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Tongue Carcinoma

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1721. Lingual thyroid carcinoma with nodal metastasis. (PubMed)

at the tongue base and was the site of the primary tumor. Management of lingual thyroid carcinoma and review of the literature is discussed.A case report and review of the literature of lingual thyroid carcinoma.A young female presented with a left neck mass diagnosed as metastatic papillary thyroid carcinoma. Review of the computed tomography scan of the neck revealed a tongue base mass, absence of an othotopic thyroid gland and bilateral cervical lymphandenopathy. Bilateral selective neck dissections (...) with removal of the tongue base lesion confirmed the diagnosis of lingual thyroid carcinoma with multiple left cervical nodal metastases.A case of lingual papillary thyroid carcinoma with cervical metastasis is reported. Treatment is best managed with surgical excision of all thyroid tissue followed by radioactive iodine ablation. Surgical approaches to the tongue base need to be considered based on the size of the lingual primary tumor and the need to address lymph node metastases gland. This is the first

2007 Laryngoscope

1722. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. (PubMed)

Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. To analyze the impact of resection margin status and histologic prognosticators on local recurrence (LR) and overall survival (OS) for patients with oral squamous cell carcinoma (OSCC). This study was both retrospective and prospective in design. Cohort 1 refers to the entire group of 292 patients with OSCC. The slides from the earliest resection (...) specimens from Cohort 1 were examined in an exploratory manner for multiple parameters. Cohort 2 refers to a subset of 203 patients, who did not receive any neoadjuvant therapy and had outcome data. Cohort 3 represents a subset of Cohort 2 (n = 168) wherein the histologic resection margin status could be reconfirmed. Cohort 4 refers a subset of 85 patients with tongue/floor of mouth tumors. Margin status was designated as follows: group 1, clearance of > or =5 mm with intraoperative analysis, no need

2005 American Journal of Surgical Pathology

1723. In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study. (PubMed)

concentrations of the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), the growth of TSCCa cells, established from a patient with squamous cell carcinoma of the tongue, was evaluated using MTT and crystal violet assay. DNA or RNA synthesis, inducible/endothelial NOS (iNOS/eNOS) mRNA expression and NO production were then examined to determine the possible mechanisms of inhibitory effects of L-NAME on TSCCa cells. L-NAME had an inhibitory effect on TSCCa cell growth in both a concentration- and time (...) In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study. It has been reported that increased nitric oxide synthase (NOS) expression and nitric oxide (NO) production may play an important role in cancer biology. The aim of this study was to determine the roles of NO in tumour cellular proliferation and DNA or RNA synthesis, and to investigate the therapeutic potential of NOS inhibitors in oral cancer. After exposure to different

2006 International Journal of Oral and Maxillofacial Surgery

1724. Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. (PubMed)

Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. The increasing incidence of oral squamous cell carcinoma (SCC) especially among younger people has been observed in many parts of the world. The objective of this study was to delineate the profile of patients with oral SCC with an emphasis on younger people in northern Thailand between 1991-2000. The medical records of 587 (median age 65, male-to-female ratio 1:3:1) patients presenting oral (...) SCC were reviewed, with details of demographic data, staging, histological grading, treatment modality and risk factor profile being collated in detail. Seventy-five patients (12.8%) were 45 years of age or below (median age, 39 years). Most patients regardless of age had stage IV disease (56.2%). The most common histological gradings were well or moderately differentiated SCC (79.4%). The most common site regardless was tongue (42.8%). Most patients (79.4%) received treatments with either

2004 International Journal of Oral and Maxillofacial Surgery

1725. Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma. (PubMed)

Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma. Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1

2003 International Journal of Oral and Maxillofacial Surgery

1726. Mandibular invasion in oral squamous cell carcinoma: investigation by clinical examination and orthopantomogram. (PubMed)

examination tends to over diagnose bone invasion in tumours adjacent to the mandible. The specificity of imaging was also found to be low pointing towards the need for more specific diagnostic tools in doubtful cases. Aggressive surgical therapy, namely segmental or hemi resection of mandible is warranted in case of tumours of the lower alveolus with definite bone invasion. In case of carcinomas of the buccal mucosa and tongue the mandibular resection can be limited to that required for clearance (...) Mandibular invasion in oral squamous cell carcinoma: investigation by clinical examination and orthopantomogram. Assessing the relationship of oral squamous carcinoma with the mandible prior to definitive therapy poses a perplexing problem for the head and neck oncologist. We carried out a prospective open study of 51 (21 female and 30 male; mean age of 53.4 years) patients undergoing mandibular resections for oral squamous cell carcinoma to examine the incidence of mandibular bone invasion

