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Tongue Carcinoma

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1581. CRACKCast E075 – Upper Respiratory Tract Infections

– Sore Throat” List 4 Centor criteria and how management proceeds Describe 3 diagnostic tests for infectious mononucleosis Describe the management of GABHS [1] List potential causes of pharyngitis; List 5 viral and 5 bacterial etiologies of pharyngitis Emergent Diagnoses for Sore Throat Diseases not to miss: Primary HIV Epiglottitis Bacterial tracheitis Corynebacterium Diphtheriae Ludwig’s angina Epstein barr virus Cancer Gonorrhea / Herpes Simplex Foreign body Angioedema Peri-tonsillar abscess Retro (...) neutropenia, thyroiditis Trauma – retained foreign body, laryngeal #, hematoma, CAUSTIC exposure, POST-tonsillectomy eschar Tumourstongue, larynx, thyroid, etc [2] What are the indications for steroids in a patient with pharyngitis? Complex issue! Cochrane review in 2012 concluded that symptoms were improved, but recurrence rates did not change. The study was also underpowered for complication, and not enough children were included for analysis. ***infectious mononucleosis, peritonsillar abscess

2017 CandiEM

1582. Joint NASPGHAN and ESPGHAN guidelines on Gastro-oesophageal Reflux Disease in Children

circumference May suggest raised intracranial pressure for example due to meningitis, brain tumor or hydrocephalus Seizures Macro/microcephaly Gastrointestinal Persistent forceful vomiting Indicative of hypertrophic pyloric stenosis (infants up to 2 months old) Nocturnal vomiting May suggest increased intracranial pressure Bilious vomiting Regarded as symptom of intestinal obstruction. Possible causes include Hirschsprung disease, intestinal atresia or mid-gut volvulus or intussusception Hematemesis (...) Joint NASPGHAN and ESPGHAN guidelines on Gastro-oesophageal Reflux Disease in Children Copyright © ESPGHAN and NASPGHAN. All rights reserved. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society forPediatricGastroenterology,Hepatology,andNutrition Rachel Rosen, y Yvan Vandenplas, z Maartje Singendonk, § Michael Cabana, jj Carlo DiLorenzo, Frederic

2018 British Society of Paediatric Gastroenterology Hepatology and Nutrition

1583. The Oral Management of Oncology Patients Requiring Radiotherapy, Chemotherapy and / or Bone Marrow Transplantation

at a late stage in England (2014) and Northern Ireland (2010-2014). Incidence rates for all cancers combined are projected to rise by 2% in the UK between 2014 and 2035, to 742 cases per 100,000 people by 2035. Conversely, the outlook following treatment for malignant disease, has improved in the last two decades since the 1995 Calman-Hine report which outlined radical reform of the UK's cancer services with the aim of improving outcomes and reducing inequalities in NHS cancer care (Department of Health (...) (National Cancer Institute, 2016). Complications may include profound functional and sensory changes to the oral mucosa, in addition to an increased susceptibility to dental caries and periodontal disease (National 5 Cancer Institute, 2016) (Sroussi et al., 2017). These may impact directly on cancer therapy resulting in the need to pause treatment, but also have a significant impact on the longevity and quality of life during and after cancer therapy (Gandhi et al., 2017). Adults with malignant disease

2018 British Society for Disability and Oral Health

1584. Palliative care - oral: Scenario: Prevention

[ ]. There is evidence that treatment with oral antifungal drugs that are completely or partially absorbed from the gastrointestinal tract is effective in preventing oral candidiasis in people with cancer receiving chemotherapy and/or radiotherapy. There is no evidence on the effect of prevention of oral candidiasis on general well-being or that effective prophylaxis is associated with a reduction in systemic disease. Little evidence is available on drug toxicity and development of microbial drug resistance (...) with fluoride is often better tolerated. Rinse the mouth after each meal and at night with warm water or 0.9% sodium chloride solution (ready made or made up). Irrigation with warm water or 0.9% sodium chloride solution helps to remove oral debris and is soothing and nontraumatic. Sodium chloride solution can be made for each rinse by dissolving half a 5 mL teaspoon of salt in 225 mL water. If the tongue is heavily furred (especially if causing distress), brush with a soft toothbrush twice a day and use

2020 NICE Clinical Knowledge Summaries

1585. Psychosis and schizophrenia: Adverse effects

be relieved by reducing the dose of the antipsychotic. Tardive dyskinesia — late-onset movement disorder that can occur with prolonged use of antipsychotics. It is characterized by rhythmical, involuntary movements, usually lip-smacking and tongue rotating, although it can affect the limbs and trunk. It may be persistent and can sometimes worsen on treatment withdrawal. The drug should be discontinued on appearance of early signs. Weight gain — common with all antipsychotics, but more frequent with second (...) levels at least annually. People taking antipsychotics who experience palpitations or any other symptoms that suggest cardiac disease should undergo electrocardiography. Stroke risk — olanzapine and risperidone are associated with an increased risk of stroke in elderly people with dementia. The Committee on Safety of Medicines has advised [ ] that: For acute psychotic conditions in elderly people with dementia, risperidone should be limited to short-term use under specialist advice. Olanzapine

