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Tongue Carcinoma

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1721. Vertigo

. It is important to differentiate peripheral from central vertigo. Peripheral vertigo is more common and is usually caused by a problem with the inner ear affecting the labyrinth or vestibular nerve (for example benign paroxysmal positional vertigo, vestibular neuronitis, labyrinthitis, and Meniere’s disease). Central vertigo is uncommon and is usually caused by pathology in the brainstem and cerebellum (for example stroke, transient ischaemic attack, cerebellar tumour, and multiple sclerosis). Examination (...) . It can be difficult to distinguish from early Meniere's disease. For more information, see the CKS topic on . Stroke and transient ischaemic attack, cerebellar tumour, acoustic neuroma, and multiple sclerosis (less common causes). For more information, see the CKS topics on , , and . Vertigo may present as part of the acute vestibular syndrome , defined as acute onset dizziness and/or vertigo; intolerance of head movement; continuous dizziness of 24 hours to several weeks' duration; spontaneous

2017 NICE Clinical Knowledge Summaries

1722. Vestibular neuronitis

diagnosis of vertigo includes benign paroxysmal positional vertigo, labyrinthitis, Meniere’s disease, and central causes such as migraine, stroke, cerebellar tumour, and multiple sclerosis. Advice should be offered regarding resuming activity as soon as possible, and safety issues such as driving, work, and prevention of falls. If symptoms are severe, short-term symptomatic drug treatment can be offered. Buccal or intramuscular prochlorperazine or intramuscular cyclizine can be considered to rapidly (...) , see the CKS topic on . Labyrinthitis (similar features to vestibular neuronitis, but also involves tinnitus and hearing loss). Meniere's disease. For more information, see the CKS topic on . Central causes (for example migraine, stroke, cerebellar tumour, and multiple sclerosis). For more information on differentiating between these conditions, see the CKS topic on . Basis for recommendation Basis for recommendation This information is based on expert opinion in review articles

2017 NICE Clinical Knowledge Summaries

1723. Clinical Guidelines and Integrated Care Pathways for the Oral Health Care of People with Learning Disabilities

are accessible on the Royal College of Surgeons of England website (, and the British Society for Disability and Oral Health website ( Whilst the guidelines explore the barriers to good oral health for people with a learning disability, their main emphasis is on the prevention of oral diseases and the maintenance of good oral health. The guidance and recommendations made for all age groups are based on: • Dietary recommendations that are in line with healthy eating policies (...) on the prevention of oral and dental diseases (see Section 5) • Training needs in the provision of oral health care for people with a learning disability aimed at health care professionals (at both undergraduate and postgraduate levels) and to carers for people with learning disabilities (see Section 6) • The current UK legislation related to capacity, consent (see Section 7), and Clinical Holding • Understanding the role of voluntary organisations concerned with the welfare of people with a learning disability

2012 Royal College of Surgeons of England

1724. Dental Implants and Conventional Prosthetics: Comparative Clinical Effectiveness and Safety

the association of dental implant placement with the development of oral cancer. In their systematic review, 1 the authors included 13 case- studies on 19 patients. Another systematic review by Javed et al. 18 assessed the relationship between the use of titanium dental implants and the occurrence of titanium sensitivity; this review included two clinical trials, two observational studies and three case-studies. Esposito et al. 19 compared the effect of using prophylactic antibiotic (1 to 2 grams (...) al. 1 reported that 19 cases of oral cancer were detected in patients who had received dental implants; it was reported that 10 of these cases had a prior history of cancer. Javed et al. 18 showed that the number of patients who had titanium sensitivity was 21/56 (37.5%) of patients included in the clinical trials and 9/35 (25%) of patients included in the observational studies. The authors concluded that whether or not dental implants caused titanium sensitivity remained unproven. 18 The risk

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

1725. Signifor - pasireotide

by the patient. There are no dose adjustments recommended in the elderly or in renal impairment. The recommended initial dose for patients with moderate or severe hepatic impairment is 0.3 mg twice a day, with a maximum recommended dose of 0.6 mg twice a day. Cushing’s disease Cushing’s disease is a very rare, debilitating, and life-threatening disease that is caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma most commonly affecting adult females. The tumours are usually (...) microadenomas ( = 1 cm in diameter); macroadenomas are rare. The elevated levels of ACTH secreted by these tumours stimulate the adrenal glands to produce excess cortisol, thereby leading to the subsequent development of the clinical signs and symptoms of hypercortisolism. In patients with Cushing’s disease, most adenomatous cells develop a high set-point for feedback inhibition of ACTH secretion by cortisol, which may lead to loss of tumour differentiation to the point where increased cortisol levels can

