based on the dialogue "The tongue" between Janellen Smith, MD, and Gary Brauner, MD. Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology.

2009 Journal of American Academy of Dermatology

1851. Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma. (Abstract)

Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma. Recent studies have found that in addition to promoting cellular invasion, overexpression of metalloproteinase -1 (MMP-1) is associated with the initial stages of cancer development. Extracellular matrix metalloproteinase inducer (EMMPRIN), a transmembrane glycoprotein, has been reported to be highly expressed in tumor cells and induce (...) production of MMPs from peritumor fibroblasts (PTFs) adjacent to the tumor cells. The expression of EMMPRIN in tongue squamous cell carcinoma (SCC) was investigated in this study. It was found that EMMPRIN was expressed at the cell membrane throughout the entire lesion in tongue SCC. Immunofluorescence staining localized EMMPRIN to the cell membrane in a highly invasive tongue SCC cell line (Tca 8113). EMMPRIN mRNA was expressed at a high level in Tca 8113, whereas MMP-1 mRNA was expressed in PTF

2009 International Journal of Oral and Maxillofacial Surgery

1852. Growth inhibition of a tongue squamous cell carcinoma cell line (Tca8113) in vitro and in vivo via siRNA-mediated down-regulation of skp2. (Abstract)

Growth inhibition of a tongue squamous cell carcinoma cell line (Tca8113) in vitro and in vivo via siRNA-mediated down-regulation of skp2. Human S-phase kinase-associated protein (skp) 2, the specific ubiquitin ligase subunit that targets the negative regulator p27(Kip1) of the cell cycle and brings about its degradation, is overexpressed in various cancers, including human oral squamous cell carcinomas; its expression levels are inversely related to those of p27(Kip1) in these cells. Recently

2008 International Journal of Oral and Maxillofacial Surgery

1853. Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. (Abstract)

Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis. It has been suggested that expression of cIAP-1 correlates with certain clinicopathological features. The possible significance of cIAP-1 expression in cervical lymph node metastasis of tongue squamous cell carcinoma (SCC) is investigated. Seventy-five (...) tongue SCCs were analyzed by immunohistochemistry. cIAP-1 immunoreactivity patterns were nuclear in 38 (51%), cytoplasmic in 47 (63%), and concurrent in 37 (49%) cases. Nuclear, cytoplasmic and concurrent cIAP-1 immunoreactions were significantly correlated with lymph node metastasis in tongue SCCs (P=0.0011, 0.0012, and 0.0006, respectively). The cleaved caspase-3, which is a marker of tumor apoptosis, and Ki-67 index, which is a marker of tumor proliferation, were immunohistochemically examined

2008 International Journal of Oral and Maxillofacial Surgery

1854. Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis. (Abstract)

Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis. To investigate the potential role of caspase-3 and caspase-8 protein expression in the biological behaviour of tongue squamous cell carcinoma.We conducted immunohistochemical analyses of 87 specimens of primary tongue squamous cell carcinoma, using monoclonal anti-caspase-3 and anti-caspase-8 antibodies. A digital image analysis assay was also (...) deregulation of caspase-8 and -3 is a frequent event in tongue squamous cell carcinoma. Activation of caspase-3, which is predominantly down-regulated, may be a crucial process for induction of apoptosis and response to therapeutic strategies.

2008 Journal of Laryngology & Otology

1855. Squamous cell carcinoma of the oral tongue: a 25-year, single institution experience. (Abstract)

Squamous cell carcinoma of the oral tongue: a 25-year, single institution experience. To report the characteristics, prognostic factors and treatment outcomes of 102 patients with squamous cell carcinoma of the oral tongue treated and followed up at a single institution over a 25-year period.This retrospective study was carried out by auditing the medical records of 102 patients diagnosed with squamous cell carcinoma of the oral tongue and treated at our institution between 1982 and 2007 (...) treatment (p = 0.001) and advanced disease stage (p = 0.05) were found to have a negative influence on survival.Our limited data suggest that, in Iran, squamous cell carcinoma of the oral tongue tends to present at a locally advanced stage, with a high frequency of locoregional failure and a poor outcome. Combined modality therapy should be considered for the majority of patients with squamous cell carcinoma of the tongue.