2020 NICE Clinical Knowledge Summaries

1586. Diarrhoea - adult's assessment: Scenario: Acute diarrhoea (less than 4 weeks)

a rectal examination to assess for rectal tenderness, stool consistency, and for blood, mucus, and possible malignancy. If acute causes have been excluded and the person has features suggestive of an early presentation of a , see . Clinical features of dehydration Mild dehydration Lassitude. Anorexia, nausea. Light-headedness. Postural hypotension. Usually no signs. Moderate dehydration Apathy/tiredness. Dizziness. Nausea/headache. Muscle cramps. Pinched face. Dry tongue or sunken eyes. Reduced skin (...) , which is often present in inflammatory bowel disease, irritable bowel syndrome, and ischaemic colitis. History of recent radiation treatment to the pelvis. Factors increasing the risk of immunosuppression (for example, human immunodeficiency virus infection, long term steroid use, or chemotherapy). Any surgery or medical conditions (for example, endocrine disease) accounting for the diarrhoea. Diet and use of alcohol or substances such as sorbitol. Assess for complications of diarrhoea

2020 NICE Clinical Knowledge Summaries

1587. HIV infection and AIDS: HIV diagnosis in people with symptoms

loss of vision but is treatable and prognosis improves with earlier diagnosis. Symptoms include floaters (due to inflammatory cells in the vitreous), reduced vision, flashing lights, and scotomas. Multiple granular white dots with retinal haemorrhages may be noted on fundoscopy. Cancers HIV infection is associated with an increased risk of malignancies many of which are associated with advanced HIV disease such as Kaposi's sarcoma, non-Hodgkin's lymphoma, and invasive cervical cancer. Lymphoma (...) as vesicles, then ulcerate and crust. See the CKS topic on for further information. Gastrointestinal conditions HIV infection may cause: Oesophageal candidiasis Symptoms include retrosternal pain or dysphagia, and oral candidiasis is also likely to be present. Diarrhoea This is very common and is usually due to virulent organisms or opportunistic infections. Bacteria, protozoa (such as Cryptosporidium species which indicates advanced HIV disease when persistent), Mycobacteria, viruses, cancers

2020 NICE Clinical Knowledge Summaries

1588. Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. (Abstract)

% (11/13). Of the HPV-16 infected oral tongue cancers, the integration rate of HPV-16 was 55% (6/11). The HPV-16 positive group showed shallower stromal invasion than the HPV-16 negative group (p=0.045). HPV-16 may be one of the causative factors in early squamous cell oral tongue carcinoma and be associated with its depth of invasion.Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (...) Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. Human papilloma virus (HPV) infection is controversial as a causative factor in oral tongue cancer. This study aimed to clarify whether HPV directly affects the carcinogenesis and biological behaviour of oral tongue cancer by analyzing HPV prevalence, the physical status of the virus and clinicopathological parameters. Archival tissue was obtained from 36 patients diagnosed with T1 and T2 oral tongue

2010 International Journal of Oral and Maxillofacial Surgery

1589. Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. (Abstract)

Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. The knotting of an intragastric tube is a rare complication, and knotting of a feeding jejunostomy tube is rarer, and the removal or replacement of the tube is difficult. There are many reports on the removal of intragastric knotted tubes, but these methods cannot be applied for the removal of knotted feeding jejunostomy tubes, which do not have a natural orifice as large as the mouth to facilitate (...) the introduction of instruments to correct the complication or remove the knotted tube. This is a stressful situation and doctors have to adopt strategies to resolve this problem safely and effectively in the absence of strong evidence-based knowledge. The author presents the case of a patient with tongue base cancer with a nasogastric feeding jejunostomy tube that knotted during the therapeutic course and describes a simple method to remove the knotted tube using Kelly clamps without additional invasive

2010 International Journal of Oral and Maxillofacial Surgery

1590. Compliance with quality assurance measures in patients treated for early oral tongue cancer. Full Text available with Trip Pro

Compliance with quality assurance measures in patients treated for early oral tongue cancer. The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer.A retrospective chart review included 116 patients treated for T1-T2/N0-N1 squamous cell carcinoma (SCC) of the oral tongue between 1998 and 2003. A set of quality measures (...) compliance with documenting the 4 parameters designated as quality measures for treatment of oral tongue SCC was acceptable, thus demonstrating that it is possible to use these data for measuring effective cancer care.Copyright (c) 2010 American Cancer Society.

