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Tongue Carcinoma

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1561. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

of the interleukin (IL) 1, IL-6, and tumor necrosis factor (TNF) signaling pathways. Study of the adaptive immune response demonstrated that both proinflammatory and regulatory T cells can be found in the circulation in the first week after fever onset. Expansion of the regulatory T-cell population after IVIG administration is associated with cessation of fever and clinical improvement. The self-limited nature of the disease coupled with a low rate of recurrence suggests emergence of T- and B-cell memory (...) Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019

2017 American Heart Association

1562. Prevention, Diagnosis & Management of infective endocarditis

Prosthetic valve endocarditis 106 5.4 Principles of surgery 107 5.4.1 Aortic valve 109 5.4.2 Mitral valve 109 5.4.3 Tricuspid valve 109 5.4.4 Periannular extension 109 5.5 Surgery for infective endocarditis in congenital heart disease 110 5.5.1 Indications for surgery 110 5.5.2 Timing of surgery 111 5.5.3 Surgical techniques 113 6.0 OUTCOME AND FOLLOW-UP 114 7.0 SPECIFIC SITUATIONS 117 7.1 Infective endocarditis in congenital heart disease 117 7.1.1 Epidemiology 117 7.1.2 Mortality 118 7.1.3 Lesion (...) specific incidence of infective endocarditis in congenital heart disease 118 7.1.4 Management of infective endocarditis in congenital heart disease 120 7.2 Infective endocarditis in paediatric patients 121 7.2.1 Infective endocarditis in neonates with normal heart structures 121 7.2.2 Clinical presentation 122 7.2.3 Management of paediatric infective endocarditis 123 7.3 Infective endocarditis in transcatheter valve implantations 124 7.3.1 Transcatheter pulmonary valve implantation 124 7.3.2

2017 Ministry of Health, Malaysia

1563. Probiotics and Prebiotics

Gastroenterology Organisation, 2017 3.11 Nonalcoholic fatty liver disease ? The usefulness of certain probiotics as a treatment option to mitigate steatohepatitis has been proven through a number of randomized clinical trials in adults and children. Probiotics provided improvements in the outcomes of homeostasis model of assessment (HOMA) scores, blood cholesterol, tumor necrosis factor-a (TNF-a), and liver function tests—alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Further studies (...) claims, and commerce 9 2.1 Understanding the marketplace 9 2.2 Products: dosages and quality 11 2.3 Product safety 11 3 Clinical applications 11 3.1 Colorectal cancer prevention 11 3.2 Diarrhea treatment and prevention 12 3.2.1 Treatment of acute diarrhea 12 3.2.2 Prevention of acute diarrhea 12 3.2.3 Prevention of antibiotic-associated diarrhea 12 3.2.4 Prevention of Clostridium difficile diarrhea 12 3.2.5 Prevention of radiation-induced diarrhea 12 3.3 Helicobacter pylori eradication 12 3.4 Hepatic

2017 World Gastroenterology Organisation

1564. Supplementary Feedings in the Healthy Term Breastfed Neonate Full Text available with Trip Pro

infant's feeding requirements and supplementation is required, donor human milk is preferable to other supplements. 3. When donor human milk is not available or appropriate, protein hydrolysate formulas may be preferable to standard infant formula as they avoid exposure to intact cow's milk proteins and reduce bilirubin levels more rapidly, (II-2) although recent data are less supportive of its role in preventing allergic disease. (I) The use of this type of formula may also convey the psychological (...) commonly used method of supplementation in more affluent regions of the world, but concerns have been raised because of distinct differences in tongue and jaw movements, and faster flow may result in higher (and unnecessary) volumes of feeds. Some experts have recommended a teat/nipple with a wide base and slow flow to try to mimic breastfeeding and to avoid nipple confusion or preference, , (II-2), but little research has been done evaluating outcomes with different teats/nipples. Research Needs

