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Tongue Carcinoma

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1781. SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration. (Abstract)

SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration. Oral cancer has a high annual incidence rate all over the world, and the tongue is the most frequently affected anatomic structure. The current standard care is ablative surgery of malignant neoplasm, followed by tongue reconstruction with free flap. However, such reconstructive modalities with postsurgery radiotherapy or chemotherapy can hardly support the functional recovery of the tongue-particularly, functional taste (...) with GMSC/SIS-ECM or exosome/SIS-ECM as compared with SIS-ECM control. Moreover, our data show that GMSCs or their derivative exosomes promoted innervation of regenerated taste buds, as evidenced by elevated expressions of neurofilament and P2X3 at the injury areas. Together, our findings indicate that GMSC/SIS-ECM and exosome/SIS-ECM constructs can facilitate taste bud regeneration and reinnervation with promising potential application in postsurgery tongue reconstruction of patients with tongue cancer.

2018 Journal of Dental Research

1782. Ustekinumab for the Treatment of Relapse of Refractory Giant Cell Arteritis

extractions, eye surgery, outpatient surgery, skin surgery) Patient with other autoimmune or auto-inflammatory disease (except RPP, autoimmune thyroiditis, Addison's disease, type 1 diabetes, Biermer's disease and presence of autoantibodies without clinical manifestation) Neoplasia < 5 years (excluding in situ cervical cancer and skin carcinomas, excluding melanomas, with healthy margin resections [R0]). Patient who has received an organ transplant (apart from a corneal transplant) Patient who has (...) with refractory GCA. Under treatment, the patient did not have a new relapse and the dose of prednisone was reduced. In addition, there was a major decrease in the percentages of circulating Th1 and Th17 lymphocytes. However, to date, no controlled studies have been conducted to confirm the efficacy of ustekinumab during GCA relapses. This guarantees the originality and innovation of this study. Condition or disease Intervention/treatment Phase Patients Relapsing Refractory Giant Cell Arteritis Drug

2018 Clinical Trials

1783. Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

head and face disease, trauma history or history of surgery; Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) Identifier: NCT03703973 Recruitment Status : Recruiting First Posted : October 12, 2018 Last Update Posted : October 12, 2018 See Sponsor: Xuzhou Medical University Information provided by (Responsible Party): Han Yuan, Xuzhou Medical University Study Details Study Description Go to Brief Summary: To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。 Condition or disease Intervention/treatment Postoperative Cognitive Dysfunction Diagnostic Test: Neuropsychology

2018 Clinical Trials

1784. Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia

not having French as their mother tongue Patients with left handedness Other neurological pathology or general disorder or major physical deficits than can interfere with cognitive functioning MRI or PET contraindication, 18-FDG contraindication Cerebral MRI data compatible with a pathological process other than the one related to SD (Vascular, traumatic, tumoral, infectious, or metabolic brain injury). A moderate or discrete leukoaraiosis will not be considered as a non- inclusion criterion (patients (...) or chirurgical intervention on the brain or the skull), skin lesions of the scalp, skull metal implants. - Patients under curatorship or tutorship - Women whose pregnancy is known or who do not have effective contraception if they are of reproductive age (checked by urinary test), breastfeeding. Healthy controls: Subjects not having French as their mother tongue Subjects having a neurological or psychiatric disease or major deficits than can interfere with cognitive functioning MRI or PET contraindication

2018 Clinical Trials

1785. Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment, and Dietary Intervention

and documented conditions or concurrent diagnoses, including (and not necessarily limited to) active cancer, severe heart disease, significant cognitive impairment, eating disorders, significant psychiatric illness, end-stage COPD, severe pulmonary hypertension, or organ transplant. Concomitant use of interfering medication(s) or devices currently or within the month prior to enrollment, including anti-retrovirals, human monoclonal antibodies, supplemental daytime oxygen, and insulin pumps. Severe (...) outcomes of WTC-LI in the study group vs controls. Condition or disease Intervention/treatment Lung Injury Particulate Matter Inhalation Injury Dietary Supplement: Low-Calorie Mediterranean Diet Combination Product: Technology based monitoring and behavioral participation Other: Usual care group Detailed Description: Investigators propose to measure metabolites on this expanded cohort with serum sampled before and after 6-month intervention with calorie restricted Mediterranean diet to: 1) determine

2018 Clinical Trials

1786. Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS)

