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Tongue Carcinoma

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1801. Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. (PubMed)

Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. The objective of this study was to compare survival in patients with squamous cell carcinoma (SCC) of the oral tongue with that in patients with SCC in other oral cavity subsites.Patients with stage I and II (T1-T2N0M0) SCC of the oral cavity diagnosed between 1988 and 2004 were queried by using the Surveillance, Epidemiology, and End Results (SEER) database. The log-rank test was used to compare the overall (...) survival (OS) and cause-specific survival (CSS) of patients who had oral tongue SCC with those of patients who had SCC of other oral cavity subsites. A Cox proportional hazards multivariate analysis was performed to evaluate the influence of covariates on the risk of CSS and OS.Between 1988 and 2004, 6791 patients with stage I and II SCC of the oral cavity were identified. Among them, 40% had oral tongue SCC, and 60% had SCC of other oral cavity subsites. The median patient age was 64 years. The 5-year

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2007 Cancer

1802. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (PubMed)

The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. Amplification at chromosome 3q26.3 is a common and crucial event in head and neck squamous cell carcinoma (HNSCC), impacting significantly on tumor progression and clinical outcome. Two novel oncogenes, namely squamous cell carcinoma (SCC)-related oncogene (SCCRO) and PIK3CA (gene encoding phosphatidylinositol-3 kinase catalytic alpha (...) -polypeptide), have been identified as targets of 3q26.3 amplification. This study aimed to delineate the role of SCCRO and PIK3CA in the pathogenesis of oral tongue SCC.The association between gene copy number for SCCRO and PIK3CA measured by fluorescence in situ hybridization and level of mRNA expression quantitated by real-time reverse transcription-PCR was assessed in a panel of human HNSCC cell lines. In addition, gene expression in 49 consecutive primary SCCs of the oral tongue was determined

2003 Clinical Cancer Research

1803. Carcinoma of the tongue: pathological considerations in management of the neck. (PubMed)

Carcinoma of the tongue: pathological considerations in management of the neck. In a series of 76 patients with carcinoma of the tongue the occurrence of metastasis was related to the size and histological features of the primary tumour. 64% of patients with metastasis and 10% of patients with clinically negative neck showed spread beyond the node capsule. Fast tracks (long lymphatic pathways uninterrupted by nodes) seemed to be involved in the spread of metastatic cancer in at least 20

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1996 Journal of the Royal Society of Medicine

1804. Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for stage I tongue carcinomas. (PubMed)

Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for stage I tongue carcinomas. To assess the clinical value of malignancy grading systems compared with nuclear DNA content, protein p53, and angiogenesis for predicting recurrence of stage I (UICC, 1987) tongue carcinomas.Histopathological malignancy grading according to Jakobsson and tumour front grading according to Bryne et al were performed on haematoxylin and eosin slides. DNA analysis was performed (...) by image cytometry. Protein p53 and angiogenesis were evaluated by immunohistochemical analysis using antibody CM1 and antibody against factor VIII related antigen, respectively.49 patients with stage I carcinomas of the mobile tongue were included, all treated by local surgical excision alone. Eight patients (16%) suffered from local recurrence during follow up, and 13 (27%) had regional recurrence. Both Jakobsson's malignancy grading system and p53 immunoreactivity proved to be useful predictors

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1999 Journal of Clinical Pathology

1805. Giant cell arteritis of the tongue associated with squamous cell carcinoma. (PubMed)

Giant cell arteritis of the tongue associated with squamous cell carcinoma. 2794070 1989 11 09 2018 11 13 0021-9746 42 9 1989 Sep Journal of clinical pathology J. Clin. Pathol. Giant cell arteritis of the tongue associated with squamous cell carcinoma. 1001 Misselevitch I I Fradis M M Podoshin L L Barel E E Boss J H JH eng Letter England J Clin Pathol 0376601 0021-9746 AIM IM J Clin Pathol. 1990 Apr;43(4):349 2386572 Carcinoma, Squamous Cell complications Giant Cell Arteritis complications (...) Humans Tongue blood supply Tongue Neoplasms complications 1989 9 1 1989 9 1 0 1 1989 9 1 0 0 ppublish 2794070 PMC501805 J Laryngol Otol. 1983 May;97(5):479-83 6854145 Ann Otol Rhinol Laryngol. 1987 Jul-Aug;96(4):373-9 3619280 Ann Intern Med. 1972 Dec;77(6):845-52 4644163 Ann Intern Med. 1967 Jan;66(1):77-86 6015594

