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Tongue Carcinoma

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1581. Portable neuromodulation stimulator for traumatic brain injury

the disease. January 2019 Selumetinib is in clinical development for children with neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease. NF1 is a rare genetic disorder characterized by the development of multiple benign tumours of nerves and skin and areas of abnormal skin colour. NF1 is caused by mutation in a gene that regulates the production of a … November 2018 Edaravone as an intravenous injection is in clinical development for people with amyotrophic lateral sclerosis (ALS). ALS (...) Comments This field is for validation purposes and should be left unchanged. This iframe contains the logic required to handle AJAX powered Gravity Forms. Get Alerts Subscribe to new content email alerts Email * Interested groups * Anaesthetics Pain Relief and ITU Cancer and Palliative Care Cardiovascular Disease and Vascular Surgery Dental and Oral Health and Maxillo-facial Surgery Ear Nose and Throat Emergency Care Endocrine Nutritional and Metabolic Eye Disease Gastrointestinal Pancreatic and Liver

2017 NIHR Innovation Observatory

1582. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury

following Paediatric Traumatic Brain Injury 6 Acquired brain injury Any type of brain damage occurring after birth (e.g., traumatic brain injury, stroke, tumour) Apraxia of speech A motor speech disorder that impairs the ability to voluntarily move and sequence speech movements (also known as dyspraxia) Articulation Ability to produce speech sounds using the articulators (e.g., tongue, lips, jaw) Augmentative and alternative communication All forms of communication other than oral speech (e.g., gesture (...) Language disorder Difficulty comprehending and/or using spoken language Morphology Structure of words (e.g., grammar) Mutism Complete absence of speech Narrative skills Skills needed for storytelling (e.g., describing events in a logical order) Oral motor The use and function of the facial muscles (lips, tongue, jaw, cheeks) Oral phase Transferring the food/fluid to the back of the mouth Oral preparatory phase Preparing the food/fluid in the oral cavity for it to be swallowed Oropharyngeal phases Oral

2017 Clinical Practice Guidelines Portal

1583. CRACKCast E075 – Upper Respiratory Tract Infections

– Sore Throat” List 4 Centor criteria and how management proceeds Describe 3 diagnostic tests for infectious mononucleosis Describe the management of GABHS [1] List potential causes of pharyngitis; List 5 viral and 5 bacterial etiologies of pharyngitis Emergent Diagnoses for Sore Throat Diseases not to miss: Primary HIV Epiglottitis Bacterial tracheitis Corynebacterium Diphtheriae Ludwig’s angina Epstein barr virus Cancer Gonorrhea / Herpes Simplex Foreign body Angioedema Peri-tonsillar abscess Retro (...) neutropenia, thyroiditis Trauma – retained foreign body, laryngeal #, hematoma, CAUSTIC exposure, POST-tonsillectomy eschar Tumourstongue, larynx, thyroid, etc [2] What are the indications for steroids in a patient with pharyngitis? Complex issue! Cochrane review in 2012 concluded that symptoms were improved, but recurrence rates did not change. The study was also underpowered for complication, and not enough children were included for analysis. ***infectious mononucleosis, peritonsillar abscess

2017 CandiEM

1584. Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. (Abstract)

Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. The knotting of an intragastric tube is a rare complication, and knotting of a feeding jejunostomy tube is rarer, and the removal or replacement of the tube is difficult. There are many reports on the removal of intragastric knotted tubes, but these methods cannot be applied for the removal of knotted feeding jejunostomy tubes, which do not have a natural orifice as large as the mouth to facilitate (...) the introduction of instruments to correct the complication or remove the knotted tube. This is a stressful situation and doctors have to adopt strategies to resolve this problem safely and effectively in the absence of strong evidence-based knowledge. The author presents the case of a patient with tongue base cancer with a nasogastric feeding jejunostomy tube that knotted during the therapeutic course and describes a simple method to remove the knotted tube using Kelly clamps without additional invasive

2010 International Journal of Oral and Maxillofacial Surgery

1585. Compliance with quality assurance measures in patients treated for early oral tongue cancer. Full Text available with Trip Pro

Compliance with quality assurance measures in patients treated for early oral tongue cancer. The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer.A retrospective chart review included 116 patients treated for T1-T2/N0-N1 squamous cell carcinoma (SCC) of the oral tongue between 1998 and 2003. A set of quality measures (...) compliance with documenting the 4 parameters designated as quality measures for treatment of oral tongue SCC was acceptable, thus demonstrating that it is possible to use these data for measuring effective cancer care.Copyright (c) 2010 American Cancer Society.

