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Tongue Carcinoma

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1461. Patient Preferences in Making Treatment Decisions in Patients With Stage I-IVA Oropharyngeal Cancer

with oropharyngeal cancer. Condition or disease Intervention/treatment Stage I Squamous Cell Carcinoma of the Oropharynx Stage II Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Oropharynx Tongue Cancer Other: questionnaire administration Procedure: quality-of-life assessment Detailed Description: PRIMARY OBJECTIVES: I. Determine the stability of Head and Neck Priorities Scale (HNPS) ranking between pre- and post-treatment (...) for newly diagnosed Head/ Neck Cancer Criteria Inclusion Criteria: Treatment naïve American Joint Committee on Cancer (AJCC) stage I-IVa squamous cell carcinoma of the head and neck with no definitive evidence of metastatic disease Sufficient vision, writing, and communication ability to complete the interviews and assessment tool Signed informed consent Exclusion Criteria: Patients who are enrolled in other head and neck cancer treatment protocols are permitted to participate in this study

2013 Clinical Trials

1462. Screening for oral cancer

). It is thus an aid to oral cancer diagnosis and not an appropriate tool for use in population screening programs in apparently healthy individuals…” Downer (2004). Project page URL Indexing Status Subject indexing assigned by CRD MeSH Head and Neck Neoplasmss; Mass Screening; Mouth Neoplasms; Tongue Neoplasms Language Published English Country of organisation United States Address for correspondence Office of Patient Care Services (11T), VA Boston Healthcare System 150 South Huntington Avenue MA 02130 (...) (TAP) for a review of the literature to identify the level of evidence available as support for use of toluidine blue (TB) as a diagnostic aid within a screening program for oral squamous cell carcinoma (OSCC) in VHA dental clinics. Specifically, VHA’s national cancer strategy (VHA, 2003) requires that screening programs meet evidence standards established by the United States Preventive Services Task Force (USPSTF). USPSTF recommends that a service be provided only where good evidence is available

2009 Health Technology Assessment (HTA) Database.

1463. Raman spectroscopy of serum: an exploratory study for detection of oral cancers. (Abstract)

Raman spectroscopy of serum: an exploratory study for detection of oral cancers. Early diagnosis of oral cancers, one of the major cancers, is of utmost importance as 5-year disease-free survival rates are some of the lowest, despite advances in treatment and surgical modalities. In vivo Raman spectroscopy has shown efficacy in the detection of normal, premalignant and malignant lesions and even of early changes such as cancer-field-effects/malignancy-associated-changes. However, the need (...) for a dedicated instrument and stringent laboratory conditions, at all diagnostic centers, limits wide screening applications of this method. In light of this, it is pertinent to explore ex vivo samples like serum due to its ease of collection, storage, transport and analysis at a centralized facility. Hence, Raman studies were carried out on serum from 14 buccal mucosa and 40 tongue cancers as well as 16 healthy control samples. Spectral features indicate differential contributions of proteins, DNA

2013 The Analyst Controlled trial quality: uncertain

1464. Botanical Therapy in Treating Mucositis in Patients With Head and Neck Cancer Who Have Undergone Chemoradiation Therapy

Responsible Party: Roswell Park Cancer Institute ClinicalTrials.gov Identifier: Other Study ID Numbers: I 184910 NCI-2012-01030 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) ) First Posted: August 28, 2012 Last Update Posted: May 15, 2013 Last Verified: May 2013 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Mucositis Nasopharyngeal (...) Carcinoma Paranasal Sinus Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases Stomatognathic Diseases Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Mouth Diseases Nasopharyngeal Neoplasms Nasopharyngeal Diseases Nose Neoplasms

