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Tongue Carcinoma

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1761. Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis—Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation Full Text available with Trip Pro

. Irradiation comprised daily fractionated irradiation (5 × 3 Gy/week) over two weeks, either alone (IR) or in combination with daily dermatan sulfate treatment of 4 mg/kg (IR + DS). Groups of mice (n = 5) were sacrificed every second day over the course of 14 days in both experimental arms, their tongues excised and evaluated. The response to irradiation with and without DS was analyzed on a morphological (cell numbers, epithelial thickness) as well as on a functional (proliferation and expression (...) Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis—Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects of DS in the same model

2018 International journal of molecular sciences

1762. Long noncoding RNA AFAP1-AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR-4695-5p/TCF4-β-catenin signaling Full Text available with Trip Pro

Long noncoding RNA AFAP1-AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR-4695-5p/TCF4-β-catenin signaling Long noncoding RNA AFAP1‑AS1 has been shown to promote tumor progression in several human cancer types, such as thyroid cancer, tongue squamous cell carcinoma and lung cancer. However, the role of AFAP1‑AS1 in osteosarcoma (OS) has not been investigated. In the present study, the expression of AFAP1‑AS1 was significantly upregulated in OS tissues (...) and cell lines. Moreover, AFAP1‑AS1 expression was negatively correlated with OS patient prognosis. Besides, AFAP1‑AS1 knockdown significantly inhibited the proliferation and invasion of OS cells in vitro. Furthermore, in vivo xenograft experiments indicated that AFAP1‑AS1 depletion delayed tumor growth. Regarding the underlying mechanism, AFAP1‑AS1 served as a sponge to repress the level of microRNA (miR)‑4695‑5p, which targeted transcription factor (TCF)4, a pivot effector of Wnt/β‑catenin signaling

2018 Molecular medicine reports

1763. The role of radioprotective spacers in clinical practice: a review Full Text available with Trip Pro

. The application of radioprotective spacers was first reported 30 years ago regarding radiotherapy of tongue and abdominal cancers; more recently, they are increasingly being used in prostate cancer. This review focuses on the published data concerning the features of different types of spacers and their application in various tumor sites. Placement-related complications and the cost-effectiveness of the spacers are also discussed. With the increasing use of high-precision radiotherapy in clinical practice (...) The role of radioprotective spacers in clinical practice: a review The delivery of high dose radiotherapy to tumors is often limited by the proximity of the surrounding radiosensitive normal tissues, even using modern techniques such as intensity modulated radiation therapy (IMRT). Previous studies have reported that placement of a spacer can effectively displace normal tissues. So that they are some distance away from the lesion, thus allowing for the safe delivery of high-dose radiation

2018 Quantitative imaging in medicine and surgery

1764. Clinical Features of Idiopathic Parotid Pain Triggered by the First Bite in Japanese Patients with Type 2 Diabetes: A Case Study of Nine Patients Full Text available with Trip Pro

Clinical Features of Idiopathic Parotid Pain Triggered by the First Bite in Japanese Patients with Type 2 Diabetes: A Case Study of Nine Patients First bite syndrome, characterized by pain in the parotid region after the first bite of each meal, predominantly develops in patients who have had head and neck surgery. Idiopathic parotid pain (IPP) that mimics first bite syndrome may present in patients without a history of surgery or evidence of an underlying tumor, but its clinical features (...) -10. The trigger factor was gustatory stimuli, and the trigger area was the posterior section of the tongue. Postprandial pain occurred within 1-10 min after meals in six patients.IPP may be considered a separate disorder, in which the pain characteristics are similar to those of first bite syndrome but the clinical features and pathophysiology are different.

2018 Pain research and treatment

1765. Dyskeratosis congenita with a novel genetic variant in the DKC1 gene: a case report. Full Text available with Trip Pro

with hypopigmented macules involving the face, neck and extremities, hyperkeratosis of palms and soles, nail dystrophy, leukoplakia of the tongue, premature graying of hair, watery eyes and dental caries. Several of his male relatives, including two maternal uncles and three maternal cousins were affected with a similar type of disease condition. Pedigree analysis suggested a possible X-linked pattern of inheritance. Genetic testing in the proband showed a novel hemizygous, non-synonymous likely pathogenic (...) Dyskeratosis congenita with a novel genetic variant in the DKC1 gene: a case report. Dyskeratosis congenita (DC) is a rare genetic disorder of bone marrow failure inherited in an X-linked, autosomal dominant or autosomal recessive pattern. It has a wide array of clinical features and patients may be cared for by many medical sub specialties. The typical clinical features consist of lacy reticular skin pigmentation, nail dystrophy and oral leukoplakia. As the disease advances, patients may