2012 European Medicines Agency - EPARs

1726. NexoBrid - concentrate of proteolytic enzymes enriched in bromelain

, the Committee for Orphan Medicinal Products (COMP) reviewed the designation of NexoBrid as an orphan medicinal product in the approved indication. The outcome of the COMP review can be found on the Agency's website: Medicine/Human medicines/Rare disease designations. 2. Scientific discussion 2.1. Introduction 2.1.1. Problem statement Debridement of eschar is essential to initiate the wound healing process and prevent further complications. Technology for this treatment in severe burns has

2012 European Medicines Agency - EPARs

1727. Lymphoseek - technetium complexed with tilmanocept

(manufacturing facilities’ inspections) having been resolved, this reviewer recommends approving the NDA 202207 for Lymphoseek as a radioactive diagnostic agent indicated for lymphatic mapping with a hand-held gamma counter to assist in the localization of lymph nodes draining a primary tumor site in patients with breast cancer or melanoma. Clinically relevant labeling issues have been all addressed during the previous review cycle. Reference ID: 3266833 (...) - 4%) 47 (30%) (23 - 38%) 9 (6%) (3 - 11%) One B 154 108 (70%) (62 - 77 %) 146 (95%) (90 - 98%) 7 (5%) (2 – 9%) 45 (29%) (22 - 37%) 1 (1%) (0 - 4%) M 196 115 (59%) (51 - 66%) 196 (100%) (98 - 100%) 0 (0 - 2%) 81 (41%) (34 - 49%) 0 (0 - 2%) Two B 180 112 (62%) (55 - 69%) 180 100%) (98 - 100%) 0 (0 - .2%) 68 (38%) (31- 45%) 0 (0 - 2%) T = tumor; M = melanoma; B = breast cancer; The percents may not add to 100% due to rounding. 95% Confidence Intervals are based on Exact Binomial and represent

2012 FDA - Drug Approval Package

1728. Perampanel (Fycompa)

disease studies resulting from post-surgical complications following injuries (hip fracture, femoral neck fracture, and cervical hematoma after a fall in a patient who had previously reported somnolence as an AE). There were 3 deaths due to malignancies 1 “primary chest malignancy”, 1 malignant lung neoplasm, and 1 metastatic adenocarcinoma. Neoplasms are discussed in more detail in Section 7.6 of Dr. Doi’s review. There was 1 death due to pancreatitis; cholelithiasis and pancreatitis are discussed (...) from “multiple organ insufficiency” after developing severe cardiac failure having been treated with perampanel (.5 mg) for 14 days; Dr. Doi notes that based on the ECG, the subject most likely sustained a pulmonary embolism and that he had risk factors due to underlying lung cancer. Subject 0407-0015 was a 71 y.o. male with Parkinson’s disease treated with perampanel for 258 days who died from hypotension on Day 259 (blood pressure was 80/50 on Day 258) after complaints of back pain on Study Day

2012 FDA - Drug Approval Package

1729. Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs. Full Text available with Trip Pro

collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis. Amplifiable DNA was extracted and in epithelial cancers, potential HPV infection was investigated. Specimens with an original diagnosis of tuberculosis were examined for mycobacterial infection. The tissues were also examined using modern histological (...) Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs. University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological

2017 PLoS ONE

1730. Spontaneous alveolar bone loss after 4NQO exposure in Wistar rats. (Abstract)

water. All animals were euthanized after 20 weeks, and the tongues were removed and analyzed macroscopically to determine the presence of oral mucosal lesions. All specimens were paraffin-embedded and histological sections were obtained. The microscopic analysis was based on routine procedure (haematoxylin and eosin stain). The analysis of spontaneous ABL was performed by a calibrated examiner using standardized photographs and imaging software. Differences in spontaneous ABL were assessed among (...) the three resulting groups: control, 4NQO with oral squamous cell carcinoma (OSCC), and 4NQO without OSCC.In the 4NQO-treated group, nine animals developed OSCC. The animals in the 4NQO with OSCC group presented significantly more spontaneous ABL (0.65 ± 0.21 mm) than the control group (0.34 ± 0.05) (p < 0.001). The animals in the 4NQO without OSCC group showed a mean spontaneous ABL of 0.47 ± 0.13 mm, which was not statistically significant different when compared to the control group (p = 0.096

