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Tongue Carcinoma

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1821. Guidelines in head and neck oncology compliance and consequences of deviations from the standard protocol for tongue and floor of mouth squamous carcinoma. (PubMed)

Guidelines in head and neck oncology compliance and consequences of deviations from the standard protocol for tongue and floor of mouth squamous carcinoma. To investigate the extent of violation of a regional guideline for the treatment of patients with carcinoma of the tongue/floor of mouth (ICD0 C02, C04). Different aspects of protocol violation (i.e. undertreatment or overtreatment) and consequences for treatment outcome were evaluated.Retrospective analysis of data from medical records.The (...) Department of Maxillofacial and Oral Surgery and the Department of Otorhinolaryngology and Head and Neck Surgery of the University Medical Centre Utrecht.A total of 217 patients treated between 1991 and 2001 for a stage II and stage III carcinoma of the tongue/floor of mouth.Protocol violation, tumour recurrence.The overall adherence to the guideline was 55%. In the non-adherence group of patients, 21% were overtreated, 71% were undertreated, and 8% were both overtreated and undertreated

2005 Clinical Otolaryngology

1822. Hyalinizing clear cell carcinoma of the base of tongue. (PubMed)

Hyalinizing clear cell carcinoma of the base of tongue. Hyalinizing clear cell carcinoma is a rare, low-grade neoplasm of the minor salivary glands. It is composed exclusively of epithelial cells with optically clear cytoplasm. There are only a few isolated cases reported in the literature involving the base of tongue. The treatment of choice is wide excision and selective neck dissection, with or without radiotherapy. The prognosis of these tumours is good. A 57-year-old male patient presented (...) with a lesion in the base of tongue, which was well enhanced on contrast computerized tomography scan. Once confirmed by biopsy, the hyalinizing clear cell carcinoma was resected via a transcervical approach. The patient underwent postoperative radiotherapy. There was no evidence of locoregional recurrence or distant metastasis at 18 months of follow up.

2007 International Journal of Oral and Maxillofacial Surgery

1823. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. (PubMed)

Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Squamous cell carcinoma (SCC) of the tongue is a common malignancy of the oral cavity. Furin convertase activates several precursor matrix metalloproteinases involved in the degradation of the extracellular matrix. The pattern of expression of furin and vascular endothelial growth factor-C (VEGF-C), two key molecules in neoplasm development, was examined during (...) the progression from normal epithelium to invasive SCC.We evaluated furin and VEGF-C expression and microvessel density (MVD) by immunohistochemistry in human tongue sections harboring normal epithelium, dysplastic epithelium, and/or SCC. Sections from 46 glossectomy specimens were assessed for furin expression. A selected group of 15 cases, each containing normal epithelium, precursor lesions, and invasive SCC, were further studied for furin and VEGF-C expression and MVD quantification. We also evaluated

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2004 Clinical Cancer Research

1824. Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. (PubMed)

Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. Patients with oral tongue carcinoma treated by intraoral excision only should be followed up carefully for cervical lymph node metastasis and salvaged immediately if found, because some patients have a more aggressive clinical course. The purpose of this study was to find useful markers for predicting late cervical metastasis in patients with stage I and II invasive squamous (...) cell carcinoma of the oral tongue.We investigated clinicopathologic factors and immunohistochemical biomarkers predicting late cervical metastasis in surgical specimens from 56 patients with T(1-2)N(0)M(0) invasive squamous cell carcinoma of the oral tongue who did not undergo elective neck dissection. Histopathologic factors including tumor thickness, mode of invasion, Broders grade, total score of three different malignancy grading systems, eight other clinicopathologic parameters