2010 Cancer

1586. Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. (Abstract)

% (11/13). Of the HPV-16 infected oral tongue cancers, the integration rate of HPV-16 was 55% (6/11). The HPV-16 positive group showed shallower stromal invasion than the HPV-16 negative group (p=0.045). HPV-16 may be one of the causative factors in early squamous cell oral tongue carcinoma and be associated with its depth of invasion.Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (...) Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. Human papilloma virus (HPV) infection is controversial as a causative factor in oral tongue cancer. This study aimed to clarify whether HPV directly affects the carcinogenesis and biological behaviour of oral tongue cancer by analyzing HPV prevalence, the physical status of the virus and clinicopathological parameters. Archival tissue was obtained from 36 patients diagnosed with T1 and T2 oral tongue

2010 International Journal of Oral and Maxillofacial Surgery

1587. Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer

ways. Some block the ability of the tumor to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Everolimus may stop the growth of tumor cells by blocking blood flow to the tumor. Giving cetuximab together with everolimus may be an effective treatment for colon cancer or head and neck cancer Condition or disease Intervention/treatment Phase Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Basal Cell Carcinoma of the Lip Recurrent (...) , Adenoid Cystic Neoplasms, Unknown Primary Carcinoma, Mucoepidermoid Granuloma Esthesioneuroblastoma, Olfactory Papilloma, Inverted Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Digestive System Diseases

2011 Clinical Trials

1588. Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High-Risk Appalachian Patients Previously Treated With Surgery For Oral Cancer

Appalachian Oral Cancer Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Oropharyngeal Neoplasms Carcinoma, Verrucous Mouth Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases Mouth Diseases Tongue Diseases (...) encompasses cancers of the oral cavity including lips, buccal mucosa, teeth, floor of the mouth and gums and those of the oropharynx consisting of the base of the tongue, soft palate, tonsillar area, and the posterior pharyngeal wall will be eligible Patients who have followed the advice of their physician and have been definitively treated for their tumor by any method and are currently disease free will be eligible Patients may be enrolled as early as their first follow-up post-operative clinic visit

2011 Clinical Trials

1589. Patterns of extralaryngeal spread of laryngeal cancer: Thyroid Cartilage Penetration Occurs in a Minority of Patients with Extralaryngeal Spread of Laryngeal Squamous Cell Cancers. (Abstract)

Patterns of extralaryngeal spread of laryngeal cancer: Thyroid Cartilage Penetration Occurs in a Minority of Patients with Extralaryngeal Spread of Laryngeal Squamous Cell Cancers. Laryngeal preservation programs for patients with advanced laryngeal squamous cell carcinomas (SCC) have generally excluded patients with T4 disease. The accuracy of preoperative imaging in evaluating thyroid cartilage penetration and extralaryngeal spread (ELS) has previously been questioned. Clinically, SCC spread (...) into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration. The current study was designed to characterize and quantify the routes and frequency of ELS.A total of 103 laryngectomy specimens with preoperative contrast-enhanced neck computed tomography scans were coded according to the observed extent of disease by pathological and radiological data. Previously irradiated tumors or those of pyriform sinus origin were omitted. Routes of spread were

2011 Cancer

1590. Does Therapy With Biofeedback Improve Swallowing in Adults With Dysphagia? A Systematic Review and Meta-Analysis Full Text available with Trip Pro

for risk of bias and quality.Data were extracted by 1 reviewer and verified by another on biofeedback type, measures of swallow function, physiology and clinical outcome, and analysed using Cochrane Review Manager (random effects models). Results are expressed as weighted mean difference (WMD) and odds ratio (OR).Of 675 articles, we included 23 studies (N=448 participants). Three main types of biofeedback were used: accelerometry, surface electromyography (sEMG), and tongue manometry. Exercises (...) included saliva swallows, maneuvers, and strength exercises. Dose varied between 6 and 72 sessions for 20-60 minutes. Five controlled studies (stroke n=95; head and neck cancer n=33; mixed etiology n=10) were included in meta-analyses. Compared to control, biofeedback augmented dysphagia therapy significantly enhanced hyoid displacement (3 studies, WMD=0.22cm; 95% confidence interval [CI] [0.04, 0.40], P=.02) but there was no significant difference in functional oral intake (WMD=1.10; 95% CI [-1.69

2019 EvidenceUpdates

1591. Laryngeal Cancer

How to Treat Nosebleeds (Epistaxis) SOCIAL MEDIA Add to Any Platform Loading , MD, Montefiore Medical Center, The University Hospital of Albert Einstein College of Medicine Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Ninety percent of laryngeal cancer is squamous cell carcinoma. Smoking, alcohol abuse, lower socioeconomic status, and being male and > 60 yr increase risk. Early diagnosis is common with vocal cord tumors because hoarseness (...) in smoking habits. Annual deaths are about 3700. Sixty percent of patients present with localized disease alone; 25% present with local disease and regional nodal metastatic disease; and 15% present with advanced disease, distant metastases, or both. Lymph node metastasis are more common in supraglottic and subglottic tumors than with glottic cancers due to the minimal lymphatic drainage of the glottis. Distant metastases occur most frequently in the lungs and liver. Common sites of origin are the true

