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Tongue Carcinoma

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4041. Carcinoma of the oropharynx: factors affecting outcome. (Abstract)

, and posterior pharyngeal wall cancer (P = .010).Patient-related factors such as age and gender were not significant in predicting disease-specific outcome. Important tumor-related factors were the American Joint Committee on Cancer stage and the T stage. Among the oropharyngeal subsites, squamous cell carcinoma of the base of tongue was associated with the worst outcome. (...) into the following subsites: 1) base of tongue, 2) tonsil and pillars, and 3) uvula, soft palate, and posterior pharyngeal wall. Patient-related factors included age and gender. Tumor-related factors included American Joint Committee on Cancer stage, T stage, N stage, and grade. These factors were compared using the end points of disease-free survival and treatment response (complete response or partial response/no response).Tumor-related factors such as American Joint Committee on Cancer stage (P = .016) and T

2005 Laryngoscope

4042. Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck. (Abstract)

worse 5-year disease-free survival rates than patients with metastasis to other neck levels (54% versus 71%; P=.04).These results suggest that elective N0 neck treatment in patients with oropharyngeal SCC, especially base of tongue cancer, should include neck levels II, III, and IV instead of levels I, II, and III. (...) of 68), respectively. Isolated metastasis to level IV occurred on the ipsilateral side in three patients. There were no cases of isolated ipsilateral level I pathologic involvement in an N-positive neck or occult metastasis to this group. The incidence rate of level IV metastasis in patients with ipsilateral nodal metastasis was significantly higher in base of tongue cancer (86% [6 of 7]) compared with tonsillar cancer (34% [20 of 59]) (P=.013). Patients with level IV metastasis had significantly

2006 Laryngoscope

4043. Sublingual gland resection in squamous cell carcinoma of the floor of mouth: is it necessary? (Abstract)

Sublingual gland resection in squamous cell carcinoma of the floor of mouth: is it necessary? Little evidence exists to guide surgeons in the management of the sublingual glands (SLG) not macroscopically involved by squamous cell carcinoma of the floor of mouth and oral tongue. This study aims to determine the frequency with which the SLG is invaded, to identify variables predicting for SLG invasion and the morbidity associated with it's resection in entirety.Retrospective cohort study.A review (...) of 164 patients treated for oral cavity cancer at a tertiary institution with a large volume of head and neck malignancy was performed. Demographic data, rates of surgical complications and follow up information was recorded. Pathologic review of resected material in this group yielded 134 specimens in the region of the SLG. A detailed analysis of 63 specimens in which the SLG was included was carried out.The median age was 58 years, mean follow up was 2.2 years, and there were 44 males and 19

2006 Laryngoscope

4044. Secondary Primary Tumor Prevention With EGFR, OSI-774, and Cyclooxygenase-2

Institute (NCI) Information provided by (Responsible Party): Dong Shin, Emory University Study Details Study Description Go to Brief Summary: This is a phase I study of second primary tumor prevention in early stage (stage I/II) patients diagnosed with squamous cell carcinoma of the head and neck (SCCHN). Condition or disease Intervention/treatment Phase Head and Neck Cancer Drug: Erlotinib Drug: Celecoxib Phase 1 Detailed Description: This is a phase I study of second primary tumor prevention in early (...) Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have, or have previously had, stage I (T1NO) or stage II (T2NO) squamous cell carcinoma of the head and neck. Tumor sites include oral cavity (buccal mucosal, gingival, floor of mouth, dorsal/ventral tongue, pharyngeal wall), oropharynx, larynx (glottis, supraglottis, subglottis, epiglottis) hypopharynx, paranasal sinus and nasal cavity. May have oral pre-malignant lesions (i.e., hyperplasia, dysplasia, carcinoma in situ

2006 Clinical Trials

4045. Safety and Efficacy of Adenoviral Endostatin in the Treatment of Advanced Solid Tumor

of hepatocellular carcinoma BEL-7402, nasopharyngeal carcinoma CNE-2, Tongue cancer Tca8113 in nude mice demonstrated significant tumor growth inhibition and reduce angiogenesis in tumors. No toxic effects of E10A administration in these pharmacology studies were identified. On the base of promising preclinical results in solid tumors, we undertook a dose-escalation phase I trial of E10A in the treatment of patients with advanced solid tumors. Study Design Go to Layout table for study information Study Type (...) years; Genders eligible for study: both; Histologic diagnosis of solid malignancies ; Performance status of 0 or 1; Tumor not amenable to standard curative or palliative therapy; An accessible tumor mass; At least 4 weeks since prior biotherapy/chemotherapy/radiotherapy; A life expectancy beyond 3 months; Ability to give signed informed consent. Exclusion Criteria: Pregnancy or lactation; Had a history of brain metastasis or a primary brain tumor; An active, potentially severe autoimmune disease