2017 Academy of Breastfeeding Medicine

1565. Evaluation of the Neck Mass in Adults Full Text available with Trip Pro

Arbor, MI 48109-5312, USA. Email: Abstract Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms. Malignant neoplasms far exceed any other etiology of adult neck mass. Importantly, an asymptomatic neck mass may be the initial or only clinically apparent manifestation of head and neck cancer, such as squamous cell carcinoma (HNSCC (...) and neck cancer, such as squamous cell carcinoma (HNSCC), lymphoma, thyroid, or salivary gland cancer. Evidence suggests that a neck mass in the adult patient should be considered malignant until proven otherwise. - Timely diagnosis of a neck mass due to metastatic HNSCC is paramount because delayed diagnosis directly affects tumor stage and worsens prognosis. - Unfortunately, despite substantial advances in testing modalities over the last few decades, diagnostic delays are common. Forty years ago

2017 American Academy of Otolaryngology - Head and Neck Surgery

1566. Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock Full Text available with Trip Pro

, Stollery Children’s Hospital/University of Alberta, Edmonton, AB, Canada. 15 Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children’s, Durham, NC. 16 Departments of Pediatrics and Critical Care, Clinical Epidemiology and Biostatistics, McMaster University, Pediatric Intensive Care Unit, McMaster Children’s Hospital, Hamilton, ON, Canada. 17 Beth Israel Medical Center, Hartsdale, NY. 18 Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor (...) a supranormal MAP above this point is likely not of benefit ( ) and may actually decrease CO by increasing afterload above the capacity of the myocardium to compensate. In addition, reduction in perfusion pressure below the critical point necessary for adequate splanchnic organ perfusion can also occur in disease states with increased intra-abdominal pressure (IAP) such as bowel wall edema, ascites, or abdominal compartment syndrome. If this increased IAP is not compensated for by an increase in MAP

2017 Society of Critical Care Medicine

1567. Cranial Neuropathy

that predicting the prognosis is difficult [95]. CT CT provides useful information regarding temporal bone fractures and trauma, presurgical osseous anatomy, nerve involvement with inflammatory middle ear disease, foraminal expansion, patterns of bone erosion, and intrinsic bone tumor matrices [83,84,96-98]. In patients with risk for contrast allergy and contrast-induced nephropathy, noncontrast CT may be sufficient if patients cannot undergo MRI. A dedicated temporal bone CT with thin sections should (...) infiltration of the tongue may be noted on imaging. Lesions of the posterior fossa, skull base, upper neck, and floor of the mouth may affect the hypoglossal nerve. They include infarctions, meningiomas, schwannomas, paragangliomas, carcinomas, metastases, subarachnoid hemorrhage, Chiari malformations, basilar invagination, and fractures [99]. MRI and CT As with the other lower cranial nerves, MRI is the preferred modality for CN XII, and CT provides complementary information on the integrity of the bony

2017 American College of Radiology

1568. ASCIA Position Paper - Hereditary Angioedema (HAE)

abnormalities. This subtype will not be discussed in this document. Acquired C1-INH deficiency (AAE) may cause angioedema in adults and must be distinguished from HAE (section 4.3). 1.2 Historical facts The first description of HAE has been attributed to Robert Graves, who in 1843 described a patient with “a tumor rising on the forehead in the space of half an hour” and then later “sometimes the lips, inside of the mouth, palate, and uvula are attacked giving rise to a very considerable inconvenience” 1 (...) swelling, which was reported in older cohort studies to result in fatal asphyxiation in up to a third of patients 12 . Attacks may be preceded by a prodrome of tingling, or a non-itchy rash (erythema marginatum 13 ) anywhere on the body. Affected patients also have higher than expected rates of autoimmune disease 14 15 . 3.1 The acute attack HAE is characterised by episodic swelling of subcutaneous tissues, gut and upper respiratory tract 16 . Clinical episodes may occur frequently or may be years

