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Tongue Carcinoma

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1681. Adult Bronchoscopy Training

, and endobronchial or transbronchial biopsy. An additional 10 must be therapeutic procedures, including “core out” of tumor, laser, dilatation of strictures, stent placement, and photodynamic therapy, or other interventions such as cryotherapy, electrocautery, or argon plasma coagula- tion. Investigation of mediastinal adenopathy requires performing 30 procedures, 10 of which must include EBUS with fi ne needle aspiration. 22 A thorough understanding of the role of bronchoscopy is necessary in the diagnostic (...) evaluation and manage- ment of patients with benign and malignant disorders of the chest. Th is understanding is of paramount impor- tance in selecting the ideal bronchoscopic technique and its role in selecting the best surgical treatment of a particular airway or pulmonary problem. Th is point is where a signifi cant diff erence emerges between pulmo- nary and thoracic surgery trainees. Whereas pulmonary fellows may be more focused on the diagnostic and palliative management of a particular chest

2015 American College of Chest Physicians

1682. Clinical practice guideline for the management of patients with Parkinson´s disease

Clinical practice guideline for the management of patients with Parkinson´s disease Clini Cal pra Cti Ce guidelines in the sns a Clinical Practice Guideline for the Management of Patients with Parkinson’s Disease CLINICAL PRACTICE GUIDELINES IN THE SPANISH NHS MINISTRY OF HEALTH, SOCIAL SERVICES AND EQUALITY Instituto Aragonés de Ciencias de la SaludClinical Practice Guideline for the Management of Patients with Parkinson’s Disease MINISTERIO DE SANIDAD, SERVICIOS SOCIALES E IGUALDAD MINISTERIO (...) of the Clinical practice g patients with parkinson’s disease. Clinical practice g patients with parkinson’s disease. Ministry of health, social services, and equality. institute of h ealth sciences of aragon; 2014. Clinical practice g uidelines of the nhs . MINISTERIO DE SANIDAD, SERVICIOS SOCIALES E IGUALDAD MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD Instituto Aragonés de Ciencias de la Salud uidelines for the Management of uidelines for the Management of Table of Contents Introduction 7 Authorship

2015 GuiaSalud

1683. Acute Pain Management: Scientific Evidence

Zealand College of Anaesthetists and its Faculty of Pain Medicine xi INTRODUCTION References Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17(1): 1–12. Johnston ME, Brouwers MC & Browman GP (2003) Keeping cancer guidelines current: results of a comprehensive prospective literature monitoring strategy for twenty clinical practice guidelines. Int J Technol Assess Health Care 19(4): 646–55. Liberati (...) 307 8.6.1 Acute abdominal pain 307 8.6.2 Herpes zoster-associated pain 310 8.6.3 Acute cardiac pain 312 8.6.4 Acute pain associated with haematological disorders 313 8.6.5 Acute headache 317 8.6.6 Acute pain associated with neurological disorders 327 8.6.7 Orofacial pain 329 8.6.8 Acute pain in patients with HIV infection 336 8.7 Acute cancer pain 339 8.7.1 Assessment of acute cancer pain 339 8.7.2 Principles of management of acute cancer pain 339xviii Acute Pain Management: Scientific Evidence

2015 Clinical Practice Guidelines Portal

1684. Menopausal Symptoms: Comparative Effectiveness of Therapies

controlled trials provided the evidence base for symptom relief. Standardized mean differences were calculated to allow pooling of outcomes from varied measures. Network meta-analyses were performed when possible, along with pairwise comparisons. Systematic reviews, cohort studies, and case-control studies provided evidence for the following long-term benefits and harms: breast, colon, endometrial, and ovarian cancer; coronary heart disease and venous thromboembolic events; gallbladder disease (...) . Over the long term, estrogen combined with progestogen has both beneficial effects (fewer osteoporotic fractures) and harmful effects (increased risk of breast cancer, gallbladder disease, venous thromboembolic events, and stroke). Estrogens given alone do not appear to increase breast cancer risk, although endometrial cancer risk is increased. There is limited evidence on the long-term effects of most nonhormone treatments. No studies were identified that examined the efficacy or safety