2005 Clinical Trials

4046. [Clinical observation on effect of shenqi fanghou recipe in preventing and treating radiation injury in patients with head and neck tumor]. (Abstract)

[Clinical observation on effect of shenqi fanghou recipe in preventing and treating radiation injury in patients with head and neck tumor]. To observe the therapeutic effect of shenqi fanghou recipe (SFR) in preventing and treating radiation injury in patients with head and neck tumor.One hundred and forty patients with head and neck tumor, including nasopharyngeal carcinoma, carcinoma of tonsil or tongue, were randomly divided into 2 groups, 70 patients in the observed group were given (...) , such as the degree of mouth-opening was better and the cervical muscular sclerosis was better in the observed group than in the control group, showing significant difference (P < 0.01).SFR has definite effect in preventing and treating radiation reaction and late stage radiation injury in patients with head and neck tumor.

2005 Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Controlled trial quality: uncertain

4047. Tonsillectomy vs. deep tonsil biopsies in detecting occult tonsil tumors. (Abstract)

, 11 primary tumors were subsequently identified (11.6%): three in the tonsil, six in the tongue base, one in the hypopharynx, and one in the nasopharynx. Tonsillectomy was performed in 27 patients. Eleven primary tumors were identified (40.7%): eight in the tonsils, two in the tongue base, and one in the hypopharynx. All tonsil primary tumors identified were ipsilateral to the presenting neck mass. The overall yield of finding an occult primary carcinoma in the tonsil was 3.2% for deep tonsil (...) Tonsillectomy vs. deep tonsil biopsies in detecting occult tonsil tumors. To compare the yield of detecting occult tumors by performing tonsillectomy and deep tonsil biopsies in patients with metastatic carcinoma to the neck in whom a primary tumor was not evident on physical examination, radiography, or panendoscopy.Retrospective study.Over a 10-year period, the charts of all patients diagnosed with metastatic carcinoma to the neck in whom a primary tumor was not evident on examination

2008 Laryngoscope

4048. Metinel Node-The First Lymph Node Draining a Metastasis-Contains Tumor-Reactive Lymphocytes. Full Text available with Trip Pro

site was colorectal cancer in seven patients, malignant melanoma in four, ovarian cancer and breast cancer in two, and one each with pancreatic cancer, cholangiocarcinoma, leiomyosarcoma, and squamous cellular cancer of the tongue. By injection of Patent blue dye or radioactive tracers around the metastases, we identified draining lymph nodes from liver metastases (n = 9), intra-abdominal local recurrences (n = 3), and regional lymph node metastases (n = 7). In six patients, a preoperative (...) Metinel Node-The First Lymph Node Draining a Metastasis-Contains Tumor-Reactive Lymphocytes. We previously identified tumor-reactive lymphocytes in the first lymph nodes that drain the primary tumor. In this study, we performed lymphatic mapping to investigate the possibility of finding the first lymph nodes that drain metastases, and of learning whether these lymph nodes contained tumor-reactive lymphocytes suitable for adoptive immunotherapy.Nineteen patients were studied. The primary tumor

2008 Annals of Surgical Oncology

4049. Phase 2 study of intratumoral cisplatin and epinephrine treatment for locally recurrent head and neck tumors. (Abstract)

and antitumor effect of intratumoral cisplatin. Fourteen patients with locally recurrent head and neck tumors (median age, 58.7 years) were included in this phase 2 trial. Recurrent tumors (squamous cell carcinomas) were located on the tongue, oral pharynx, or cervical nodes. Prior therapy was surgery and/or radiotherapy with or without intravenous chemotherapy. Inclusion criteria included an Eastern Cooperative Oncology Group/World Health Organization performance status of 0, 1, or 2, an anticipated (...) at a concentration of 0.02 mg/mL. Intratumoral injections were repeated every 2 to 3 weeks at different locations in the tumors to obtain a homogeneous distribution. Tumor response was evaluated by clinical examination and computed tomography. Eight objective responses were registered among the 14 patients. Four were complete responses, and 4 were partial responses. The average time to disease progression was 11.5 +/- 8.9 weeks. Local adverse effects were transient pain, swelling, and erythema at the site