2017 Australasian Society of Clinical Immunology and Allergy

1569. The UK guidelines for management and surveillance of Tuberous Sclerosis Complex Full Text available with Trip Pro

, UK Search for other works by this author on: , C Harland Epsom & St Helier Hospital, Wrythe Lane, Carshalton, Surrey, UK Search for other works by this author on: , S R Johnson Division of Respiratory Medicine, Faculty of Medicine & Health Sciences, Nottingham University, Nottingham, UK Search for other works by this author on: , A Parker Addenbrooke's Hospital, Hills Road, Cambridge, Cambridgeshire, UK Search for other works by this author on: , J R Sampson Division of Cancer and Genetics (...) were neurologists, nephrologists, psychiatrist, psychologists, oncologists, general paediatricians, dermatologist, urologists, radiologists, clinical geneticists, neurosurgeons, respiratory and neurodisability clinicians. Conclusions These new UK guidelines for the management and surveillance of TSC patients provide consensus guidance for delivery of best clinical care to individuals with TSC in the UK. Introduction Tuberous Sclerosis Complex (TSC) is a genetic disease caused by mutations

2018 Tuberous Sclerosis Association

1570. Midostaurin for the indication of Acute Myeloid Leukaemia

MACE amsacrine, cytarabine, and etoposide MAH marketing-authorisation holder MDS myelodysplastic syndrome PTJA01 - Midostaurin with standard chemotherapy in FLT3 positive acute myeloid leukaemia Version 1.3, Novermber 2017 EUnetHTA Joint Action 3 WP4 10 MEC mitoxantrone + etoposide + cytarabine MeSH Medical Subject Headings MidAC mitoxantrone and cytarabine MRD minimal residual disease NCCN National Comprehensive Cancer Network NCT National Clinical Trial NE not estimable NICE National Institute (...) assessment is newly diagnosed FLT3 mutation- positive AML. AML is a haematological malignancy characterised by abnormal growth of haema- topoietic cells of myeloid lineage in the bone marrow, blood and other tissues. Overall, the 5-year survival rate for AML is 20%–30%. Younger patients have better outcomes compared with older patients. Patients with FLT3 mutation-positive AML have worse outcomes for overall survival (OS), time to relapse and disease-free survival (DFS) compared with patients without

2017 EUnetHTA

1571. European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome

, Doernbecher Children’s Hospital, Portland, Oregon, USA 16 Väestöliitto Fertility Clinics, Helsinki, Finland 17 Center for Rare Diseases, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark 18 Department of Pediatric Endocrinology, Radboud University Medical Center, Amalia Children’s Hospital, Nijmegen, The Netherlands 19 Department of Pediatric Endocrinology, Children’s Hospital, University of Bonn, Bonn, Germany 20 Cincinnati Children’s Hospital Medical Center, University of Cincinnati (...) areas in TS care: 1) diagnostic and genetic issues, 2) growth and development during childhood and adolescence, 3) congenital and acquired cardiovascular disease, 4) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the present guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate systematic review

2017 European Society of Endocrinology

1572. CRACKCast E089 – Esophagus, Stomach & Duodenum

, stridor, rhonchi, poor feeding Causes of esophageal obstruction: Mechanical obstruction: Internal Foreign body Adults – meat/bones; dentures; pen caps, etc. Kids – coins/batteries Strictures / rings ( Schatzki’s ring ) / webs Eosinophilic esophagitis Malignancy External factors Large Left atrium / ventricle Goiter Mediastinal tumour Motor factors (remember than the distal 2/3rds are innervated by involuntary smooth muscle) Achalasia Infectious (botulism, tetanus, etc.) Food bolus therapies: (from Ep (...) Pregnancy Obesity Coughing / bending / Supine position Gastroparesis / neuromuscular disease leading to gastric outlet obstruction Decreased esophageal motility Achalasia DM Scleroderma GEeRD = “gastric emptying; esophageal relaxation drugs” mnemonic Complications of GERD Esophagitis Progressing to Barrett’s metaplasia, erosion, ulcerations, scarring Stricture formation due to persistent scarring and inflammation Reflux induced asthma Microaspiration of Adenocarcinoma of the esophagus Esophageal

