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Tongue Carcinoma

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4061. Neurilemmoma of tongue Full Text available with Trip Pro

Neurilemmoma of tongue Neurilemmoma is usually soimry, benign tumour derived from schwan cells of the Sheaths of peripheral cranial or autonomie nerves. In thehead and neck region it occurs most commonly in association with acoustic nerve within the skuil and is rely fottnd in the oral cavity (1,2). We report here two cases of the iongue diagnosed on histopathohgy.

2003 Indian Journal of Otolaryngology and Head & Neck Surgery

4062. A giant teratoma of the tongue. (Abstract)

A giant teratoma of the tongue. Teratoma of the tongue is an extremely rare tumour of the oral cavity, which is composed of ectoderm, mesoderm and endoderm with differentiation to identifiable tissues and organs. We described a female neonate with a giant teratoma of the tongue and an incomplete cleft palate. The tumour was attached to 1/3 right anterior of her tongue and its largest diameter was 13 cm. Histopathologically, it consisted of stratified squamous epithelium on the surface

2002 International Journal of Pediatric Otorhinolaryngology

4063. Fasciocutaneous flap reconstruction of the tongue and floor of mouth: outcomes and techniques. (Abstract)

Fasciocutaneous flap reconstruction of the tongue and floor of mouth: outcomes and techniques. To quantify functional and other outcomes after major resection and fasciocutaneous free-flap reconstruction of the tongue and floor of mouth, and to describe reconstructive technique.A hypothesis-generating, retrospective cohort study of 43 patients who underwent, at minimum, a hemiglossectomy and resection of the floor of the mouth for oral cancer followed by fasciocutaneous free-flap (...) reconstruction.A tertiary academic medical center in the midwestern United States.Speech intelligibility, swallowing, interval to decannulation, length of stay, free-flap success rates, patient survival, and complications.Thirty patients underwent oral tongue reconstructions, and 13, tongue base reconstructions. Median intelligibility scores were greater among patients in the tongue base group (98% intelligibility) than in the oral-tongue group (76% intelligibility) (P<.001). Of the 38 patients undergoing

2002 Archives of Otolaryngology Head and Neck Surgery

4064. Epithelioid sarcoma with metastatic spread to the tongue. (Abstract)

Epithelioid sarcoma with metastatic spread to the tongue. Epithelioid sarcoma (ES) is a rare tumour that seldom presents to the otolaryngologist. It typically occurs in the extremities of young adolescents; however, it has the capability of metastasizing, often to the lungs or skin. The diagnosis is by histopathological examination and immunohistochemistry. We present a case of metastatic ES occuring in the tongue, a tumour not reported previously in the English literature.

2002 Journal of Laryngology & Otology

4065. Repair of anterior floor of mouth defects by a central or paramedian island tongue flap. (Abstract)

Repair of anterior floor of mouth defects by a central or paramedian island tongue flap. One method for restoring the anterior floor of mouth defects resulting from T(1) and especially T(2) cancer excision involves the creation of a myomucosal island flap from the dorsal median portion of the tongue and transferring it as a transit flap to the floor of the mouth. We are not the first to advocate this method. In this paper we present a previously unreported, slightly modified technique utilizing (...) this tongue flap. The modification consists of a 90 degrees twisting of the flap to achieve a more appropriate adaptation to the defect. In the case of spreading carcinoma from the floor of the mouth to the central portion of the tongue, a similar paramedian one-sided tongue flap was created instead of a central island tongue flap. Our present experience consists of a small series of 12 patients. The procedures were successful in all patients. No remarkable disturbances of speech or deglutition were

2003 Journal of Laryngology & Otology

4066. Rhabdomyoma of the base of the tongue. (Abstract)

Rhabdomyoma of the base of the tongue. The histopathological and imaging findings of a rhabdomyoma of the base of the tongue were studied. An immunohistochemical examination of the tumour cells showed positive immunostaining for myoglobin, desmin, and striated muscle actin, but negative immunostaining for smooth muscle actin. Electron microscopy showed many glycogen granules and mitochondria in the tumour cells. The T2-weighted and contrast-enhanced magnetic resonance images (MRI) clearly (...) delineated morphological features of this tumour, but T1-weighted MRI and computed tomography (CT) images showed no important features. These findings are typical for an adult extracardiac rhabdomyoma located in the head and neck region, and they will be useful for diagnosis of this tumour.

