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Tongue Carcinoma

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1841. National trends in oropharyngeal cancer surgery and the effect of surgeon and hospital volume on short-term outcomes and cost of care. (Abstract)

in tonsil (OR, 1.4; P < .001) and tongue base (OR, 1.3; P = .001) tumors; an increase in patients aged 40 to 64 years (OR, 1.5; P < .001); a decrease in partial glossectomy (OR, 0.8; P < .001), pharyngectomy (OR, 0.8; P = .003), mandibulectomy (OR, 0.6; P < .001) and laryngectomy procedures (OR, 0.6; P < .001); and an increase in prior radiation (OR, 1.7; P = .026), advanced comorbidity (OR, 1.4; P = .007), and wound complications (OR, 1.5; P = .029), compared to 1993 through 2000. High-volume hospitals (...) National trends in oropharyngeal cancer surgery and the effect of surgeon and hospital volume on short-term outcomes and cost of care. The past 2 decades have witnessed an increase in the use of chemoradiation in the treatment of oropharyngeal cancer. We sought to characterize contemporary patterns of oropharyngeal cancer surgical care and the effect of volume on surgical care and short-term outcomes.Retrospective cross-sectional study.Using the Nationwide Inpatient Sample database, temporal

2011 Laryngoscope

1842. Unilateral Radiotherapy for the Treatment of Tonsil Cancer. (Abstract)

recurrence and was salvaged with contralateral neck dissection only and remains alive and free of disease. The other patient presented with a contralateral base of tongue tumor and involved cervical lymph node, which may have represented a second primary tumor, and died of disease.Unilateral radiotherapy for patients with TX-T2, N0-N2b primary tonsil carcinoma results in high rates of disease control, with low rates of contralateral nodal failure and a low incidence of acute toxicity requiring (...) Unilateral Radiotherapy for the Treatment of Tonsil Cancer. To assess, through a retrospective review, clinical outcomes of patients with squamous cell carcinoma of the tonsil treated at the M. D. Anderson Cancer Center with unilateral radiotherapy techniques that irradiate the involved tonsil region and ipsilateral neck only.Of 901 patients with newly diagnosed squamous cell carcinoma of the tonsil treated with radiotherapy at our institution, we identified 102 that were treated using

2011 Biology and Physics

1843. The Effect of Prophylactic Swallowing Exercises on Head and Neck Cancer Patients

provided by (Responsible Party): Icahn School of Medicine at Mount Sinai Study Details Study Description Go to Brief Summary: The purpose of this study is to find out if doing prophylactic or preventative swallowing exercises from the start of cancer treatment can improve the ability to swallow when the treatment is completed and beyond. Condition or disease Intervention/treatment Phase Dysphagia Behavioral: Swallowing Exercise Group Not Applicable Detailed Description: Study Type: Prospective (...) the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion criteria: Patient diagnosed with head and neck cancer who will be receiving radiation therapy either alone of with chemotherapy as their treatment modality. Exclusion criteria: Patients with a history of neurologic disease Patients with previous head and neck cancer

2011 Clinical Trials

1844. LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy

Patients with smoking history of less than or equal to 10 pack years and with primary tumour site of base of tongue and/or tonsil Any other malignancy (except for simultaneous HNSCC primaries, appropriately treated superficial basal cell skin cancer and surgically cured cervical cancer in situ) unless free of disease for at least five years Known pre-existing Interstitial Lung Disease (ILD) Pregnancy or breast feeding Contacts and Locations Go to Information from the National Library of Medicine (...) carcinoma (HNSCC). The objectives of the trial are to compare the efficacy and safety of afatinib (BIBW 2992) with placebo as adjuvant therapy to patients who have received definitive chemo-radiotherapy. Condition or disease Intervention/treatment Phase Head and Neck Neoplasms Drug: Placebo Drug: Afatinib Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 617 participants Allocation: Randomized Intervention Model: Parallel

