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Tongue Carcinoma

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1421. Cancer and Rehabilitation (Treatment)

improved in both whites and African Americans. Cancer sites for which survival has not improved substantially over the last 25 years include the uterine corpus, uterine cervix, larynx, liver, lung, pancreas, stomach, and esophagus. Neoplastic disease can develop in virtually any organ system. This unregulated growth injures and compromises organ systems that are functioning normally. Cancer-related diseases are often treated with therapeutic modalities that, in themselves, compromise normally (...) Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire QOL index Cancer rehabilitation evaluation system Functional assessment of cancer therapy Global adjustment-to-illness scale Purpose and emphasis of rehabilitation The purpose of rehabilitation for patients with cancer is similar to that for patients with other diseases. However, the pathology of the tumor, the anticipated progression of disease, and any associated treatments must be considered carefully when goals are formed. When

2014 eMedicine.com

1422. Cancers of the Oral Mucosa (Treatment)

Program. Available at . Accessed: May 20, 2017. Nagler R, Dayan D. The dual role of saliva in oral carcinogenesis. Oncology . 2006. 71(1-2):10-7. . Tomar SL, Loree M, Logan H. Racial differences in oral and pharyngeal cancer treatment and survival in Florida. Cancer Causes Control . 2004 Aug. 15(6):601-9. . Scully C, Bedi R. Ethnicity and oral cancer. Lancet Oncol . 2000 Sep. 1(1):37-42. . Scully C. Challenges in predicting which oral mucosal potentially malignant disease will progress to neoplasia (...) and treatment of oral complications whenever possible are important and should be performed by an oncologic team including a dental practitioner and an oral hygienist. Prevention and treatment planning before cancer therapy Prevention of oral disease and careful treatment planning are essential to minimize oral disease and the need for, and possible adverse consequences of, operative intervention. Adults with malignant head and neck disease unfortunately often have poor oral hygiene and care and are poorly

2014 eMedicine.com

1423. Cancer and Rehabilitation (Diagnosis)

improved in both whites and African Americans. Cancer sites for which survival has not improved substantially over the last 25 years include the uterine corpus, uterine cervix, larynx, liver, lung, pancreas, stomach, and esophagus. Neoplastic disease can develop in virtually any organ system. This unregulated growth injures and compromises organ systems that are functioning normally. Cancer-related diseases are often treated with therapeutic modalities that, in themselves, compromise normally (...) Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire QOL index Cancer rehabilitation evaluation system Functional assessment of cancer therapy Global adjustment-to-illness scale Purpose and emphasis of rehabilitation The purpose of rehabilitation for patients with cancer is similar to that for patients with other diseases. However, the pathology of the tumor, the anticipated progression of disease, and any associated treatments must be considered carefully when goals are formed. When

2014 eMedicine.com

1424. Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma

scan). Condition or disease Intervention/treatment Phase HEAD & NECK Cancer Drug: ribavirin Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 7 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Study (...) ClinicalTrials.gov Identifier: Other Study ID Numbers: 10-218 First Posted: December 31, 2010 Last Update Posted: October 29, 2018 Last Verified: October 2018 Keywords provided by Memorial Sloan Kettering Cancer Center: ribavirin VIRAZOLE tonsil base of tongue squamous cell carcinoma 10-218 Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Ribavirin Antimetabolites

2010 Clinical Trials

1425. Survival patterns in patients with carcinoma base of tongue treated with external beam irradiation and salvage surgery Full Text available with Trip Pro

IV 60/78 (76.92%) as per AJCC staging. Radiotherapy in the dose of 60 Gy was given primarily to the patients with stage III tongue base cancer. Patients with early stage IV cancer were given split course radiotherapy followed by assessment for surgery. For the patients with advanced stage IV disease with poor general condition, palliative radiotherapy of 24 Gy with or without palliative chemotherapy was given. 15 patients were subjected to salvage surgery in the form of radical neck dissection (...) Survival patterns in patients with carcinoma base of tongue treated with external beam irradiation and salvage surgery The current study was designed to assess the treatment results and survival in the patients with carcinoma of base of tongue that were treated with primary radiotherapy, radiotherapy with chemotherapy and salvage surgery when indicated.A prospective study was carried out in 78 cases of carcinoma of the base of tongue between 1995 and 1999.The majority of cases belonged to stage

2010 Indian Journal of Otolaryngology and Head & Neck Surgery

1426. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. Full Text available with Trip Pro

Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent (...) premalignant dysplasias, 15 normal tongue mucosa, and 32 lymph node metastatic diseases by immunohistochemistry (IHC).The SOD2 mRNA level in primary TSCC tissue is reversely correlated with lymph node metastasis in the first TSCC patient cohort. The SOD2 protein level in primary TSCC tissue is also reversely correlated with lymph node metastasis in the second TSCC patient cohort. Deregulation of SOD2 expression is a common event in TSCC and appears to be associated with disease progression. Statistical

2010 BMC Cancer

1427. Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue Full Text available with Trip Pro

types.Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi-1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above.A (...) Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer

2010 British journal of cancer

1428. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma Full Text available with Trip Pro

Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma MicroRNA deregulation is a critical event in tumor initiation and progression. The down-regulation of microRNA-138 has been frequently observed in various cancers, including tongue squamous cell carcinoma (TSCC). Our previous studies suggest that deregulation of miR-138 is associated with the enhanced proliferation and invasion (...) . These targets include: chloride channel, nucleotide-sensitive, 1A (CLNS1A), G protein alpha inhibiting activity polypeptide 2 (GNAI2), solute carrier family 20, member 1 (SLC20A1), eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1), and Rho-related GTP-binding protein C (RhoC). GNAI2 is a known proto-oncogene that is involved in the initiation and progression of several different types of tumors. Direct targeting of miR-138 to two candidate binding sequences located in the 3

2010 Human Genetics

1429. Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome. (Abstract)

Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome. To assess the possible effect of young age on clinical behaviour and survival outcome of squamous cell carcinoma of the oral tongue.Retrospective, case control study.A major tertiary referral centre.Eighty-five patients with oral tongue squamous cell carcinoma with at least 2 years of follow-up.Clinical and histopathological staging, disease-free survival, disease-specific (...) survival.In this study, patients younger than 30 years of age presented with advanced tumour stages and with a different failure pattern compared to the older age group. This may be attributable to age-related biologic behaviour or delayed cancer diagnosis. Differences in disease free survival and overall survival could not be established.

2010 Clinical Otolaryngology

1430. Angiopoietin-2 inhibits the growth of tongue carcinoma without affecting expression of vascular endothelial growth factor. (Abstract)

Angiopoietin-2 inhibits the growth of tongue carcinoma without affecting expression of vascular endothelial growth factor. Angiopoietin-2 (Ang-2) has been identified as an important factor in tumour angiogenesis through its action in blocking the stabilizing actions of Ang-2 and leading to new tumour vessel growth in the presence of vascular endothelial growth factor (VEGF). In the authors' previous study, over-expression of Ang-2 in Tca8113 tongue tumour cells inhibited growth. The current (...) study aims to clarify the mechanisms of Ang-2-mediated tumour growth inhibition and its role in the regulation of VEGF expression. These studies used tumours derived from Ang-2-transfected Tca8113 cells injected into nude mice. The results showed that Ang-2-transfected tumours displayed aberrant angiogenic vessels with few associated smooth muscle cells. No detectable differences in VEGF expression were observed between Ang-2-transfected and parental tumours. Tumours produced by the Ang-2

2010 International Journal of Oral and Maxillofacial Surgery

1431. Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival. Full Text available with Trip Pro

Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival. To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge.Retrospective matched-pair cohort study.Memorial Sloan-Kettering Cancer Center, New York, New York.A total of 10 pediatric (...) and 40 adult patients diagnosed as having SCC of the oral tongue.Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P = .97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P = .90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P = .54).When pediatric and adult patients were matched for sex

2010 Archives of Otolaryngology Head and Neck Surgery

1432. Tongue and Buccal Mucosa Carcinoma: Is There a Difference in Outcome? (Abstract)

18%, P = 0.0231). In pN0/pNx subjects, neck control was predicted by perineural invasion and the absence of neck dissection in tongue cancer, and by poor differentiation in buccal cancer. In pN+ patients, distant metastases were predicted by pT3-4 disease, age at onset ≤40 years, poor differentiation, and pN+ ≥ 5 nodes in tongue cancer, and by poor differentiation and pN+ ≥ 5 nodes in buccal cancer.There are significant differences in the failure pattern of tongue and buccal carcinomas (...) Tongue and Buccal Mucosa Carcinoma: Is There a Difference in Outcome? We sought to determine the differences in clinical outcome of tongue and buccal carcinomas.Five-year locoregional control, distant metastasis, and survival rates were examined in 456 patients with tongue cancer and 407 patients with buccal cancer.Five-year rates for patients with tongue and buccal carcinomas were as follows: local control, 85% and 87% (P = 0.9366); neck control, 81% and 87% (P = 0.0304); distant metastasis, 8

2010 Annals of Surgical Oncology

1433. A Study to Assess Radiation Induced Mucositis in Patients of Head and Neck Cancer Administered Chemo-Radiation With or Without P276-00

Have undergone induction CT History of malignant tumors other than HNC (except non-melanoma skin cancer) unless disease free for a minimum of 3 years Severe co-morbidity, defined as: Symptomatic and/or uncontrolled cardiac disease, New York Heart Association Classification III or IV Acute myocardial infarction within the last 6 months Acute bacterial or fungal infection requiring systemic antibiotics at the time of enrollment Subjects known to be seropositive for human immunodeficiency virus (HIV (...) : NCT01903018 Recruitment Status : Completed First Posted : July 19, 2013 Last Update Posted : September 4, 2014 Sponsor: Piramal Enterprises Limited Information provided by (Responsible Party): Piramal Enterprises Limited Study Details Study Description Go to Brief Summary: A Clinical Study to Assess Radiation Induced Mucositis in Subjects with Locally Advanced Squamous Cell Carcinoma of the Head and Neck Condition or disease Intervention/treatment Phase Radiation Induced Mucositis in Head and Neck Cancer