2003 Journal of Laryngology & Otology

4067. Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer Full Text available with Trip Pro

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, alphavbeta6 integrin, the laminin-5 gamma2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8 (...) -type mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) alpha and beta. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.

2008 British journal of cancer

4068. Breast cancer metastasizing to the tongue Full Text available with Trip Pro

Keratin-14 IM Adult Breast Neoplasms Carcinoma, Ductal, Breast metabolism pathology Fatal Outcome Female Humans Immunohistochemistry Keratin-14 metabolism Lung Neoplasms secondary Neoplasm Invasiveness Tongue Neoplasms metabolism pathology secondary 2008 8 7 9 0 2008 9 10 9 0 2008 8 7 9 0 ppublish 18682793 PMC2496587 Indian J Cancer. 1967 Sep;4(3):340-2 5590041 J Oral Maxillofac Surg. 1986 Jun;44(6):484-6 3009760 Oral Surg Oral Med Oral Pathol. 1973 Feb;35(2):202-11 4513066 (...) Breast cancer metastasizing to the tongue 18682793 2008 09 09 2018 11 13 1488-2310 51 3 2008 Jun Canadian journal of surgery. Journal canadien de chirurgie Can J Surg Breast cancer metastasizing to the tongue. E63-4 Neelakantan Pratap P Department of Medical Oncology, Charing Cross Hospital, London, UK. McLean Sean R SR Kenny Sinead S Nathan Myooran M Panchal Lajja L Sandhu Gurpreet G Coombes Charles R CR Palmieri Carlo C eng Case Reports Journal Article Canada Can J Surg 0372715 0008-428X 0

2008 Canadian Journal of Surgery

4069. Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (Abstract)

Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracellular matrix and neovascularization are related to tumor infiltration mechanism. By studying the tissues of early stage oral tongue cancer patients, we are intending to clarify the invasion-related factors.To (...) demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction-related molecules (MMP-2, MMP-9) and neovascularization-related molecule (VEGF) were observed by immunohistochemical study. Also, staining of CD31 was done for quantification of neovascularization. We analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates, and cervical lymph node metastasis rate.The expression rates of MMP-2, MMP

2006 Journal of Surgical Oncology

4071. Arterial Chemoradiotherapy for Locally Advanced Tongue Cancer: Analysis of Retrospective Study of Therapeutic Results in 88 Patients. (Abstract)

Arterial Chemoradiotherapy for Locally Advanced Tongue Cancer: Analysis of Retrospective Study of Therapeutic Results in 88 Patients. To retrospectively investigate the therapeutic results of arterial injection therapy by way of the superficial temporal artery for 88 cases of Stage III and IV (M0) tongue cancer and to clarify the factors that affected the therapeutic results.We administered intra-arterial chemoradiotherapy by continuous infusion of carboplatin in 39 patients between January (...) thiosulfate were excellent, and we believe it will be a new therapy for advanced tongue cancer.

2008 Biology and Physics

4072. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection. (Abstract)

Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection. The role of elective and therapeutic selective neck dissection in patients with early stage cancer of the oral tongue remains controversial. The purpose was to investigate the role of neck treatment in the management of this condition.A total of 380 patients with cT1-2N0 oral tongue cancer were retrospectively reviewed. Patients were staged by means (...) 5.2% for cT1 lesions and 14.6% for cT2 lesion (P = .005). The 5-year OS (P = .029) and NCR rates (P = .001) were significantly better in the END group compared with the OBS group. Patients who received MRND had a better 5-year NCR compared with SOND, albeit not significantly (91.4% vs 85.3%, P = .415). Multivariate analysis showed that END and stage were independent predictors of both NCR and OS.END should be performed routinely in patients with early-stage oral tongue cancer, even in the presence