2011 Clinical Trials

1845. Induction Chemo Then Concurrent Chemoradiotherapy With Cetuximab in Locally Advanced Head and Neck Squamous Cell Cancer

portals; the lower neck node bearing area will be treated through an anterior port. The standard total dose for the targeted tumor bed and electively treated lymphatics is 50 Gy/25 fractions, and then, an additional boost dose to the neoplasm-bearing site(s) of 16 Gy to 20 Gy. The total dose received by the spinal cord should not be allowed to exceed 46 Gy. For N1 to N3 disease, they also shall need a total dose (boost included) of 66 Gy and perhaps up to 70 Gy if it can be safely given 6.4 Study (...) cancer Prior history of radiation to head and neck area Known malignancy other than the current cancer Uncontrolled intercurrent illness including but not limited to ongoing active infection, history of cardiac disease, e.g. uncontrolled hypertension, unstable angina, congestive heart failure, myocardial infarction within last six months or ventricular arrhythmias requiring medication, psychiatric illness that would impair patients ability to comply with study requirements Pregnant or lactating women

2011 Clinical Trials

1846. Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)

Last Update Posted: April 20, 2016 Last Verified: April 2016 Keywords provided by Keunchil Park, Samsung Medical Center: neoadjuvant chemotherapy definitive chemoradiation therapy head and neck cancer base of tongue Locally advanced Additional relevant MeSH terms: Layout table for MeSH terms Hypopharyngeal Neoplasms Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Neoplasms Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases (...) Volunteers: No Criteria Inclusion Criteria: Histologically/cytologically proven stage III/IVM0 hypopharyngeal or base of tongue cancer One or more evaluable or measurable lesion No prior chemotherapy, radiation, or surgery ECOG 0-2 Exclusion Criteria: Distant metastasis Other malignancy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2011 Clinical Trials

1847. Everolimus, Carboplatin, and Paclitaxel in Locally Advanced Head and Neck Cancer That Cannot Be Removed by Surgery

carcinoma of the hypopharynx stage IV squamous cell carcinoma of the larynx stage IV verrucous carcinoma of the larynx stage IV squamous cell carcinoma of the lip and oral cavity stage IV verrucous carcinoma of the oral cavity stage IV squamous cell carcinoma of the oropharynx tongue cancer Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma, Squamous Cell Head and Neck Neoplasms Squamous Cell Carcinoma of Head and Neck Carcinoma Neoplasms, Glandular and Epithelial Neoplasms (...) ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase I/II trial is studying the side effects and best dose of giving everolimus together with carboplatin and paclitaxel in treating patients with locally advanced head and neck cancer that cannot be removed by surgery. Condition or disease Intervention/treatment Phase Head and Neck Cancer Drug: carboplatin Drug: RAD001 Drug: paclitaxel Phase 1 Phase 2 Detailed Description

2011 Clinical Trials

1848. TLR8 Agonist VTX-2337 and Cetuximab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Squamous Cell Cancer of Head and Neck

: April 13, 2011 Last Update Posted: March 5, 2015 Last Verified: March 2015 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Squamous Cell Carcinoma of Head and Neck Salivary Gland Neoplasms Nasopharyngeal Carcinoma Paranasal Sinus Neoplasms Neoplasms, Unknown Primary Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type (...) . Condition or disease Intervention/treatment Phase Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous

2011 Clinical Trials

1849. Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation Therapy

Carcinoma, Squamous Cell Head and Neck Neoplasms Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Salivary Gland Neoplasms Paranasal Sinus Neoplasms Neoplasms, Unknown Primary Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases (...) (RAD001) and erlotinib hydrochloride together with radiation therapy in treating patients with recurrent head and neck cancer previously treated with radiation therapy. RAD001 and erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x rays to kill tumor cells. Giving RAD001 and erlotinib hydrochloride together with radiation therapy may kill more tumor cells. Condition or disease Intervention/treatment

2011 Clinical Trials

1850. Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients. (Abstract)

an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests.70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant (...) Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients. To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer.This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign

2011 Medicina oral, patología oral y cirugía bucal Controlled trial quality: uncertain

1851. Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer. (Abstract)

in vitro; in vivo; and on histological analysis with sufficient tumor-to-background ratios of the contrast agents.This study demonstrates the feasibility of optical imaging of oral squamous cell carcinoma based on targeting of αvβ3 integrins and the EPR effect. Once these NIR fluorescence agents become available for clinical testing, optical image-guided surgery could reduce residual disease after oral cancer surgery.Copyright © 2011 Wiley Periodicals, Inc. (...) and retention (EPR) effect in an orthotopic mouse model of oral cancer.Binding of the integrin-targeted agent to tumor cells was assessed in vitro. Oral cancer was induced in 6 BALB/c nu/nu mice by submucosal inoculation of human OSC19-luc cells into the tongue. Tumor growth was followed with bioluminescence imaging. A combination of agents targeting integrins or EPR effect was injected followed by fluorescence imaging in vivo and ex vivo after resection of the tongues.Oral cancer was clearly demarcated