2017 CandiEM

1573. Portable neuromodulation stimulator for multiple sclerosis

of the brain by spreading from brain cell to brain cell leading to their damage. Over time, PSP gets progressively worse, with people becoming severely disabled within three to five years of onset. Currently, there is no cure for PSP and no treatment to slow down the disease. January 2019 Selumetinib is in clinical development for children with neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease. NF1 is a rare genetic disorder characterized by the development of multiple benign tumours (...) * Anaesthetics Pain Relief and ITU Cancer and Palliative Care Cardiovascular Disease and Vascular Surgery Dental and Oral Health and Maxillo-facial Surgery Ear Nose and Throat Emergency Care Endocrine Nutritional and Metabolic Eye Disease Gastrointestinal Pancreatic and Liver Disease Gynaecology Womens Sexual Health and Benign Breast Disease Haematology and Blood Products Health Promotion and Protection including Screening Immunology and Allergy Infectious Disease and Immunisation Mens Health and Sexual

2017 NIHR Innovation Observatory

1574. Portable neuromodulation stimulator for traumatic brain injury

the disease. January 2019 Selumetinib is in clinical development for children with neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease. NF1 is a rare genetic disorder characterized by the development of multiple benign tumours of nerves and skin and areas of abnormal skin colour. NF1 is caused by mutation in a gene that regulates the production of a … November 2018 Edaravone as an intravenous injection is in clinical development for people with amyotrophic lateral sclerosis (ALS). ALS (...) Comments This field is for validation purposes and should be left unchanged. This iframe contains the logic required to handle AJAX powered Gravity Forms. Get Alerts Subscribe to new content email alerts Email * Interested groups * Anaesthetics Pain Relief and ITU Cancer and Palliative Care Cardiovascular Disease and Vascular Surgery Dental and Oral Health and Maxillo-facial Surgery Ear Nose and Throat Emergency Care Endocrine Nutritional and Metabolic Eye Disease Gastrointestinal Pancreatic and Liver

2017 NIHR Innovation Observatory

1575. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury

following Paediatric Traumatic Brain Injury 6 Acquired brain injury Any type of brain damage occurring after birth (e.g., traumatic brain injury, stroke, tumour) Apraxia of speech A motor speech disorder that impairs the ability to voluntarily move and sequence speech movements (also known as dyspraxia) Articulation Ability to produce speech sounds using the articulators (e.g., tongue, lips, jaw) Augmentative and alternative communication All forms of communication other than oral speech (e.g., gesture (...) Language disorder Difficulty comprehending and/or using spoken language Morphology Structure of words (e.g., grammar) Mutism Complete absence of speech Narrative skills Skills needed for storytelling (e.g., describing events in a logical order) Oral motor The use and function of the facial muscles (lips, tongue, jaw, cheeks) Oral phase Transferring the food/fluid to the back of the mouth Oral preparatory phase Preparing the food/fluid in the oral cavity for it to be swallowed Oropharyngeal phases Oral

2017 Clinical Practice Guidelines Portal

1576. CRACKCast E075 – Upper Respiratory Tract Infections

– Sore Throat” List 4 Centor criteria and how management proceeds Describe 3 diagnostic tests for infectious mononucleosis Describe the management of GABHS [1] List potential causes of pharyngitis; List 5 viral and 5 bacterial etiologies of pharyngitis Emergent Diagnoses for Sore Throat Diseases not to miss: Primary HIV Epiglottitis Bacterial tracheitis Corynebacterium Diphtheriae Ludwig’s angina Epstein barr virus Cancer Gonorrhea / Herpes Simplex Foreign body Angioedema Peri-tonsillar abscess Retro (...) neutropenia, thyroiditis Trauma – retained foreign body, laryngeal #, hematoma, CAUSTIC exposure, POST-tonsillectomy eschar Tumourstongue, larynx, thyroid, etc [2] What are the indications for steroids in a patient with pharyngitis? Complex issue! Cochrane review in 2012 concluded that symptoms were improved, but recurrence rates did not change. The study was also underpowered for complication, and not enough children were included for analysis. ***infectious mononucleosis, peritonsillar abscess