2010 Cancer

1591. Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High-Risk Appalachian Patients Previously Treated With Surgery For Oral Cancer

Appalachian Oral Cancer Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Oropharyngeal Neoplasms Carcinoma, Verrucous Mouth Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases Mouth Diseases Tongue Diseases (...) encompasses cancers of the oral cavity including lips, buccal mucosa, teeth, floor of the mouth and gums and those of the oropharynx consisting of the base of the tongue, soft palate, tonsillar area, and the posterior pharyngeal wall will be eligible Patients who have followed the advice of their physician and have been definitively treated for their tumor by any method and are currently disease free will be eligible Patients may be enrolled as early as their first follow-up post-operative clinic visit

2011 Clinical Trials

1592. Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer

ways. Some block the ability of the tumor to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Everolimus may stop the growth of tumor cells by blocking blood flow to the tumor. Giving cetuximab together with everolimus may be an effective treatment for colon cancer or head and neck cancer Condition or disease Intervention/treatment Phase Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Basal Cell Carcinoma of the Lip Recurrent (...) , Adenoid Cystic Neoplasms, Unknown Primary Carcinoma, Mucoepidermoid Granuloma Esthesioneuroblastoma, Olfactory Papilloma, Inverted Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Digestive System Diseases

2011 Clinical Trials

1593. Patterns of extralaryngeal spread of laryngeal cancer: Thyroid Cartilage Penetration Occurs in a Minority of Patients with Extralaryngeal Spread of Laryngeal Squamous Cell Cancers. (Abstract)

Patterns of extralaryngeal spread of laryngeal cancer: Thyroid Cartilage Penetration Occurs in a Minority of Patients with Extralaryngeal Spread of Laryngeal Squamous Cell Cancers. Laryngeal preservation programs for patients with advanced laryngeal squamous cell carcinomas (SCC) have generally excluded patients with T4 disease. The accuracy of preoperative imaging in evaluating thyroid cartilage penetration and extralaryngeal spread (ELS) has previously been questioned. Clinically, SCC spread (...) into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration. The current study was designed to characterize and quantify the routes and frequency of ELS.A total of 103 laryngectomy specimens with preoperative contrast-enhanced neck computed tomography scans were coded according to the observed extent of disease by pathological and radiological data. Previously irradiated tumors or those of pyriform sinus origin were omitted. Routes of spread were

2011 Cancer

1594. Tagrisso - osimertinib

interval at steady state BCRP Breast Cancer Resistance Protein BCS Biopharmaceutics Classification System BICR Blinded independent central review CAS chemical abstract service CEP certificate European pharmacopoeia CFU colony-forming unit CI Confidence interval Cmax Maximum plasma concentration Cmin Minimum plasma concentration CMC Chemistry manufacturing and controls c-QTc Concentration-QTc CR Complete Response Ct Circulating tumour CTCAE Common terminology criteria for adverse events CTD common (...) QTcF QTc Fredericia corrected QTPP Quality target product profile r correlation coefficient RECIST Response Evaluation Criteria in Solid Tumours RH relative humidity RSD relative standard deviation SAE Serious adverse event SAP Statistical Analysis Plan SD Stable disease SmPC Summary of Product Characteristics TAMC total aerobic microbial count THF tetrahydrofuran TKI Tyrosine kinase inhibitor tmax Time to reach maximum concentration TTC threshold of toxicological concern TYMC total combined yeasts

2016 European Medicines Agency - EPARs

1595. Vaxelis - diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and Haemophilus type b conjugate vaccine (adsorbed)

and invasive diseases caused by Haemophilus influenzae type b (Hib), in children from the age of 6 weeks up to the fifth birthday. Vaxelis should be used in accordance with official recommendations. The legal basis for this application refers to: Article 8.3 of Directive 2001/83/EC - complete and independent application. The applicant indicated that ‘diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and haemophilus type b conjugate vaccine (adsorbed (...) discussion within the Committee, issued a positive opinion for granting a Marketing Authorisation to Vaxelis. 2. Scientific discussion 2.1. Introduction Vaxelis or PR5I is a hexavalent paediatric combination vaccine for primary and booster immunization of infants and toddlers above the age of 6 weeks. Vaxelis is referred to as PR5I throughout the report. It is designed to provide active immunization against diseases caused by Corynebacterium diphtheria, Clostridium tetani, Bordetella pertussis

2016 European Medicines Agency - EPARs

1596. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals ? protocol version 5.3

