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Tongue Carcinoma

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1401. 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

multiforme (GBM) and other cancers requiring antiangiogenesis treatment. Condition or disease Intervention/treatment Phase Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Male Breast Cancer Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Adult Brain Tumor Recurrent Basal Cell Carcinoma of the Lip Recurrent Breast Cancer Recurrent Colon Cancer Recurrent Esthesioneuroblastoma of the Paranasal (...) Colon Cancer Stage IVA Rectal Cancer Stage IVA Salivary Gland Cancer Stage IVB Colon Cancer Stage IVB Salivary Gland Cancer Stage IVC Salivary Gland Cancer Tongue Cancer Unspecified Adult Solid Tumor, Protocol Specific Drug: fludeoxyglucose F 18 Drug: 2-fluoropropionyl-labeled pegylated dimeric RGD peptide Diagnostic Test: positron emission tomography Diagnostic Test: computed tomography Other: laboratory biomarker analysis Phase 1 Phase 2 Detailed Description: PRIMARY OBJECTIVES: I. Evaluate 18F

2013 Clinical Trials

1402. Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer

Carcinoma Paranasal Sinus Neoplasms Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases Stomatognathic Diseases Mouth Neoplasms Mouth Diseases Salivary Gland Diseases Nasopharyngeal Neoplasms Nasopharyngeal Diseases Nose Neoplasms (...) albumin-stabilized nanoparticle formulation followed by chemoradiation therapy may be an effective treatment for head and neck cancer. Condition or disease Intervention/treatment Phase Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous

2013 Clinical Trials

1403. Efficacy and Safety Study of Etodolac and Propranolol in Patients With Clinically Progressive Prostate Cancer

: May 20, 2013 Last Update Posted : April 26, 2018 Sponsor: Vicus Therapeutics Information provided by (Responsible Party): Vicus Therapeutics Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the clinical benefit of the co-administration of propranolol and etodolac (VT-122 therapy) in patients with clinically progressive prostate cancer. Condition or disease Intervention/treatment Phase Prostatic Neoplasms Drug: VT-122 Drug: Placebo Phase 2 Study Design (...) [aspartate transaminase (AST), alanine transaminase (ALT)] ≤2 x ULN Able to provide written informed consent prior to any study specific screening procedures with the understanding that the patient has the right to withdraw from the study at any time, for any reason without prejudice Exclusion Criteria: The patient has a history of another primary cancer, with the exception of: Curatively resected non-melanomatous skin cancer; Other primary solid tumor with no known active disease presents

2013 Clinical Trials

1404. Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer

factor receptor (EGFR) analysis and for oropharyngeal cancer patients, human papilloma virus (HPV) analysis Exclusion Criteria: Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 1095 days (3 years); noninvasive cancers (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible) are permitted even if diagnosed and treated < 3 years ago Patients with simultaneous primaries or bilateral tumors are excluded (...) , Squamous Cell Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases Stomatognathic Diseases Mouth Neoplasms Mouth Diseases Tongue Diseases Cisplatin Docetaxel

2013 Clinical Trials

1405. PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumors to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving PI3K inhibitor BKM120 together with cetuximab may kill more tumor cells Condition or disease Intervention/treatment Phase Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma (...) and Neck Neoplasms Laryngeal Diseases Laryngeal Neoplasms Oropharyngeal Neoplasms Carcinoma, Verrucous Salivary Gland Neoplasms Nasopharyngeal Carcinoma Paranasal Sinus Neoplasms Neoplasms, Unknown Primary Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Respiratory Tract Diseases Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Respiratory Tract Neoplasms Pharyngeal Neoplasms Pharyngeal Diseases

2013 Clinical Trials

1406. Direct Visual Fluorescence in Finding Oral Cancer in High-Risk Patients and Patients Undergoing Routine Dental Care

and diagnose oral cancer. Condition or disease Intervention/treatment Phase Lip and Oral Cavity Squamous Cell Carcinoma Oral Cavity Verrucous Carcinoma Stage 0 Lip and Oral Cavity Cancer Tongue Cancer Procedure: fluorescence imaging Procedure: biopsy Procedure: examination Procedure: Comparison of surgical margins by COE vs. DVFE Not Applicable Detailed Description: PRIMARY OBJECTIVES: I. To assess the diagnostic benefit of the VELscope (direct visual fluorescence) inspection in oral examination. II (...) Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma Carcinoma, Squamous Cell Carcinoma, Verrucous Mouth Neoplasms Tongue Neoplasms Lip Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Head and Neck Neoplasms Neoplasms by Site Mouth Diseases Stomatognathic Diseases Tongue Diseases Lip Diseases