2015 Effective Health Care Program (AHRQ)

1685. Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma Full Text available with Trip Pro

our treatment policy for tonsillar and base of tongue carcinoma. We first changed the treatment for the lesions with worst prognosis, i.e., those with T3-T4 carcinomas, from radiotherapy only, to radical surgery and postoperative radiotherapy. We have since that time increasingly also operated the smaller oropharyngeal carcinomas. The 2 years' overall survival and disease-specific survival for all patients diagnosed in the 1992-1997 period was 56 and 63%, respectively. The results from a similar (...) Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma Since 1992 we have prospectively included all head and neck cancer patients in our health region in a departmental based register. Our hospital takes care of all head and neck cancer patients in our health region consisting of approximately 1 million people. In 1997, we evaluated the results of the treatment of oropharyngeal cancer in the 1992-1997 period. On the basis of this evaluation, we changed

2010 European Archives of Oto-Rhino-Laryngology

1686. Papillary carcinoma arising in a submentalintralingual thyroglossal duct cyst Full Text available with Trip Pro

Papillary carcinoma arising in a submentalintralingual thyroglossal duct cyst An extremely rare case of papillary carcinoma is described arising in a submental-intralingual thyroglossal duct cyst. A 27-year-old male presented with a painless swelling in the submental region extending to the tongue which had gradually been increasing in size over the last three months. Upon examination of the neck, a tender right paramedian mass was found in the submental region just above the hyoid bone (...) , it was mobile upon swallowing without clinical evidence of cervical nodes. The Sistrunk surgical technique, extended to the submental and intra lingual region was used to radically remove the mass. The occurrence of carcinoma of the thyroglossal duct cyst, even though rare and unexpected, should always be considered an option, and histologically ruled out mainly on account of the atypical localization, such as the submental-intralingual reported herein. The two different surgical approaches reported

2010 Acta Otorhinolaryngologica Italica

1687. Dysphagia Rehabilitation for Nasopharyngeal Carcinoma Patients Post Radiotherapy

should provide justification for rehabilitation time, clinicians' efforts, costs involved and resources used in rehabilitating the swallowing difficulties of the NPC patients. Condition or disease Intervention/treatment Phase Nasopharyngeal Carcinoma Radiotherapy Behavioral: Traditional rehabilitation (TR) Behavioral: Transcutaneous electrical stimulation (ES) Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 160 (...) to Layout table for additonal information Responsible Party: Michael Tong, Professor, Chinese University of Hong Kong ClinicalTrials.gov Identifier: Other Study ID Numbers: GRF 475210 First Posted: November 10, 2010 Last Update Posted: February 26, 2013 Last Verified: February 2013 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Nasopharyngeal Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Nasopharyngeal Neoplasms Pharyngeal Neoplasms

2010 Clinical Trials

1688. Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma

visits for tests 1 day and 1 week after the end of rapamycin treatment, followed by HNSCC surgery. Participants will have a final visit to provide blood samples 30 days after surgery. Participants medical records will be reviewed 1 year after surgery; however, participants will not need to have further study visits at this time. Condition or disease Intervention/treatment Phase Mouth Neoplasms Head and Neck Neoplasms Tongue Neoplasms Carcinoma, Squamous Cell Drug: Sirolimus Phase 1 Phase 2 Study (...) for MeSH terms Carcinoma Neoplasms Carcinoma, Squamous Cell Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms Mouth Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms, Squamous Cell Neoplasms by Site Mouth Diseases Stomatognathic Diseases Tongue Diseases Sirolimus Everolimus Anti-Bacterial Agents Anti-Infective Agents Antibiotics, Antineoplastic Antineoplastic Agents Antifungal Agents Immunosuppressive Agents Immunologic Factors