Posted : July 9, 2018 Last Update Posted : January 16, 2019 See Sponsor: Elijah W. Stommel Collaborator: Brain Chemistry Labs, Institute for Ethnomedicine Information provided by (Responsible Party): Elijah W. Stommel, Dartmouth-Hitchcock Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the tolerability of L-Serine oral doses for ALS patients and assess preliminary indications of efficacy Condition or disease Intervention/treatment Phase (...) of disease. The ALSFRS includes ten questions that ask the physician to rate his/her impression of the patients level of functional impairment in performing one of ten common tasks, e.g. climbing stairs. Each task is rated on a five-point scale from 0 = can't do, to 4 = normal ability. Individual item scores are summed to produce a reported score of between 0=worst and 40=best. Efficacy based on neurological exam [ Time Frame: Baseline, 6 months ] Change in neurological exams with testing of muscle

2018 Clinical Trials

1787. A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication

bilirubin [TBL]) or a result > 1.5 times above the upper limit of normal (ULN) at screening or repeated within 1 week prior to potential randomization (day 1). In such a case, the assessment may be repeated once Subject has any history or evidence of any clinically significant allergic, cardiovascular, gastrointestinal, endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, history of seizure disorder, renal and/or other major disease or malignancy (...) will also evaluate the effects of ASP4345 compared to placebo on functional capacity using the University of California San Diego Performance-based Skills Assessment-2 Extended Range (UPSA-2-ER) total score and evaluate the pharmacokinetic profile of ASP4345 and its metabolites, if necessary. Condition or disease Intervention/treatment Phase Schizophrenia Drug: ASP4345 Drug: placebo Drug: risperidone Drug: quetiapine Drug: olanzapine Drug: ziprasidone Drug: aripiprazole Drug: brexpiprazole Drug

2018 Clinical Trials

1788. A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)

, methamphetamine, cocaine, barbiturates, methadone and/or its metabolites, ecstasy). Participant has self-reported severe, unstable disease states (e.g. myocardial infarction, congestive heart failure, diabetes, cirrhosis, cancer, epilepsy, or stroke), pain syndromes, (e.g. fibromyalgia) or any medical or surgical condition that places the Participant at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study or who in the judgement (...) . Condition or disease Intervention/treatment Phase Congestion, Nasal Device: Breathe Right Tan (small/medium) nasal strips Other: Placebo nasal strip Phase 2 Detailed Description: The study had a screening phase, a one-week baseline qualification and a two-week treatment phase. Participants who met the entrance criteria, who were currently suffering from nasal congestion every night or almost every night, reported trouble with their sleep and had baseline nasal openness scores at bedtime during

2018 Clinical Trials

1789. A Pivotal Subjective Sleep Study of a Nasal Dilator (Breathe Right Tan)

more than 3 drinks per day) or has a recent history (within last 2 years) of substance or alcohol abuse Participant has a positive urine drug screening result (dipstick) for drugs of abuse (cannabinoids, opiates, amphetamines, methamphetamine, cocaine, barbiturates, methadone and/or its metabolites, ecstasy). Participant has self-reported severe, unstable disease states (e.g. myocardial infarction, congestive heart failure, diabetes, cirrhosis, cancer, epilepsy, or stroke), pain syndromes, (e.g (...) the qualification phase of ≤ 70 on a 100-point Visual Analogue Scale (VAS) on at least four of seven qualification nights were randomized to one of two treatments for use at home. Participants returned to the study site after 7 and 14 days of nightly nasal strip use where they self-administered the validated subjective questionnaire "the Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ)". Condition or disease Intervention/treatment Phase Congestion, Nasal Device: Breathe Right Tan (small

2018 Clinical Trials

1790. The Heroes Circle Opioid Project

control, reduce the impact of stressors and chronic pain, drug craving, affective and physical function, and lower reliance on pharmacological interventions. Condition or disease Intervention/treatment Opioid-use Disorder Behavioral: Kids Kicking Cancer program Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 45 participants Observational Model: Cohort Time Perspective: Prospective Official Title: The Heroes Circle Opioid Project Actual Study (...) Start Date : August 1, 2018 Estimated Primary Completion Date : August 2019 Estimated Study Completion Date : September 2019 Groups and Cohorts Go to Group/Cohort Intervention/treatment Phase 1 Behavioral: Kids Kicking Cancer program Individual instruction on how to lower stress and life challenges. Patient and martial artist will work together to identify obstacles that interfere with methadone goal reduction. Training will include learning certain martial arts rituals and breathing techniques