2004 Clinical Cancer Research

1825. p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. (PubMed)

p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. The INK4A-ARF locus at chromosome 9p21 is frequently altered in head and neck squamous cell carcinoma (SCC) and encodes two distinct tumor suppressors, p16(INK4A) and p14(ARF). This study addressed the role of p14(ARF) as a potential prognostic marker in this disease.p14(ARF) protein expression was assessed by immunohistochemistry in a cohort of 140 patients with SCC (...) of the anterior tongue. Using univariate and multivariate Cox's proportional hazards models, the outcomes examined were time to disease recurrence or death, with or without clinicopathologic covariates, including nodal status, disease stage, treatment status, Ki-67 staining, and molecular markers with known functional or genetic relationships with p14(ARF) (p16(INK4A), p53, pRb, p21(WAF1/CIP1), E2F-1).On multivariate analysis, p14(ARF) positivity (nucleolar p14(ARF) staining and/or nuclear p14(ARF) staining

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2005 Clinical Cancer Research

1826. Overexpression of E2F-1 is associated with increased disease-free survival in squamous cell carcinoma of the anterior tongue. (PubMed)

Overexpression of E2F-1 is associated with increased disease-free survival in squamous cell carcinoma of the anterior tongue. Overexpression of E2F-1 is associated with increased invasiveness in head and neck squamous cell carcinoma cell lines in vitro, but its significance in vivo is unknown. This study sought to determine the relationship between E2F-1 and retinoblastoma protein (pRb) expression and disease outcome in squamous cell carcinoma (SCC) of the anterior tongue.pRb and E2F-1 protein (...) expression was assessed by immunohistochemistry in a cohort of 145 patients with SCC of the anterior tongue. The outcomes examined were time to disease recurrence or death. The relationships between E2F-1 or pRb expression and outcome were assessed by univariate and multivariate Cox's proportional hazards model, with or without clinicopathological covariates, including nodal status, disease stage, treatment status, and molecular markers (cyclin D1, p16(INK4A), and Ki-67) previously measured

2003 Clinical Cancer Research

1827. Perivascular-submandibular lymph node metastasis in squamous cell carcinoma of the tongue and floor of mouth. (PubMed)

Perivascular-submandibular lymph node metastasis in squamous cell carcinoma of the tongue and floor of mouth. The goal of this study was to investigate the incidence of occult metastasis in perivascular lymph node and nodal recurrence in these nodal pads in squamous cell carcinoma (SCC) of the tongue and floor of mouth.We performed a prospective analysis of the incidence of an occult metastasis in the perivascular lymph nodes in 55 patients (41 with an oral tongue carcinoma and 14 with a mouth (...) floor carcinoma) who underwent an elective supraomohyoid neck dissection (SOHND) for SCC of the tongue and floor of mouth, from 1997 to 2002. 99 SOHND procedures were performed as follows: 72 in tongue carcinomas and 27 in the mouth floor carcinomas.Clinically occult, but pathologically positive perivascular lymph nodes occurred in four of 72 of the tongue carcinomas and two of 27 of the mouth floor carcinomas. The incidence of the regional recurrence at level I was three of 45.This preliminary

2004 European Journal of Surgical Oncology

1828. Effect of treatment time on outcome of radiotherapy for oral tongue carcinoma. (PubMed)

Effect of treatment time on outcome of radiotherapy for oral tongue carcinoma. To investigate the importance of total treatment time on the outcome of external beam radiotherapy (EBRT) followed by internal brachytherapy for the treatment of oral tongue carcinoma.Ninety-four patients with T1-T2N0 squamous cell carcinoma of the oral tongue were treated using 35-40 Gy EBRT followed by 35-40 Gy interstitial (137)Cs brachytherapy between 1985 and 1995. The interval between the end of EBRT (...) ).The total treatment time was associated with the local control rate in the RT of oral tongue carcinoma. The loss in local control was estimated to be 2.0% per additional day in our series for oral tongue carcinoma.

