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Tongue Carcinoma

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41. Oral Tongue Malignancies in Autoimmune Polyendocrine Syndrome Type 1 Full Text available with Trip Pro

Oral Tongue Malignancies in Autoimmune Polyendocrine Syndrome Type 1 Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) or Autoimmune polyendocrine syndrome type-1 (APS-1) (APECED, OMIM 240300) is a rare, childhood onset, monogenic disease caused by mutations in the Autoimmune Regulator (AIRE) gene. The overall mortality is increased compared to the general population and a major cause of death includes malignant diseases, especially oral and esophageal cancers. We here (...) present a case series of four APS-1 patients with oral tongue cancers, an entity not described in detail previously. Scrutiny of history and clinical phenotypes indicate that chronic mucocutaneous candidiasis and smoking are significant risk factors. Preventive measures and early diagnosis are important to successfully manage this potentially fatal disease.

2018 Frontiers in endocrinology

42. Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features Full Text available with Trip Pro

Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features Actinomycosis of the tongue is rare. It may be difficult to differentiate this infection clinically and radiologically from other tongue pathology especially neoplasia. We report a substantial tongue lesion which mimicked malignancy at presentation. The patient was treated successfully with 4 weeks of oral antibiotic therapy. It is also important that clinicians are aware

2018 Radiology Case Reports

43. Preliminary Results Suggest miR-139-5p Is a Viable Salivary Biomarker for Diagnosis of Tongue Squamous Cell Carcinoma (TSCC)

weeks after surgical removal of the tumor showed no statistically significant difference in miR-139-5p expression levels when compared to the control samples (p>0.05), and possessed sufficient power to distinguish from pre-operative TSCC saliva samples (AUC with 95% CI=0.713). Evidence Search ("saliva"[MeSH Terms] OR "saliva"[All Fields]) AND (("mouth neoplasms"[MeSH Terms] OR ("mouth"[All Fields] AND "neoplasms"[All Fields]) OR "mouth neoplasms"[All Fields] OR ("oral"[All Fields] AND "cancer"[All (...) other salivary biomarkers for early diagnosis of TSCC. Applicability Oral squamous cell carcinoma is a very common human malignancy with increasing prevalence. Despite numerous technological advances in the past 50 years, the 5-year survival rate for these patients has not changed. The study conducted by Duz et al. focused on tongue squamous cell carcinoma, which accounts for 41% of these carcinomas and is highly aggressive. Discovering a novel microRNA salivary biomarker could mean earlier

2016 UTHSCSA Dental School CAT Library

44. Depth of invasion (DOI) as a predictor of cervical nodal metastasis and local recurrence in early stage squamous cell carcinoma of oral tongue (ESSCOT). Full Text available with Trip Pro

Depth of invasion (DOI) as a predictor of cervical nodal metastasis and local recurrence in early stage squamous cell carcinoma of oral tongue (ESSCOT). The new AJCC staging system (8th edition) incorporates depth of invasion to stage oral cancers. It is a recognized predictor for neck nodal metastasis and local recurrence, the associated risk is not well defined. The aim of this study was to explore the risk of occult neck nodal metastasis and local recurrence in relation to depth in early (...) stage squamous cell carcinoma of oral tongue.We have evaluated records of 179 patients with early tongue cancer treated in our unit from 2006-2015 with a mean age of 57.92 ± 11.93 years. Treatment modalities used were surgery (26%), surgery followed by radiotherapy (64%) and chemo-radiation (10%). Neck dissection was ipsilateral in 94% and bilateral in 6% of the patients. Patients were grouped according to the AJCC cut off points in 8th edition for depth; group A: 1-5 mm (35%), group B: 6-10 mm (47

