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1,845 results for

Tongue Carcinoma

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1841. Split-course radiation therapy of carcinoma of the base of the tongue: results of a prospective national collaborative clinical trial conducted by the Radiation Therapy Oncology Group. (PubMed)

Split-course radiation therapy of carcinoma of the base of the tongue: results of a prospective national collaborative clinical trial conducted by the Radiation Therapy Oncology Group. One hundred forty-one patients with carcinoma of the base of tongue were randomized to receive either continuous course radiotherapy (6600 rad in 30/33 fractions over 7-8 weeks) or split course therapy (3000 rad in 10 fractions over 2 weeks, a three-week rest, 3000 rad in 10 fractions over 2 weeks). Both

1983 International journal of radiation oncology, biology, physics Controlled trial quality: uncertain

1842. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. (PubMed)

Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. This paper presents the first report of an ongoing prospective randomised clinical trial in early T1T2N0 carcinoma of the oral tongue. The problems of regular follow-up in an indigent population from the vast rural expanse of India has been successfully overcome in this trial by close personal follow-up. The trial addresses itself specifically to prophylactic vs. therapeutic surgical (...) management of the neck in T1T2N0 patients with cancer of the oral tongue. Overall disease, free survival (median follow-up 22 months) is higher (64% vs. 47%) in the group receiving prophylactic neck dissection. Disease-free survival for those with positive nodes at prophylactic neck dissection was twice that of those who underwent a subsequent therapeutic neck dissection (57% vs. 28%). Contralateral neck node metastasis has been identified as a significant factor in neck failures in those patients

1989 Seminars in surgical oncology Controlled trial quality: uncertain

1843. [Clinical experience with different modes of preoperative radiotherapy in advanced carcinomas of the tongue and the floor of the mouth]. (PubMed)

[Clinical experience with different modes of preoperative radiotherapy in advanced carcinomas of the tongue and the floor of the mouth]. In a controlled prospective study of 90 patients with locally advanced but operable epidermoid carcinomas (T2/T3N0-3M0) of the tongue and the floor of the mouth underwent 3 types of preoperative radiation: 1.5 x 5 Gy; 2.15 x 2 Gy and 3.5 x 2.5 Gy. The preoperative radiation led to a marked decrease of local recidives and to a lengthening of the recidive-free

1990 Deutsche Zeitschrift für Mund-, Kiefer- und Gesichts-Chirurgie Controlled trial quality: uncertain

1844. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. (PubMed)

Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. A prospective, randomized trial was carried out to assess the value of elective versus therapeutic neck dissection in early squamous cell carcinoma of the oral tongue. Disease-free survival (median follow-up 20 months) was 52 percent versus 63 percent in patients who underwent hemiglossectomy alone and those who underwent hemiglossectomy and radical neck dissection, respectively (difference not statistically

1989 American journal of surgery Controlled trial quality: uncertain

1845. Nuclear DNA content and p53 overexpression in stage I squamous cell carcinoma of the tongue compared with advanced tongue carcinomas. (PubMed)

Nuclear DNA content and p53 overexpression in stage I squamous cell carcinoma of the tongue compared with advanced tongue carcinomas. To evaluate the predictive value of the nuclear DNA content (image cytometry) and p53 overexpression (immuno-histochemistry using antibody CM-1) in uniformly treated stage I carcinomas of the mobile tongue. Also, to compare stage I carcinomas with advanced tongue carcinomas (stages II-IV).Archival formalin fixed, paraffin wax embedded tumour specimens from 54 (...) patients with stage I squamous cell carcinoma and 37 patients with advanced squamous cell carcinoma were analysed. Mean follow up time of the stage I carcinomas was 71 months (median, 62.5; range, 6-175).Twenty three patients (stage I) had recurring disease: 10 had local recurrence (in the tongue) and 13 had regional recurrence (cervical metastases). Locally recurring stage I carcinomas had a more pronounced DNA deviation than the other stage I carcinomas and this degree of deviation was comparable

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1998 Molecular Pathology

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