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1989 Journal of Clinical Pathology

1806. Radiotherapy of stage I and II carcinomas of the mobile tongue and/or floor of the mouth. (PubMed)

Radiotherapy of stage I and II carcinomas of the mobile tongue and/or floor of the mouth. From 1977 to 1990, 94 evaluable patients were treated with iridium-192 implantation in the Centre Claudius Regaud for a Stage I (52 patients) or a Stage II (42 patients) squamous cell carcinoma of the mobile tongue and/or the floor of the mouth. Interstitial brachytherapy was associated with external irradiation in 68 patients (group 1; mean dose, 48 Gy for external irradiation, 26 Gy for brachytherapy (...) ) or was exclusive in 26 patients (group 2; mean dose, 66 Gy). The mean follow-up was 44 months. Eleven acute complications were noted during or immediately after the implant (1 lethal myocardial infarction, 6 hematomas of the tongue which spontaneously resolved, 3 local sepsis). The mean duration of the mucositis was 9 weeks (from 4 to 20 weeks). Ten patients (17%) experienced a late complication (8 in group 1, 2 in group 2): 3 bone necroses requiring hemimandibulectomy (1 post-operative death), 1 tongue

1994 Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

1807. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. (PubMed)

Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. This paper presents the first report of an ongoing prospective randomised clinical trial in early T1T2N0 carcinoma of the oral tongue. The problems of regular follow-up in an indigent population from the vast rural expanse of India has been successfully overcome in this trial by close personal follow-up. The trial addresses itself specifically to prophylactic vs. therapeutic surgical (...) management of the neck in T1T2N0 patients with cancer of the oral tongue. Overall disease, free survival (median follow-up 22 months) is higher (64% vs. 47%) in the group receiving prophylactic neck dissection. Disease-free survival for those with positive nodes at prophylactic neck dissection was twice that of those who underwent a subsequent therapeutic neck dissection (57% vs. 28%). Contralateral neck node metastasis has been identified as a significant factor in neck failures in those patients

1989 Seminars in surgical oncology

1808. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. (PubMed)

Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. A prospective, randomized trial was carried out to assess the value of elective versus therapeutic neck dissection in early squamous cell carcinoma of the oral tongue. Disease-free survival (median follow-up 20 months) was 52 percent versus 63 percent in patients who underwent hemiglossectomy alone and those who underwent hemiglossectomy and radical neck dissection, respectively (difference not statistically

1989 American journal of surgery

1809. [Clinical experience with different modes of preoperative radiotherapy in advanced carcinomas of the tongue and the floor of the mouth]. (PubMed)

[Clinical experience with different modes of preoperative radiotherapy in advanced carcinomas of the tongue and the floor of the mouth]. In a controlled prospective study of 90 patients with locally advanced but operable epidermoid carcinomas (T2/T3N0-3M0) of the tongue and the floor of the mouth underwent 3 types of preoperative radiation: 1.5 x 5 Gy; 2.15 x 2 Gy and 3.5 x 2.5 Gy. The preoperative radiation led to a marked decrease of local recidives and to a lengthening of the recidive-free

1990 Deutsche Zeitschrift für Mund-, Kiefer- und Gesichts-Chirurgie

1810. [Evolution of the N0 patients with primary carcinoma of the oral tongue treated by interstitial radiumtherapy (author's transl)]. (PubMed)

[Evolution of the N0 patients with primary carcinoma of the oral tongue treated by interstitial radiumtherapy (author's transl)]. In a retrospective and not randomized clinical study we have selected 175 cases of squamous carcinoma of the anterior 2/3 of the tongue treated by interstitial radium therapy on the primary from January 1959 to December 1970. At the end of the treatment 64 patients (36.6%) were operated by radical neck dissection in homolateral lymphatic areas and 111 underwent

