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Tongue Carcinoma

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121. Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins. Full Text available with Trip Pro

Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins. We aimed to investigate the association of the expression levels of five epithelial-mesenchymal transition (EMT)-related proteins (Snail, Twist, E-cadherin, N-cadherin, and Vimentin) with tumorigenesis, pathologic parameters and prognosis in tongue squamous cell carcinoma (TSCC) patients by immunohistochemistry of tissue microarray. The expression levels (...) of Snail, E-cadherin, N-cadherin and Vimentin were significantly different between the tumor adjacent normal and tumor tissues. In tumor tissues, lower E-cadherin and higher N-cadherin levels were associated with a higher grade of cell differentiation, advanced stage of disease, and lymph node metastasis. However, higher Vimentin expression was associated with poor cell differentiation and lymph node metastasis. Patients with low E-cadherin expression had poor disease-specific survival (DSS

2017 PLoS ONE

122. Role of MRI in Evaluation of Malignant Lesions of Tongue and Oral Cavity Full Text available with Trip Pro

Role of MRI in Evaluation of Malignant Lesions of Tongue and Oral Cavity Aim of the present study was to evaluate the role of MRI in staging of malignant lesions of the oral cavity and to correlate MRI findings with clinical/surgical and anatomical-pathological findings, wherever possible.The study included 50 patients who presented with malignant lesions of the oral cavity and were referred to radiology departments for MRI. All patients included were subjected to a detailed physical (...) examination following which MRI was carried out on Philips Gyroscan Achieva 1.5 Tesla unit.In the study, the highest number of patients were found to have tongue malignancy (82%) followed by buccal mucosa and gingivobuccal sulcus malignancy (18%). The highest number of patients was in the age group of 51-60 years (32%). The incidence was higher in males (96%). There was moderate agreement (k=0.537) for T stage between the clinical and MRI staging assessments. The agreement for N stage between clinical

2017 Polish Journal of Radiology

123. Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control. Full Text available with Trip Pro

Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control. Positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma (SCC). However, wide variation exists in the margin sampling technique.To determine the effect of the margin sampling technique on local recurrence (LR) in patients with stage I or II oral tongue SCC.A retrospective study was conducted from January 1, 1986, to December 31, 2012, in 5 (...) tertiary care centers following tumor resection and elective neck dissection in 280 patients with pathologic (p)T1-2 pN0 oral tongue SCC. Analysis was conducted from June 1, 2013, to January 20, 2015.In group 1 (n = 119), tumor bed margins were not sampled. In group 2 (n = 61), margins were examined from the glossectomy specimen, found to be positive or suboptimal, and revised with additional tumor bed margins. In group 3 (n = 100), margins were primarily sampled from the tumor bed without preceding

2015 JAMA otolaryngology-- head & neck surgery

124. Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients Full Text available with Trip Pro

Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients The occurrence of squamous cell carcinoma of the tongue (SCCT) of young patients increased. There are still controversies about patient prognosis. The underlying molecular mechanisms remain unclear.276 patients (66 ≤45, 210 >45 years) with SCCT were included. Clinical parameters and survival data were assessed. Oncogenes and tumor suppressors were analyzed via immunohistochemistry (p53, CXCR4, p16 (...) , EGFR) and qPCR (CDK4, CDKN2A, TP53, MDM2, AKT1, PIK3CA, NRAS, HRAS, KRAS, HGF, MET, EGF, ATM, BRCA1, E2F1, FHIT, RUNX3, STK11, BCL2, CTNNB1).The median overall survival was 142 (≤45 years) and 34 months (>45 years) (p < 0.0001; HR [95%CI]: 0.37 [0.30-0.58]). Disease specific survival in patients ≤45 years was with 181 months significantly higher than in patients >45 years (p < 0.0001; HR [95%CI]: 0.33 [0.26-0.57]). Immunhistochemistry visualized a comparable expression of analyzed proteins. QPCR

2015 Oncotarget

125. The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips Full Text available with Trip Pro

The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips 17857409 2007 09 17 2008 11 20 0003-4932 10 4 1889 Oct Annals of surgery Ann. Surg. The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips. 249-54 Browning W W eng Journal Article United States Ann Surg 0372354 0003-4932 1889 10 1 0 0 1889 10 1 0 1 1889 10 1 0 0 ppublish 17857409 PMC1428258

1889 Annals of Surgery

126. Tumor PD-L1 expression is associated with improved survival and lower recurrence risk in young women with oral cavity squamous cell carcinoma. (Abstract)