2011 Journal of Surgical Oncology

1852. Dysphagia

in the pharynx to account for the patients’ symptoms [15,16]. A study by Miles et al [12] of 111 patients with complaints of dysphagia for solids showed that 68% had abnormal esophageal transit and in one-third of these the abnormality in the esophagus was the only finding. In addition, patients with pharyngeal carcinomas have a significantly increased risk of synchronous esophageal carcinomas. A complete examination of the esophagus should be performed once a pharyngeal tumor is identified [15]. In patients (...) inlet and the xiphoid process. Because retrosternal dysphagia can be caused by esophageal motility disorders or by structural abnormalities of the esophagus or cardia (ie, esophagitis, rings, strictures, or tumors), a biphasic esophagram is the preferable imaging procedure. Fluoroscopy Biphasic Esophagram The biphasic esophagram permits detection of both structural and functional abnormalities of the esophagus. Structural lesions include esophagitis, strictures, rings, and carcinoma. Functional

2013 American College of Radiology

1853. Treatment and recommendations for homeless people/Unstably Housed Patients with HIV/AIDS

with other medical or service providers rather than making passive referrals. Facilitate patients’ ability to self-manage their own HIV disease. ? Access to mainstream health care system – Network with community service providers and medical sub-specialists to facilitate specialty referrals; assist with transportation; accompany patients to appointments; consider the use of treatment advocates, peer navigators, and others who can facilitate access and retention in HIV care and services. Engagement (...) intervention, related to either HIV disease progression, new opportunistic infections (OIs) or co-morbid conditions, or potential side effects of therapy; assess for chronic symptomatology (weight loss, increasing fatigue, fevers/night sweats, cognitive dysfunction, etc.). ? Current living situation – Ask where the patient sleeps and spends time during day; document patient contact information and specify how to contact clinical team. Ask about access to food, shelter, restrooms, place to store medications

2013 National Health Care for the Homeless Council

1854. Clinical Practice Guideline for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit

of Critical Care Medicine (ACCM) is currently developing separate guidelines on analgesia and sedation for pediatric ICU patients. This version of the guidelines places a greater emphasis on the psychometric aspects of PAD monitoring tools. It includes both pharmacologic and nonpharmacologic approaches to manage PAD in ICU patients. There is also greater emphasis placed on preventing, diagnosing, and treating delirium , reflecting our growing understanding of this disease process in critically ill (...) 50% or higher in both medical and surgical ICU patients ( , . In addition to experiencing pain at rest ( ) and pain related to surgery, trauma, burns, or cancer, patients also experience procedural pain ( ). This was highlighted in the first practice guideline published on acute pain management 20 yr ago by the Agency for Health Care Policy and Research ( ). Pain related to procedures is ubiquitous, and inadequate treatment of procedural pain remains a significant problem for many ICU patients

2013 Society of Critical Care Medicine

1855. Improving Voice Outcomes After Thyroid Surgery

dissection or completion thyroidectomy, based on the extent of disease and final pathology results. Surgeons performing thyroidectomy include otolaryngologists and general surgeons. Thyroid surgery rates have tripled over the past 3 decades. Between 118,000 and 166,000 patients in the United States undergo thyroidectomy per year for benign or malignant disease. Thyroidectomy is performed on patients of both genders, but more commonly on women. Thyroid cancer is the most common malignancy of the endocrine (...) system and the cancer with the fastest growing incidence among women. It is estimated that 36,550 women and 11,470 men (48,020 total) in the United States were diagnosed with thyroid cancer in 2011, with 56,000 projected in 2012. Palpable thyroid nodules occur in 3% to 7% of the population; ultrasound indicates that the actual prevalence of thyroid nodules is up to 50%. On fine needle aspiration biopsy (FNAB), 5% of thyroid nodules are malignant and 10% are suspicious. FNAB has increased