1981 La Radiologia medica

1811. Split-course radiation therapy of carcinoma of the base of the tongue: results of a prospective national collaborative clinical trial conducted by the Radiation Therapy Oncology Group. (PubMed)

Split-course radiation therapy of carcinoma of the base of the tongue: results of a prospective national collaborative clinical trial conducted by the Radiation Therapy Oncology Group. One hundred forty-one patients with carcinoma of the base of tongue were randomized to receive either continuous course radiotherapy (6600 rad in 30/33 fractions over 7-8 weeks) or split course therapy (3000 rad in 10 fractions over 2 weeks, a three-week rest, 3000 rad in 10 fractions over 2 weeks). Both

1983 International journal of radiation oncology, biology, physics

1812. MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells. (PubMed)

MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells. Various human cancer cells express tumor-associated trypsinogen-2 (TAT-2), which can efficiently activate matrix metalloproteinases (MMPs) in vitro. MMP-2 and MMP-9 are particularly associated with the invasive malignant potential of several tumors. To investigate the role of TAT-2 in tumor invasion, we overexpressed TAT-2 in two malignant human squamous cell carcinoma cell lines of tongue and in non

2002 Journal of Dental Research

1813. Hyalinizing clear cell carcinoma of the base of the tongue. (PubMed)

Hyalinizing clear cell carcinoma of the base of the tongue. Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC). Most of the HCCC occur in the oral

2002 Journal of Laryngology & Otology

1814. Long-term survival outcome in transhyoid resection of base of tongue squamous cell carcinoma. (PubMed)

Long-term survival outcome in transhyoid resection of base of tongue squamous cell carcinoma. The transhyoid approach for the resection of squamous cell carcinoma (SCC) of the base of the tongue continues to evolve and remains controversial. We previously reported that the functional outcome of this operation is superior to that of the traditional transmandibular approaches.To report our long-term survival rates for T1, T2, and select T3 SCCs of the base of the tongue using the transhyoid (...) approach.Twenty-eight patients with SCC of the base of the tongue were treated using a transhyoid approach at the University of California, Los Angeles, Medical Center between 1981 and 1998.All 28 patients underwent simultaneous neck dissection, and 27 patients underwent postoperative radiation therapy. The majority of the patients had advanced stage III or IV SCC. Twenty-five of the 28 patients had clear margins in the final pathologic specimen. The overall 3- and 5-year patient survival rates were 88.5

2002 Archives of Otolaryngology Head and Neck Surgery

1815. Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma. (PubMed)

Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma. There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral tongue carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral tongue carcinoma, (2) squamous cell (...) carcinoma, (3) primary surgical treatment.Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data.Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival.Bcl-2 expression played a minor role in oral tongue carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis

2002 European Journal of Surgical Oncology

1816. Nuclear DNA content and p53 overexpression in stage I squamous cell carcinoma of the tongue compared with advanced tongue carcinomas. (PubMed)

Nuclear DNA content and p53 overexpression in stage I squamous cell carcinoma of the tongue compared with advanced tongue carcinomas. To evaluate the predictive value of the nuclear DNA content (image cytometry) and p53 overexpression (immuno-histochemistry using antibody CM-1) in uniformly treated stage I carcinomas of the mobile tongue. Also, to compare stage I carcinomas with advanced tongue carcinomas (stages II-IV).Archival formalin fixed, paraffin wax embedded tumour specimens from 54 (...) patients with stage I squamous cell carcinoma and 37 patients with advanced squamous cell carcinoma were analysed. Mean follow up time of the stage I carcinomas was 71 months (median, 62.5; range, 6-175).Twenty three patients (stage I) had recurring disease: 10 had local recurrence (in the tongue) and 13 had regional recurrence (cervical metastases). Locally recurring stage I carcinomas had a more pronounced DNA deviation than the other stage I carcinomas and this degree of deviation was comparable

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1998 Molecular Pathology

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