Tumor PD-L1 expression is associated with improved survival and lower recurrence risk in young women with oral cavity squamous cell carcinoma. Young patients with oral cavity squamous cell carcinoma (OCSCC) are often recognized as a distinct epidemiological cohort. In this study, genomic and immune-based metrics were correlated with long-term outcomes for a young patient population treated at a single institution. A fully clinically annotated, retrospective cohort of 81 patients aged ≤45 years (...) with OCSCC is described, and the impact of clinicopathological features on long-term survival outcomes is reported. Genomic and immune parameters were integrated utilizing a whole-exome sequencing and immunohistochemical approach among females in the cohort. It was found that young OCSCC patients had favorable outcomes (10-year disease-free survival 79.1%, overall survival 80.0%) regardless of sex, particularly if they presented with oral tongue primaries and early stage disease. While mutational

2017 International Journal of Oral and Maxillofacial Surgery

127. Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases Full Text available with Trip Pro

are likely to progress to cancer would be vital to guide their future clinical management. The present study reported two patients with tongue squamous cell carcinoma: Case study 1 was diagnosed with a simultaneous leukoplakia and case study 2 developed an erythroleukoplakia following the primary tumor treatment. Whole genome copy number alterations were analyzed using array comparative genomic hybridization. The present study determined more genomic imbalances in the tissues from leukoplakia (...) Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions

2017 Molecular medicine reports

128. Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®): Patient Version

. Amyloidosis may cause the following signs and symptoms: Feeling very tired. Purple spots on the skin. Enlarged tongue. . Swelling caused by in your body's tissues. Tingling or numbness in your legs and feet. Age can affect the risk of plasma cell neoplasms. Anything that increases your risk of getting a disease is called a . Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk (...) . The plasma cells also make an antibody , called , that is not needed by the body and does not help fight infection. These antibody proteins build up in the bone marrow and can cause the to thicken or can damage the . Plasma cell neoplasms can be benign (not cancer) or malignant (cancer). (MGUS) is not cancer but can become . The following types of plasma cell neoplasms are cancer: . (See for more information.) . . There are several types of plasma cell neoplasms. Plasma cell neoplasms include

2017 PDQ - NCI's Comprehensive Cancer Database

129. Gene expression profiles and protein-protein interaction networks during tongue carcinogenesis in the tumor microenvironment Full Text available with Trip Pro

Gene expression profiles and protein-protein interaction networks during tongue carcinogenesis in the tumor microenvironment Oral tongue squamous cell carcinoma (OTSCC) has a high incidence and is associated with a high mortality rate. Studies regarding the potential molecular mechanism of OTSCC in the tumor microenvironment (TME) are required. The present study aimed to perform bioinformatic analysis to identify important nodes, clusters and functional pathways during tongue carcinogenesis (...) in the TME. After downloading the gene expression data of GSE42780, differentially expressed genes (DEGs) among carcinoma, dysplastic and normal samples in epithelia and fibroblasts were identified using the affy and limma packages with R version 3.3. Subsequently, the Database for Annotation, Visualization and Integrated Discovery was employed to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Furthermore, a protein‑protein interaction (PPI) network

2017 Molecular medicine reports

130. Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 as a candidate to predict metastases Full Text available with Trip Pro

Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 as a candidate to predict metastases Nodal metastases status among early stage tongue squamous cell cancer patients plays a decisive role in the choice of treatment, wherein about 70% patients can be spared from surgery with an accurate prediction of negative pathological lymph node status. This underscores an unmet need for prognostic biomarkers to stratify the patients who are likely (...) -expression analysis of 253 tongue tumors suggested an upregulation of metastases-related pathways and over-expression of MMP10 in 48% tumors that may be crucial to predict nodal metastases in early tongue cancer patients. In overall, we present the first descriptive portrait of somatic alterations underlying the genome of tobacco/nut chewing HPV-negative early tongue cancer, and identify MMP10 asa potential prognostic biomarker to stratify those likely to develop metastases.Copyright © 2017 The Author(s

2017 Oral oncology

131. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : I. THE SPONTANEOUS TUMOR AND ASSOCIATED ABNORMALITIES. Full Text available with Trip Pro

of the parenchymatous organs, atrophy of the thymus and lymphoid system, with chronic lymphadenitis, atrophy, degeneration, and necrosis of the suprarenals, and atrophy and hyperplasia of the thyroid with chronic thyroiditis. The conclusion was reached that the growth in the scrotum represented a neoplasm of epithelial origin which was composed of cells allied to those found in the bulb and root sheath of the hair. No explanation was offered for the origin or unusual malignancy displayed by the tumor pending (...) STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : I. THE SPONTANEOUS TUMOR AND ASSOCIATED ABNORMALITIES. A malignant tumor which developed at the site of a primary syphilitic lesion in the scrotum of a rabbit, about 4 years after inoculation, and eventually led to the death of the animal, has formed the basis for an extensive series of investigations beginning with the study of the spontaneous tumor. The present report contains the clinical history of the animal from the time of inoculation