2012 Clinical Trials

1465. Endoscopic Resection or Ablation for Patients With Dysplasia or Cancer Requiring Treatment of Barrett's Esophagus

with Barrett's esophagus(BE) containing high grade dysplasia or intramucosal cancer and compare the effects of endoscopically-guided radiofrequency ablation system(RFA) and endoscopically-guided stepwise endoscopic mucosal resection(S-EMR). Condition or disease Intervention/treatment Phase Barrett's Esophagus Esophageal Neoplasms Device: Radiofrequency Ablation(RFA) by HALO device. Device: Endoscopic mucosal resection(EMR) by mucosectomy kit. Not Applicable Detailed Description: This is a multi-center (...) Study ID Numbers: PS0058 First Posted: April 6, 2012 Last Update Posted: May 30, 2017 Last Verified: May 2017 Keywords provided by PRATEEK SHARMA, Midwest Biomedical Research Foundation: Barrett's Esophagus Esophageal neoplasms Radiofrequency ablation Endoscopic mucosal resection Additional relevant MeSH terms: Layout table for MeSH terms Barrett Esophagus Esophageal Neoplasms Precancerous Conditions Neoplasms Esophageal Diseases Gastrointestinal Diseases Digestive System Diseases Gastrointestinal

2012 Clinical Trials

1466. Effect of Lactobacillus Brevis CD2 in Prevention of Radio-chemotherapy Induced Oral Mucositis in Head and Neck Cancer

, larynx tumour. Presence of metastasis, detected with contrast-enhances TC TB and/or PET/TC Major surgery of the oral cavity within the last 4 weeks Patients previoucly treated with radiotherapy of head and neck Antifungal or antiviral therapy for oral pathological conditions in the last Other serious concomitant disease History of insulin-dependent Diabetes Mellituss History of oral ulceration, herpes simplex, oral candidiasis, severe gingivitis, active or chronic mucositis or Xerostomia Patients (...) : Layout table for MeSH terms Head and Neck Neoplasms Mucositis Stomatitis Neoplasms by Site Neoplasms Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Mouth Diseases Stomatognathic Diseases

2012 Clinical Trials

1467. Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent Oral Cavity or Oropharyngeal Cancer

) ) First Posted: October 31, 2012 Last Update Posted: September 3, 2014 Last Verified: September 2014 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Oropharyngeal Neoplasms Carcinoma, Verrucous Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Pharyngeal Diseases Stomatognathic Diseases (...) . Photodynamic therapy uses a drug, such as temoporfin, that is absorbed by tumor cells. The drug becomes active when it is exposed to light. When the drug is active, tumor cells are killed. Giving photodynamic therapy using temoporfin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Condition or disease Intervention/treatment Phase Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Oropharynx

2012 Clinical Trials

1468. Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC)

Identifier: Other Study ID Numbers: 12-150 First Posted: November 5, 2012 Last Update Posted: October 25, 2017 Last Verified: October 2017 Keywords provided by Memorial Sloan Kettering Cancer Center: BIBW2992 (AFATINIB) CARBOPLATIN RIBAVIRIN-ICN (VIRAZOLE) TAXOL (PACLITAXEL) OROPHARYNX HPV associated 12-150 Additional relevant MeSH terms: Layout table for MeSH terms Head and Neck Neoplasms Neoplasms, Squamous Cell Carcinoma, Squamous Cell Neoplasms by Site Neoplasms Neoplasms, Glandular and Epithelial (...) is a combination of two pill drugs taken by mouth and two drugs given by vein. This is a phase I study, which means that the primary goal is to establish the recommended dose of an investigational drug when added to chemotherapy. The researchers wish to evaluate the effects, good and bad, of the investigational drug. Condition or disease Intervention/treatment Phase Head and Neck Cancer Squamous Cell Cancer Drug: Afatinib, Ribavirin, and weekly carboplatin/paclitaxel Phase 1 Study Design Go to Layout table

2012 Clinical Trials

1469. Entolimod in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Receiving Cisplatin and Radiation Therapy

Last Verified: December 2013 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Mucositis Squamous Cell Carcinoma of Head and Neck Nasopharyngeal Carcinoma Paranasal Sinus Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Respiratory Tract Diseases Otorhinolaryngologic Diseases (...) and radiation therapy may kill more tumor cells Condition or disease Intervention/treatment Phase Mucositis Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous

2012 Clinical Trials

1470. A study on conventional IMRT and RapidArc treatment planning techniques for head and neck cancers Full Text available with Trip Pro

A study on conventional IMRT and RapidArc treatment planning techniques for head and neck cancers To evaluate the performance of volumetric arc modulation with RapidArc against conventional IMRT for head and neck cancers.RapidArc is a novel technique that has recently been made available for clinical use. Planning study was done for volumetric arc modulation with RapidArc against conventional IMRT for head and neck cancers.Ten patients with advanced tumors of the nasopharynx, oropharynx (...) of elective nodal regions. Planning was done for IMRT using 9 fields and RapidArc with single arc, double arc. Beam was equally placed for IMRT plans. Single arc RapidArc plan utilizes full 360° gantry rotation and double arc consists of 2 co-planar arcs of 360° in clockwise and counter clockwise direction. Collimator was rotated from 35 to 45° to cover the entire tumor, which reduced the tongue and groove effect during gantry rotation. All plans were generated with 6 MV X-rays for CLINAC 2100 Linear

2012 Reports of Practical Oncology and Radiotherapy

1471. Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients

in similar patients receiving chemo-RT and to compare the toxicity in patients receiving cetuximab-RT to similar patients treated with 7 weeks of chemotherapy concurrent with RT ("standard therapy") in UMCC 2-21. Condition or disease Intervention/treatment Phase Squamous Cell Carcinoma of the Oropharynx HPV Drug: Cetuximab Radiation: Radiotherapy Not Applicable Detailed Description: The investigators have shown in past experience a high success in getting rid of oropharyngeal cancer (tonsil or base (...) of tongue cancer) using chemotherapy and radiation therapy in patients who have not smoked, or only smoked a minimal amount of cigarettes or equivalent. In these patients, the cancer is thought to be caused by a virus (Human Papilloma Virus, or HPV). HPV is a virus that infects the epidermis (outermost layer of skin) and mucous membranes of humans. In general, patients with HPV-related cancer such as yours have a better prognosis compared with patients whose tumors are smoking-related. Taking

2012 Clinical Trials

1472. Cross-Sectional Study of Oral Health in Patients After Parotid-Sparing Radiation Therapy for Head and Neck Cancer

, the investigators will be collecting, storing, and analyzing the quality of saliva, including the protein content, collected from patients following radiation therapy as well as saliva collected from normal healthy adults. Condition or disease Intervention/treatment Phase Head and Neck Cancer Procedure: Saliva Sample Not Applicable Detailed Description: Radiation-induced xerostomia is the most common long term complication of head and neck radiation, is usually permanent and is the most frequent reason (...) Active Comparator: Healthy Adults Healthy adults over the age of 18, with no history of surgery to the salivary glands, or cancer therapy. Procedure: Saliva Sample Small plastic cups will be placed on the inside of subject cheeks, and held in place with gentle suction. These cups are attached to tubes which will allow the collection of saliva into a test tube. Saliva will also be collected from the glands underneath the tongue using a small gentle suction device, similar to the one used by a dentist

2012 Clinical Trials

1473. Imaging in oral cancers Full Text available with Trip Pro

Imaging in oral cancers Oral cavity squamous cell cancers form a significant percentage of the cancers seen in India. While clinical examination allows direct visualization, it cannot evaluate deep extension of disease. Cross-sectional imaging has become the cornerstone in the pretreatment evaluation of these cancers and provides accurate information about the extent and depth of disease that can help decide the appropriate management strategy and indicate prognosis. Early cancers are treated (...) and the focus of the review is squamous cancers of the gingivobuccal region, oral tongue and retromolar trigone as these are most frequently encountered in the subcontinent. References for this review were identified by searching Medline and PubMed databases. Only articles published in English language literature were selected. This review aims to familiarize the radiologist with the relevant anatomy of the oral cavity, discuss the specific issues that influence prognosis and management at the above