2018 Clinical Trials

1791. Airway Injuries After Intubation Using Videolaryngoscopy Versus Direct Laryngoscopy for Adult Patients Requiring Tracheal Intubation

to retract the tongue and soft tissues of the mouth to achieve a line of sight for the larynx. Generally, Macintosh blade laryngoscopy is used to achieve the tracheal intubation. However, difficulties with the tracheal intubation arise the need to use alternative laryngoscopes that use digital or fiberoptic technology, to improve the larynx visibility. Among these devices, highly curved blade videolaryngoscope uses a curved blade to retract the soft tissues of floor of the mouth and transmits a video (...) at the first attempt, successful global intubation, degree of larynx visibility according to classification Cormack - Lehane and time taken to perform intubation in videolaryngoscopy vs direct laryngoscopy. Finally, we assess the risk of presenting serious adverse event with the use of videolaryngoscopy compared with Macintosh laryngoscopy in hypoxemia, bradycardia and heart arrest. Condition or disease Intervention/treatment Phase Airway Trauma Airway Complication of Anesthesia Device: Video laryngoscopy

2018 Clinical Trials

1792. Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients

. Luca Levrini, Università degli Studi dell'Insubria Study Details Study Description Go to Brief Summary: Xerostomia is defined as the subjective complaint of dry mouth. Symptoms of dry mouth may range from mild oral discomfort to significant oral disease that can compromise patients' health, dietary intake and quality of life. Xerostomia is accompanied by numerous signs and symptoms mainly in the mucous membranes, lips, tongue, salivary glands and teeth. This study was designed to verify efficacy (...) and safety of a novel dietary supplement (Aqualief),designed with the aim of stabilizing the saliva flux and pH at a neutral level and to improve the acid buffering capacity of saliva. Condition or disease Intervention/treatment Phase Xerostomia Due to Hyposecretion of Salivary Gland pH Saliva Quality of Life Dietary Supplement: Aqualief Dietary Supplement: Placebo Not Applicable Detailed Description: Sixty patients with xerostomia (grade 1-2 according to RTOG/EORTC) from different etiologies were

2018 Clinical Trials

1793. Sample Collection From Healthy Volunteers for Assay Optimization

disease. Diabetes mellitus. Cancer chemotherapy within the past 5 years. Currently receiving treatment for an active malignancy. Surgery within the past 8 weeks. History of recent (within the past 30 days) infection. History of parasitic, amebic, fungal or mycobacterial infections within the past 5 years. Infected with HIV and/or hepatitis B and/or C. Use of an oral glucocorticoid within the past 30 days. History of a bleeding disorder. Complete blood count with differential and/or acute care panel (...) Institute of Allergy and Infectious Diseases (NIAID) Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ) Study Details Study Description Go to Brief Summary: Background: The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. They study how parts of living things come together to make a whole. LISB designs and improves research tests on human

2018 Clinical Trials

1794. A Multicentric T-Cell Lymphoma with a Plasmacytoid Morphology in a Dog Full Text available with Trip Pro

, and the pre-hepatic lymph node and spleen were also enlarged. Multiple dermal pustules were present around the mouth and on the ear, and small ulcers were present on the tongue. Histopathological examination detected the presence of neoplastic lymphocytes with a plasmacytoid morphology in these tissues as well as in the tongue and skin lesions. Immunohistochemical (CD3⁺/CD18⁺) evaluation was consistent with a T-cell lymphoma, which could be classified as a peripheral T-cell lymphoma, not otherwise (...) A Multicentric T-Cell Lymphoma with a Plasmacytoid Morphology in a Dog An 8-year-old male (neutered) Labrador with a history of erythematous skin lesions and exercise intolerance for a prolonged period was suddenly found dead. Necropsy findings revealed an infiltrative, focally extensive mass which occupied 25% of the cardiac interventricular septum. Severe endocardiosis was also found on the bicuspid and tricuspid valves. The submandibular lymph nodes and kidneys were bilaterally enlarged

2018 Veterinary Sciences

1795. Lymphocytic Esophagitis: A Rare Disease on the Rise Full Text available with Trip Pro

Lymphocytic Esophagitis: A Rare Disease on the Rise Lymphocytic esophagitis is a rare, poorly understood disease. This case report presents a patient with a history of squamous cell carcinoma of the tongue who presented with dysphagia. He received esophageal dilation that unfortunately resulted in perforation. Biopsies showed lymphocytic esophagitis. There are very few cases in the literature describing perforation in lymphocytic esophagitis. In addition, management and treatment have been