2010 Clinical Trials

1689. Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma

of tumor cells by blocking some of the enzymes needed for cell growth. Condition or disease Intervention/treatment Phase Recurrent Oral Cavity Adenoid Cystic Carcinoma Recurrent Salivary Gland Carcinoma Salivary Gland Adenoid Cystic Carcinoma Stage III Major Salivary Gland Cancer AJCC v7 Stage III Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Stage IVA Major Salivary Gland Cancer AJCC v7 Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Stage IVB Major Salivary Gland Cancer AJCC v7 (...) Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Stage IVC Major Salivary Gland Cancer AJCC v7 Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Tongue Carcinoma Other: Laboratory Biomarker Analysis Drug: Vorinostat Phase 2 Detailed Description: PRIMARY OBJECTIVES: I. To evaluate the efficacy by means of response rate (based on Response Evaluation Criteria in Solid Tumors [RECIST] 1.1 criteria) of vorinostat in the treatment of patients with locally advanced, recurrent

2010 Clinical Trials

1690. Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract

) pathology will be used to see whether both tests tended to agree on diagnoses. Condition or disease Intervention/treatment Phase Upper Aerodigestive Tract Lesions Neoplasms, Oropharyngeal Oropharyngeal Cancer Neoplasms, Hypopharyngeal Hypopharyngeal Cancer Head and Neck Neoplasms UADT Neoplasms Carcinoma, Squamous Cell Papilloma Device: Direct Rigid Endoscopy Device: Transnasal Flexible Endoscopy with Narrowband Imaging Not Applicable Study Design Go to Layout table for study information Study Type (...) Comprehensive Cancer Center ) First Posted: August 4, 2010 Last Update Posted: August 19, 2014 Last Verified: August 2014 Keywords provided by University of California, San Francisco: laryngoscopy Laryngoscopic Surgery laryngoscopes upper aerodigestive tract lesions endoscopy biopsy Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Neoplasms Papilloma Head and Neck Neoplasms Oropharyngeal Neoplasms Carcinoma, Squamous Cell Hypopharyngeal Neoplasms Neoplasms, Glandular and Epithelial

2010 Clinical Trials

1691. Study of Sorafenib With or Without VT-122 in Patients With Hepatocellular Carcinoma (HCC)

Therapeutics ClinicalTrials.gov Identifier: Other Study ID Numbers: VT1-CAX-200 First Posted: December 23, 2010 Last Update Posted: December 9, 2015 Last Verified: December 2015 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma, Hepatocellular Adenocarcinoma Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Liver Neoplasms Digestive System Neoplasms Neoplasms by Site Digestive System Diseases Liver Diseases Sorafenib Etodolac Propranolol Antineoplastic (...) specific screening procedures with the understanding that the patient has the right to withdraw from the study at any time, for any reason without prejudice. Exclusion Criteria: Participants must not have any of the following criteria to be considered eligible for inclusion in the study: The patient has a history of another primary cancer, with the exception of: a) curatively resected non-melanomatous skin cancer; b) curatively treated cervical carcinoma in-situ; or c) other primary solid tumor

2010 Clinical Trials

1692. Ph I Vorinostat in the Treatment of Advanced Staged Oropharyngeal Squamous Cell Carcinoma

palate, base of tongue, lateral and posterior pharyngeal wall Patient must be AJCC (American Joint Committee on Cancer) Stage III (T3N0, T1-2N1) or Stage IVa (T1-4N2-3M0, T4N0-1 M0) and be either unresectable or borderline resectable No prior therapy for the tumor, including extensive surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy or any other investigational agents; surgical biopsy prior to beginning the study is allowable Prior malignancies at sites other than the head (...) and neck are allowable if there has been greater than or equal to a 3 year disease free interval; basal cell carcinoma of the skin and in-situ cervix dysplasias are allowable within this 3 year interval if completely resected There must be documentation of evaluable tumor within four weeks of beginning therapy ECOG (Eastern Cooperative Oncology Group) Performance Status 0-2, (Karnofsky > 60%) Ability to understand and the willingness to sign a written informed consent Patient must have normal liver

2010 Clinical Trials

1693. Multiple squamous cell carcinomas of the oral cavity in a young patient with graft-versus-host disease following allogenic bone marrow transplantation. (Abstract)

