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Tongue Carcinoma

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4101. Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma. (Abstract)

Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma. Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 (...) overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.

2003 International Journal of Oral and Maxillofacial Surgery

4102. Metastatic renal cell carcinoma to the head and neck. (Abstract)

Metastatic renal cell carcinoma to the head and neck. The objectives of the study were to present four cases of renal cell carcinoma (RCC) metastatic to the head and neck, to recognize the appearance on radiographic studies, to understand the importance of preoperative embolization, and to review the results of treatment.Retrospective review of patients diagnosed with metastatic RCC to the head and neck.The records of four patients diagnosed with metastatic RCC at a tertiary medical center over (...) a 5-year period from 1996 to 2001 were reviewed and analyzed for demographic and outcomes data.Metastatic RCC to the head and neck was seen in the following locations: nasal cavity, lower lip, hard palate, tongue, and maxillary sinus. Presenting signs were loose upper molars, dysphagia, nasal obstruction, lower lip lesion, recurrent epistaxis, and foul nasal drainage. Histological studies confirmed metastasis of RCC in all four patients. Treatment consisted of preoperative radiation therapy

2002 Laryngoscope

4103. A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. (Abstract)

. For each case in the latter, elderly group, a reference group case was randomly matched for gender, year of diagnosis, cancer stage, extent of surgery, and radiation therapy. Overall survival and disease-specific survival were compared between the two groups with stage stratification with the Kaplan-Meier method.Cases of glottic carcinoma (1882), tongue carcinoma (426), and tonsillar carcinoma (200) in elderly patients were matched to the reference group. Overall mean survival differences were (...) significant for glottic carcinoma (73.9 vs. 96.7 mo, elderly and younger groups, respectively) (P <.001) and tongue carcinoma (59.5 vs. 73.1 mo) ( P=.002) but not for tonsillar carcinoma (46.0 vs. 54.4 mo) ( P=.220). Disease-specific survival differences were significant but small in magnitude for glottic carcinoma (105.9 vs. 114.1 mo, respectively (P <.001) and tongue carcinoma (81.6 vs. 93.6 mo) (P =.009) but not for tonsillar carcinoma (71.5 vs. 70.7 mo) (P =.422). However, after stage stratification

2003 Laryngoscope

4104. Implication of 18F-fluoro-2-deoxy-D-glucose positron emission tomography on management of carcinoma of unknown primary in the head and neck: a Danish cohort study. (Abstract)

modified in relation to the findings from PET scanning.Prospective cohort study of consecutive patients.Forty-two consecutive patients with squamous cell or undifferentiated metastatic disease in the neck from a carcinoma of unknown primary were enrolled after standard clinical workups. These patients underwent extensive clinical investigations including endoscopy under anesthesia with multiple mucosal biopsies and diagnostic imaging as well. If no primary site was indicated at this stage, a whole-body (...) 18F-FDG PET scan was performed.Potential focal pathological uptake indicated a primary tumor in 20 of 42 cases (48%). After PET, this was confirmed by additional investigations in 10 patients (24%). Of these, seven primaries were found in the head and neck region (hypopharynx [three], base of tongue/vallecula [two], nasopharynx [1], floor of mouth [1]), and three primaries were found below the clavicles (lung [1], esophagus [1], and abdomen [1]. Positron emission tomography resulted in significant

2002 Laryngoscope

4105. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. (Abstract)

Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Sentinel lymph node biopsy is a minimally invasive method to stage the regional lymphatics that has revolutionized the management of patients with intermediate-thickness cutaneous melanoma. Head and neck surgeons have been encouraged by the accuracy of sentinel lymph node biopsy in cutaneous melanoma and have applied the technique to patients with head and neck squamous cell carcinoma (HNSCC). The objectives of the study were (...) , a retrospective review of 33 patients with HNSCC was conducted. Twenty patients (stage N0) whose treatment included elective neck dissection were studied with preoperative lymphoscintigraphy and underwent intraoperative identification of the sentinel lymph node to determine the accuracy and feasibility of sentinel lymph node biopsy. Eight patients with palpable neck disease and five patients with recurrent or second primary disease whose previous treatment included neck dissection were also studied