2004 Rhinology and Laryngology

4050. Lingual tumors in infants: a case report and review of the literature. (Abstract)

Lingual tumors in infants: a case report and review of the literature. Tumors of the tongue and the base of mouth are seen rarely in children. The incidence of the ones that are large enough to fill the oral cavity is especially low. If not recognized and treated, tongue tumors may obstruct the upper aero-digestive tract and be fatal. A case of a huge lingual cystic tumor mimicking ranula, and obstructing the upper aero-digestive tract, which was diagnosed antenatal and treated during and after

2004 International Journal of Pediatric Otorhinolaryngology

4051. Scholastic achievements of children with brain tumors at the end of comprehensive education: a nationwide, register-based study. (Abstract)

Scholastic achievements of children with brain tumors at the end of comprehensive education: a nationwide, register-based study. Cancer treatment may affect school performance. Scholastic achievements after childhood brain tumors have not been previously reported on the level of actual grades.Patients with brain tumor (n = 300) were identified from the Finnish Cancer Registry. Population controls (n = 1,473) were matched for age, gender, and place of living. Their ninth grade school reports (...) school age, had poorer results than their controls (95% CI -0.65, -0.18). The grades of patients were significantly lower in each school subject, and differed most in foreign language. Young girls with CRT had greatest differences from their controls (95% CI -1.73, -0.86) in this subject. In mathematics, patients diagnosed before school age had greatest difference from their controls. In their mother tongue, patients differed less from their controls.Few patients with brain tumor missed the ninth

2007 Neurology

4052. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. (Abstract)

%.FDG-PET detected primary tumors that went undetected by other modalities in approximately 25% of cases and was sensitive in the detection of previously unrecognized regional or distant metastases in 27% of cases. FDG-PET had low specificity for tonsillar tumors and low sensitivity for base-of-tongue malignancies.(c) 2004 American Cancer Society (...) workup. FDG-PET imaging also led to the detection of previously unrecognized metastases in 27.1% of patients (regional, 15.9%; distant, 11.2%). FDG-PET had notably low specificity and a high false-positive rate (39.3%) in the tonsils. In contrast, the false-positive rates for FDG-PET of the base of tongue and hypopharynx were only 21.4% and 8.3%, respectively. FDG-PET exhibited decreased sensitivity to tumors in the base of tongue (81.5%). The sensitivity of this technique at other sites was 90.5

2004 Cancer

4053. Adenoid Cystic Carcinoma

have a better prognosis. ACCs are often slow-growing but locally aggressive and particularly prone to recurrence. Epidemiology ACC accounts for about 1% of all head and neck malignancies. [ ] ACC of the breast is a rare subtype of breast cancer. [ ] The age range is unusually wide and it can occur in children. It is most common between the ages of 40 and 70 years. It occurs more often in females in a 3:2 ratio. The p53 tumour suppressor gene may be inactivated in advanced disease but otherwise (...) to 40 % of patients. The lungs are the most common site, but liver, kidney, bones and brain are also affected by metastatic disease. [ ] Differential diagnosis : Benign mixed salivary gland tumour. Mucoepidermoid carcinoma. Polymorphous low-grade adenocarcinoma (PLGA) shares features with ACC. Squamous cell carcinoma. Investigations Tumour (new or recurrent) may be identified by CT scan or at MRI. There are no serological markers, although a recent report using CD43 (a sialoglycoprotein) may

2008 Mentor

4054. Epithelioid sarcoma of the tongue. Full Text available with Trip Pro

Epithelioid sarcoma of the tongue. A case of epithelioid sarcoma in the tongue is reported. The patient, a 35 year old woman, presented with a non-ulcerated painful lesion of the tongue. Microscopically, the tumour was characterised by multiple coalescent nodules with central geographic necrosis infiltrating the lingual muscle. The tumour cells were epithelioid with abundant eosinophilic cytoplasm and atypical nuclei. Immunohistochemically, the tumour cells stained for vimentin, keratin (...) , and epithelial membrane antigen. These morphological and immunohistochemical appearances led to the diagnosis of epithelioid sarcoma of the tongue. Seven years later, the patient died with metastatic dissemination to the scalp, lungs, and brain. No case of epithelioid sarcoma arising in the tongue has been described previously.