2003 Biology and Physics

1829. Exclusive low-dose-rate brachytherapy in 279 patients with T2N0 mobile tongue carcinoma. (PubMed)

Exclusive low-dose-rate brachytherapy in 279 patients with T2N0 mobile tongue carcinoma. To evaluate the therapeutic results obtained with (192)Ir low-dose-rate interstitial brachytherapy in T2N0 mobile tongue carcinoma.Between December 1979 and January 1998, 279 patients with T2N0 mobile tongue carcinoma were treated by exclusive low-dose-rate brachytherapy, with or without neck dissection. (192)Ir brachytherapy was performed according to the "Paris system" with a median total dose of 60 Gy (...) , esophagus, or bronchus).Exclusive low-dose-rate brachytherapy is an effective treatment for T2 tongue carcinoma. Regional control and survival are excellent in patients undergoing systematic neck dissection, which is mandatory in our experience because of a high rate of occult lymph node metastases.

2005 Biology and Physics

1830. Tongue carcinoma: tumor volume measurement. (PubMed)

Tongue carcinoma: tumor volume measurement. To validate the semiautomated methods of tongue carcinoma tumor volume measurement by comparing the conventional manual trace method with 2 semiautomated computer methods: seed growing and region deformation.The study population consisted of 16 patients with histology-proven tongue carcinoma. Two head-and-neck radiologists independently measured the tumor volume demonstrated on pretreatment T2-weighted magnetic resonance data sets. The tumor volumes (...) tracing and semiautomated segmentation methods in interobserver reliability at pixel level.The semiautomated methods could achieve satisfactory segmentation results. They could also reduce interoperator variance and obtain a higher interobserver reliability. This study validates the use of semiautomated volume measurement methods for tongue carcinoma.

2004 Biology and Physics

1831. Combined-modality treatment for advanced oral tongue squamous cell carcinoma. (PubMed)

Combined-modality treatment for advanced oral tongue squamous cell carcinoma. The aim of this study was to investigate prognostic factors in advanced-stage oral tongue cancer treated with postoperative adjuvant therapy and to identify indications for adjuvant concomitant chemoradiotherapy (CCRT).We retrospectively reviewed the records of 201 patients with advanced squamous cell carcinoma of the oral tongue managed between January 1995 and November 2002. All had undergone wide excision and neck

2007 Biology and Physics

1832. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. (PubMed)

Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe. Although the association between human papillomavirus infection and tonsillar carcinoma is now well established, to the authors' knowledge little is known about incidence trends in tonsillar carcinoma among younger adults. The objective of the current study was to explore the trends in both oral cavity (...) and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.Using the 1973-2001 Surveillance, Epidemiology and End Results (SEER) database, we computed age, race, and site-specific trends of oral and pharyngeal (excluding nasopharynx) carcinoma incidence rates. The percent change (PC) and annual percent change (APC) were computed to explore trends in incidence rates over time.There were 2262 SCC of the oral cavity and 1251 SCC of the pharynx reported

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2005 Cancer

1833. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. (PubMed)

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Regional lymph node metastasis is the most reliable predictor of treatment outcomes for patients with squamous cell carcinoma of the oral tongue (SCCOT). A recent American Joint Committee on Cancer staging update of malignant melanoma has incorporated pathologic lymph node staging. The authors hypothesized that pathologic lymph node staging (pN) would be a more reliable

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2003 Cancer

1834. Management of the node negative early carcinoma tongue (PubMed)

Management of the node negative early carcinoma tongue To determine the role of thickness of the primary lesion in early Squamous Cell Carcinoma (SCC) of the oral tongue for decision-making regarding the management of possible occult cervical node metastases.Tertiary referral centrePatients who were treated by the authors for early (T1, T2) primary lesions in the oral tongue in two malignancy treatment centres of the Armed Forces Medical Services were included in this prospective study. Where (...) % and this compares well with survival rates achieved by other workers.Treatment of neck nodes in early (T1,T2) SCC of the oral tongue can be expectant in cases where tumour thickness is less than 04 mm, but where it is more than 04 mm elective treatment of the neck is recommended.