2013 Merck Manual (19th Edition)

1592. Tagrisso - osimertinib

interval at steady state BCRP Breast Cancer Resistance Protein BCS Biopharmaceutics Classification System BICR Blinded independent central review CAS chemical abstract service CEP certificate European pharmacopoeia CFU colony-forming unit CI Confidence interval Cmax Maximum plasma concentration Cmin Minimum plasma concentration CMC Chemistry manufacturing and controls c-QTc Concentration-QTc CR Complete Response Ct Circulating tumour CTCAE Common terminology criteria for adverse events CTD common (...) QTcF QTc Fredericia corrected QTPP Quality target product profile r correlation coefficient RECIST Response Evaluation Criteria in Solid Tumours RH relative humidity RSD relative standard deviation SAE Serious adverse event SAP Statistical Analysis Plan SD Stable disease SmPC Summary of Product Characteristics TAMC total aerobic microbial count THF tetrahydrofuran TKI Tyrosine kinase inhibitor tmax Time to reach maximum concentration TTC threshold of toxicological concern TYMC total combined yeasts

2016 European Medicines Agency - EPARs

1593. Vaxelis - diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and Haemophilus type b conjugate vaccine (adsorbed)

and invasive diseases caused by Haemophilus influenzae type b (Hib), in children from the age of 6 weeks up to the fifth birthday. Vaxelis should be used in accordance with official recommendations. The legal basis for this application refers to: Article 8.3 of Directive 2001/83/EC - complete and independent application. The applicant indicated that ‘diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and haemophilus type b conjugate vaccine (adsorbed (...) discussion within the Committee, issued a positive opinion for granting a Marketing Authorisation to Vaxelis. 2. Scientific discussion 2.1. Introduction Vaxelis or PR5I is a hexavalent paediatric combination vaccine for primary and booster immunization of infants and toddlers above the age of 6 weeks. Vaxelis is referred to as PR5I throughout the report. It is designed to provide active immunization against diseases caused by Corynebacterium diphtheria, Clostridium tetani, Bordetella pertussis

2016 European Medicines Agency - EPARs

1594. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals ? protocol version 5.3

Suggested citation: European Centre for Disease Prevention and Control. Point prevalence survey of healthcare- associated infections and antimicrobial use in European acute care hospitals – protocol version 5.3. Stockholm: ECDC; 2016. Stockholm, October 2016 ISBN 978-92-9193-993-0 doi 10.2900/374985 TQ-04-16-903-EN-N © European Centre for Disease Prevention and Control, 2016 Reproduction is authorised, provided the source is acknowledged. TECHNICAL DOCUMENT PPS of HAIs and antimicrobial use in European (...) AM Antimicrobial/antimicrobial agent AMR Antimicrobial resistance ATC Anatomical Therapeutic Chemical classification system (WHO) AU Antimicrobial use BSI Bloodstream infection CDC Centres for Disease Control and Prevention (Atlanta, USA) CDI Clostridium difficile infections CFU Colony-forming units CVC Central vascular catheter DSN Dedicated surveillance network EARS-Net European Antimicrobial Resistance Surveillance Network (at ECDC) ECDC European Centre for Disease Prevention and Control EEA

2016 European Centre for Disease Prevention and Control - Technical Guidance

1595. Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines

disorders). - Severe atopic disease. - Concurrent medications which increase the risk (e.g.b-adrenergic blockers, angiotensin-converting enzyme inhibitors). • If there is a high risk of a rapid tumour lysis at initiation of chemotherapy and/or targeted therapies, in malignancies with a high tumour burden, consider: - Addition of rasburicase and increased hydration [I, A]. - Delivering MoAbs in a fractionated way [III, B]. Signsandsymptoms • The National Cancer Institute CTCAE version 4.03 distinguishes (...) for developing an anaphylactic reaction are: age-related fac- tors, concomitant diseases such as chronic respiratory dis- eases, cardiovascular diseases, mastocytosis or clonal mast cell disorders and severe atopic disease [V, C] [15]. Some concur- rent medications such as b-adrenergic blockers and angiotensin-converting enzyme inhibitors might also increase the risk. In malignancies with a high tumour burden and at risk of a rapid tumour lysis or shrinkage at initiation of chemotherapy and/or targeted

2017 European Society for Medical Oncology

1596. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Full Text available with Trip Pro