1923 The Journal of experimental medicine

132. Tongue surface model can predict radiation tongue mucositis due to intensity-modulated radiation therapy for head and neck cancer. (Abstract)

Tongue surface model can predict radiation tongue mucositis due to intensity-modulated radiation therapy for head and neck cancer. Acute radiation tongue mucositis has a profound effect on talking and eating. We examined whether the dose-volume histogram obtained from the tongue surface model correlates with mucositis severity, and whether it is useful for predicting acute radiation tongue mucositis in patients with head and neck cancer treated with intensity-modulated radiation therapy. Thirty (...) -six patients who received intensity-modulated radiation therapy for head and neck cancer were analysed for acute radiation tongue mucositis according to the Common Terminology Criteria for Adverse Events, version 4.0, as well as the Radiation Therapy Oncology Group scoring systems. The corresponding high-dose locations in anatomical sub-regions in the tongue surface model and the development of high-grade acute radiation tongue mucositis were compared. The mucositis sites coincided with the high

2019 International Journal of Oral and Maxillofacial Surgery

133. Accuracy of MRI in Prediction of Tumour Thickness and Nodal Stage in Oral Tongue and Gingivobuccal Cancer With Clinical Correlation and Staging Full Text available with Trip Pro

Accuracy of MRI in Prediction of Tumour Thickness and Nodal Stage in Oral Tongue and Gingivobuccal Cancer With Clinical Correlation and Staging Squamous cell carcinoma of lower gingivo-buccal complex and tongue are the most common cancer in the Indian sub-continent. The value of imaging in the staging of Oral Squamous Cell Carcinoma (OSCC) is in judging operability, assessment of the prognostic characteristics and dimensions of the primary tumour, depth of tumour invasion, the presence (...) of cervical metastasis and detection of bone infiltration.This study evaluated squamous cell carcinomas of the oral cavity (tongue and gingivo-buccal complex) on the basis of their appearance, soft tissue extent, depth of tumour invasion and staging. Further, this study assessed the accuracy of MRI in the detection of cervical lymph nodal metastasis on the basis of ADC values on diffusion weighted MR sequence.T1- and T2-weighted MR, diffusion-weighted sequences and post contrast T1W sequences were

2016 Journal of clinical and diagnostic research : JCDR

134. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: a report of the American Dental Association.

care with or without clinically evident lesions in the oral cavity, encompassing the labial mucosae, buccal mucosae, gingival or alveolar ridge mucosae, tongue, floor of mouth, hard and soft palate, and retromolar trigone. If clinically evident, lesions could manifest as seemingly innocuous or nonsuspicious, suspicious, or seemingly malignant. The reviewers excluded studies involving patients seeking care for cancers of the lips, oropharynx, and salivary glands. Index Tests and the Criterion (...) : Definitions for the quality of the evidence ( High , Moderate , Low , Very Low ) and the strength of recommendations ( Strong , Conditional ) are provided at the end of the "Major Recommendations" field. Summary of Good Practice Statements and Clinical Recommendations for the Evaluation of Potentially Malignant Disorders and Oral Squamous Cell Carcinomas in the Oral Cavity Clinical Question Recommendation Quality of the Evidence Strength of Recommendation No corresponding clinical question Good practice

2017 National Guideline Clearinghouse (partial archive)

135. ESMO Consensus Conference on Malignant Lymphoma: Management of ?ultra-high-risk? Patients

Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; 3 Comprehensive Cancer Center Ulm and Department of Internal Medicine III, Institute of Experimental Cancer Research University Hospital, Ulm, Germany; 4 Department of Onco-Hematology Medicine, Unit of Lymphoid Malignancies, IRCCS San Raffaele Scienti?c Institute, Milan, Italy; 5 Innere Medizin I, University Klinik des Saarlandes, Hamburg; 6 Department of Hematology, Oncology and Stem Cell Transplantation (...) poorly to therapy and eventually die from their disease. A number of clinical and pathological factors de?ne groups of patients who are at very high risk of such treatment failure. For these ‘ultra-high-risk’ patients, there is no international consensus regarding the opti- mal management approach. In 2015, the European Society for Medical Oncology (ESMO) held a consensus conference on malignant lymphoma in order to develop recommendations on critical subjects that were dif?cult to consider in detail