2018 Archives of oral biology Controlled trial quality: uncertain

1731. Human papillomavirus (HPV) vaccine effectiveness and potential herd immunity for reducing oncogenic oropharyngeal HPV16 prevalence in the UK; a cross-sectional study. Full Text available with Trip Pro

to vaccinate boys, especially in countries with high vaccination coverage of girls.Subjects aged 0-65 years undergoing tonsillectomy for non-malignant indications were recruited in 6 UK hospitals. Oral samples were collected in following order: oral rinse, tongue base and pharyngeal wall brushes, then tonsil tissue (tonsillectomy). Vaccination data was obtained from regional health authorities. All samples were centrally tested for HPV-DNA by PCR amplification. (NCT01330147).Of 940 subjects, 243 girls (...) Human papillomavirus (HPV) vaccine effectiveness and potential herd immunity for reducing oncogenic oropharyngeal HPV16 prevalence in the UK; a cross-sectional study. Oropharyngeal cancer incidence is rapidly rising due to human papillomavirus (HPV) 16 infection. The dearth of data on effectiveness of national girl-only vaccination program in preventing oral HPV infection and the potential herd immunity effect on unvaccinated boys has resulted in considerable controversy regarding the need

2018 Clinical Infectious Diseases

1732. Free thyroid transfer to anterolateral thigh for prevention of radiation induced hypothyroidism: An initial experience. (Abstract)

during August 2017 to May 2018. Six Patients with stage III/IV patients of oral cavity cancers who required wide excision/composite resections with microvascular free flap (ALT) reconstruction and adjuvant radiation therapy were enrolled. A written informed consent was obtained from all patients prior to the procedure.The mean age of cohort was 51 years with tongue most common site of primary cancer. The free transfer of thyroid gland to anterolateral thigh was done using microvascular technique

2018 American Journal of Otolaryngology

1733. Office-based transnasal esophagoscopy biopsies for histological diagnosis of head and neck patients. (Abstract)

as well as the histological diagnosis and additional histological diagnostic procedures.During the observation period, 134 TNE-guided procedures were attempted. The procedure could not be completed in 19 patients. There were 102/115 (89%) patients who did not require further interventions for histological diagnosis of the tumor. The most common biopsied area was the larynx (53), followed by the tongue base (29). The most common malignancy was invasive squamous cell carcinoma in 42/115 (36.5%).The work (...) presented in this article strongly suggests that TNE-guided biopsy is a valuable diagnostic tool for patients suspected of having carcinoma of the UADT.4 Laryngoscope, 2018.© 2018 The American Laryngological, Rhinological and Otological Society, Inc.

2018 Laryngoscope

1734. Sublingual cysts of different entities in an infant - A case report and literature review. (Abstract)

diagnostic clarification. A persisting congenital fistula of the tongue is a clear indication of dysontogenetic lesions, including malformations, tumors, and tumor-like lesions. Congenital sublingual cysts are rare in infants, but can be life threatening when present. Surgical excision with histopathological analysis is essential to exclude any form of malignancy and malignant transformation.Copyright © 2018 Elsevier B.V. All rights reserved. (...) Sublingual cysts of different entities in an infant - A case report and literature review. Congenital cysts and fistulas of the neck are common in children, often located in the head and neck area. Belonging to the group of tumor-like conditions, dermoid and epidermoid cysts are dysontogenetic lesions with seldom multiple co-occurrences in infants.We report on a nine-month-old female with a persisting congenital fistula of the tongue. The patient was admitted with acute poor feeding

2018 International Journal of Pediatric Otorhinolaryngology

1735. Ventilation Efficacy of Size 3 or Size 4 I-gel in Female Patient Weighing 50 to 60 Kilograms

in this cohort. Condition or disease Intervention/treatment Phase Body Weight Breast Neoplasms Laryngeal Masks Device: size 3 i-gel supraglottic airway device Device: size 4 i-gel supraglottic airway device Not Applicable Detailed Description: With the introduction of the laryngeal mask, it has been widely used for the management of airway during general anesthesia. Compared to the endotracheal tube, it has the advantages of easier and faster placing, reducing the proportion of a sore throat and other (...) Product: No Keywords provided by National Taiwan University Hospital: laryngeal mask airway breast surgery Additional relevant MeSH terms: Layout table for MeSH terms Breast Neoplasms Body Weight Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Signs and Symptoms

