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Tongue Carcinoma

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1541. Breastfeeding - Promoting and Supporting the Initiation, Exclusivity, and Continuation of Breastfeeding in Newborns, Infants and Young Children

Tongue Assessment Tool CASP Critical Appraisal Skills Program CIHI Canadian Institute for Health Information CPNP Canadian Prenatal Nutrition Program EBM expressed breast milk FDA Food and Drug Administration HATLFF Hazelbaker Assessment Tool for Lingual Frenulum Function GDM gestational diabetes mellitus HSV herpes simplex virus IBCLC ® International Board Certified Lactation Consultant ® IBLCE ® International Board of Lactation Consultant Examiners ® ILCA ® International Lactation Consultant (...) and institutionalize the baby-friendly hospital initiative in health systems Empower women to exclusively breastfeed 38% 800,000 Globally, only Suboptimal breastfeeding contributes to infant deaths of infants are exclusively breastfed BENEFITS OF BREASTFEEDING LIMIT FORMULA MARKETING STRENGTHEN HEALTH SYSTEMS SUPPORT MOTHERS SUPPORT PAID LEAVE WHY IT MATTERS RECOMMENDED ACTIONS SCOPE OF THE PROBLEM 5 BREASTFEEDING | Folasin Niacin B6 E A D K C B1 B2 B12 the nutrition from respiratory infections, diarrhoeal disease

2018 Registered Nurses' Association of Ontario

1542. Screening of fetal aneuploidies whereby non-invasive prenatal test (NIPT)

chromosomal aneuploidies in the scope of this assessment? A0003 What are the known risk factors for fetal chromosomal aneuploidies? A0004 What is the natural course of fetal chromosomal aneuploidies? A0005 What are the symptoms and the burden of disease of chromosomal aneuploidies? A0006 What are the consequences of chromosomal aneuploidies for society? A0007 Who is the target population for prenatal aneuploidy screening? A0011 How much is NIPT used? A0023 How many people belong to the target population (...) for prenatal aneuploidy screening? A0024 How are chromosomal aneuploidies currently screened and diagnosed according to published guidelines and practice? A0025 How are chromosomal aneuploidy pregnancies currently managed according to published guidelines and in practice? 4.2 Results Overview of the disease or health condition [A0002] – What are the fetal chromosomal aneuploidies in the scope of this assessment? Noninvasive prenatal tests are validated for use in pregnant women and are currently applied

2018 EUnetHTA

1543. Baricitinib (Olumiant) - rheumatoid arthritis

with mild, limited RA usually have minimal joint destruction. Patients with moderately to severely active disease have persistent systemic inflammation with elevated acute phase proteins and pro-inflammatory cytokines contributing to symptoms of fatigue, pain, joint stiffness, and associated comorbidities of cardiovascular disease, infections, mental health disorders, and malignancies (CDC 2015). Within the joint, inflammation directly affects the synovial membrane and bone resulting in damage (...) by the CHMP with all information of a commercially confidential nature deleted. EMA/13493/2017 Page 2/132 Table of contents 1. Background information on the procedure 9 1.1. Submission of the dossier 9 1.2. Steps taken for the assessment of the product 10 2. Scientific discussion 11 2.1. Problem statement 11 2.1.1. Disease or condition 11 2.1.2. Epidemiology 11 2.1.3. Clinical presentation 11 2.1.4. Management 11 2.1.5. Introduction 15 2.1.6. Active Substance 16 2.1.7. Finished Medicinal Product 19 2.1.8

2017 European Medicines Agency - EPARs

1544. Theory based evaluation of long term conditions and MacMillan benefit advice service in Queen Elizabeth University Hospital, Glasgow

of all cancers Chapter II – Neoplasms** 488 61.5% 100.0% 8,918 100% C00-C14 - Malignant neoplasms of lip, oral cavity and pharynx 28 3.5% 5.7% 217 2.40% C15-C26 - Malignant neoplasms of digestive organs 79 10.0% 16.2% 1477 16.60% C30-C39 - Malignant neoplasms of respiratory and intrathoracic organs 107 13.5% 21.9% 1403 15.70% C50 - Malignant neoplasm of breast 60 7.6% 12.3% 969 10.90% C51-C58 - Malignant neoplasms of female genital organs 30 3.8% 6.1% 348 3.90% C60-C63 - Malignant neoplasms of male (...) genital organs 35 4.4% 7.2% 624 7.00% C64-C68 - Malignant neoplasms of urinary tract 16 2.0% 3.3% 359 4.00% C69-C75 - Malignant neoplasms of eye, brain and other parts of central nervous system, or thyroid and other endocrine glands 22 2.8% 4.5% 169 1.90% C76-C80 - Malignant neoplasms of ill-defined, secondary and unspecified sites 36 4.5% 7.4% 209 2.30% C81-C96 - Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue 23 2.9% 4.7% 468 5.20% Cancer could