2013 Clinical Trials

1407. Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment

Banerji, Massachusetts General Hospital: Recurrent Ovarian Cancer Platinum Sensitive Ovarian Cancer Additional relevant MeSH terms: Layout table for MeSH terms Ovarian Neoplasms Carcinoma, Ovarian Epithelial Hypersensitivity Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Ovarian Diseases Adnexal Diseases Genital Diseases, Female Genital Neoplasms, Female Urogenital Neoplasms Endocrine System Diseases Gonadal Disorders Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type (...) the frequency and severity of future hypersensitivity reactions. Condition or disease Intervention/treatment Phase Recurrent Ovarian Cancer Platinum Sensitive Ovarian Cancer Drug: Carboplatin Phase 4 Detailed Description: For women with recurrent ovarian cancer, re-treatment with carboplatin is frequently recommended. However, carboplatin re-treatment can result in an allergic or allergic-like reaction called a hypersensitivity reaction. Symptoms of a hypersensitivity reaction can include

2013 Clinical Trials

1408. Use of Computer-based Patient-reported Data to Assess Long Term and Late Effects of Head and Neck Cancer at the Point-of-care

(semi structured interview and participant observations) of attitudes among clinicians and patients regarding the use of tool at the point of care. Condition or disease Intervention/treatment Phase Head and Neck Cancer Patients Late Effects Behavioral: WebCan Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open (...) Volunteers: No Criteria Inclusion Criteria: Prevalent recurrence free patients with cancers in the tongue, oral cavity, pharynx and larynx attending the oncology clinic at Herlev Hospital, Herlev, Denmark. 9 months to 5 years after end of treatment Exclusion Criteria: Patients with recurrence of their cancers and patients still in treatment. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research

2013 Clinical Trials

1409. Effect of Midazolam Premedication Before Induction on the Functional Recovery After General Anesthesia in the Patients Undergoing Breast Surgery Due to Breast Cancer

validity for such research has been verified. Therefore, investigators can investigate the degree of postoperational functional recovery through the QoR-40 by comparing cases in which an operation is performed with or without midazolam. Condition or disease Intervention/treatment Phase Breast Cancer Drug: midazolam premedication Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 82 participants Allocation: Randomized (...) information Ages Eligible for Study: 20 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Women aged between 20 and 65 years who are scheduled to undergo mastectomy because of breast cancer, who are classified as 1-2 according to the American Society of Anesthesiologists (ASA) physical status classification, and who use Korean as their mother tongue will be chosen as participants after obtaining informed consent from them

2013 Clinical Trials

1410. HPV Serum DNA Levels Predicting Outcome in p16+ Squamous Cell Head and Neck Cancer

for subtypes 16 and 18 in p16+ and/or HPV+ oropharyngeal cancer patients. This will entail analysis of both initial pre-therapy HPV level as a continuous variable and initial post-therapy HPV level as a dichotomous variable. Condition or disease Intervention/treatment Phase Subjects With p16+/HPV+ Squamous Cell Carcinomas of the Oropharynx. Other: Obtaining Human tissue Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment (...) terms Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Oropharyngeal Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Neoplasms by Site Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases

2013 Clinical Trials

1411. Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage III-IV Oropharyngeal Cancer

cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy with radiation therapy may kill more tumor cells. It is not yet known whether radiation therapy and cisplatin are more effective with or without surgery in treating patients with oropharyngeal cancer. Condition or disease Intervention/treatment Phase Stage III Squamous Cell Carcinoma of the Oropharynx Stage (...) : Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 1095 days (3 years) (for example, carcinoma in situ of the breast or cervix are all permissible) Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields Severe, active co-morbidity, defined as follows: > 2 based on the American