Suggested citation: European Centre for Disease Prevention and Control. Point prevalence survey of healthcare- associated infections and antimicrobial use in European acute care hospitals – protocol version 5.3. Stockholm: ECDC; 2016. Stockholm, October 2016 ISBN 978-92-9193-993-0 doi 10.2900/374985 TQ-04-16-903-EN-N © European Centre for Disease Prevention and Control, 2016 Reproduction is authorised, provided the source is acknowledged. TECHNICAL DOCUMENT PPS of HAIs and antimicrobial use in European (...) AM Antimicrobial/antimicrobial agent AMR Antimicrobial resistance ATC Anatomical Therapeutic Chemical classification system (WHO) AU Antimicrobial use BSI Bloodstream infection CDC Centres for Disease Control and Prevention (Atlanta, USA) CDI Clostridium difficile infections CFU Colony-forming units CVC Central vascular catheter DSN Dedicated surveillance network EARS-Net European Antimicrobial Resistance Surveillance Network (at ECDC) ECDC European Centre for Disease Prevention and Control EEA

2016 European Centre for Disease Prevention and Control - Technical Guidance

1597. Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines

disorders). - Severe atopic disease. - Concurrent medications which increase the risk (e.g.b-adrenergic blockers, angiotensin-converting enzyme inhibitors). • If there is a high risk of a rapid tumour lysis at initiation of chemotherapy and/or targeted therapies, in malignancies with a high tumour burden, consider: - Addition of rasburicase and increased hydration [I, A]. - Delivering MoAbs in a fractionated way [III, B]. Signsandsymptoms • The National Cancer Institute CTCAE version 4.03 distinguishes (...) for developing an anaphylactic reaction are: age-related fac- tors, concomitant diseases such as chronic respiratory dis- eases, cardiovascular diseases, mastocytosis or clonal mast cell disorders and severe atopic disease [V, C] [15]. Some concur- rent medications such as b-adrenergic blockers and angiotensin-converting enzyme inhibitors might also increase the risk. In malignancies with a high tumour burden and at risk of a rapid tumour lysis or shrinkage at initiation of chemotherapy and/or targeted

2017 European Society for Medical Oncology

1598. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Full Text available with Trip Pro

Department of Pediatrics, Doernbecher Children’s Hospital, Portland, Oregon, USA 16 Väestöliitto Fertility Clinics, Helsinki, Finland 17 Center for Rare Diseases, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark 18 Department of Pediatric Endocrinology, Radboud University Medical Center, Amalia Children’s Hospital, Nijmegen, The Netherlands 19 Department of Pediatric Endocrinology, Children’s Hospital, University of Bonn, Bonn, Germany 20 Cincinnati Children’s Hospital Medical Center (...) each addressed important areas in TS care: 1) diagnostic and genetic issues, 2) growth and development during childhood and adolescence, 3) congenital and acquired cardiovascular disease, 4) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the present guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate

2016 European Society of Human Reproduction and Embryology

1599. Laryngeal Cancer

How to Treat Nosebleeds (Epistaxis) SOCIAL MEDIA Add to Any Platform Loading , MD, Montefiore Medical Center, The University Hospital of Albert Einstein College of Medicine Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Ninety percent of laryngeal cancer is squamous cell carcinoma. Smoking, alcohol abuse, lower socioeconomic status, and being male and > 60 yr increase risk. Early diagnosis is common with vocal cord tumors because hoarseness (...) in smoking habits. Annual deaths are about 3700. Sixty percent of patients present with localized disease alone; 25% present with local disease and regional nodal metastatic disease; and 15% present with advanced disease, distant metastases, or both. Lymph node metastasis are more common in supraglottic and subglottic tumors than with glottic cancers due to the minimal lymphatic drainage of the glottis. Distant metastases occur most frequently in the lungs and liver. Common sites of origin are the true

2013 Merck Manual (19th Edition)

1600. Lenvima - lenvatinib

cancer OOL optional open label ORR objective response rate OS overall survival PD pharmacodynamic(s) PD progressive disease PFS progression-free survival P-gp P-glycoprotein PK pharmacokinetic(s) PPE palmar-plantar erythrodysaesthesia PR partial response QD quaque die, once a day RAF Rapidly Accelerated Fibrosarcoma RECIST Response Evaluation Criteria in Solid Tumors EMA/250082/2015 Page 7/169 RPLS reversible posterior leukoencephalopathy syndrome RPSFT rank-preserving structural failure time RR (...) complete response CRF case report form CSE Clinically significant adverse event CSR clinical study report CTCAE Common Terminology Criteria for Adverse Event CV coefficient of variance CYP cytochrome P450 CYP3A4 Cytochrome P450 3A4 DBP diastolic blood pressure DECISION acronym for the Phase 3 sorafenib trial: “StuDy of sorafEnib in loCally advanced or metastatIc patientS with radioactive Iodine refractory thyrOid caNcer” DCR disease control rate DDI drug-drug interaction DFG motif central to function

2015 European Medicines Agency - EPARs

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