2004 International Journal of Oral and Maxillofacial Surgery

1727. Two stage reconstruction with revascularized grafts after resection of retromolar and oropharyngeal carcinoma. (PubMed)

Two stage reconstruction with revascularized grafts after resection of retromolar and oropharyngeal carcinoma. The clinical outcome of two stage reconstruction with revascularized grafts after resection of extensive retromolar and oropharyngeal squamous cell carcinoma in 17 patients is presented. In the first operation, the intraoral soft tissue defect was covered by a revascularized jejunal flap, and the mandibular defect was bridged by a reconstruction plate. After a period of 5-28 months (...) of the tongue, thus supporting functional restoration. Despite the gravity of disease and invasiveness of therapy, the two stage procedure leads to satisfying functional and aesthetic results thus obtaining appropriate QOL.

2004 International Journal of Oral and Maxillofacial Surgery

1728. Sublingual gland resection in squamous cell carcinoma of the floor of mouth: is it necessary? (PubMed)

Sublingual gland resection in squamous cell carcinoma of the floor of mouth: is it necessary? Little evidence exists to guide surgeons in the management of the sublingual glands (SLG) not macroscopically involved by squamous cell carcinoma of the floor of mouth and oral tongue. This study aims to determine the frequency with which the SLG is invaded, to identify variables predicting for SLG invasion and the morbidity associated with it's resection in entirety.Retrospective cohort study.A review (...) from 14% in patients without SLG resection to 25% (p = 0.05).Total SLG resection in early stage and thin squamous cell carcinoma of the floor of mouth and oral tongue provides minimal oncologic benefit and is associated with increased perioperative morbidity due to neck wound complications.

2006 Laryngoscope

1729. Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. (PubMed)

Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. This study sought to investigate the patterns and distributions of lymph node metastases in oropharyngeal squamous cell carcinoma (SCC) and improve the rationale for elective treatment of N0 neck.One hundred four patients with oropharyngeal SCC who underwent neck dissection between 1992 and 2003 were analyzed retrospectively. All patients had curative surgery as their initial (...) of 68), respectively. Isolated metastasis to level IV occurred on the ipsilateral side in three patients. There were no cases of isolated ipsilateral level I pathologic involvement in an N-positive neck or occult metastasis to this group. The incidence rate of level IV metastasis in patients with ipsilateral nodal metastasis was significantly higher in base of tongue cancer (86% [6 of 7]) compared with tonsillar cancer (34% [20 of 59]) (P=.013). Patients with level IV metastasis had significantly

2006 Laryngoscope

1730. Positron emission tomography in the management of unknown primary head and neck carcinoma. (PubMed)

Positron emission tomography in the management of unknown primary head and neck carcinoma. To assess the role of positron emission tomography (PET) in the management of unknown primary carcinoma of the head and neck region.Prospective case series at an academic medical center.Twenty-six patients with an open excisional biopsy or a fine-needle aspiration biopsy finding that confirmed squamous cell carcinoma of the cervical lymph nodes and no visible primary tumor (as determined by results (...) primary tumors in 26 patients (detection rate, 30.8%). Four occult primary tumors (2 at the base of the tongue and 2 in the tonsil) were detected during routine panendoscopy with negative PET findings. The sensitivity of PET was 66.0%, with a specificity of 92.9%. The positive predictive value was 88.8%, and the negative predictive value was 76.5%.Positron emission tomography can be a valuable tool to identify a subset of patients with an occult primary tumor in the head and neck region. In addition

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2005 Archives of Otolaryngology Head and Neck Surgery

1731. Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck. (PubMed)

Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck. To study the expression of integrin-linked kinase (ILK) in human squamous cell carcinoma of the head and neck (SCCHN) tumor specimens and cell lines and the efficacy of the novel small molecule QLT0267.Immunohistochemical analysis of 17 SCCHN tumor tissue specimens and 3 normal tongue tissue specimens for ILK expression and in vitro analysis of the effectiveness of QLT0267 on SCCHN (...) cells.Academic medical center.Expression levels of ILK in SCCHN tumor specimens and cell lines and the efficacy of QLT0267 in inhibiting cell growth and inducing apoptosis in SCCHN cell lines.Most SCCHN tumor specimens stained for ILK, whereas none of the 3 normal tongue tissue specimens stained for ILK. Integrin-linked kinase was expressed in all 6 SCCHN cell lines tested. In 4 pairs of normal and SCCHN tumor specimens, ILK expression and activity were higher in most tumor samples tested. A kinase assay

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2007 Archives of Otolaryngology Head and Neck Surgery

1732. Racial differences in stage and survival in head and neck squamous cell carcinoma. (PubMed)

Racial differences in stage and survival in head and neck squamous cell carcinoma. The goal of this study was to characterize differences in survival between black patients and white patients with squamous cell carcinoma of the head and neck (HNSCCA).Cases of oral tongue and glottic SCCA in black patients or white patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (years 1988-2002). For each primary site, TNM staging was imputed, and staging (...) distributions were compared between races. For each black patient, a randomly selected white control was matched for age at diagnosis, sex, stage, surgical treatment, and radiation. Kaplan-Meier survival comparisons for both overall and disease-specific survival were then conducted for the matched pairs.From 1,919 cases of carcinoma of the oral tongue, those of 151 black and 1,768 white patients were extracted. Black patients had a significantly elevated T stage (P = .001) and N stage (P = .002) at primary

2007 Laryngoscope

1733. A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. (PubMed)

A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. To determine whether elderly patients manifest poorer survivals for head and neck squamous cell carcinoma.Cases of squamous cell carcinoma of the glottic larynx, oral tongue, and tonsil were extracted from the Surveillance, Epidemiology and End Results database for 1988 to 1998. For each primary site, patients were segregated into two age groups: 50 to 69 years of age and 70 years of age and older (...) . For each case in the latter, elderly group, a reference group case was randomly matched for gender, year of diagnosis, cancer stage, extent of surgery, and radiation therapy. Overall survival and disease-specific survival were compared between the two groups with stage stratification with the Kaplan-Meier method.Cases of glottic carcinoma (1882), tongue carcinoma (426), and tonsillar carcinoma (200) in elderly patients were matched to the reference group. Overall mean survival differences were

2003 Laryngoscope

1734. Level IIb lymph nodes metastasis in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma: a molecular-based study. (PubMed)

and constituted 22% of patients with tongue lesions. There was no instance of isolated metastasis to level IIb lymph nodes without involvement of other nodes in the SOHND specimens.In this study, level IIb lymph node metastasis was only found in association with tongue carcinoma. Although this region may be preserved in elective SOHND in patients with SCC of the oral cavity, it should be included whenever the tongue is the primary site. (...) Level IIb lymph nodes metastasis in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma: a molecular-based study. To identify the incidence of level IIb lymph nodes metastasis in elective supraomohyoid neck dissection (SOHND) as a treatment for patients with squamous cell carcinoma (SCC) of the oral cavity.Prospective analysis of a case series.Forty-eight patients with SCC of the oral cavity and with no palpable lymph nodes at the neck who underwent an elective SOHND

2005 Laryngoscope

1735. Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma. (PubMed)

time of diagnosis to start of radiation therapy, dose of radiation, number of treatment days, duration of treatment, and 1 and 3 year survival were recorded. Differences between the two groups were analyzed using Student's t test.The time course from diagnosis of nasopharyngeal carcinoma to start of radiation therapy was 56 days at SFGH compared with 34 days at UCSFMC. This difference was statistically significant (P = .0001). Difference in diagnosis to treatment intervals for base of tongue cancer (...) Impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring carcinoma. To examine the impact of socioeconomic status on the diagnosis to treatment interval in Waldeyer's ring cancers by comparing the experience of a public hospital and an academic tertiary care medical center.Retrospective review.Otolaryngology clinic of a public hospital and an academic medical center.One hundred seven patients with Waldeyer's ring carcinoma who were diagnosed and treated at San