2013 Clinical Trials

1412. Patient Preferences in Making Treatment Decisions in Patients With Stage I-IVA Oropharyngeal Cancer

with oropharyngeal cancer. Condition or disease Intervention/treatment Stage I Squamous Cell Carcinoma of the Oropharynx Stage II Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Oropharynx Tongue Cancer Other: questionnaire administration Procedure: quality-of-life assessment Detailed Description: PRIMARY OBJECTIVES: I. Determine the stability of Head and Neck Priorities Scale (HNPS) ranking between pre- and post-treatment (...) for newly diagnosed Head/ Neck Cancer Criteria Inclusion Criteria: Treatment naïve American Joint Committee on Cancer (AJCC) stage I-IVa squamous cell carcinoma of the head and neck with no definitive evidence of metastatic disease Sufficient vision, writing, and communication ability to complete the interviews and assessment tool Signed informed consent Exclusion Criteria: Patients who are enrolled in other head and neck cancer treatment protocols are permitted to participate in this study

2013 Clinical Trials

1413. Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy

posterior tongue base backward and who could not elevate their pharyngeal during swallowing severe swallowing disorder or aspirate defined by videofluorography other malignances, neurovascular disease, demyelinating disease cancer relapse or metastases Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) Head and Neck Neoplasms Neoplasms by Site Neoplasms Nasopharyngeal Diseases Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type

2013 Clinical Trials

1414. Raman spectroscopy of serum: an exploratory study for detection of oral cancers. (Abstract)

Raman spectroscopy of serum: an exploratory study for detection of oral cancers. Early diagnosis of oral cancers, one of the major cancers, is of utmost importance as 5-year disease-free survival rates are some of the lowest, despite advances in treatment and surgical modalities. In vivo Raman spectroscopy has shown efficacy in the detection of normal, premalignant and malignant lesions and even of early changes such as cancer-field-effects/malignancy-associated-changes. However, the need (...) for a dedicated instrument and stringent laboratory conditions, at all diagnostic centers, limits wide screening applications of this method. In light of this, it is pertinent to explore ex vivo samples like serum due to its ease of collection, storage, transport and analysis at a centralized facility. Hence, Raman studies were carried out on serum from 14 buccal mucosa and 40 tongue cancers as well as 16 healthy control samples. Spectral features indicate differential contributions of proteins, DNA

2013 The Analyst Controlled trial quality: uncertain

1415. Transoral partial epiglottidectomy to treat dysphagia in post-treatment head and neck cancer patients: A preliminary report. Full Text available with Trip Pro

-treatment head and neck cancer patients with swallowing disorders. Ideal candidates have intact tongue base contraction and poor retroflexion of the epiglottis, which results in bolus obstruction at the level of the valleculae. Partial epiglottic resection enables improved bolus passage in the pharyngeal phase. Minimal postoperative morbidity occurs in the appropriately selected patient.© 2013 The American Laryngological, Rhinological and Otological Society, Inc. (...) Transoral partial epiglottidectomy to treat dysphagia in post-treatment head and neck cancer patients: A preliminary report. To determine symptoms and findings in patients with dysphagia related to epiglottic dysfunction. To analyze outcomes in patients who underwent partial epiglottidectomy due to dysphagia related to epiglottic dysfunction.Review and analysis of clinical data obtained as part of the diagnosis and treatment of patients with dysphagia related to epiglottic dysfunction.A

2013 Laryngoscope

1416. Randomized, controlled phase II study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer. Full Text available with Trip Pro

Randomized, controlled phase II study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer. The aim of this study is to evaluate clinical benefits of recombinant adenoviral human p53 (rAd-p53) gene therapy combined with radiotherapy in prevention of oral cancer recurrence after a radical resection. A total of 51 patients with tongue cancer (TCa) and 56 patients with gingival carcinoma (GCa) satisfying the inclusion criteria were (...) /26) GCa patients in CG had a local recurrence. Both recurrent rates of TCa (33.3%) and GCa (30.8%) in CG are statistically significantly higher than those of TCa (7.4%) and GCa (6.7%) in EG, respectively. The overall recurrent rate in EG is 7%, which is also statistically significantly lower than that (32%) in CG. The 3-year overall survival (OS) rate and 3-year disease-free survival (DFS) rate of EG is 100% and 93%, respectively. The 3-year OS and DFS rates of CG are 94 and 68%, respectively