2008 Cancer

4073. Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. (Abstract)

Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. Although genetic abnormalities on 3p have been suggested to be linked to the development of squamous cell carcinoma of the head and neck, to the authors' knowledge no study to date has examined such genetic abnormalities in patients with squamous cell carcinoma of the tongue. In the current study, loss of heterozygosity (LOH) was evaluated at several loci within 3p, including the von (...) Hippel-Lindau gene (VHL), in samples of tongue squamous cell carcinoma. In addition, the coding region of the intact VHL allele was screened for sequence mutations.DNA was extracted from tumor and nontumor tissues collected from 28 patients with tongue squamous cell carcinoma. LOH was investigated by analysis of single nucleotide polymorphisms within exon 3 of VHL and by microsatellite analysis within another 10 loci. Mutation analysis of the VHL gene was performed by polymerase chain reaction (PCR

2007 Cancer

4074. Heparanase up-regulation in tongue cancer: tissue and saliva analysis. (Abstract)

Heparanase up-regulation in tongue cancer: tissue and saliva analysis. Heparanase up-regulation has been correlated with reduced postoperative survival in various cancers.Heparanase expression was analyzed in 60 consenting tongue (mobile) cancer patients by means of immunohistochemistry. Heparanase levels were also analyzed in the saliva of both healthy controls and tongue cancer patients using a novel heparanase enzyme-linked immunosorbent assay method.Heparanase staining was positive (>0 (...) ) in 92% and negative (=0) in 8% of the tumors and staining intensity correlated with tumor size and tumor stage. Moreover, the survival probability of patients negative for heparanase (=0) at 60 months was 100%, compared with only 41% for patients positive for heparanase (>0), suggesting that heparanase may serve as a prognostic factor for this malignancy and an attractive target for anticancer drug development. Heparanase was detected in the saliva of healthy controls and the mean concentration

2007 Cancer

4075. Value of minimal residual disease in patients with early cancer of the tongue. (Abstract)

Value of minimal residual disease in patients with early cancer of the tongue. The clinical course of patients with squamous cell carcinoma (SCC) of the tongue is often unpredictable. Some patients have a fair course with good response to treatment, whereas others have aggressive locoregional disease despite diagnosis at an early stage. The purpose of the present study was to determine if histochemical staining for cytokeratins of the negative neck nodes obtained in prophylactic neck dissection (...) could predict treatment failure in patients with SCC of the tongue.Between 1990 and 2000, 18 patients with early squamous cell carcinoma of the tongue (T1,T2N0M0) underwent partial glossectomy with neck dissection at the Rabin Medical Center in Israel. All had clear resection margins and no evidence of neck metastasis and were expected to do well. Nevertheless, 6 patients had an aggressive course and died of disease shortly after presentation because of local or regional failure. In an attempt

2004 American Journal of Otolaryngology

4076. Chronic periodontitis and the risk of tongue cancer. Full Text available with Trip Pro

, and the controls, 54 non-Hispanic white men evaluated during the same period but with negative results for malignancy. Children (aged <21 years), edentulous or immunocompromised patients, and those with history of any cancer were excluded. History of periodontitis was assessed by alveolar bone loss measured from panoramic radiographs by 1 examiner blind to cancer status.Incidence of tongue cancer obtained from the RPCI Tumor Registry.After adjusting for the effects of age at diagnosis, smoking status (...) Chronic periodontitis and the risk of tongue cancer. To assess the association between the history of chronic periodontitis and the risk of tongue cancer.Case-control study using preexisting data from patients admitted between June 15, 1999, and November 17, 2005.Department of Dentistry and Maxillofacial Prosthetics at Roswell Park Cancer Institute (RPCI), Buffalo, NY.The cases comprised 51 non-Hispanic white men newly diagnosed as having primary squamous cell carcinoma of the tongue