Multiple squamous cell carcinomas of the oral cavity in a young patient with graft-versus-host disease following allogenic bone marrow transplantation. The development of secondary malignancies is a potential long-term complication after haematopoietic stem cell transplantation (HSCT). In particular, a higher incidence of oral squamous cell carcinoma (OSCC) has been reported in patients experiencing chronic graft versus host disease (cGvHD) secondary to HSCT. This report describes (...) the development of two synchronous SCC of the buccal mucosa in a young female patient treated with HSCT for beta thalassemia major. She had undergone HSCT at the age of 9 years and developed oral GvHD 6 months after transplant. 17 years after HSCT she developed two synchronous carcinomatous lesions on the tongue and floor of the mouth. The current case highlights the association between oral cGvHD and OSCC, and the possible development of OSCC in young patients even many years after HSCT. This evidence

2010 International Journal of Oral and Maxillofacial Surgery

1694. Population-based analysis of oral and oropharyngeal carcinoma: Changing trends of histopathologic differentiation, survival and patient demographics. (Abstract)

Population-based analysis of oral and oropharyngeal carcinoma: Changing trends of histopathologic differentiation, survival and patient demographics. To examine demographic, histologic, and survival trends of oral cavity and oropharyngeal (OC/OP) squamous cell carcinoma (SCCA) patients over the past 3 decades. To test the hypothesis that decreased histologic differentiation and increased disease-specific survival is related to a decline in smoking rates and an increased percentage of human (...) papillomavirus (HPV)-related tumors.Retrospective cohort analysis was done using the Surveillance, Epidemiology, and End-Results (SEER) database of the national cancer institute.SEER data were used to design seven cohorts: 1975-1979, 1980-1984, 1985-1989, 1990-1994, 1995-1999, 2000-2004, and 2005-2006. Incidence rates, histologic tumor grade. and 5-year survival rates were analyzed over time. Further subgroup analysis was performed according to subsite, age, gender, and stage.In both OC and OP, well

2010 Laryngoscope

1695. The Impact of Adjuvant Radiotherapy on Survival in T1-2N1 Squamous Cell Carcinoma of the Oral Cavity. Full Text available with Trip Pro

survival in patients with T1-2N1 OCSCC.Postoperative RT improved the 5-year overall survival rate (41.4% for surgery alone vs 54.2% for surgery plus RT [P < .001]). Improvement in overall survival in patients with T1N1 disease did not achieve statistical significance with the addition of RT in contradistinction to that in patients with T2N1 disease. Adjuvant RT improved survival in patients with T2 tongue and floor of mouth disease (52.3% vs 37.9% [P = .002] and 39.9% vs 17.7% [P = .003], respectively (...) ).In cases involving T1-2N1 OCSCC in the Surveillance, Epidemiology, and End Results database, the use of RT is associated with statistically significant improved overall survival and cause-specific survival in patients with T2 disease, most strongly in the oral tongue and the floor of the mouth.

2010 Archives of Otolaryngology Head and Neck Surgery

1696. Long noncoding RNA MPRL promotes mitochondrial fission and cisplatin chemosensitivity via disruption of pre-miRNA processing. Full Text available with Trip Pro

Long noncoding RNA MPRL promotes mitochondrial fission and cisplatin chemosensitivity via disruption of pre-miRNA processing. The overall biological roles and clinical significance of most long noncoding RNAs (lncRNA) in chemosensitivity are not fully understood. We investigated the biological function, mechanism, and clinical significance of lncRNA NR_034085, which we termed miRNA processing-related lncRNA (MPRL), in tongue squamous cell carcinoma (TSCC).LncRNA expression in TSCC cell lines (...) fission and cisplatin sensitivity through miR-483-5p. In exploring the underlying interaction between MPRL and miR-483-5p, we identified that cytoplasmic MPRL directly binds to pre-miR-483 within the loop region and blocks pre-miR-483 recognition and cleavage by TRBP-DICER-complex, thereby inhibiting miR-483-5p generation and upregulating miR-483-5p downstream target-FIS1 expression. Furthermore, overexpression or knockdown MPRL altered tumor apoptosis and growth in mouse xenografts. Importantly, we