Department of Pediatrics, Doernbecher Children’s Hospital, Portland, Oregon, USA 16 Väestöliitto Fertility Clinics, Helsinki, Finland 17 Center for Rare Diseases, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark 18 Department of Pediatric Endocrinology, Radboud University Medical Center, Amalia Children’s Hospital, Nijmegen, The Netherlands 19 Department of Pediatric Endocrinology, Children’s Hospital, University of Bonn, Bonn, Germany 20 Cincinnati Children’s Hospital Medical Center (...) each addressed important areas in TS care: 1) diagnostic and genetic issues, 2) growth and development during childhood and adolescence, 3) congenital and acquired cardiovascular disease, 4) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the present guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate

2016 European Society of Human Reproduction and Embryology

1597. Breastfeeding Healthy Term Infants

Discharge 16 72 hours to 7 days and beyond 16D. Breastfeeding Challenges in the Postpartum Period 17 Infant Challenges Near -T erm Infant 17 Hypoglycemia 18 Neonatal Jaundice 18 Ankyloglossia (tongue tie) 19 Maternal Challenges Breast Fullness 19 Breast Engorgement 19 Areolar Engorgement 20 Plugged or Blocked Duct 20 Milk Blister or Blocked Nipple Pore 20 Overabundance of Breastmilk 20 Mastitis 21 Breast Abscess 22 Inverted or Flat Nipples 22 Nipple pain 22 Maternal conditions (such as Vasospasm (...) in postpartum care section, 2 – 24 hours) Positions appropriate for breastfeeding for mother and infant Principles for enabling the infant to latch-on effectively Removing the infant from the breast Hand expression of colostrum/breastmilk • Potential contraindications to breastfeeding Contraindications are rare and breastfeeding is recommended during most maternal infectious diseases, antimicrobial therapy, or immunizations. Contraindications are: Permanent conditions: Mothers advised

2015 British Columbia Perinatal Health Program

1598. NHMRC Statement on Homeopathy and NHMRC Information Paper - Evidence on the effectiveness of homeopathy for treating health conditions

, and • that highly diluted preparations retain a ‘memory’ of the original substance. Homeopathic medicines are prepared by taking a substance (e.g. plant, animal material, or chemical), diluting it in water or alcohol, then forcefully hitting the container against a hand or a surface. This process is repeated several times. Homeopathic medicines include pellets placed under the tongue, tablets, liquids, ointments, sprays and creams. Methods The National Health and Medical Research Council (NHMRC) undertook (...) it in water or alcohol. The container holding the preparation is then forcefully hit against a hand or a surface in a process known as ‘potentiation’ or ‘dynamisation’. Homeopathic medicines can include pellets placed under the tongue, tablets, liquids, ointments, sprays and creams. Homeopaths provide either ‘individualised homeopathy’ or ‘clinical homeopathy’. In individualised homeopathy, the homeopath matches all the person’s symptoms to a single homeopathic medicine, rather than treating the person

2015 National Health and Medical Research Council

1599. Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis Full Text available with Trip Pro

of presentation. Thus IE should be suspected in a variety of very different clinical situations. It may present as an acute, rapidly progressive infection, but also as a subacute or chronic disease with low-grade fever and non-specific symptoms that may mislead or confuse initial assessment. Patients may therefore present to a variety of specialists who may consider a range of alternative diagnoses, including chronic infection; rheumatological, neurological and autoimmune diseases; or malignancy. The early (...) congenital heart disease CIED cardiac implantable electronic device CoNS coagulase-negative staphylococci CPG Committee for Practice Guidelines CRP C-reactive protein CT computed tomography E. Enterococcus ESC European Society of Cardiology ESR erythrocyte sedimentation rate EuroSCORE European System for Cardiac Operative Risk Evaluation FDG fluorodeoxyglucose HF heart failure HIV human immunodeficiency virus HLAR high-level aminoglycoside resistance i.m. intramuscular i.v. intravenous ICE International

2015 European Society of Cardiology

1600. Acute pain management: scientific evidence (3rd Edition)

in every case, early recognition and treatment of incipient chronic pain by a vigilant healthcare system is necessary for cost- effective intervention. The National Pain Strategy document that underpins the 2010 Australian Pain Summit summarises the emerging literature on social, human and economic costs of undertreated acute and chronic pain — establishing pain as a major disease burden ( and proposing an integrated new framework for management of acute, chronic and cancer pain (...) . Anesthesiology 110(5): 955–6. Johnston M, Brouwers M & Browman G (2003) Keeping cancer guidelines current: results of a comprehensive prospective literature monitoring strategy for twenty clinical practice guidelines. Int J Technol Assess Health Care 19: 646–55. Marret E, Elia N, Dahl JB et al (2009) Susceptibility to fraud in systematic reviews. Anesthesiology 111: 1279–89. Neal JM (2009) Retraction. Reg Anesth Pain Med 34(4): 385. NHMRC (1999) A Guide to the Development, Implementation and Evaluation

2015 National Health and Medical Research Council

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