2018 Cureus

1796. Mandibular reconstruction using customized three-dimensional titanium implant Full Text available with Trip Pro

Mandibular reconstruction using customized three-dimensional titanium implant Mandibular defects lead to severe deformation and functional deficiency. Vascularized osteocutaneous tissue has been widely used to reconstruct the mandible. However, it is technically challenging to shape this type of grafts in such a manner that they resemble the configuration of the mandible. A 48-year-old female patient who underwent anterolateral thigh (ALT) flap coverage after a tongue cancer excision (...) was diagnosed with a tumor recurrence during the follow-up. A wide excision mandibulectomy and mandibular reconstruction with an ALT flap and a titanium implant were performed. The prefabricated titanium implant was fixed to the condyle. Then, an ALT flap was harvested from the ipsilateral thigh and anastomosed. After confirming that the circulation of the flap was intact, the implant was fixed to the parasymphysis. On the radiograph taken after the surgery, the prosthesis was well positioned and overall

2018 Archives of Craniofacial Surgery

1797. Earable RCC: Development of an Earphone-Type Reliable Chewing-Count Measurement Device Full Text available with Trip Pro

Earable RCC: Development of an Earphone-Type Reliable Chewing-Count Measurement Device Gastric cancer patients having undergone gastrectomy are at a high risk of becoming malnourished owing to decreased gastric function. To prevent malnutrition, patients need to thoroughly chew a mouthful of food at least 30 times. For these gastrectomy patients requiring dietary support, we developed a chewing-count measurement device named earable RCC using an earphone-type sensor. Experiments to evaluate (...) at the timing of chewing. The experimental results also imply that earphone-type sensors may be used to measure swallowing, occlusal force, and tongue motion. Our future plans include clinical testing of the earphone-type chewing-count measurement device to determine its utility in patients who have undergone gastrectomy. We also intend to expand the application of this device for use in other patients to aid in dementia prevention and dietary support.

2018 Journal of healthcare engineering

1798. Olfactory Function and Postoperative Cognitive Dysfunction

sclerosis, schizophrenia, depression, etc.; The ASA class I or II; The people signed informed consent. Exclusion Criteria: Had severe head and face disease, trauma history or history of surgery; Had a history of influenza in 3 weeks; The serious body disease and tobacco, wine and other substance abuse history; The presence of malignant tumor with shorter survival disease. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may (...) or equal to 65 years old; Han Nationality, mother tongue is chinese; The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; Being able to complete the assessments without serious visual or hearing difficulty; Without serious heart, brain, liver, kidney, lung and other organs; Without serious neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple

2018 Clinical Trials

1799. Single-Dose Bioequivalence Study Comparing Two 4 mg Nicotine Lozenges

, or xerostomia. Presence of tongue piercings or other foreign objects likely to interfere with dissolution procedure of IMP in the opinion of the investigator. Use of St. John's Wort or kava-kava within 3 months prior to screening. History of malignancy including leukemia and lymphoma (except basal cell skin cancer) within the past 5 years prior to screening. Vegetarian or any abnormal diet (for whatever reason). Any condition not identified in the protocol that in the opinion of the investigator (...) Details Study Description Go to Brief Summary: The purpose of the study is to compare the pharmacokinetic (PK) profiles and assess bioequivalence between a new nicotine lozenge and a reference nicotine lozenge in healthy smokers Condition or disease Intervention/treatment Phase Smoking Cessation Drug: Nicotine lozenge Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 42 participants Allocation: Randomized Intervention Model

2018 Clinical Trials

1800. Hyposalivation Response To Transcutaneous Electrical Nerve Stimulation In Diabetic Type 2 Patients

: No Criteria Inclusion Criteria: non-smoker diabetic patients type II Patients with unstimulated resting saliva ≤ 0.16 ml/min considered to be abnormally low flow rate and included in the study (Navazesh et al., 1992) Exclusion Criteria: Cancer patients (patients on chemotherapy/immunotherapy and history of head and neck radiotherapy). Cardiac patients (cardiac pacemakers and defibrillators). Patients wearing hearing aids. Chronic inflammatory autoimmune diseases Acute oral inflammatory disorders Patients (...) on bilateral parotid glands. Condition or disease Intervention/treatment Phase Diabetes type2 Hyposalivation Device: TENS Not Applicable Detailed Description: Diabetes mellitus is the most significant disorder associated with varied oral manifestation ranging from xerostomia (subjective sensation od dry mouth) to serious bacterial and fungal infections due to alterations in flow rate of saliva. Systemic agents increase rate of stimulated salivary flow but often have unfavourable side effects

2018 Clinical Trials

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