2018 PLoS ONE

45. Squamous cell carcinoma of the anterior tongue: is tumour thickness an indicator for cervical metastasis? (Abstract)

Squamous cell carcinoma of the anterior tongue: is tumour thickness an indicator for cervical metastasis? The incidence of squamous cell carcinoma (SCC) of the tongue accounts for 90% of all malignancies affecting the oral cavity and oropharynx. The distribution between the anterior and posterior tongue is equal. Nodal metastasis is dependent on various factors including tumour thickness, site, size, differentiation, and perineural and perivascular invasion. There is increasing evidence (...) . Four of them subsequently developed neck metastasis within a 6- to 18-month period. The results of this study support recent publications associating tumour thickness with nodal disease. Therefore, it is postulated that prophylactic neck dissection should be considered when the tumour thickness of anterior tongue SCC exceeds 5mm, in order to prevent lymphatic spread and improve the survival rate.Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

2016 International Journal of Oral and Maxillofacial Surgery

46. Computerized tomography based tumor-thickness measurement is useful to predict postoperative pathological tumor thickness in oral tongue squamous cell carcinoma Full Text available with Trip Pro

Computerized tomography based tumor-thickness measurement is useful to predict postoperative pathological tumor thickness in oral tongue squamous cell carcinoma Tumor thickness has been shown in oral tongue squamous cell carcinoma (OTSCC) to be a predictor of cervical metastasis. The postoperative histological measurement is certainly the most accurate, but it would be of clinical interest to gain this information prior to treatment planning. This retrospective study aimed to compare the tumor (...) thickness measurement between preoperative, CT scan, and surgical specimens .We retrospectively included 116 OTSCC patients between 2001 and 2013. Thickness was measured on computer tomography imaging and again surgical specimens.The median age was 66 years. 62.8 % of patients were smokers with a mean of 31.4 pack-years. Positive nodal disease was reported in 41.2 %. Mean follow-up time was 33.1 months. The correlation between CT scan-based tumor thickness and surgical specimens based thickness

2015 Journal of Otolaryngology - Head & Neck Surgery

47. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors Full Text available with Trip Pro

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors The 4th edition of the World Health Organization's Classification of Head and Neck Tumours was published in January of 2017. This article provides a summary of the changes to Chapter 4 Tumours of the oral cavity and mobile tongue and Chapter 8 Odontogenic and maxillofacial bone tumours. Odontogenic cysts which were eliminated from the 3rd 2005 edition (...) were included in the 4th edition as well as other unique allied conditons of the jaws. Many new tumors published since 2005 have been included in the 2017 classification.

2017 Head and neck pathology

48. Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation. Full Text available with Trip Pro

Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation. Patients with oral cancer report severe pain during function. Inflammation plays a role in the oral cancer microenvironment; however, the role of immune cells and associated secretion of inflammatory mediators in oral cancer pain has not been well defined. In this study, we used 2 oral cancer mouse models: a cell line supernatant injection model and the 4-nitroquinoline (...) -1-oxide (4NQO) chemical carcinogenesis model. We used the 2 models to study changes in immune cell infiltrate and orofacial nociception associated with oral squamous cell carcinoma (oSCC). Oral cancer cell line supernatant inoculation and 4NQO-induced oSCC resulted in functional allodynia and neuronal sensitization of trigeminal tongue afferent neurons. Although the infiltration of immune cells is a prominent component of both oral cancer models, our use of immune-deficient mice demonstrated

2017 Pain

49. TMEM207 hinders the tumour suppressor function of WWOX in oral squamous cell carcinoma Full Text available with Trip Pro

TMEM207 hinders the tumour suppressor function of WWOX in oral squamous cell carcinoma The WW domain-containing oxidoreductase (WWOX) functions as a tumour suppressor in oral carcinogenesis. As aberrant TMEM207 expression may lead to tumour progression by hampering the tumour suppressor function of WWOX in various cancers, we explored the expression and pathobiological properties of TMEM207, focusing on the WWOX-mediated regulation of the HIF-1α pathway in oral squamous cell carcinoma (OSCC (...) conditions, and promoted tumour growth in a xenoplant assay using SAS tongue squamous cancer cells. In contrast, TMEM207 knockdown decreased GLUT-1 expression in two OSCC cell lines. As a whole, our findings indicate that the aberrant expression of TMEM207 contributes to tumour progression in OSCC, possibly via promoting aerobic glycolysis.© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