2002 Laryngoscope

4106. Immunocytochemical identification of epithelium-derived human tumors with antibodies to desmosomal plaque proteins. Full Text available with Trip Pro

at the light and electron microscope levels, we show that these antibodies bind specifically to desmosomal plaques. Antibodies to desmoplakins have been used successfully for detection of desmosomal proteins in a broad variety of epithelium-derived human tumors, including primary carcinomas and their metastases, irrespective of the morphology of the specific tumor. Nonepithelial tumors examined have been negative. We propose to use antibodies to desmoplakins and to cytokeratins in pathological diagnosis (...) Immunocytochemical identification of epithelium-derived human tumors with antibodies to desmosomal plaque proteins. Epithelial cells contain desmosomes, special intercellular junctions providing sites of membrane attachment for intermediate-sized filaments of the cytokeratin type (tonofilaments). Such sites of anchorage of tonofilaments appear as dense plaques on the cytoplasmic side of the desmosomal membrane. We have isolated desmosome-enriched fractions from bovine snout epidermis and tongue

1983 Proceedings of the National Academy of Sciences of the United States of America

4107. The Effects of Upper Airway and Digestive Tract Tumors on the Immune System

. Researchers are hoping to learn more about what signals give tumor cells an advantage to live and grow, how tumor cells control these signals, and how these signals affect the rest of the body. This study will look closer at researchers belief that tumors in the vocal tract contain genes (genetic information) that abnormally function to allow the tumors to survive and grow against the attack of the body's normal immune system Patients with cancerous tumors (squamous cell carcinoma) and benign (non (...) of their immune systems and metabolism. Condition or disease Esophageal Neoplasm Head and Neck Neoplasm Laryngeal Neoplasm Papilloma Squamous Cell Carcinoma Detailed Description: Patients with squamous cell carcinoma or papilloma of the upper aerodigestive tract who are candidates for standard or investigational therapy are eligible to participate in this pilot immunopathogenesis study. Patients with these neoplasms exhibit alterations in immune and metabolic regulation. These alterations in immunoregulation

1999 Clinical Trials

4108. Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors

spectroscopic imaging, may improve the ability to detect the extent of cancer in the brain. PURPOSE: Phase II trial to study the effectiveness of functional magnetic resonance imaging and 1H-nuclear magnetic resonance spectroscopic imaging in treating patients who have newly diagnosed brain tumors. Condition or disease Intervention/treatment Phase Brain and Central Nervous System Tumors Procedure: conventional surgery Procedure: magnetic resonance imaging Procedure: magnetic resonance spectroscopic imaging (...) below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 55 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria DISEASE CHARACTERISTICS: Newly diagnosed brain tumor Neuroradiological and clinical evidence of probable glioma Lesion in close proximity to language and motor areas No prior resection PATIENT CHARACTERISTICS: Age: 18 to 55 Performance status: Not specified Life expectancy: Not specified Hematopoietic

2000 Clinical Trials

4109. Induction chemotherapy in primary resectable head and neck tumors - a prospective randomized trial. (Abstract)

of carboplatin/5-FU prior to surgery and radiotherapy (arm A, 49 patients) or standard treatment with surgery and radiotherapy (arm B, 47 patients). Patients were stratified by primary tumor site and neck disease. After a follow-up of 12-48 months overall survival was 72% in arm A and 53% in arm B (n.s.). Considering only the patients with cancer of the oral cavity and the tonsil overall survival was 88% in arm A and 44% in arm B (p<0.05). As of today, the number of patients with carcinomas (...) of the hypopharynx and base of tongue is too small for a statistically significant statement, but preliminary data indicate a better overall and disease-free survival without chemotherapy in these patients. Therefore, we recommend controlled trials with induction chemotherapy in patients with primary resectable carcinomas of the oral cavity and the tonsil, stages T2-T3 and N0-N2, prior to surgery but not in patients with cancer of the hypopharynx and base of the tongue.

1994 International journal of oncology Controlled trial quality: uncertain

4110. Mouth and Tongue Cancer

. You may find the article more useful, or one of our other . In this article In This Article Cancers of the Oral Cavity In this article See also the separate article. Most cancers of the oral cavity and pharynx are squamous cell carcinomas (SCCs) [ ] . About one third of oral cancers are diagnosed in the mouth cavity and a similar proportion on the tongue [ ] . Lip cancer is the least frequent type of oral cancer. Oral cavity cancer includes tumours of the [ ] : Buccal mucosa. Retromolar triangle (...) differentiated. Because of the difficulties with direct visualisation, they may extend into the oral tongue or have clinical lymph metastases before the diagnosis is established. Tonsillar cancer More than 70% of tonsillar cancers are SCC. Most of the others are lymphomas. Metastases to the palatine tonsils are rare but there have been reports of secondaries from breast, lung, renal, pancreatic and colorectal malignancies. Patients with tonsillar carcinomas may present with a neck mass, usually