2005 Laryngoscope

1736. Carcinoma of the oropharynx: factors affecting outcome. (PubMed)

, and posterior pharyngeal wall cancer (P = .010).Patient-related factors such as age and gender were not significant in predicting disease-specific outcome. Important tumor-related factors were the American Joint Committee on Cancer stage and the T stage. Among the oropharyngeal subsites, squamous cell carcinoma of the base of tongue was associated with the worst outcome. (...) Carcinoma of the oropharynx: factors affecting outcome. To assess the value of both patient- and tumor-related factors of oropharyngeal squamous cell carcinoma in predicting patient outcome, with respect to the three primary subsites of the disease. It was hypothesized that the subsite has a significant impact on outcome.Historical cohort study.A chart review was conducted of 126 patients diagnosed with squamous cell carcinoma of the oropharynx over a 10-year period. The oropharynx was divided

2005 Laryngoscope

1737. Thyroid medullary carcinoma in a teenager with Cowden syndrome. (PubMed)

Thyroid medullary carcinoma in a teenager with Cowden syndrome. Cowden syndrome is a multisystemic cancer predisposition disorder, in which the mucocutaneous lesions are the most constant features. We present a case of Cowden syndrome in a teenage boy with hyperkeratotic papules of the facial skin, especially on the eyelids, with episcleritis, proptosis, and papillomatous lesions on the tip of the tongue and lip mucosa. In addition, two nodules in the thyroid gland were detected. On laboratory (...) examination, the carcinoembryonic antigen (CEA) was 34 ng/mL (normal limits: 0-3 ng/mL). Total thyroidectomy was performed. Histopathologic examination of the specimen revealed thyroid medullary carcinoma. After operation, levels of CEA decreased to normal limits.

2007 Laryngoscope

1738. Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma. (PubMed)

Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma. Head and neck squamous cell carcinoma (HNSCC) has high morbidity and mortality, and its relationship with tumor angiogenesis as measured by microvessel density (MVD) or vascular endothelial growth factor (VEGF) expression has shown mixed results, with some, but not others, reporting correlation with outcome.A retrospective study of 186 patients (...) with HNSCC was performed. Patients were evaluated for MVD and VEGF and to correlate the levels with clinical parameters, including age at diagnosis, sex, site of tumor, stage, survival (disease free and overall), pathological tumor grade, and the presence of lymph node metastases.The 186 cancers included the following sites: oral tongue (n = 69), palate (n = 9), maxillary sinus (n = 8), floor of mouth (n = 13), oropharynx (n = 27), hypopharynx (n = 26) and larynx (n = 34). Over three-quarters of patients

2007 Annals of Surgical Oncology

1739. Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma. (PubMed)

Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma. Moesin is a linking protein of the submembraneous cytoskeleton and plays a key role in the control of cell morphology, adhesion, and motility. The aim of the present study was to elucidate the clinical significance of expression patterns of moesin in patients with oral squamous cell carcinoma (OSCC).Immunohistochemistry for moesin monoclonal antibody was performed on 103 paraffin-embedded (...) specimens from patients with primary OSCC, including 30 patients with locoregional lymph node metastasis, and in the sections from nude mice transplanted with two cell lines derived from a single human tongue cancer (SQUU-A and SQUU-B).Expression patterns of moesin in OSCCs were divided into three groups: membranous pattern; mixed pattern; and cytoplasmic pattern. These expression patterns correlated with tumor size, lymph node metastasis, mode of invasion, differentiation, and lymphocytic infiltration

2004 Clinical Cancer Research

1740. The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. (PubMed)

). Bleomycin with electroporation had a significantly (p<0.001) greater number of patients showing a partial or complete response to the therapy when compared to bleomycin alone. Thirteen adverse events were reported which included five episodes of local bleeding, six local infections, one local tongue swelling and one cardiac arrhythmia.Fifty-seven percent of squamous cell carcinomas of the head and neck demonstrated a partial or complete response to intratumour electroporation with bleomycin suggesting (...) The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. To determine the safety and efficacy of electroporation with bleomycin in patients with advanced squamous cell carcinoma of the head and neck.Two open-label, multicenter, single-arm Phase II studies of intratumour electroporation therapy. Sixty-two patients with 86 squamous cell carcinoma tumours of the head and neck were enrolled. Twenty-five patients

2005 European Journal of Surgical Oncology

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