2012 The Indian journal of radiology & imaging

1474. Breast Cancer Presents with a Paraneoplastic Neurologic Syndrome Full Text available with Trip Pro

accompanied by a left tongue deviation, an upward vertical nystagmus, moderate spastic paraparesis, dystonic posturing of the left foot, lower limb hyperreflexia and bilateral extensor plantar reflex. After ruling out all other potential neurologic causes, PNS was suspected but no ONAs were found. A PET-CT scan detected increased metabolism in the right breast, as well as an ipsilateral thoracic interpectoral adenopathy. Core biopsy confirmed the presence of an infiltrating duct carcinoma. After breast (...) Breast Cancer Presents with a Paraneoplastic Neurologic Syndrome Paraneoplastic neurologic syndromes (PNS) pose quite an uncommon neurological complication, affecting less than 1% of patients with breast cancer. Nearly one third of these patients lack detectable onconeural antibodies (ONAs), and improvement in neurologic deficits with concomitant cancer treatments is achieved in less than 30% of cases.A 42-year-old, premenopausal woman presented with facial paralysis on the central left side

2012 Case reports in oncology

1475. Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study. Full Text available with Trip Pro

Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study. Little is known about the risk of cancer in patients with chronic obstructive pulmonary disease (COPD), including which cancer sites are most affected. We examined the short- and long-term risk of lung and extrapulmonary cancer in a nationwide cohort of COPD patients.We linked the Danish National Registry of Patients and the nationwide cancer registry, and examined the incidence of various cancers (...) -5.2) for all tobacco-related cancers, and 1.9 (1.9-2.0) for other cancers. In the following years, cancer incidence was increased 1.4-fold (1.4-1.5) in COPD patients. These patients had an increased risk of developing tobacco-related cancers (SIR = 2.1; 95% CI 2.0-2.1), including cancers of the lung, larynx, tongue, oral cavity, pharynx, esophagus, stomach, liver, pancreas, cervix uteri, and urinary tract (with SIRs ranging between 1.3 and 2.8).Patients with first-time hospital-diagnosed COPD

2012 Respiratory medicine

1476. Use of Panitumumab-IRDye800 to Image Microscopic Head and Neck Cancer in an Orthotopic Surgical Model. Full Text available with Trip Pro

) and fluorescence intensity was correlated with pathologic confirmation of disease.Orthotopic tongue tumors were clearly delineated from normal tissue with tumor-to-background ratios of 2.9 (Pearl) and 2.3 (SPY). Disease detection was significantly improved with panitumumab-IRDye compared to IgG-IRDye800 (P < 0.05). Tissue biopsy samples (average size 3.7 mm) positive for fluorescence were confirmed for pathologic disease by histology and immunohistochemistry (n = 25 of 25). Biopsy samples of nonfluorescent (...) Use of Panitumumab-IRDye800 to Image Microscopic Head and Neck Cancer in an Orthotopic Surgical Model. Fluorescence imaging hardware (SPY) has recently been developed for intraoperative assessment of blood flow via detection of probes emitting in the near-infrared (NIR) spectrum. This study sought to determine if this imaging system was capable of detecting micrometastatic head and neck squamous cell carcinoma (HNSCC) in preclinical models.A NIR fluorescent probe (IRDye800CW) was covalently

2012 Annals of Surgical Oncology

1477. Pharyngolaryngo-Esophagectomy with Laparoscopic Gastric Pull-Up: A Reappraisal for the Pharyngoesophageal Junction Cancer. Full Text available with Trip Pro