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2007 Indian Journal of Otolaryngology and Head & Neck Surgery

1835. Expression of C-Myc mRNA in squamous cell carcinoma of the tongue. (PubMed)

Expression of C-Myc mRNA in squamous cell carcinoma of the tongue. The aim of this study was to evaluate clinical significance of C-myc mRNA in patients with tongue cancer.C-myc mRNA expression was studied by RT-PCR in peripheral blood of 25 tongue cancer patients and 24 controls. C-myc protein expression was studied by immunohistochemistry.In tongue cancer patients, pretherapeutic C-myc mRNA expression was significantly higher as compared to controls. In tumor tissues, a trend of low (...) was noted in 72% of the tumors and an inverse correlation was noted between C-myc protein expression and disease stage. In early stage disease, an inverse correlation was noted while in advanced stage disease, a positive correlation was noted.In tongue cancer, downregulation of C-myc mRNA associated with advancement of the disease and worse prognosis.

2007 Journal of Surgical Oncology

1836. Significance of neo-angiogenesis and immuno-surveillance cells in squamous cell carcinoma of the tongue (PubMed)

Significance of neo-angiogenesis and immuno-surveillance cells in squamous cell carcinoma of the tongue Neo-angiogenesis is an essential process in physiological and pathological conditions. However, it is a complex process. Several studies demonstrated that intra-tumoural microvessel number is a significant predictor of metastasis and clinical outcome in many tumours, including oral malignancies. The immuno-surveillance cells, mast cells and eosinophils are implicated in the biological (...) . Therefore, this study was designed to investigate the prognostic value of microvessel, mast cell and eosinophil densities in the context of clinico-pathological parameters and survival in squamous cell carcinoma of the tongue.Anti-CD105 and anti-tryptase monoclonal antibodies were utilized to highlight and count microvessels and mast cells respectively in 81 cases of tongue squamous cell carcinoma. Eosinophils were demonstrated using carbol chromotrope histochemical stain. The densities were counted per

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2007 The Libyan journal of medicine

1837. Imaging of tongue carcinoma (PubMed)

Imaging of tongue carcinoma The tongue enables taste and plays a critical role in formation of food bolus and deglutition. The tongue is also crucial for speech and the earliest sign of tongue paresis is a change in the quality of speech. Given the importance of the tongue, tongue carcinoma should be accurately staged in order to optimise treatment options and preserve organ function. The intent of this review is to familiarize radiologists with the pertinent anatomy of the tongue (...) and the behaviour of tongue carcinoma so as to map malignant infiltration accurately.(c) International Cancer Imaging Society.

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2006 Cancer Imaging

1838. Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue (PubMed)

Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor (...) . The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

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2007 Head and neck pathology

1839. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (PubMed)

The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. Amplification at chromosome 3q26.3 is a common and crucial event in head and neck squamous cell carcinoma (HNSCC), impacting significantly on tumor progression and clinical outcome. Two novel oncogenes, namely squamous cell carcinoma (SCC)-related oncogene (SCCRO) and PIK3CA (gene encoding phosphatidylinositol-3 kinase catalytic alpha (...) -polypeptide), have been identified as targets of 3q26.3 amplification. This study aimed to delineate the role of SCCRO and PIK3CA in the pathogenesis of oral tongue SCC.The association between gene copy number for SCCRO and PIK3CA measured by fluorescence in situ hybridization and level of mRNA expression quantitated by real-time reverse transcription-PCR was assessed in a panel of human HNSCC cell lines. In addition, gene expression in 49 consecutive primary SCCs of the oral tongue was determined

2003 Clinical Cancer Research

1840. Carcinoma of the tongue: pathological considerations in management of the neck. (PubMed)

Carcinoma of the tongue: pathological considerations in management of the neck. In a series of 76 patients with carcinoma of the tongue the occurrence of metastasis was related to the size and histological features of the primary tumour. 64% of patients with metastasis and 10% of patients with clinically negative neck showed spread beyond the node capsule. Fast tracks (long lymphatic pathways uninterrupted by nodes) seemed to be involved in the spread of metastatic cancer in at least 20

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1996 Journal of the Royal Society of Medicine

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