2018 BMC Medical Genetics

1766. Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2. Full Text available with Trip Pro

Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2. High-risk human papillomavirus (HPV) is a major risk factor for oral and pharyngeal cancers (OPCs), yet the detailed mechanisms by which HPV promotes OPCs are not understood. Forkhead box M1B (FoxM1B) is an oncogene essential for cell cycle progression and tumorigenesis, and it is aberrantly overexpressed in many tumors. We previously showed that FoxM1B was the putative target of an epithelial-specific transcription (...) directly bound and regulated the FoxM1B gene promoter activity. Using epithelial-specific Grhl2 conditional knockout mice, we exposed wild-type (WT) and Grhl2 KO mice to 4-nitroquinolin 1-oxide (4-NQO), which led to induction of FoxM1B in the tongue tissues and rampant oral tumor development in the WT mice. However, 4-NQO exposure failed to induce tongue tumors or induction of FoxM1B expression in Grhl2 KO mice. Collectively, these results indicate that HPV-16 induces FoxM1B in part through GRHL2

2018 Journal of Dental Research

1767. Progressive functional improvement in hemiglossectomy defects reconstructed with radial forearm free flap at 6-months. (Abstract)

Progressive functional improvement in hemiglossectomy defects reconstructed with radial forearm free flap at 6-months. The purposes of the study was to evaluate for the functional improvement of outcomes of patients undergoing surgical management for tongue cancer at varying periods after surgery.Case series with intervention.Thirty consecutive patients, from 2011 to 2015, with carcinoma of the tongue undergoing surgical resection and reconstruction with a radial forearm free flap.The Speech (...) Intelligibility Test (SIT) is used for objective evaluation of speech function. The 7-point ordinal scale Functional Oral Intake Score (FOIS) was used to estimate the swallowing function.The patients included were 25 men and 5 women with a mean age of 50.4 years (range - 27-65). All tumors were squamous cell carcinomas and all patients underwent a hemiglossectomy. There were two complete flap failures, with a resultant flap success rate of 93.3%. The initial mean speech intelligibility scores at 1-month

2018 American Journal of Otolaryngology

1768. Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report. Full Text available with Trip Pro

Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report. Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously.A 51-year-old (...) female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months. From gastroscopy, an ulcer of 1.0 cm × 1.2 cm at the entrance of cardia and stiffness of peripheral mucosa were found, leading to suspicion of cardia cancer. F-FDG PET/CT was performed for further diagnosis and staging.According to pathological findings in combination with immunohistochemical features, diagnosis of gastric LGMS was made.To relieve

2018 Medicine

1769. Guilingji Capsule for Mild-to-moderate Cognitive Impairment

of the study Signed and dated written informed consent. The subject's caregiver must also consent to participate in the study Exclusion Criteria: Significant neurological disease, other than AD MCI and VaD, that may affect cognition, such as the Parkinson's disease, the Huntington's disease, normal pressure hydrocephalus, brain tumors, progressive supra-nuclear palsy, epilepsy, chronic subdural hematoma and multiple sclerosis, history of severe head trauma with persistent neurological deficits or known (...) tablet with Gulingji mimetic. Condition or disease Intervention/treatment Phase Cognitive Dysfunction Drug: Gulingji capsules Drug: Ginko Biloba Extract tablet Phase 2 Detailed Description: This study is a multi-center, randomized, positive control, noninferiority clinical trials. Experimental arm (174 cases) take 0.6 g of Gulingji capsules once a day and 19.2 mg of Ginko Biloba Extract mimetic three times a day. Active Comparator arm (174 cases) should take 0.6 g of Gulingji mimetic once a day

2018 Clinical Trials

1770. Biofeedback Rehabilitation to Improve Speaking and Eating in Public

Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Oral cavity carcinoma involving the tongue or floor of the mouth Primary surgical treatment or/ Primary surgical treatment with adjuvant radiation therapy or/ Salvage surgical treatment At least 2 weeks post treatment Exclusion Criteria: Anatomic palate abnormality that precludes fitting a mouthpiece Cognitively unable to participate in biofeedback Persistent Cancer Does not speak English Contacts (...) Last Verified: October 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by University Health Network, Toronto: Oral Cavity Squamous Cell Carcinoma Biofeedback Rehabilitation Head and Neck Cancer electropalatography EPG Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma, Squamous Cell Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms

2018 Clinical Trials

1771. Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression

feeding women. History of severe personality disorder. Acute suicidal ideation. Patients with advanced stage cardiovascular disease. Patients under immunosuppressive or chemo therapy because of malignant disease. Patients who had previous intracranial surgery. Patients who are currently under DBS therapy or have implanted any kind of stimulator already. Patients with aneurysm clips. Patients with cochlear implants. Patients with planned diathermy. Persons who are in a relationship of dependence (...) Brain Stimulation (DBS) in patients with treatment resistant major depression using the Boston Scientific implantable Vercise™ GEVIA™ DBS system compared to sham. Condition or disease Intervention/treatment Phase Treatment-resistant Depression Device: Vercise GEVIA deep brain stimulation (DBS) system Not Applicable Detailed Description: The main objective of this clinical trial is to assess the putative antidepressant efficacy of a therapeutic method called Deep Brain Stimulation (DBS) in patients

2018 Clinical Trials

1772. Awake Intraoperative Language Mapping and Chinese Probabilistic Map Construction

for MeSH terms Glioma Neoplasms, Neuroepithelial Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue (...) parameters will be explored, factors affecting postoperative function morbidity and survival will also be analyzed. Condition or disease Intervention/treatment Phase Glioma Procedure: Intraoperative direct cortical electrical stimulation Procedure: Intraoperative direct subcortical electrical stimulation Not Applicable Detailed Description: The study aims at constructing a Chinese language probabilistic map by awake intraoperative direct electrical stimulation (DES) language mapping. The "maximal safe

2018 Clinical Trials

1773. Validity and Reliability of the Turkish Version of the Functional Shoulder Score

shoulder, primary shoulder arthritis, inflammatory/ neoplastic/neurological conditions, cervical spine induced pain) Systemic musculoskeletal disease Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03658707 Contacts Layout table for location contacts (...) Posted : December 21, 2018 See Sponsor: Dokuz Eylul University Information provided by (Responsible Party): Damla Karabay, Izmir Katip Celebi University Study Details Study Description Go to Brief Summary: The aim of this study is to determine the validity and reliability of the Turkish version of the Functional Shoulder Score in Turkish patients with subacromial impingement syndrome (SIS). Condition or disease Intervention/treatment Subacromial Impingement Syndrome Other: questionnaire Detailed

2018 Clinical Trials

1774. Photodynamic Therapy With Red Leds in Microorganisms Related to Halitosis

between the continuous variables will be applied the correlation test by Pearson. In the analyzes of the experimental differences in each group the Wilcoxon test will be used. For all analyzes a level of significance of 95% (p <0.05) will be considered. Condition or disease Intervention/treatment Phase Halitosis Procedure: photodynamic therapy Procedure: Tongue scraper Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment (...) and treatment of halitosis. Young adults diagnosed with halitosis presenting Oralchroma S2H ≥ 112 ppb and / or CH3SH ≥ 26. Exclusion Criteria: With dentofacial anomalies, In orthodontic and / or orthopedic treatment, Using a removable device, implant and / or prosthesis, With periodontal disease, With teeth with carious lesions, In cancer treatment, On antibiotic treatment up to 1 month prior to the survey, Pregnant, With hypersensitivity to the photosensitizer to be used. Contacts and Locations Go

2018 Clinical Trials

1775. Riluzole Oral Soluble Film Swallowing Safety in Amyotrophic Lateral Sclerosis

disease, renal disease, or any other medical condition judged to be exclusionary by the investigator Subjects who are unwilling to sign informed consent or subjects who for any other reason in the judgment of investigator are unable to complete the study Female subjects who have a positive urine pregnancy test (βhCG) at screening or Visit 1, are trying to become pregnant or are breastfeeding. Subjects with active cancer within the previous 2 years, except treated basal cell carcinoma of the skin (...) Therapeutics Collaborators: inVentiv Health Clinical Covance Information provided by (Responsible Party): Aquestive Therapeutics Study Details Study Description Go to Brief Summary: The primary objective is to evaluate the effect, if any, of a single 50 mg dose of Riluzole Oral Soluble Film (ROSF) on swallowing safety in individuals with amyotrophic lateral sclerosis. Condition or disease Intervention/treatment Phase Amyotrophic Lateral Sclerosis Drug: Riluzole Oral Soluble film (ROSF) 50 mg Phase 2