2017 Scottish Collaboration for Public Health Research & Policy

1545. A Trial of Photodynamic Therapy With HPPH for Treatment of Dysplasia, Carcinoma in Situ and T1 Carcinoma of the Oral Cavity and/or Oropharynx

or not they may have received prior therapy, e.g. radiation therapy Condition or disease Intervention/treatment Phase Dysplasia Carcinoma of the Oral Cavity Carcinoma of the Oropharynx Drug: HPPH Phase 1 Detailed Description: We propose to initiate a Phase 1 a clinical trial using HPPH and 665 nm light in patients with cancer of the oral cavity and/or oropharynx, including lesions of moderate to severe dysplasia, squamous carcinoma in situ and T1 squamous cells carcinoma. The study will employ a fixed HPPH (...) : October 16, 2018 Last Verified: October 2018 Keywords provided by Roswell Park Cancer Institute: Photodynamic Therapy Oral dysplasia oral cavity carcinoma oropharynx carcinoma. Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Hyperplasia Oropharyngeal Neoplasms Carcinoma in Situ Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Pathologic Processes Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Pharyngeal

2010 Clinical Trials

1546. Sepsis: recognition, diagnosis and early management

for cancer with chemotherapy (see recommendation 1.1.9) people who have impaired immune function (for example, people with diabetes, people who have had a splenectomy, or people with sickle cell disease) people taking long-term steroids people taking immunosuppressant drugs to treat non-malignant disorders such as rheumatoid arthritis people who have had surgery, or other invasive procedures, in the past 6 weeks people with any breach of skin integrity (for example, cuts, burns, blisters or skin (...) of the skin, lips or tongue, non-blanching rash of the skin, any breach of skin integrity (for example, cuts, burns or skin infections) or other rash indicating potential infection. 1.3.8 Ask the person, parent or carer about frequency of urination in the past 18 hours. 1.4 Stratifying risk of severe illness or death from sepsis 1.4.1 Use the person's history and physical examination results to grade risk of severe illness or death from sepsis using criteria based on age (see tables 1, 2 and 3). Adults

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

1547. Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers. (Abstract)

Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers. To evaluate the outcome of definitive radiotherapy (RT) for oral cavity cancers and to assess prognostic factors.Definitive RT was performed on 115 patients with oral cavity cancers at Stages III, IVA, and IVB, with a distribution of 6%, 47%, and 47%, respectively. The median dose of RT was 72 Gy (range, 62-76 Gy). Cisplatin-based chemotherapy was administered to 95 (...) % of the patients. Eleven patients underwent salvage surgery after RT failure.Eight-eight (76.5%) patients responded partially and 23 (20%) completely; of the patients who responded, 18% and 57%, respectively, experienced a durable effect of treatment. The 3-year overall survival, disease-specific survival, and progression-free survival were 22%, 27%, and 25%, respectively. The 3-year PFS rates based on the primary tumor sites were as follows: Group I (buccal, mouth floor, and gum) 51%, Group II (retromolar

2010 Biology and Physics

1548. Recommendation for Record-Keeping

compulsive disorder Psychiatric problems/treatment406 RECOMMENDATIONS: BEST PRACTICES REFERENCE MANUAL V 40 / NO 6 18 / 19 Endocrine Diabetes Growth delays Hormonal problems Precocious puberty Thyroid problems Hematologic/lymphatic/immunologic Anemia Blood disorder Transfusion Excessive bleeding Bruising easily Hemophilia Sickle cell disease/trait Cancer, tumor, other malignancy Immune disorder Chemotherapy Radiation therapy Hematopoietic cell (bone marrow) transplant Infectious Measles Mumps Rubella (...) , and outcome General Complications during pregnancy and/or birth Prematurity Congenital anomalies Cleft lip/palate Inherited disorders Nutritional deficiencies Problems of growth or stature Head, ears, eyes, nose, throat Lesions in/around mouth Chronic adenoid/tonsil infections Chronic ear infections Ear problems Hearing impairments Eye problems Visual impairments Sinusitis Speech impairments Apnea/snoring Mouth breathing Cardiovascular Congenital heart defect/disease Heart murmur Infective endocarditis