2013 American Academy of Otolaryngology - Head and Neck Surgery

1856. Practice Guidelines for Management of the Difficult Airway

. , age, obesity, obstructive sleep apnea, history of snoring) and difficult laryngoscopy or intubation ( Category B2-H evidence ). Observational studies report difficult intubation or extubation occurring in patients with mediastinal masses ( Category B3-H evidence ). , Case reports of difficult laryngoscopy or intubation among patients with a variety of acquired or congenital disease states ( e.g. , ankylosis, degenerative osteoarthritis, subglottic stenosis, lingual thyroid or tonsillar hypertrophy (...) ( Category B4-H evidence ). One observational study reports that the laryngeal tube provides adequate ventilation for 95% of patients with pharyngeal and laryngeal tumors. ILMA. RCTs comparing the ILMA with standard laryngoscopic intubation were only available for nondifficult airway patients. Observational studies report successful intubation in 71.4–100% of difficult airway patients when an ILMA was used ( Category B3-B evidence ). One observational study indicated that when the ILMA is used

2013 American Society of Anesthesiologists

1857. Bell's palsy

for Bell’s palsy has been identified. Other conditions may cause facial paralysis, including stroke, brain tumors, tumors of the parotid gland or infratemporal fossa, cancer involving the facial nerve, and systemic and infectious diseases, including zoster, sarcoidosis, and Lyme disease. , - Bell’s palsy is typically self-limited. Bell’s palsy may occur in men, women, and children but is more common in those 15 to 45 years old; those with diabetes, upper respiratory ailments, or compromised immune (...) , skin cancers on the head or face, parotid tumors, facial/head trauma, or recent infections ( ). The timing of onset of symptoms remains important. Symptoms associated with neoplastic or infectious causes of facial paralysis often progress gradually, relative to the sudden-onset characteristic of Bell’s palsy. Symptoms suggestive of Bell’s palsy may include pain in the ear and postauricular region; weakness of facial musculature, including the inability to chew food without difficulty; poor

2013 American Academy of Otolaryngology - Head and Neck Surgery

1858. Infectious causes of cancer

cause cancer in animals, especially leukemias and lymphomas. Human T cell lymphotropic virus ( ) was the first human discovered by and colleagues at . The virus causes , a disease first described by Takatsuki and colleagues in Japan and other neurological diseases. is the most recently discovered human cancer virus, isolated from tissues in 2008, by the same group that discovered /HHV-8 in 1994, using a new technology called . About 80% of Merkel cell carcinomas are caused by Merkel cell (...) polyomavirus; the remaining tumors have an unknown etiology and possibly a separate histogenesis. This is the only member of this group of viruses known to cause human cancer but other polyomaviruses are suspects for being additional cancer viruses. does not directly cause cancer, but it is associated with a number of malignancies, especially , , and . Kaposi's sarcoma is caused by . -related cases of anal cancer and cervical cancer are commonly caused by . After HIV destroys the immune system, the body

2012 Wikipedia

1859. HPV-positive oropharyngeal cancer Full Text available with Trip Pro

in advanced cases, with up to 90% local control and disease specific survival. Postoperative swallowing was excellent in 87%, but long term dysphagia was associated with larger (T4) cancers, especially if involving the base of the tongue. The details of the surgical approach depend on the location and size of the primary tumour and its N stage. to examine the draining lymph nodes may be carried out simultaneously or as a second staging procedure. For tumours of the tonsil and lateral pharyngeal wall (...) accept reduced radiation. Carcinoma of unknown primary [ ] In some situations HPV+OPC may present with cervical lymph nodes but no evident disease of a primary tumour (T0 N1-3) and is therefore classed as . The lack of any such evidence of a primary tumour occurs in 2-4% of patients presenting with metastatic cancer in the cervical nodes. The incidence of HPV positivity is increasing at a similar rate to that seen in OPC. In such situations, resection of the lingual and palatine tonsils, together

2012 Wikipedia

1860. Laryngeal cancer Full Text available with Trip Pro

Laryngeal cancer Laryngeal cancer - Wikipedia Laryngeal cancer From Wikipedia, the free encyclopedia Laryngeal cancer Other names Cancer of the larynx, laryngeal carcinoma Larynx cancer - endoscopic view Laryngeal cancer are mostly , reflecting their origin from the skin of the larynx. can develop in any part of the , but the cure rate is affected by the location of the tumour. For the purposes of tumour , the larynx is divided into three anatomical regions: the (true vocal cords, anterior (...) on the site, stage (tumour size, nodal spread, distant ), and histological type. The overall health and wishes of the patient must also be taken into account. A prognostic multigene classifier has been shown to be potentially useful for the distinction of laryngeal cancer of low or high risk of recurrence and might influence the treatment choice in future. Staging [ ] Epithelial tumors are classified according to the guidelines set by the International Union Against Cancer (UICC) (3,4). Staging considers

2012 Wikipedia

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