2017 Journal of cellular and molecular medicine

50. Malignant Tumour at Base of Tongue almost dispersed by Radium Full Text available with Trip Pro

Malignant Tumour at Base of Tongue almost dispersed by Radium 19978694 2010 06 24 2010 06 24 0035-9157 8 Laryngol Sect 1915 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Malignant Tumour at Base of Tongue almost dispersed by Radium. 101 Hill W W eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1915 1 1 0 0 1915 1 1 0 1 ppublish 19978694 PMC2004148

1915 Proceedings of the Royal Society of Medicine

51. A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue. (Abstract)

A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue. Panendoscopy is routinely used for the identification of occult second primary tumours in head and neck squamous cell carcinoma. However, its role in low risk subgroups, particularly non-smoking, non-drinking patients and patients presenting with early stage oral cavity lesions, is debatable.The records of 112 patients with T₁ or T₂ oral tongue squamous cell carcinoma were retrospectively (...) reviewed. Demographic, disease characteristics and survival data were collected.Average follow-up duration was 71.7 months (range, 3.6-238.3 months). Thirty-five patients died within this period. Thirteen second primary events were identified in 11 patients, with all but 2 tumours in the oral cavity or oropharynx. There was a single synchronous primary - a lung adenocarcinoma; all other events were metachronous. No non-smoking, non-drinking patients re-presented with a second primary tumour; tobacco

2015 Journal of Laryngology & Otology

52. Response to “Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC)” Full Text available with Trip Pro

Response to “Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC)” 29128950 2018 11 13 1936-0568 12 2 2018 Jun Head and neck pathology Head Neck Pathol Response to "Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC)". 294-295 10.1007/s12105-017-0865-3 Bell Diana D Department of Pathology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA. Diana.bell@mdanderson.org. eng Letter 2017 11 11 United States Head Neck Pathol

2017 Head and neck pathology

53. Colonic-type Adenocarcinoma of the Tongue and Oral Cavity (CATOC) Full Text available with Trip Pro

Colonic-type Adenocarcinoma of the Tongue and Oral Cavity (CATOC) 28779466 2018 11 13 1936-0568 12 2 2018 Jun Head and neck pathology Head Neck Pathol Colonic-type Adenocarcinoma of the Tongue and Oral Cavity (CATOC). 291-293 10.1007/s12105-017-0843-9 Agaimy Abbas A Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. abbas.agaimy@uk-erlangen.de. eng Letter 2017 08 04 United States Head Neck Pathol 101304010 1936-055X 2017 07 08 2017 07 29 2017 8 6 6 0

2017 Head and neck pathology

54. In Reply: Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC) Full Text available with Trip Pro

In Reply: Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC) 29139085 2018 11 14 1936-0568 12 2 2018 Jun Head and neck pathology Head Neck Pathol In Reply: Colonic-Type Adenocarcinoma of the Tongue and Oral Cavity (CATOC). 296-297 10.1007/s12105-017-0866-2 Agaimy Abbas A Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054, Erlangen, Germany. abbas.agaimy@uk-erlangen.de. eng Letter 2017 11 14 United States Head Neck Pathol

2017 Head and neck pathology

55. Treatment of adenoid cystic carcinoma of the mobile tongue with anterolateral thigh flap reconstruction: A case report. Full Text available with Trip Pro

Treatment of adenoid cystic carcinoma of the mobile tongue with anterolateral thigh flap reconstruction: A case report. Adenoid cystic carcinoma (ACC) is an infrequent malignant neoplasm of the salivary glands. The clinical and pathological characteristics include slow growth, perineural invasion, and local recurrence. ACC of the mobile tongue is rarely reported in the literature.We describe a case of a 43-year-old man patient with numbness and growth in the tongue for 1 month duration (...) . The patient reported a long-term smoking and drinking habit.A biopsy was carried out and histopathological analysis confirmed as diagnosis of adenoid cystic carcinoma. Computed tomography (CT) of the head and neck enhanced scanning revealed an ill-defined high density mass with altered enhanced signal entities involving the anterior 2/3rd of the tongue.The patient was treated with surgery and adjuvant radiotherapy. Incision was placed over the anteriorly till 2/3rd of tongue and then the femoral