2017 American Academy of Pediatric Dentistry

1549. Towards tailoring of KCE guidelines to end-users' needs

), Ward Rommel (Kom op tegen Kanker), Karin Rondia (KCE), Hans Van Brabandt (KCE), Thierry Van der Schueren (Société Scientifique de Médecine Générale – SSMG), Didier Vander Steichel (Fondation contre le cancer), Michel Vanhalewyn (SSMG), Inez Vanoverschelde (EBMPracticenet), Geneviève Veereman (KCE), Leen Verleye (KCE), Mieke Vermandere (Katholieke Universiteit Leuven, CEBAM, EBMPracticeNet), Joan Vlayen (KCE), Patrick Wérrion (Association de défense professionnelle de la kinésithérapie – AXXON (...) Institute for Health Care Improvement] CPG Clinical Practice Guideline EBM Evidence Based Medicine GDG Guideline development group GP General practitioners HAS Haute Autorité de Santé IKNL Integraal Kankercentrum Nederland [Netherlands Comprehensive Cancer. Organisation] IQWIG Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen [Insitute for Quality and Efficiency in Health Care] KNGF Koninklijk Nederlands Genootschap voor Fysiotherapie [ Royal Dutch Society for Physical Therapy] NHG

2017 Belgian Health Care Knowledge Centre

1550. Active B12 assay for diagnosing vitamin B12 deficiency

knowledge summary on anaemia, about 30% of people with it have a family history of pernicious anaemia. The condition is more common in people over 60 years, and in women and in people with other autoimmune conditions, such as primary myxoedema, thyrotoxicosis, Hashimoto's disease, Addison's disease and vitiligo. People with pernicious anaemia have a higher risk of developing gastric cancer. Malabsorption of vitamin B12 may occur in people with gastric, pancreatic or intestinal diseases (including (...) indicate cobalamin deficiency. However, levels may not accurately indicate a deficiency in people aged over 65 years with kidney disease, small bowel bacterial overgrowth or reduced fluid content of the blood because these conditions can also cause elevated MMA levels (Devalia et al. 2014; Hunt et al. 2014). T otal serum Hcy is an indicator of vitamin B12 deficiency because cobalamin is needed for the synthesis of methionine from Hcy, and low levels of vitamin B12 lead to increased total serum Hcy

2015 National Institute for Health and Clinical Excellence - Advice

1551. Oral Thrush - Guidelines for Prescribing Oral Nystatin

of age unless related to antibiotic use, immunosuppression or steroid inhaler use without post-use mouth rinsing. Risk factors: Medical conditions: Immunosuppression Malignancy Sjogren's disease Diabetes Cushings disease Medications: Inhaled corticosteroids (if not rinsing mouth properly) Recent broad-spectrum antibiotic use Chemotherapy or radiation therapy Age (newborns, or over 65) Pregnancy Dentures Poor oral hygiene Chronic dry mouth For photos and more information go to : Three types of oral (...) (e.g. chlorhexidine 0.12 % oral rinse) Burns will cause significant redness and swelling in the mouth, which should not be seen with oral thrush. Common in bottle-fed infants. causes chronic lesions seen mostly in smokers and males over 30. These are small, translucent white plaques, usually on the tongue. The plaques cannot be wiped off as easily as oral thrush. These lesions can be cancerous, so a biopsy is recommended if this condition is suspected. are one or more shallow, usually painful sores

2017 medSask

1552. Oral Aphthous Ulcer - Guidelines for Prescribing Triamcinolone Dental Paste

butterfly rash, usually painless oral ulcers Celiac disease - history of intolerance to gluten Squamous cell carcinoma - if ulcers persist without healing. Refer to patient's primary care provider if lesions are present for over 3 weeks. Drug related oral ulcers - NSAIDs, beta-blockers, cytotoxic agents such as methotrexate. Stomatitis caused by radiation therapy . Refer to attending physician for treatment. Patients with signs / symptoms typical of canker sores usually do not require further (...) in diameter Oval in shape Clearly defined outline with red and inflamed borders On lips, cheeks, floor of mouth, underside of tongue, and soft palate Painful Resolve spontaneously in 7 to 10 days Frequent recurrences possible Major (12%) Occur in clusters of 2 or more lesions More than 10 millimeters in diameter May be irregular in shape More common in patients with compromised immune system May take up to six weeks to heal May cause scarring Herpetiform (8 %) Often in clusters of 5 - 100 small sores 0.5