2013 Cancer gene therapy Controlled trial quality: uncertain

1417. The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Full Text available with Trip Pro

RPLN status. Demographic, clinical, and outcome data were retrieved and analyzed.The cohort consisted of 981 patients. The median follow-up was 69 months. The base of the tongue (47%) and the tonsil (46%) were the most common primary sites. The majority of patients had stage T1 to T2 primary tumors (64%), and 94% had stage 3 to 4B disease. Intensity-modulated radiation therapy was used in 77% of patients, and systemic therapy was administered in 58% of patients. The incidence of radiographic RPLN (...) involvement was 10% and was highest for the pharyngeal wall (23%) and lowest for the base of the tongue (6%). RPLN adenopathy correlated with several patient and tumor factors. RPLN involvement was associated with poorer 5-year outcomes on univariate analysis (P<.001 for all) for local control (79% vs 92%), nodal control (80% vs 93%), recurrence-free survival (51% vs 81%), distant metastases-free survival (66% vs 89%), and overall survival (52% vs 82%) and maintained significance on multivariate analysis

2013 Cancer

1418. The association between T-stage and clinical nodal metastasis In HPV-positive oropharyngeal cancer. (Abstract)

cancers were more likely to present with cN2c disease compared to tonsillar complex tumors (35% vs. 7%, p=0.01).In HPV-positive tonsillar complex cancers, T-stage does not appear to predict the presence of clinical nodal metastasis (N0 vs. N1-N3), but may predict the extent of metastasis when present. This association does not appear to affect base of tongue cancers. Further, base of tongue cancers have a greater incidence of cN2c disease compared to tonsillar complex cancers.Copyright © 2014 Elsevier (...) The association between T-stage and clinical nodal metastasis In HPV-positive oropharyngeal cancer. To evaluate the association between T-stage and primary tumor subsite with clinical nodal metastasis in HPV-positive oropharyngeal squamous cell carcinomas.Retrospective medical record review.A retrospective analysis of all previously untreated patients with HPV-positive oropharyngeal squamous cell carcinoma evaluated by the senior author in a tertiary-care center over a 5-year period

2013 American Journal of Otolaryngology

1419. Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody Full Text available with Trip Pro

Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody Intraoperative near-infrared (NIR) fluorescence imaging is a technology with high potential to provide the surgeon with real-time visualization of tumors during surgery. Our study explores the feasibility for clinical translation of an epidermal growth factor receptor (EGFR)-targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors (...) and cervical lymph node metastases. The anti-EGFR nanobody 7D12 and the negative control nanobody R2 were conjugated to the NIR fluorophore IRDye800CW (7D12-800CW and R2-800CW). Orthotopic tongue tumors were induced in nude mice using the OSC-19-luc2-cGFP cell line. Tumor-bearing mice were injected with 25 µg 7D12-800CW, R2-800CW or 11 µg 800CW. Subsequently, other mice were injected with 50 or 75 µg of 7D12-800CW. The FLARE imaging system and the IVIS spectrum were used to identify, delineate and resect

2013 International journal of cancer. Journal international du cancer

1420. Microvascular free flap reconstruction for head and neck cancer in a resource-constrained environment in rural India Full Text available with Trip Pro

of infrastructure, selection of the case, choice of flap, estimation of cost and complications associated with treatment are evaluated and the merits and demerits of such an approach are discussed.We performed 22 cases of free flaps in a six-month period (2008-2009). Majority (17) of the patients had oral cancer. Seven were related to the tongue and eight to the buccal mucosa. Radial forearm free flap (RFF: 9) and anterolateral thigh flap (ALT: 9) were the most commonly used flaps. A fibula flap (1) was done (...) Microvascular free flap reconstruction for head and neck cancer in a resource-constrained environment in rural India Reconstruction with free flaps has significantly changed the outcome of patients with head and neck cancer. Microsurgery is still considered a specialised procedure and is not routinely performed in the resource-constrained environment of certain developing parts of India.This article focuses on the practice environment in a cancer clinic in rural India. Availability

2013 Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

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