2018 Clinical Trials

1776. Nasopharyngeal Airway Guide Nasogastric Tube Placement

and tongue drop also made the NG tube coil in the mouth easily. Investigators assume nasopharyngeal airway can facilitate NG tube insertion by opening a channel from nostril to epiglottis and reduce complications by protecting nasal cavity while inserting NG. Condition or disease Intervention/treatment Phase Nasogastric Tube Nasopharyngeal Airway Anesthesia, General Procedure: With nasopharyngeal airway Procedure: Without nasopharyngeal airway Not Applicable Study Design Go to Layout table for study (...) , Esophageal cancer, trauma or previous esophageal surgery Gastric cancer involve cardiac orifice Corrosive chemical (strong acid or alkali) ingestion Skull base fracture Recent nasal surgery, nasal fracture or severe nasal obstruction Loose teeth that make endotracheal tube can not fix right side Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2018 Clinical Trials

1777. The Probiotic for Oral Health (PRO Health) Study

to 45 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy adults; Age 21-45 years of age; BMI between 18-30; No history of infectious disease; heart, metabolic, autoimmune endocrine, liver, or kidney diseases; GI related conditions such as malabsorption disease, Crohn's disease, colitis, inflammatory bowel disease; Type 1 or 2 diabetes mellitus, any type of cancer, heart disease; Practices good oral hygiene according to the American Dental (...) cleanings during the five-week study period. Exclusion Criteria: Currently pregnant or plans to become pregnant several weeks prior to enrollment and during the five-week study period; History of periodontal disease, or gingivitis; Dental trauma or injury to the teeth and/or periodontium (gums, periodontal ligament, alveolar bone), and nearby soft tissues such as the lips, tongue within the past 4 weeks; Any oral surgery or intensive procedures made to the oral cavity (such as fillings, wisdom tooth

2018 Clinical Trials

1778. Gustatory Function Following Radiotherapy to the Head and Neck

glands, and correlate them with both qualitative and quantitative data for dysgeusia. Condition or disease Intervention/treatment Head and Neck Cancer Other: Olfactory screening Other: Quantative Gustatory Testing using Taste Strips Detailed Description: This study aims to collect data from patients with HNC undergoing RT or chemo-RT to correlate quantitative chemosensory gustatory function with Detailed dosimetric data for critical structures relevant to perception of taste Fungiform papillae (...) provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population Patients with H&N cancer staged at T1-T4 disease and N0-N3 disease attending RMH who have consented to treatment with curative intent using RT or chemo-RT. Criteria Inclusion Criteria: Age >/= 18 years Undergoing unilateral or bilateral RT

2018 Clinical Trials

1779. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails. Full Text available with Trip Pro

% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. BRAF inhibitors mostly induce secondary skin tumors, squamous cell carcinoma and keratoacanthomas, changes in pre-existing pigmented lesions, as well as hand-foot skin reactions and maculopapular hypersensitivity-like rash. Immune checkpoint inhibitors (ICIs) most frequently induce nonspecific maculopapular rash, but also eczema-like or psoriatic lesions, lichenoid dermatitis, xerosis (...) Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails. Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25-85

2018 American journal of clinical dermatology

1780. PoNS Clinical Experience Program (TBI)

on an individual case where surgery was performed that did not remove or significantly alter brain tissue (e.g., to treat a brain aneurysm). Surgery must have been performed at least 6 months prior to screening and a CT scan must be provided to demonstrate no large residual lesions. Oral health problems active at the time of recruitment. Any history of oral health problems (e.g., gum disease or cankers) will be noted on the data collection form. Oral surgery within 3 months of screening. History of oral cancer (...) , excluding basal cell carcinoma. Neurological disorders other than those attributed to the primary diagnosis, (e.g., neurodegenerative diseases such as Multiple Sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD) or other dementia, Amyotrophic Lateral Sclerosis (ALS). Lower back pain, lumbar spine abnormalities, or history of lumbar spine surgery with no residual clinical significant lower extremity weakness are not excluded. History of epileptic or other seizure disorders . Known ischemic

2018 Clinical Trials

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