2019 Clinical Cancer Research

1697. FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway. Full Text available with Trip Pro

FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFκB pathway. Although the prognosis of chronic myeloid leukemia (CML) has dramatically improved, the pathogenesis of CML remains elusive. Studies have shown that sustained phosphorylation of AKT1 plays a crucial role in the proliferation of CML cells. Evidence indicates that in tongue cancer cells, FAM168A, also known as tongue cancer resistance-associated protein (TCRP1), can directly bind to AKT1 (...) ) -Abelson murine leukemia (ABL1) fusion protein and AKT1, respectively. Animal experiments confirmed that FAM168A interference prolonged the survival and reduced the tumor formation in mice inoculated with K562 cells. The results of clinical specimens showed that FAM168A expression and AKT1 phosphorylation were significantly elevated in CML patients.This study demonstrates that FAM168A may act as a linker protein that binds to BCR-ABL1 and AKT1, which further mediates the downstream signaling pathways

2019 BMC Cancer

1698. Anesthesia and ventilation options for flex robotic assisted laryngopharyngeal surgery. (Abstract)

Anesthesia and ventilation options for flex robotic assisted laryngopharyngeal surgery. Transoral treatment of benign and malignant lesions of laryngopharynx has limitations in exposure and access, partially due to the endotracheal tube (ETT). With a proper airway control to tailor ventilation and maximize exposure, transoral Flex robotic surgery (FLEX), using its 3D camera and instruments, can expand its ability. Choosing the right ETT, including a novel concept of using jet ventilation (JV (...) indications for trans-oral robotic surgery including the feasibility of JV in FLEX procedures were shown.Lesions of the tongue base, hypopharynx, larynx and trachea have the possibility to be managed with adequate exposure with minimal obstruction from ETT. Robotic HD camera permits both the surgeon and anesthesiologist to observe surgery and safely monitor the airway. An algorithm was developed for selecting ideal ventilation method for different procedures. The FLEX and the utilization of JV allows

2019 American Journal of Otolaryngology

1699. Total Glossectomy With Free Flap Reconstruction: Twenty-Year Experience at a Tertiary Medical Center. (Abstract)

31, 2014 were included in the analysis. Patient characteristics and clinical outcomes were reviewed.Forty-eight patients underwent total glossectomy for oral tongue and base of tongue cancer. The mean age of the patients was 56 (range, 29-92 years). History of tobacco and heavy alcohol use was found in 76% and 11% of patients, respectively. The majority of patients had advanced cancer (91.7% at stage IV), and 60.4% had salvage therapy for recurrent disease. T4 disease comprised 81% of patients (...) . Sixty percent had clinical or radiographic evidence of nodal metastasis. Reconstruction of the defect was performed with free flaps from the rectus abdominus (40%), fibula (25%), anterolateral thigh (23%), and other donor tissues. One- and 5-year survival rates were 42% and 26%, with locoregional and distant recurrence reported at 36% and 25%, respectively.Total glossectomy for oncologic control is most commonly performed in patients who have stage IV cancers. Despite high reconstructive success

2019 Laryngoscope

1700. Syphilis of the oropharynx: Case series of "The Great Masquerader". (Abstract)

Syphilis of the oropharynx: Case series of "The Great Masquerader". Syphilis is a sexually transmitted infection with various presentations. Although, oropharyngeal manifestations are known to occur, the purpose of this study is to present the first case series in which the lesions were initially mistaken for human-papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).A multi-institutional retrospective review.Six cases of oropharyngeal syphilis were initially thought (...) to be secondary to OPSCC due to presentation. Symptoms were vague and exam findings consisted of either a tonsillar or base of tongue mass, or lymphadenopathy. Biopsies were negative for OPSCC. Further workup diagnosed syphilis, with resolution of symptoms and lesions after antibiotic treatment.Head and neck manifestations of syphilis have been reported in the literature. However, this is the first series reporting on oropharyngeal syphilis masquerading as HPV-related OPSCC. Ultimately, otolaryngologists must

2019 American Journal of Otolaryngology

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