2017 medSask

1553. Herpes Zoster - Diagnosis

of age) exhibiting HZ, particularly in case of widespread multi- dermatomal or recurrent HZ, simultaneous lesions in different disease stages, or presence of other risk factors for HIV seroposi- tivity, it isrecommended to test for HIVinfection (Table 13). Searching for occult cancer in patients with HZ remains debated. In a large cohort of HZ patients, subsequent incidence rates of various types of cancer were analysed. Standardized inci- dence rates were not increased in this sample. 95 In contrast (...) are tested positive for VZV-DNA in up to 100% of cases 33 and may persist positive for weeks. 34 Other clinical specimens appropriate for PCR testing are biopsies, cerebro spinal ?uid (CSF), intra- ocular ?uids and blood samples for the detection of VZV vire- mia. 35 Real-time PCR, ideally in combination with serology on paired serum and CSF/intra-ocular ?uid in patients sampled at >2–3 weeks after onset of disease, is the method of choice for diagnosis of HZ with cerebral and ocular complications

2017 European Dermatology Forum

1554. Clinical practice guideline: evaluation of the neck mass in adults.

, potentially reduce risk of distant metastases through earlier cancer identification, psychological benefit of timely evaluation, facilitate further care Risks, harms, costs: False-positive clinical diagnosis resulting in subsequent tests and anxiety in patients with nonmalignant disease Benefit-harm assessment: Preponderance of benefit over harm Value judgments: The risk of missed or delayed diagnosis of malignancy is more important than the risk of a false-positive clinical diagnosis. Despite any direct (...) stage of disease, prioritize testing for increased-risk patients, potentially reduce risk of distant metastases through earlier cancer identification, psychological benefit of timely evaluation, facilitate further care Risks, harms, costs: False-positive clinical diagnosis resulting in subsequent tests and anxiety in patients with nonmalignant disease Benefit-harm assessment: Preponderance of benefit over harm Value judgments: The risk of missing or delaying diagnosis of malignancy in an increased

2017 National Guideline Clearinghouse (partial archive)

1555. CRACKCast E102 – Seizures

epilepticus can mimic Hypoglycemia CNS infection CNS vascular event Drug toxicity Psychiatric disorder Metabolic encephalopathy Migraine Transient global amnesia [4] What factors predict abnormal CT findings in seizure patients? See Box 92.3 – Differential Diagnosis of AMS in Patient Who Has Seized Focal abnormality on neurological examination Malignancy Closed head injury Neurocutaneous disorder Focal onset of seizure Absence of a history of alcohol abuse History of cysticercosis Altered mental status (...) damage Rhabdomyolysis Autonomic discharge & bulbar muscle involvement may result in Urinary or fecal incontinence Vomiting Tongue biting Potential airway impairment. Posterior shoulder dislocations or fractures [9] Describe the legal implications of diagnosis of new seizure According to the Government of British Columbia New onset seizure has a private driving restriction: With a seizure free period up to 6 months; Or Medical clearance to drive by a Neurologist Professional Drivers must be: Seizure

2017 CandiEM

1556. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

, Tornatore LA, Brancazio L, et al. Can children with autism spectrum disorders "hear" a speaking face? Child Dev. 2011 Sep-Oct;82(5):1397-403. doi: 10.1111/j.1467-8624.2011.01619.x. PMID: 21790542.X-1 682. Ishikawa T, Takahashi K, Ikeda N, et al. Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)- Based Photodynamic Diagnosis of Malignant Brain Tumor: Molecular Design of ABCG2 Inhibitors. Pharmaceutics. 2011;3(3):615-35. doi: 10.3390/pharmaceutics3030615. PMID: 24310600.X-1 (...) . J Autism Dev Disord. 2011 Sep;41(9):1214-27. doi: 10.1007/s10803-010-1140-6. PMID: 21103917.X-1 695. Kim HJ, Lee JE, Shin SJ, et al. Analysis of the substantia innominata volume in patients with Parkinson's disease with dementia, dementia with lewy bodies, and Alzheimer's disease. J Mov Disord. 2011 Oct;4(2):68-72. doi: 10.14802/jmd.11014. PMID: 24868398.X-1 696. Kim WS. Mammalian target of rapamycin inhibitors for treatment in tuberous sclerosis. Korean J Pediatr. 2011 Jun;54(6):241-5. doi