2019 Medicine

56. Nomograms to predict survival of stage IV tongue squamous cell carcinoma after surgery. Full Text available with Trip Pro

Nomograms to predict survival of stage IV tongue squamous cell carcinoma after surgery. To develop clinical nomograms for prediction of overall survival (OS) and cancer-specific survival (CSS) in patients with stage IV tongue squamous cell carcinoma (TSCC) after surgery based on the Surveillance, Epidemiology, and End Results (SEER) program database.We collected data of resected stage IV TSCC patients from the SEER database, and divided them into the training set and validation set by 7:3 (...) , marital status, tumor site, AJCC T/N/M status, and radiotherapy were recognized as independent prognostic factors associated with OS as well as CSS. Then nomograms were developed based on these variables. The calibration curves displayed a good agreement between the predicted and actual values of 3-year and 5-year probabilities for OS and CSS. The C-indices predicting OS were corrected as 0.705 in the training set, and 0.664 in the validation set. As for CSS, corrected C-indices were 0.708

2019 Medicine

57. Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. (Abstract)

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. To investigate the role of lingual lymph node (LLN) metastasis on locoregional control (LRC) in patients with locally advanced tongue squamous cell carcinoma (SCC).A total of 231 patients were prospectively enrolled. Analyses focused on the association between the LLN metastasis and clinical pathologic variables as well as the significance of LLN metastasis in predicting prognosis.LLNs were noted (...) in 58 patients, 33 of whom were positive for LLN metastasis. LLN metastasis was significantly related to adverse pathologic characteristics. In patients with LLN metastasis, the 5-year LRC rate was 45%. In patients without LLN metastasis, the 5-year LRC rate was 65% and the difference was significant (P = 0.013). Further, Cox model analysis confirmed the independence of LLN metastasis from prognosis prediction.LLN metastasis in locally advanced tongue SCC is relatively uncommon; however, LLNs should

2019 Laryngoscope

58. Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. Full Text available with Trip Pro

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby affecting and regulating the expression of mRNAs and target genes. These lncRNA-associated ceRNAs have been theorized to play a significant role in cancer initiation and progression. However, the roles and functions of the lncRNA-miRNA-mRNA ceRNA network (...) in squamous cell carcinoma of the tongue (SCCT) are still unclear.The miRNA, mRNA and lncRNA expression profiles from 138 patients with SCCT were downloaded from The Cancer Genome Atlas database. We identified the differential expression of miRNAs, mRNAs, and lncRNAs using the limma package of R software. We used the clusterProfiler package for GO and KEGG pathway annotations. The survival package was used to estimate survival analysis according to the Kaplan-Meier curve. Finally, the GDCRNATools package

2019 BMC Cancer

59. Using weighted gene co-expression network analysis to identify key modules and hub genes in tongue squamous cell carcinoma. Full Text available with Trip Pro

Using weighted gene co-expression network analysis to identify key modules and hub genes in tongue squamous cell carcinoma. Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors in head and neck, but its molecular mechanism is not clear.Weighted gene co-expression network analysis (WGCNA) combining with gene differential expression analysis, survival analysis to screen key modules and hub genes related to the progress of TSCC. Gene Set Enrichment Analysis (GSEA

2019 Medicine

60. Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma. Full Text available with Trip Pro

Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma. Tongue squamous cell carcinoma (TSCC) is a special type of oral cancer. Cervical lymph node relapse may occur in a large percentage of TSCC patients, which usually indicates poor prognosis. In this cohort study, we focused on the predictive value of the pathological features on cervical lymph node relapse and TSCC prognosis (disease free survival).One hundred forty-one TSCC patients

2019 BMC Cancer

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