Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
How to Trip Rapid Review
Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)
Step 2: press
Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.
or disease Intervention/treatment Phase Lip and Oral Cavity Cancer Oropharyngeal Cancer Stage 0 Lip and Oral Cavity Cancer Stage 0 Oropharyngeal Cancer Tongue Cancer Biological: Ad5CMV-p53 gene Other: laboratory biomarker analysis Phase 1 Phase 2 Detailed Description: OBJECTIVES: I. Determine the acute toxic effects of Ad5CMV-p53 gene administered as an oral rinse and as an intramucosal injection in patients with diffuse premalignant carcinoma of the oral cavity or oral pharynx. II. Determine the maximum (...) Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100
A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. To determine whether elderly patients manifest poorer survivals for head and neck squamous cell carcinoma.Cases of squamous cell carcinoma of the glottic larynx, oral tongue, and tonsil were extracted from the Surveillance, Epidemiology and End Results database for 1988 to 1998. For each primary site, patients were segregated into two age groups: 50 to 69 years of age and 70 years of age and older (...) . For each case in the latter, elderly group, a reference group case was randomly matched for gender, year of diagnosis, cancer stage, extent of surgery, and radiation therapy. Overall survival and disease-specific survival were compared between the two groups with stage stratification with the Kaplan-Meier method.Cases of glottic carcinoma (1882), tonguecarcinoma (426), and tonsillar carcinoma (200) in elderly patients were matched to the reference group. Overall mean survival differences were
Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Sentinel lymph node biopsy is a minimally invasive method to stage the regional lymphatics that has revolutionized the management of patients with intermediate-thickness cutaneous melanoma. Head and neck surgeons have been encouraged by the accuracy of sentinel lymph node biopsy in cutaneous melanoma and have applied the technique to patients with head and neck squamous cell carcinoma (HNSCC). The objectives of the study were (...) with lymphoscintigraphy before neck dissection.In the feline study, both Tc-SC and isosulfan blue dye traversed the lymphatics rapidly, appearing in the sentinel lymph node in less than 5 minutes. Modification of the injection technique used for cutaneous melanoma was required to depict the sentinel lymph node of the base of tongue. In the human study, the sentinel lymph node was accurately identified in 19 of 20 (95%) N0 patients. On average, 2.9 sentinel lymph nodes (range, 1-5) were identified in 2.2 (range, 1-4
Metastatic renal cell carcinoma to the head and neck. The objectives of the study were to present four cases of renal cell carcinoma (RCC) metastatic to the head and neck, to recognize the appearance on radiographic studies, to understand the importance of preoperative embolization, and to review the results of treatment.Retrospective review of patients diagnosed with metastatic RCC to the head and neck.The records of four patients diagnosed with metastatic RCC at a tertiary medical center over (...) a 5-year period from 1996 to 2001 were reviewed and analyzed for demographic and outcomes data.Metastatic RCC to the head and neck was seen in the following locations: nasal cavity, lower lip, hard palate, tongue, and maxillary sinus. Presenting signs were loose upper molars, dysphagia, nasal obstruction, lower lip lesion, recurrent epistaxis, and foul nasal drainage. Histological studies confirmed metastasis of RCC in all four patients. Treatment consisted of preoperative radiation therapy
Implication of 18F-fluoro-2-deoxy-D-glucose positron emission tomography on management of carcinoma of unknown primary in the head and neck: a Danish cohort study. To demonstrate the efficacy of whole-body 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) in the detection of a carcinoma of unknown primary after conventional diagnostic workup in patients with a metastatic neck lesion and to demonstrate how the treatment policy of wide-field irradiation can be safely (...) modified in relation to the findings from PET scanning.Prospective cohort study of consecutive patients.Forty-two consecutive patients with squamous cell or undifferentiated metastatic disease in the neck from a carcinoma of unknown primary were enrolled after standard clinical workups. These patients underwent extensive clinical investigations including endoscopy under anesthesia with multiple mucosal biopsies and diagnostic imaging as well. If no primary site was indicated at this stage, a whole-body
Choroidal metastasis from medullary thyroid carcinoma in multiple endocrine neoplasia. To report choroidal metastasis from medullary thyroid carcinoma in a patient with multiple endocrine neoplasia (MEN) type 2b.Interventional case report.Medullary thyroid carcinoma developed in a 20-year-old woman and led to the diagnosis of MEN 2b. She had mucosal neuromas on the lips and tongue and prominent corneal nerves in both eyes. Right choroidal metastasis developed when she was 36 years of age.The (...) eye was treated with irradiation, but 9 months later the patient died of widespread metastases.In patients with MEN type 2b, choroidal metastasis can develop from medullary thyroid carcinoma. Although fundus abnormalities typically do not occur with MEN 2b, choroidal metastasis from medullary thyroid carcinoma is a potential fundus finding.
. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com What are the causes of a sore tongue? GP Notebook has a chapter on sore tongue , this reports: “Sore tongues fall into three main categories: the result of recognisable disease: - glossitis of anaemia e.g. B12 or folate deficiency - Crohn's disease - coeliac disease - carcinoma geographic tongue - benign migratory (...) What are the causes of a sore tongue? What are the causes of a sore tongue? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example
pizza, etc.), or injury from a sharp tooth or jagged dental plate. Other painful focal lesions are carcinoma, tuberculosis, syphilis (often painless), and herpes simplex ulcers. When the tongue is completely normal, trigeminal neuralgia, polymyositis, trichinosis, and calculus of the submaxillary gland should be considered. DIAGNOSTIC WORKUP Most lesions will respond to conservative treatment and time. In patients with signs of systemic disease and vitamin deficiency, the workup includes serum B12 (...) What investigations are helpful for recurrent sore tongue with probable lingual papillitis in the absence of oral thrush? What investigations are helpful for recurrent sore tongue with probable lingual papillitis in the absence of oral thrush? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, alphavbeta6 integrin, the laminin-5 gamma2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8 (...) -type mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tonguecarcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) alpha and beta. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.
Keratin-14 IM Adult Breast Neoplasms Carcinoma, Ductal, Breast metabolism pathology Fatal Outcome Female Humans Immunohistochemistry Keratin-14 metabolism Lung Neoplasms secondary Neoplasm Invasiveness Tongue Neoplasms metabolism pathology secondary 2008 8 7 9 0 2008 9 10 9 0 2008 8 7 9 0 ppublish 18682793 PMC2496587 Indian J Cancer. 1967 Sep;4(3):340-2 5590041 J Oral Maxillofac Surg. 1986 Jun;44(6):484-6 3009760 Oral Surg Oral Med Oral Pathol. 1973 Feb;35(2):202-11 4513066 (...) Breast cancer metastasizing to the tongue 18682793 2008 09 09 2018 11 13 1488-2310 51 3 2008 Jun Canadian journal of surgery. Journal canadien de chirurgie Can J Surg Breast cancer metastasizing to the tongue. E63-4 Neelakantan Pratap P Department of Medical Oncology, Charing Cross Hospital, London, UK. McLean Sean R SR Kenny Sinead S Nathan Myooran M Panchal Lajja L Sandhu Gurpreet G Coombes Charles R CR Palmieri Carlo C eng Case Reports Journal Article Canada Can J Surg 0372715 0008-428X 0
Med 101231360 1549-1277 IM Carcinoma, Squamous Cell classification diagnosis pathology Diagnosis, Differential Humans Lichen Planus, Oral diagnosis pathology Male Middle Aged Tongue pathology Tongue Neoplasms diagnosis pathology 2008 11 13 9 0 2009 2 6 9 0 2008 11 13 9 0 ppublish 18998767 07-PLME-LF-2246 10.1371/journal.pmed.0050212 PMC2581624 J Am Dent Assoc. 2001 Nov;132 Suppl:36S-40S 11803651 Cancer. 2008 Jan 15;112(2):345-51 18041071 Curr Treat Options Oncol. 2003 Feb;4(1):27-41 12525277 N (...) Multiple Masses on the Tongue of a Patient with Generalized Mucocutaneous Lesions 18998767 2009 02 05 2018 11 13 1549-1676 5 11 2008 Nov 11 PLoS medicine PLoS Med. Multiple masses on the tongue of a patient with generalized mucocutaneous lesions. e212 10.1371/journal.pmed.0050212 Pastore Luca L Department of Surgical Sciences, University of Foggia, Foggia, Italy. firstname.lastname@example.org Fiorella Maria Luisa ML Fiorella Raffaele R Lo Muzio Lorenzo L eng Case Reports Journal Article United States PLoS
surgery of the upper aerodigestive tract, particularly in the restoration of the muscular components in small and medium tongue defects. The surgical technique and the postoperative outcomes are described. STUDY DESIGN:: Retrospective study. METHODS:: During the period 2000 to 2006, 32 patients with squamous cell carcinoma of the tongue were surgically treated using a pure infrahyoid myocutaneous neurovascular flap. RESULTS:: The flap was successful in all cases without flap necrosis, fistula (...) One-Stage Reconstruction of the Tongue using the Infrahyoid Myocutaneous Flap after Resection for Oral Cancer as an Alternative to Free Flaps. Ahead of Print article withdrawn by publisher:OBJECTIVES/HYPOTHESIS:: The aim of this study was to describe our results in reconstructive surgery after cancer ablation using the less popular infrahyoid myocutaneous flap as an alternative method to free flaps. Infrahyoid muscles are very useful as a neurovascular myofascial flap in plastic reconstructive
cells activated by the DC-based vaccine killed Tca8113 cells in vitro (P<0.01), postponed tumour doubling time of the implanted tumours in nude mice (P<0.01) and inhibited the growth of the tumours (P<0.05). These results show that DCs from monocytes induce a lymphocyte-mediated immune response against tongue squamous carcinoma, and could be used as a vehicle for tumour antigens. (...) Effect of dendritic cell vaccine against a tongue squamous cell cancer cell line (Tca8113) in vivo and in vitro. Dendritic cells (DCs), as primary antigen-presenting cells with the capacity to activate naïve T lymphocytes, are considered to be promising adjuvants for immunity against cancer. In this study, the effect of T lymphocyte-mediated immunity induced by a DC vaccine against Tca8113 cells in vivo and in vitro was evaluated. DCs were from human peripheral blood monocytes cultured
Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. Although genetic abnormalities on 3p have been suggested to be linked to the development of squamous cell carcinoma of the head and neck, to the authors' knowledge no study to date has examined such genetic abnormalities in patients with squamous cell carcinoma of the tongue. In the current study, loss of heterozygosity (LOH) was evaluated at several loci within 3p, including the von (...) Hippel-Lindau gene (VHL), in samples of tongue squamous cell carcinoma. In addition, the coding region of the intact VHL allele was screened for sequence mutations.DNA was extracted from tumor and nontumor tissues collected from 28 patients with tongue squamous cell carcinoma. LOH was investigated by analysis of single nucleotide polymorphisms within exon 3 of VHL and by microsatellite analysis within another 10 loci. Mutation analysis of the VHL gene was performed by polymerase chain reaction (PCR
: Sheba Medical Center Information provided by: Sheba Medical Center Study Details Study Description Go to Brief Summary: Study comparing level of free radicals in tumor tissue, blood serum and saliva in patients with Squamous Cell Carcinoma of tongue and mouth floor. Patients with benign fibroma of oral cavity and normal gingiva around extracted lower wisdom tooth are used for control Condition or disease Squamous Cell Carcinoma Study Design Go to Layout table for study information Study Type (...) : February 21, 2007 Last Verified: February 2007 Keywords provided by Sheba Medical Center: Squamous Cell Carcinoma of Tongue and mouth floor Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma, Squamous Cell Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell
Rectangle tongue template for reconstruction of the hemiglossectomy defect. To determine if a rectangular template free tissue transfer is effective for the reconstruction of the hemiglossectomy defect.Prospective case series.Tertiary care academic medical center.A total of 13 patients (male to female ratio, 8:5; mean age, 55 years) presenting with squamous cell carcinoma of the oral tongue from May 2000 to December 2002.Of the 13 patients, 7 received postoperative radiotherapy and 2 received (...) prior radiotherapy. The radial forearm was the donor site in 11 patients and the lateral arm and anterolateral thigh in 1 patient each. The mean flap area was 50 cm(2) (range, 24-80 cm(2)).Major and minor complications, speech and swallowing assessment, oral cavity obliteration, premaxillary contact, tongue elevation, and tongue protrusion.There were no major complications, and 2 of the 13 patients experienced minor complications. Of the 13 patients, 12 achieved the goals of oral cavity obliteration
Quality of life after free-flap tongue reconstruction. To analyse correlations between quality of life measures, aspiration and extent of surgical resection in patients who have undergone free-flap tongue reconstruction.Nine consecutive patients (seven men and two women; average age 51 years) who had been diagnosed with T4a carcinoma of the mobile tongue and/or tongue base and treated by glossectomy, free-flap reconstruction, and either radiation therapy or chemoradiation responded (...) domains of the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire were significantly correlated with the extent of tongue base resection (Spearman's correlation, p = 0.037 and 0.042, respectively). Despite a strong correlation between the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire results and the performance status scale global scores (correlation coefficient = 0.89, p = 0.048), the performance status scale domain
Swallowing function in patients with base of tongue cancers treated with primary surgery and reconstructed with a modified radial forearm free flap. To report swallowing outcomes and biomechanical properties of the base of the tongue (BOT) and the posterior pharyngeal wall (PPW) in patients who undergo surgical reconstruction with the beavertail modification of radial forearm free flap after primary resection of BOT cancer.Prospective cohort study with a 1-year minimum follow-up performed (...) between October 1, 2001, and August 31, 2005.Tertiary care facility.Patients diagnosed as having primary carcinoma of the BOT were treated with primary surgical resection and reconstruction followed by radiotherapy. Inclusion criteria were collection of videofluoroscopic swallowing study (VFSS) data before and 1 year after surgery. Forty-one patients were treated during a 5-year period, and 20 were included in the final analysis.Reconstruction of BOT defects with the beavertail modification of radial
Chronic periodontitis and the risk of tongue cancer. To assess the association between the history of chronic periodontitis and the risk of tongue cancer.Case-control study using preexisting data from patients admitted between June 15, 1999, and November 17, 2005.Department of Dentistry and Maxillofacial Prosthetics at Roswell Park Cancer Institute (RPCI), Buffalo, NY.The cases comprised 51 non-Hispanic white men newly diagnosed as having primary squamous cell carcinoma of the tongue (...) , and the controls, 54 non-Hispanic white men evaluated during the same period but with negative results for malignancy. Children (aged <21 years), edentulous or immunocompromised patients, and those with history of any cancer were excluded. History of periodontitis was assessed by alveolar bone loss measured from panoramic radiographs by 1 examiner blind to cancer status.Incidence of tongue cancer obtained from the RPCI Tumor Registry.After adjusting for the effects of age at diagnosis, smoking status