2018 European Society for Medical Oncology

136. ESMO Consensus Conference on Malignant Lymphoma: Management of ?ultra-high-risk? Patients

Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; 3 Comprehensive Cancer Center Ulm and Department of Internal Medicine III, Institute of Experimental Cancer Research University Hospital, Ulm, Germany; 4 Department of Onco-Hematology Medicine, Unit of Lymphoid Malignancies, IRCCS San Raffaele Scienti?c Institute, Milan, Italy; 5 Innere Medizin I, University Klinik des Saarlandes, Hamburg; 6 Department of Hematology, Oncology and Stem Cell Transplantation (...) poorly to therapy and eventually die from their disease. A number of clinical and pathological factors de?ne groups of patients who are at very high risk of such treatment failure. For these ‘ultra-high-risk’ patients, there is no international consensus regarding the opti- mal management approach. In 2015, the European Society for Medical Oncology (ESMO) held a consensus conference on malignant lymphoma in order to develop recommendations on critical subjects that were dif?cult to consider in detail

2018 European Society for Medical Oncology

137. High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway Full Text available with Trip Pro

High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relationship between DM and TSCC was assessed in a retrospective study. The role and its mechanism (...) , migration, invasion and upregulated PKM2 (pyruvate kinase M2) expression. Whereas, these effect was abolished after knockdown of PKM2 in TSCC cells. High glucose promoted tumour growth and lung metastasis of TSCC in a DM animal model. Our results confirm DM as a risk factor for the development of TSCC. High glucose enhances the metastatic potential of TSCC through stimulation of the PKM2 pathway.

2017 Oncotarget

138. Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis Full Text available with Trip Pro

Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis BACKGROUND Tongue squamous cell carcinoma (TSCC) is a major type of oral cancers and has remained an intractable cancer over the past decades. The aim of this study was to identify differentially expressed genes (DEGs) during TSCC and reveal their potential mechanisms. MATERIAL AND METHODS The gene expression profiles of GSE13601 were downloaded from the GEO database. The GSE13601 dataset (...) contains 57 samples, including 31 tongue SCC samples and 26 matched normal mucosa samples. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed; Cytoscape software was used for the protein-protein interaction (PPI) network and module analysis of the DEGs. RESULTS We identified a total of 1,050 upregulated DEGs (uDEGs) and 702 downregulated DEGs (dDEGs) of TSCC. The GO analysis results showed that uDEGs were significantly enriched

2017 Medical science monitor : international medical journal of experimental and clinical research

139. MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma Full Text available with Trip Pro

MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma MicroRNAs (miRs) are expected to serve as prognostic tools for cancer. However, many miRs have been reported as prognostic markers of recurrence or metastasis in oral squamous cell carcinoma patients. We aimed to determine the prognostic markers in early-stage tongue squamous cell carcinoma (TSCC). Based on previous studies, we hypothesized that miR-10a, 10b, 196a-5p (...) , 196a-3p, and 196b were prognostic markers and we retrospectively performed miR expression analyses using formalin-fixed paraffin-embedded sections of surgical specimens. Total RNA was isolated from cancer tissues and adjacent normal tissue as control, and samples were collected by laser-capture microdissection. After cDNA synthesis, reverse transcription-quantitative polymerase chain reaction was performed. Statistical analyses for patient clinicopathological characteristics, recurrence/metastasis

2017 Oncology letters

140. Analysis of the outcome of young age tongue squamous cell carcinoma Full Text available with Trip Pro

carcinoma of the oral tongue. Patients were divided into two age groups, older (ages over 40) and younger (ages 40 and younger). Data were compared between the two groups, and survival rates were analyzed.The results show that there are significant differences in overall, disease-free, and distant metastasis-free survival rates between the two groups. Five-year overall survival rates were 70% in older patients and 42% in young patients (p = 0.033). Five-year disease-free survival rates were 73% in older (...) Analysis of the outcome of young age tongue squamous cell carcinoma The incidence of tongue squamous cell carcinoma (TSCC) in young patients has recently increased, and these TSCCs are believed to be etiologically distinct from those in older patients, who have longer exposure to risk factors such as tobacco and alcohol. The prognosis of TSCCs in young patients remains controversial.We retrospectively reviewed the records of 117 patients (2001-2011) who were diagnosed with squamous cell

2017 Maxillofacial Plastic and Reconstructive Surgery

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