2018 Clinical Trials

1736. Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome

that described in traditional Chinese medicine. The basic symptoms included feverish sensation, thirst that preferring cold drink, bad breath, flushed face, bound stool, scanty yellowish urine, red tongue with dry and yellowish fur, and the forceful or rapid pulse. The disease-specific symptoms included tooth or/and gums for acute pericoronitis, ulcer for recurrent aphthous stomatitis and herpes for recurrent herpes simplex labialis. Each symptom was assessed by the Visual Analogue Scale(VAS),where a higher (...) (one of the common TCM syndrome)of acute pericoronitis,minor recurrent aphthous stomatitis and recurrent herpes simplex labialis,meanwhile, exploring the pharmacological mechanism and potential biomarkers of this traditional formula. Condition or disease Intervention/treatment Phase Intense-exuberant Stomach Fire Syndrom Acute Pericoronitis Recurrent Aphthous Stomatitis Recurrent Herpes Simplex Labialis Drug: Huanglian-Jiedu Decoction Phase 1 Phase 2 Detailed Description: Huanglian-Jiedu Decoction

2018 Clinical Trials

1737. Surgical Planning and Informed Consent

more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: having a cerebral tumor no visual/auditory deficit no psychiatric illness italian mother-tongue Exclusion Criteria: younger than 18 or older than 70 pre-existing (...) consent: through tridimensional representation of anatomic structures of the brain, these devices are able to help patients understand better their own anatomy and the surgical approach to their disease. The aim of our study is therefore to understand whether this high-technology 3D planning, used as a tool to optimize patient-doctor communication, can effectively improve patients' understanding of the disease and the surgical procedure they will be going through (for which they are supposed to sign

2018 Clinical Trials

1738. Effect of Time-Restricted Feeding on Fat Loss and Cardiometabolic Risk Factors in Overweight Adults

reduces body weight, improves blood sugar control, and reduces the risk of cardiovascular disease—even when food intake is matched to the control group or no weight loss occurs. Preliminary evidence suggests that TRF may also increase weight loss, fat loss, and reduce the risk of diabetes and cardiovascular disease in humans. This study will test whether TRF enhances fat loss and increases weight loss in adults with obesity, relative to conventional dieting alone. In addition, this study (...) will determine whether TRF reduces risk factors for type 2 diabetes and cardiovascular disease and will measure the feasibility and acceptability of TRF. In conjunction with the parent study described above, four ancillary studies will be conducted: Effect of weight loss on nitrogen metabolism and bacteria in the mouth. The primary endpoints for this ancillary study are plasma and salivary nitrate and nitrite, and the secondary endpoints are salivary nitrate reductase activity and salivary bacterial

2018 Clinical Trials

1739. Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy

epilepsy. For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery. Condition or disease Intervention/treatment Phase Epilepsy Other: MRI exam Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 40 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Basic Science Official Title: Feasibility Study (...) Inclusion Criteria: Patients with diagnosis of pharmaco-resistant focal epilepsy Patient candidate for surgery to resect the epileptogenic zone Patients affiliated to a social security scheme or beneficiaries of such a scheme Patients with French as their mother tongue Patients who have given signed informed consent before performing any procedure related to the study. Exclusion Criteria: Contraindication to performing an MRI: Intellectual disability objectified by a Mini Mental Score (MMS) score <24

2018 Clinical Trials

1740. Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Stroke - ischemic type; Dysphagia following stroke; 40 to 70 years old; Exclusive enteral Feeding; Glasgow > 11. Exclusion Criteria: Pregnants; Febrile Condition; Neoplasia; Pacemaker; Cochlear Implant; Anxious Patient; Degenerative Neurological Diseases. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) groups, where in the intervention group the speech therapy is associated to functional electrical stimulation, and in the control group, the patients will receive the conventional speech therapy with electrical stimulation Placebo with intensity 0hz. Condition or disease Intervention/treatment Phase Dysphagia, Oropharyngeal Stroke, Ischemic Other: Functional Electrical Stimulation Other: Conventional Speech Therapy Not Applicable Detailed Description: Since the 1980's, electrical stimulation has been

2018 Clinical Trials

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