1997 Journal of Clinical Pathology

4055. Radiation response of the mouse tongue epithelium. Full Text available with Trip Pro

Radiation response of the mouse tongue epithelium. 3459514 1986 08 14 2018 11 13 0306-9443 7 1986 The British journal of cancer. Supplement Br. J. Cancer Suppl. Radiation response of the mouse tongue epithelium. 12-5 Moses R R Kummermehr J J eng Journal Article England Br J Cancer Suppl 7506975 0306-9443 IM Animals Body Weight radiation effects Dose-Response Relationship, Radiation Epithelium radiation effects Female Mice Mice, Inbred C3H Mitosis radiation effects Time Factors Tongue radiation (...) effects Tongue Diseases etiology Ulcer etiology 1986 1 1 1986 1 1 0 1 1986 1 1 0 0 ppublish 3459514 PMC2149840 Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Aug;46(2):103-20 6381354 Radiat Res. 1985 Jan;101(1):162-9 3969442 Radiother Oncol. 1984 Mar;1(4):369-74 6505271 Radiother Oncol. 1983 Nov;1(2):159-65 6680220

1986 The British journal of cancer. Supplement

4056. The applications of tongue flaps in head and neck surgery. Full Text available with Trip Pro

The applications of tongue flaps in head and neck surgery. 3465414 1987 01 07 2018 11 13 0028-7091 62 8 1986 Oct Bulletin of the New York Academy of Medicine Bull N Y Acad Med The applications of tongue flaps in head and neck surgery. 847-53 Komisar A A eng Journal Article United States Bull N Y Acad Med 7505398 0028-7091 IM Humans Methods Mouth Neoplasms surgery Pharyngeal Neoplasms surgery Surgical Flaps Tongue 1986 10 1 1986 10 1 0 1 1986 10 1 0 0 ppublish 3465414 PMC1629149 Cancer. 1956 Nov

1986 Bulletin of the New York Academy of Medicine

4057. Development of Normative Ultrasound Databases of Tongue Surface Configuration

will be used to create baseline data categories. In addition, new parameters and improved instruments will be developed as previously to produce a data base which can be used across disciplines. Condition or disease Healthy Speech Disorders Detailed Description: Our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations. Subjects with normal speech and hearing who represent different ages and sexes, will be studied (...) may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Healthy normal subjects. No reconstructive tongue surgery. No radiation for head and neck malignancy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may

1999 Clinical Trials

4058. Ultrasound Evaluation of Tongue Movements in Speech and Swallowing

, 1999 Last Update Posted: March 4, 2008 Last Verified: November 2004 Keywords provided by National Institutes of Health Clinical Center (CC): Dysphagia Dysarthria Tongue Motion Xerostomia Swallowing Speech Polymyositis Speech Disorders Oral-Facial Paralysis Ultrasound Additional relevant MeSH terms: Layout table for MeSH terms Neoplasms Polymyositis Speech Disorders Otorhinolaryngologic Diseases Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms Myositis Muscular Diseases Musculoskeletal Diseases (...) with tumors of the oral cavity, pharynx or larynx being treated at the Greater Baltimore Medical Center. Participants will undergo a 30-minute speech and oral motion evaluation, in which they imitate sounds, words and oral movements while a speech pathologist evaluates their lip, tongue and palate movements. They may also be asked to drink a small amount of water for examination of swallowing function. For the ultrasound examination, a 3/4-inch transducer (device for transmitting and receiving sound waves

1999 Clinical Trials

4059. Study of Tongue Pressures

cancer that caused tongue weakness and dysphagia may be eligible for this study. Such medical conditions may include stroke, Parkinson's disease, multiple sclerosis corticobasal degeneration, progressive supranuclear palsy, Gaucher's disease, leukodystrophy, cerebral palsy, myositis, or mouth, throat or neck cancer. Volunteers who have not participated in a NIH protocol for 1 year will be screened with a brief medical history and physical examination. Dysphagic patients not currently enrolled (...) . This protocol, therefore, proposes to test these hypotheses in healthy individuals of different ages, and in patients with reduced tongue strength and oral-oropharyngeal dysphagia associated with neurologic disorders, musculoskeletal diseases, or head and neck cancer. Our goals are to: (a) acquire a better and more complete understanding of normal tongue pressure phenomena as a function of swallowing tasks, (b) characterize the interrelationship between task-induced lingual pressure differences and result

2001 Clinical Trials

4060. Peripheral ameloblastoma involving tongue-a rare case Full Text available with Trip Pro

Peripheral ameloblastoma involving tongue-a rare case Peripheral ameloblastoma is a rare tumour of oral cavity. It presents as a mass without bony continuity. Here we report a unique case of peripheral ameloblastoma involving tongue, with review of relevant literature.

1998 Indian Journal of Otolaryngology and Head & Neck Surgery

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