2008 Mentor

4111. A hypothyroid neonate with a lingual tumour Full Text available with Trip Pro

A hypothyroid neonate with a lingual tumour 17337662 2007 04 09 2018 11 13 1359-2998 92 2 2007 Mar Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. A hypothyroid neonate with a lingual tumour. F142 Heitink-Pollé K M J KM Department of Pediatrics, Wilhelmina Childrens Hospital, Utrecht, The Netherlands. Ultee C A CA van der Deure J J Lasham C C eng Case Reports Journal Article England Arch Dis Child Fetal Neonatal Ed 9501297 1359-2998 AIM IM (...) Congenital Hypothyroidism complications Hamartoma complications diagnosis Humans Infant, Newborn Male Tongue Diseases complications diagnosis 2007 3 6 9 0 2007 4 10 9 0 2007 3 6 9 0 ppublish 17337662 92/2/F142 10.1136/adc.2006.098756 PMC2675463 J Laryngol Otol. 1993 Apr;107(4):363-7 8320532

2007 Archives of Disease in Childhood. Fetal and Neonatal Edition

4112. A case of solitary fibrous tumour of the nose and paranasal sinuses Full Text available with Trip Pro

A case of solitary fibrous tumour of the nose and paranasal sinuses Solitary fibrous tumours (SFT), formerly known as benign fibrous mesothelioma, are rare mesenchymal spindle cell neoplasms, originally described in the pleura, but now found to arise in many other locations such as mediastinum, urogenital tract, face, nose, paranasal sinuses, orbit, meninges, ear, buccal mucosa, tongue, salivary gland etc. It was first described as a distinct neoplasm in 1931 by Klemperer and Rabin (...) . On reviewing the literature, so far, 21 cases have been reported involving the nose and paranasal sinuses. A case of solitary fibrous tumour of the nose and paranasal sinuses is presented.

2006 Indian Journal of Otolaryngology and Head & Neck Surgery

4113. Granular cell tumour vocal cord in an adolescent child-A case report Full Text available with Trip Pro

Granular cell tumour vocal cord in an adolescent child-A case report Granular cell tumors are benign relatively rare lesions that can occur in any organ in the body. Tongue is the most predilected site. Granular cell tumor vocal cord is even rarer and typically occurs in the third decade of life. It generally presents as a single lesion, but multiple lesions can also occur. Patients present with hoarseness andor airway obstruction. Granular cell tumors are resistant to radiotherapy (...) , and therefore surgical excision is the treatment of choice. We report the case of granular cell tumor vocal cord in a 13-year-old male child in whom direct laryngoscopic excision of the tumor was advocated.

2007 Indian Journal of Otolaryngology and Head & Neck Surgery

4114. Parapharyngeal granular cell tumour: a unique surgical challenge. (Abstract)

Parapharyngeal granular cell tumour: a unique surgical challenge. A granular cell tumour is a rare lesion of probable nerve sheath origin. It is typically benign but up to seven per cent may be malignant. Since its original description in the tongue in 1926, the tumour has been reported to occur at many other sites in the body. The authors report a case of a 49-year-old African woman with an oro-naso-parapharyngeal granular cell neoplasm causing mild dysphagia. The location of this tumour

2005 Journal of Laryngology & Otology

4115. Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. (Abstract)

hypoxia-inducible factor-1alpha (HIF-1alpha) expression in a homogeneous series of patients who underwent radiotherapy.An audit identified 133 consecutive patients with histologically proven squamous cell carcinoma of the tonsil or tongue base. All patients received primary radiotherapy between 1996 and 2001. Tumor HIF-1alpha expression was examined in 79 patients.Features associated with poor locoregional control were low Hb level (p = 0.05) and advancing T (p = 0.008), N (p = 0.03), and disease (p (...) Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. Head-and-neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of patients in terms of subsite, treatment, and biology. Currently most management decisions are based on clinical parameters with little appreciation of patient differences in underlying tumor biology. We investigated the prognostic significance of clinicopathologic features and tumor

2008 Biology and Physics

4116. Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer. Full Text available with Trip Pro

Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer. Oral squamous cell carcinoma (OSCC) is a common human malignancy. Circulatory epithelial tumor markers were previously investigated in the serum of OSCC patients but almost never in their saliva, in spite of the fact that there is a direct contact between the saliva and the oral cancer lesion. The purpose of the current study was to examine tumor markers in the saliva of OSCC patients.We measured (...) the concentrations of the six most studied epithelial serum circulatory tumor markers in the saliva of OSCC (tongue) patients.Significant increases (of 400%) in salivary concentrations of Cyfra 21-1, tissue polypeptide antigen, and CA125 were shown. Salivary concentrations of CA19-9, SCC, and carcinoembryonic antigen were increased without statistical significance. A concurrent analysis of the three significantly increased markers revealed sensitivity, specificity, and negative and positive predictive values

2006 Clinical Cancer Research

4117. Salivary Gland Tumours

(grade III): mucoepidermoid carcinoma is the most common malignancy of the parotid gland and is the second most common of the submandibular gland (after adenoid cystic carcinoma). It represents about 8% of all parotid tumours. Adenocarcinoma - poorly differentiated carcinoma and anaplastic carcinoma; represents 2-3% of salivary tumours. Squamous cell carcinoma. Malignant mixed tumours. Adenoid cystic carcinoma. Low-grade Acinic cell tumours: represent 1% of all salivary gland neoplasms. 95% arise (...) and the seventh decade in men. [ ] Rarities including oncocytomas and monomorphic adenomas. Regional metastases from skin or mucosal malignancies may present as salivary gland masses. 1-3% of patients with cutaneous squamous cell carcinoma of the head and neck experience metastatic spread to the parotid-area lymph nodes. Lymphomas may occasionally present in a salivary gland. [ ] Epidemiology [ ] The majority of salivary neoplasms are benign (65-70%). Nearly 80% of parotid gland tumours are benign. Based

2008 Mentor

4118. Oropharyngeal Tumours

Guidelines. You may find the article more useful, or one of our other . In this article In This Article Head and Neck Cancers In this article Squamous cell carcinoma (SCC) represents more than 90% of all head and neck cancers. The majority of cancers of the head and neck arise from the surface layers of the upper aerodigestive tract (UAT). UAT cancers include: , which include tumours of the buccal mucosa, retromolar triangle, alveolus, hard palate, anterior two thirds of the tongue, floor of the mouth (...) , and the mucosal surface of the lip. [ ] : Cancers of the oropharynx, which include tumours of the base of the tongue, the tonsil and the under surface of the soft palate. [ ] Cancers of the hypopharynx (bottom part of the throat), which include tumours of the postcricoid area, pyriform sinus and the posterior pharyngeal wall. [ ] Cancers of the nasopharynx (behind the nose). . Other UAT sites include the salivary glands, nose, sinuses and middle ear but these cancers are relatively rare. Cancer originating

2008 Mentor

4119. Mucosal neuroma syndrome--a phenotype for malignancy. Full Text available with Trip Pro

Mucosal neuroma syndrome--a phenotype for malignancy. The mucosal neuroma syndrome is characterised by a typical physical appearance, neuromata on tongue and buccal mucosa, and a high risk of developing medullary thyroid carcinoma and phaeochromocytoma. A case is described and the importance of early recognition for prevention of malignancy is stressed.

1985 Archives of Disease in Childhood

4120. Malignancy of the larynx: (Experimentation on Animal, Construction of Biologic Neo-Larynx and Rehabilitation of the Laryngectomee—20 Years Experience) Full Text available with Trip Pro

Malignancy of the larynx: (Experimentation on Animal, Construction of Biologic Neo-Larynx and Rehabilitation of the Laryngectomee—20 Years Experience) Squamous cell carcinoma is by far the commonest malignancy of the larynx and I would confine my present paper mainly to this along with the management and post-operative rehabilitation after total laryngectomy. High survival rate in majority of the cases, if diagnosed and treated early and adequately, provokes and encourages the interested (...) knowledge) and a Neo-Glottis are ingeniously constructed in order to enable the laryngectomee to phonate tracheooesophageally (c.f. pharyngoesophageally). The Neo-Glottis is transversely disposed since it offers better protection against aspiration than the vertically disposed one. The Neo-Epiglottis is constructed from the posterior tracheal wall, inferiorly based, or from the superiorly based tongue-shaped flap, raised from the full-thickness membranous posterior tracheal wall, or from the anterior

1997 Indian Journal of Otolaryngology and Head & Neck Surgery

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