2007 Archives of Otolaryngology Head and Neck Surgery

4077. Effects of tea polyphenols on telomerase activity of a tongue cancer cell line: a preliminary study. (Abstract)

Effects of tea polyphenols on telomerase activity of a tongue cancer cell line: a preliminary study. The aim of this study was to determine, at the mRNA and protein levels, whether tea polyphenols (TPs) affect the expression of the human telomerase reverse transcriptase (hTERT) gene in the Tca8113 cancerous cell line. The expression of this gene was determined at the mRNA level by reverse transcription and polymerase chain reaction and at the protein level by Western blotting. The semi (...) , disabling telomerase activity and thereby terminating unlimited cancer cell proliferation. These findings suggest a mechanism behind TP's anticancer activity.

2006 International Journal of Oral and Maxillofacial Surgery

4078. Effect of dendritic cell vaccine against a tongue squamous cell cancer cell line (Tca8113) in vivo and in vitro. (Abstract)

cells activated by the DC-based vaccine killed Tca8113 cells in vitro (P<0.01), postponed tumour doubling time of the implanted tumours in nude mice (P<0.01) and inhibited the growth of the tumours (P<0.05). These results show that DCs from monocytes induce a lymphocyte-mediated immune response against tongue squamous carcinoma, and could be used as a vehicle for tumour antigens. (...) Effect of dendritic cell vaccine against a tongue squamous cell cancer cell line (Tca8113) in vivo and in vitro. Dendritic cells (DCs), as primary antigen-presenting cells with the capacity to activate naïve T lymphocytes, are considered to be promising adjuvants for immunity against cancer. In this study, the effect of T lymphocyte-mediated immunity induced by a DC vaccine against Tca8113 cells in vivo and in vitro was evaluated. DCs were from human peripheral blood monocytes cultured

2006 International Journal of Oral and Maxillofacial Surgery

4079. Treatment results and prognostic factors in oral tongue cancer: analysis of 80 patients. (Abstract)

Treatment results and prognostic factors in oral tongue cancer: analysis of 80 patients. Treatment results and prognostic factors for 80 patients with oral tongue cancer admitted to Istanbul University Oncology Institute between 1987 and 2000 were retrospectively analysed. The patients were treated by surgery and postoperative or curative radiotherapy. Median age was 55 (22-93) out of which 41 patients (51%) were male and 39 (49%) were female. One patient (1%) had stage I disease, 28 patients (...) -year overall survival rates were 16% in group A and 49% in group B (P=0.0002). The 5-year disease-specific survival rate was 23% in group A while in group B it was 49%; the difference was statistically significant (P=0.02). Combined treatment improves overall and disease-free survival in patients with stage II, III and IVA oral tongue cancer. In patients who are not candidates for surgery, the effect of radiotherapy may be increased with the use of brachytherapy.

2006 International Journal of Oral and Maxillofacial Surgery

4080. Histopathological factors affecting nodal metastasis in tongue cancer: analysis of 94 patients in Taiwan. (Abstract)

of tongue cancer treated in the Taipei Veterans General Hospital was performed. All 94 patients were clinically diagnosed with stage I-IV tongue cancer before surgery and received primary tumor-wide excision and neck dissection. There were 42 (45%) patients with nodal metastasis. Univariate analysis revealed that cases of tongue cancer with moderate or poor differentiation, an invasion depth more than 3mm and positive perineural invasion or lymphovascular permeation at the time of presentation may (...) Histopathological factors affecting nodal metastasis in tongue cancer: analysis of 94 patients in Taiwan. The overall prognosis for tongue cancer patients in Taiwan is unpredictable, even when patients are treated following the guidelines according to TNM stages. In order to determine the optimal treatment modality for tongue cancer in Taiwan the authors aimed to correlate histopathological parameters with neck nodal metastasis. A retrospective analysis of 94 patients with different stages

2008 International Journal of Oral and Maxillofacial Surgery

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