Pharyngolaryngo-Esophagectomy with Laparoscopic Gastric Pull-Up: A Reappraisal for the Pharyngoesophageal Junction Cancer. Surgical treatment of advanced hypopharyngeal tumors is still a surgical challenge. We report a case of a hypopharyngeal tumor treated with a pharyngolaryngo-esophagectomy (PLE) and laparoscopic gastric tubulization and interposition.A 56-year-old man presented with a relapsing hypopharynx carcinoma, after primary chemoradiation therapy. Preoperative workup showed a stage (...) of dissected cervical lymph nodes was 32. Oral feeding was started after 10 days, and the patient was discharged after 14 days. Stage of disease was pT4N1M0 G3 R0.Laparoscopic surgery allows a minimally invasive gastric tailoring and tubulization and transhiatal esophageal dissection and represents a valuable alternative for intestinal reconstruction after PLE. CT scan showing a large hypopharynx carcinoma involving cervical lymph nodes and cervical esophagus.

2012 Annals of Surgical Oncology

1478. Venous Invasion in Colorectal Cancer: Impact of an Elastin Stain on Detection and Interobserver Agreement Among Gastrointestinal and Nongastrointestinal Pathologists. (Abstract)

Venous Invasion in Colorectal Cancer: Impact of an Elastin Stain on Detection and Interobserver Agreement Among Gastrointestinal and Nongastrointestinal Pathologists. Venous invasion (VI) is an independent prognostic indicator in colorectal cancer and may prompt consideration for adjuvant chemotherapy in patients with stage II tumors. Recent evidence suggests that VI is underreported in colorectal cancer and that detection may be enhanced by an elastin stain. This study aimed (1) to determine (...) similar diagnostic criteria but that GI pathologists more frequently applied "orphan arteriole" and "protruding tongue" signs as diagnostic clues to VI. This study confirms that VI is underdetected on H&E and highlights the role of elastin staining in improving VI detection and interobserver agreement. Strategies to improve VI detection are warranted.

2012 American Journal of Surgical Pathology

1479. Transoral robotic surgery alone for oropharyngeal cancer: an analysis of local control. Full Text available with Trip Pro

Transoral robotic surgery alone for oropharyngeal cancer: an analysis of local control. To evaluate local control following transoral robotic surgery (TORS) with the da Vinci Surgical System (Intuitive Surgical Inc) as a single treatment modality for oropharyngeal squamous cell carcinoma (OSCC).Prospective, single-center, observational study.Academic university health system and tertiary referral center.Thirty adults with previously untreated OSCC.Transoral robotic surgery with staged neck (...) dissection as indicated.Local control and margin status.Thirty patients were enrolled with previously untreated OSCC and no prior head and neck radiation therapy. Follow-up duration was at least 18 months. At the time of diagnosis, 9 tumors were T1 (30%); 16 were T2 (53%); 4 were T3 (13%); and 1 was T4a (3%). The anatomic sites of these primary tumors were tonsil in 14 (47%), tongue base in 9 (30%), glossotonsillar sulcus in 3 (10%), soft palate in 3 (10%), and oropharyngeal wall in 1 (3

2012 Archives of Otolaryngology Head and Neck Surgery

1480. Your Doctor Not Screening You for Liver Cancer? Time for a Talk

and Veterans Affairs researchers wrote in the journal article. Current medical guidelines are clear that anyone with cirrhosis (liver scarring) should be screened twice a year or more frequently for liver cancer, using ultrasound examinations and an alpha fetoprotein (AFP) test, which is a blood test that is moderately successful at identifying cancerous tumors. There’s good reason for this mandate–about 80 percent of people diagnosed with liver cancer also have cirrhosis. The guidelines also state (...) about hepatitis B or this blog post, please email or call 215-489-4900. 3 thoughts on “Your Doctor Not Screening You for Liver Cancer? Time for a Talk” Can u guys please explain dis to me?Hbsag Hbeag -Hbsab -Hbcab-Hbeab- What do i do guys… I my palms are red and mottled, tongue problem, abdominalpain etc Hello: All that you have asked about are antigens — proteins that make up the hepatitis B virus — and antibodies, which the immune system creates to fight and destroy each of those “enemy” antigens

2015 hepbblog

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