2013 Clinical Trials

1434. Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer

Carcinoma Paranasal Sinus Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases Stomatognathic Diseases Mouth Neoplasms Mouth Diseases Salivary Gland Diseases Nasopharyngeal Neoplasms Nasopharyngeal Diseases Nose Neoplasms (...) albumin-stabilized nanoparticle formulation followed by chemoradiation therapy may be an effective treatment for head and neck cancer. Condition or disease Intervention/treatment Phase Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous

2013 Clinical Trials

1435. Efficacy and Safety Study of Etodolac and Propranolol in Patients With Clinically Progressive Prostate Cancer

: May 20, 2013 Last Update Posted : April 26, 2018 Sponsor: Vicus Therapeutics Information provided by (Responsible Party): Vicus Therapeutics Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the clinical benefit of the co-administration of propranolol and etodolac (VT-122 therapy) in patients with clinically progressive prostate cancer. Condition or disease Intervention/treatment Phase Prostatic Neoplasms Drug: VT-122 Drug: Placebo Phase 2 Study Design (...) [aspartate transaminase (AST), alanine transaminase (ALT)] ≤2 x ULN Able to provide written informed consent prior to any study specific screening procedures with the understanding that the patient has the right to withdraw from the study at any time, for any reason without prejudice Exclusion Criteria: The patient has a history of another primary cancer, with the exception of: Curatively resected non-melanomatous skin cancer; Other primary solid tumor with no known active disease presents

2013 Clinical Trials

1436. 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

multiforme (GBM) and other cancers requiring antiangiogenesis treatment. Condition or disease Intervention/treatment Phase Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Male Breast Cancer Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Adult Brain Tumor Recurrent Basal Cell Carcinoma of the Lip Recurrent Breast Cancer Recurrent Colon Cancer Recurrent Esthesioneuroblastoma of the Paranasal (...) Colon Cancer Stage IVA Rectal Cancer Stage IVA Salivary Gland Cancer Stage IVB Colon Cancer Stage IVB Salivary Gland Cancer Stage IVC Salivary Gland Cancer Tongue Cancer Unspecified Adult Solid Tumor, Protocol Specific Drug: fludeoxyglucose F 18 Drug: 2-fluoropropionyl-labeled pegylated dimeric RGD peptide Diagnostic Test: positron emission tomography Diagnostic Test: computed tomography Other: laboratory biomarker analysis Phase 1 Phase 2 Detailed Description: PRIMARY OBJECTIVES: I. Evaluate 18F

2013 Clinical Trials

1437. Use of Computer-based Patient-reported Data to Assess Long Term and Late Effects of Head and Neck Cancer at the Point-of-care

(semi structured interview and participant observations) of attitudes among clinicians and patients regarding the use of tool at the point of care. Condition or disease Intervention/treatment Phase Head and Neck Cancer Patients Late Effects Behavioral: WebCan Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open (...) Volunteers: No Criteria Inclusion Criteria: Prevalent recurrence free patients with cancers in the tongue, oral cavity, pharynx and larynx attending the oncology clinic at Herlev Hospital, Herlev, Denmark. 9 months to 5 years after end of treatment Exclusion Criteria: Patients with recurrence of their cancers and patients still in treatment. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research

2013 Clinical Trials

1438. Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer

factor receptor (EGFR) analysis and for oropharyngeal cancer patients, human papilloma virus (HPV) analysis Exclusion Criteria: Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 1095 days (3 years); noninvasive cancers (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible) are permitted even if diagnosed and treated < 3 years ago Patients with simultaneous primaries or bilateral tumors are excluded (...) , Squamous Cell Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases Stomatognathic Diseases Mouth Neoplasms Mouth Diseases Tongue Diseases Cisplatin Docetaxel

2013 Clinical Trials

1439. PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumors to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving PI3K inhibitor BKM120 together with cetuximab may kill more tumor cells Condition or disease Intervention/treatment Phase Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma (...) and Neck Neoplasms Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Salivary Gland Neoplasms Nasopharyngeal Carcinoma Paranasal Sinus Neoplasms Neoplasms, Unknown Primary Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases

2013 Clinical Trials

1440. Direct Visual Fluorescence in Finding Oral Cancer in High-Risk Patients and Patients Undergoing Routine Dental Care

and diagnose oral cancer. Condition or disease Intervention/treatment Phase Lip and Oral Cavity Squamous Cell Carcinoma Oral Cavity Verrucous Carcinoma Stage 0 Lip and Oral Cavity Cancer Tongue Cancer Procedure: fluorescence imaging Procedure: biopsy Procedure: examination Procedure: Comparison of surgical margins by COE vs. DVFE Not Applicable Detailed Description: PRIMARY OBJECTIVES: I. To assess the diagnostic benefit of the VELscope (direct visual fluorescence) inspection in oral examination. II (...) Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Carcinoma, Verrucous Mouth Neoplasms Tongue Neoplasms Lip Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Head and Neck Neoplasms Neoplasms by Site Mouth Diseases Stomatognathic Diseases Tongue Diseases Lip Diseases

2013 Clinical Trials

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