2008 Journal of Laryngology & Otology

1856. p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. Full Text available with Trip Pro

p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. The INK4A-ARF locus at chromosome 9p21 is frequently altered in head and neck squamous cell carcinoma (SCC) and encodes two distinct tumor suppressors, p16(INK4A) and p14(ARF). This study addressed the role of p14(ARF) as a potential prognostic marker in this disease.p14(ARF) protein expression was assessed by immunohistochemistry in a cohort of 140 patients with SCC (...) of the anterior tongue. Using univariate and multivariate Cox's proportional hazards models, the outcomes examined were time to disease recurrence or death, with or without clinicopathologic covariates, including nodal status, disease stage, treatment status, Ki-67 staining, and molecular markers with known functional or genetic relationships with p14(ARF) (p16(INK4A), p53, pRb, p21(WAF1/CIP1), E2F-1).On multivariate analysis, p14(ARF) positivity (nucleolar p14(ARF) staining and/or nuclear p14(ARF) staining

2005 Clinical Cancer Research

1857. Hyalinizing clear cell carcinoma of the base of tongue. (Abstract)

Hyalinizing clear cell carcinoma of the base of tongue. Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands. It is composed exclusively of epithelial cells with optically clear cytoplasm. There are only a few isolated cases reported in the literature involving the base of tongue. The treatment of choice is wide excision and selective neck dissection, with or without radiotherapy. The prognosis of these tumours is good. A 57-year-old male patient presented (...) with a lesion in the base of tongue, which was well enhanced on contrast computerized tomography scan. Once confirmed by biopsy, the hyalinizing clear cell carcinoma was resected via a transcervical approach. The patient underwent postoperative radiotherapy. There was no evidence of locoregional recurrence or distant metastasis at 18 months of follow up.

2007 International Journal of Oral and Maxillofacial Surgery

1858. Myokymia (fasciculation) of the tongue as a unique presentation of mucoepidermoid carcinoma. (Abstract)

Myokymia (fasciculation) of the tongue as a unique presentation of mucoepidermoid carcinoma. Neural invasion is a relatively common feature of squamous cell carcinomas of the head and neck and malignant salivary gland tumours. The symptoms depend on the location and the particular nerves involved, and include pain, anaesthesia, paraesthesia and cranial nerve palsy. The present case appears to be unique. A mucoepidermoid carcinoma showed evidence of neural involvement and presented with nerve

2007 International Journal of Oral and Maxillofacial Surgery

1859. Contralateral lymph neck node metastasis of primary squamous cell carcinoma of the tongue: a retrospective analytic study of 203 patients. (Abstract)

Contralateral lymph neck node metastasis of primary squamous cell carcinoma of the tongue: a retrospective analytic study of 203 patients. In primary squamous cell carcinoma (SCC) of the oral cavity, many clinical and histopathological factors have been described as predictive for cervical lymph-node metastasis, but there are no data available on this association for surgical resection of lateral tongue primary SCC. The aim of this study was to analyse factors related to contralateral neck (...) relapse in a series of 203 consecutive patients with SCC of the lateral aspect of the tongue treated by surgery with or without adjuvant radiotherapy. Several clinical features were analyzed. Histological study included pTNM classification, tumour size, surgical margins, extracapsular spread of lymph-node metastasis, perineural infiltration, peritumoral inflammation and bone involvement. The mean duration of follow up for surviving patients was 70.9+/-49.6 months; 47 patients eventually died

2007 International Journal of Oral and Maxillofacial Surgery

1860. Correlation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue. (Abstract)

Correlation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue. We examined expression of syndecan-1 in squamous cell carcinoma (SCC) of tongue using immunohistochemistry. Forty-three cases of SCC arising in lateral border of tongue were investigated. From the immunohistochemical staining pattern, the cases were divided into two groups based on expression of syndecan-1 at the supra-peripheral cells of the tumor nest: Group (...) correlates to histological grade, tumor size and mode of invasion in tongue SCC.

2006 International Journal of Oral and Maxillofacial Surgery

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