2017 Effective Health Care Program (AHRQ)

1557. CRACKCast E110 – Thought Disorders

erythematosus Temporal (giant cell) arteritis ORGAN FAILURE Hepatic encephalopathy Uremia NEUROLOGIC DISORDERS Alzheimer’s disease Cerebrovascular disease Encephalitis (including HIV infection) Encephalopathies Epilepsy Huntington’s disease Multiple sclerosis Neoplasms Normal-pressure hydrocephalus Parkinson’s disease Pick’s disease Wilson’s disease ENDOCRINE DISORDERS Addison’s disease Cushing’s disease Panhypopituitarism Parathyroid disease Postpartum psychosis Recurrent menstrual psychosis Sydenham’s (...) chorea Thyroid disease DEFICIENCY STATES Niacin Thiamine Vitamin B12 and folate “Psychosis” Postpartum Sarcoid thYroid Calcium and Carbon (high) HypoNa/02/Glycemia SLE Itis – encephalItis Substrate deficiency states Niacin, thiamine, Vit b12. [2] List 10 pharmacologic agents that may cause acute psychosis (Box) BOX 100.2 Pharmacologic Agents That May Cause Acute Psychosis ANTIANXIETY AGENTS Alprazolam Chlordiazepoxide Clonazepam Clorazepate Diazepam Ethchlorvynol ANTIBIOTICS Isoniazid Rifampin

2017 CandiEM

1558. CRACKCast E105 – Brain and Cranial Nerve Disorders

= Carbamazapine 100mg PO BID. Other options: Phenytoin Baclofen Valproate sodium Lamotrigine Gabapentin Levetiracetam Disposition: Neurology with +/- Neurosurgery or ENT consult if surgical decompression is required [4] Facial nerve paralysis: List 6 differential diagnoses for facial (CN VII) paralysis Bell’s palsy Ramsey Hunt syndrome (herpes zoster oticus) Lyme disease (neuroborreliosis) Bacterial infections of the middle ear, mastoid, or external auditory canal Guillain-Barré syndrome HIV infection Tumor (...) risk factors Inflammatory disease: SLE, Behçet’s disease, GPanG, IBD, sarcoidosis Malignancy Hematologic conditions Procoagulant disease Antithrombin deficiency Protein C/S deficiency Factor V Leiden mutation Hyperhomocysteinemia Polycythemia Congenital heart disease Thyroid disease What CT findings may be seen in cerebral venous thrombosis? What is the most common CT finding? Delta Sign / Dense Triangle / Empty Triangle Sign Ref: Cerebral Edema Absent Venous Flow Hemorrhage secondary to venous

2017 CandiEM

1559. CRACKCast 107 – Peripheral Nerve Disorders

polyradiculoplexoneuropathy Malignant disease Human immunodeficiency virus (HIV) infection Hepatitis B Buckthorn Diphtheria [4] Describe the pathophysiology of GBS, and list common precipitating organisms According to UpToDate: “GBS is thought to result from an immune response to a preceding infection that cross-reacts with peripheral nerve components because of molecular mimicry. The immune response can be directed towards the myelin or the axon of peripheral nerve, resulting in demyelinating and axonal forms of GBS (...) [16] List 3 causes of a mononeuropathy multiplex Refer to box 97.8 in Rosen’s 9 th Edition for a list of etiologies of mononeuropathy multiplex Mononeuropathy multiplex etiologies: Vasculitis Systemic vasculitis Polyarteritis nodosa Rheumatoid arthritis Systemic lupus erythematosus Sjörgen’s syndrome (keratoconjunctivitis sicca) Nonsystemic vasculitis Diabetes mellitus Neoplastic Paraneoplastic Direct infiltration Infectious Lyme disease HIV infection Sarcoid Toxic (lead) Transiet (polycythemia

2017 CandiEM

1560. BSR guideline Management of Adults with Primary Sjögren's Syndrome Full Text available with Trip Pro

infiltration of exocrine glands [ ]. Patients characteristically complain of drying of the eyes and mucosal surfaces along with fatigue and arthralgia. There is an association with autoimmune thyroid disease, coeliac disease and primary biliary cirrhosis. Systemic features include inflammatory arthritis, scLE, immune thrombocytopenia (ITP), vasculitis with purpura, salivary gland inflammation, neuropathies, interstitial lung disease (ILD) and a 5–10% lifetime risk of B cell lymphoma [ , ]. NICE has (...) presenting with symptoms suggestive of SS are referred to a specialist centre for evaluation and treatment. In addition this guideline does not cover the detailed management of patients with secondary Sjögren’s. Where patients have secondary SS their systemic management should address the primary disease but the advice on topical management contained in these guidelines is applicable to sicca symptoms from any cause. This guideline does not cover the detailed management of patients with lymphoma, who

2017 British Society for Rheumatology

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