2017 CandiEM

1577. Joint NASPGHAN and ESPGHAN guidelines on Gastro-oesophageal Reflux Disease in Children

circumference May suggest raised intracranial pressure for example due to meningitis, brain tumor or hydrocephalus Seizures Macro/microcephaly Gastrointestinal Persistent forceful vomiting Indicative of hypertrophic pyloric stenosis (infants up to 2 months old) Nocturnal vomiting May suggest increased intracranial pressure Bilious vomiting Regarded as symptom of intestinal obstruction. Possible causes include Hirschsprung disease, intestinal atresia or mid-gut volvulus or intussusception Hematemesis (...) Joint NASPGHAN and ESPGHAN guidelines on Gastro-oesophageal Reflux Disease in Children Copyright © ESPGHAN and NASPGHAN. All rights reserved. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society forPediatricGastroenterology,Hepatology,andNutrition Rachel Rosen, y Yvan Vandenplas, z Maartje Singendonk, § Michael Cabana, jj Carlo DiLorenzo, Frederic

2018 British Society of Paediatric Gastroenterology Hepatology and Nutrition

1578. The Oral Management of Oncology Patients Requiring Radiotherapy, Chemotherapy and / or Bone Marrow Transplantation

at a late stage in England (2014) and Northern Ireland (2010-2014). Incidence rates for all cancers combined are projected to rise by 2% in the UK between 2014 and 2035, to 742 cases per 100,000 people by 2035. Conversely, the outlook following treatment for malignant disease, has improved in the last two decades since the 1995 Calman-Hine report which outlined radical reform of the UK's cancer services with the aim of improving outcomes and reducing inequalities in NHS cancer care (Department of Health (...) (National Cancer Institute, 2016). Complications may include profound functional and sensory changes to the oral mucosa, in addition to an increased susceptibility to dental caries and periodontal disease (National 5 Cancer Institute, 2016) (Sroussi et al., 2017). These may impact directly on cancer therapy resulting in the need to pause treatment, but also have a significant impact on the longevity and quality of life during and after cancer therapy (Gandhi et al., 2017). Adults with malignant disease

2018 British Society for Disability and Oral Health

1579. Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. (Abstract)

% (11/13). Of the HPV-16 infected oral tongue cancers, the integration rate of HPV-16 was 55% (6/11). The HPV-16 positive group showed shallower stromal invasion than the HPV-16 negative group (p=0.045). HPV-16 may be one of the causative factors in early squamous cell oral tongue carcinoma and be associated with its depth of invasion.Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. (...) Relevance of human papilloma virus (HPV) infection to carcinogenesis of oral tongue cancer. Human papilloma virus (HPV) infection is controversial as a causative factor in oral tongue cancer. This study aimed to clarify whether HPV directly affects the carcinogenesis and biological behaviour of oral tongue cancer by analyzing HPV prevalence, the physical status of the virus and clinicopathological parameters. Archival tissue was obtained from 36 patients diagnosed with T1 and T2 oral tongue

2010 International Journal of Oral and Maxillofacial Surgery

1580. Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. (Abstract)

Removal of a self-knotted feeding jejunostomy tube in a patient with tongue base cancer. The knotting of an intragastric tube is a rare complication, and knotting of a feeding jejunostomy tube is rarer, and the removal or replacement of the tube is difficult. There are many reports on the removal of intragastric knotted tubes, but these methods cannot be applied for the removal of knotted feeding jejunostomy tubes, which do not have a natural orifice as large as the mouth to facilitate (...) the introduction of instruments to correct the complication or remove the knotted tube. This is a stressful situation and doctors have to adopt strategies to resolve this problem safely and effectively in the absence of strong evidence-based knowledge. The author presents the case of a patient with tongue base cancer with a nasogastric feeding jejunostomy tube that knotted during the therapeutic course and describes a simple method to remove the knotted tube using Kelly clamps without additional invasive

2010 International Journal of Oral and Maxillofacial Surgery

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