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Tongue Carcinoma

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21. A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. (PubMed)

A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer.Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year (...)  = 0.0335).This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.

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2018 Annals of Surgical Oncology

22. miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma (PubMed)

miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortality. However, the therapeutic benefits of chemotherapy are usually attenuated due to intrinsic and/or acquired drug resistance, and a large proportion of TSCC

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2018 Journal of experimental & clinical cancer research : CR

23. Depth of invasion in superficial oral tongue carcinoma quantified using intraoral ultrasonography. (PubMed)

Depth of invasion in superficial oral tongue carcinoma quantified using intraoral ultrasonography. Depth of invasion (DOI) in oral carcinoma has been integrated into the primary tumor categories in the current tumor-node-metastasis staging (8th edition). However, there is no standard modality to determine DOI preoperatively. The aims of the present study were to evaluate the accuracy of a preoperative measurement of DOI using ultrasonography (US) for superficial oral tongue carcinomas (...) , and to correlate the values obtained with histologically determined DOI measurements.We retrospectively analyzed the records of 56 patients with oral tongue carcinoma who underwent intraoral US preoperatively, followed by curative surgery at the Shizuoka Cancer Center Hospital in Japan. For the measurement of DOI with US, our unique technique (water balloon method) was evaluated.The histologically measured tumor size (maximum diameter) showed a distribution of 7.0 to 40.0 mm (mean, 18.6 mm). The correlation

2018 Laryngoscope

24. Squamous-Cell Carcinoma of the Tongue. (PubMed)

Squamous-Cell Carcinoma of the Tongue. 27332922 2016 07 13 2016 06 23 1533-4406 374 25 2016 Jun 23 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma of the Tongue. e32 10.1056/NEJMicm1513456 Albuquerque Rui P P RP University of Birmingham, Birmingham, United Kingdom r.p.p.d.albuquerque@bham.ac.uk. Richards Andrea A University of Birmingham, Birmingham, United Kingdom r.p.p.d.albuquerque@bham.ac.uk. eng Case Reports Journal Article United (...) States N Engl J Med 0255562 0028-4793 AIM IM Aged Biopsy Carcinoma, Squamous Cell pathology Female Humans Tongue pathology Tongue Neoplasms pathology 2016 6 23 6 0 2016 6 23 6 0 2016 7 14 6 0 ppublish 27332922 10.1056/NEJMicm1513456

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2016 NEJM

25. C-reactive Protein is an independent prognostic marker in Patients with Tongue Carcinoma - a retrospective Study. (PubMed)

C-reactive Protein is an independent prognostic marker in Patients with Tongue Carcinoma - a retrospective Study. Reliable prognostic markers are lacking for tongue carcinoma. C-reactive protein (CRP) and a ratio from neutrophils/lymphocytes (NLR) are biomarkers, associated with prognosis in solid cancers. Aim of this work was to investigate the role of CRP and NLR in prognosis of patients with tongue carcinoma.Retrospective cohort study.We retrospectively analysed data of patients treated (...) for tongue carcinoma at our institution. Levels of CRP, Neutrophils and Lymphocytes were measured pretherapeutic.197 patients treated for squamous cell carcinoma of the tongue between 2002 and 2015.Overall survival, disease-free survival.Elevated CRP was significantly associated with shorter overall survival in our cohort in uni- and multivariate analysis. NLR was not associated with prognosis.In the present study we could confirm the role of CRP as an independent prognostic marker in patients

2018 Clinical Otolaryngology

26. Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis".

Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". 29449674 2019 01 21 2019 03 06 1532-1827 118 5 2018 03 06 British journal of cancer Br. J. Cancer Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". e12 10.1038/bjc.2017.491 Almangush Alhadi A Department of Pathology, University of Helsinki, Helsinki, Finland. Department of Oral and Maxillofacial (...) , Finland. Medical Research Center, Oulu University Hospital, Oulu, Finland. eng Letter Comment 2018 02 15 England Br J Cancer 0370635 0007-0920 0 Biomarkers IM Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Br J Cancer. 2018 Mar 6;118(5):e11 29449675 Biomarkers Humans Prognosis Squamous Cell Carcinoma of Head and Neck Tongue Neoplasms 2018 2 17 6 0 2019 1 22 6 0 2018 2 17 6 0 ppublish 29449674 bjc2017491 10.1038/bjc.2017.491 PMC5846078 Neoplasma. 2011;58(3):217-26 21391738 Br J Cancer. 2017 Sep 5;117

2018 British journal of cancer

27. Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'.

Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. 29449675 2019 01 21 2019 03 06 1532-1827 118 5 2018 03 06 British journal of cancer Br. J. Cancer Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. e11 10.1038/bjc.2017.482 Jayaraj Rama R Charles Darwin University, Darwin, NT 0909, Australia. Kumarasamy Chellan C Charles Darwin University, Darwin, NT 0909, Australia (...) . eng Letter Comment 2018 02 15 England Br J Cancer 0370635 0007-0920 0 Biomarkers IM Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Br J Cancer. 2018 Mar 6;118(5):e12 29449674 Biomarkers Humans Prognosis Squamous Cell Carcinoma of Head and Neck Tongue Neoplasms 2018 2 17 6 0 2019 1 22 6 0 2018 2 17 6 0 ppublish 29449675 bjc2017482 10.1038/bjc.2017.482 PMC5846075 Oncogene. 1997 Jul 31;15(5):579-84 9247311 Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Anticancer Res. 2000 May-Jun;20(3A):1343-51

2018 British journal of cancer

28. Utilizing the nanosecond pulse technique to improve antigen intracellular delivery and presentation to treat tongue squamous cell carcinoma (PubMed)

Utilizing the nanosecond pulse technique to improve antigen intracellular delivery and presentation to treat tongue squamous cell carcinoma Tongue squamous cell carcinoma is the most common squamous cell carcinoma of the head and neck. Immunotherapy has great potential in the treatment of tongue squamous cell carcinoma because of its unique advantages. However, the efficacy of immunotherapy is limited by the efficiency of antigen phagocytosis by immune cells.We extracted dendritic cells (DCs (...) of DCs to tumour lysing proteins and have good biosafety. The tumour cell killing rate of the nsPEF group was higher than the other group (p < 0.05).Utilizing nsPEF to improve the phagocytic and presenting ability of DCs could greatly activate the adaptive immune cells to enhance the immunotherapeutic effect on tongue squamous cell carcinoma.

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2018 Medicina oral, patología oral y cirugía bucal

29. CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma (PubMed)

CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma The present study evaluated the expression and potential role of CD63 in the migration and invasion of tongue squamous cell carcinoma (TSCC) cells. Immunohistochemistry (IHC) was used to investigate the association between the expression level of CD63 protein and the histological differentiation of samples from 40 patients with TSCC and four normal tongue tissue specimens. RNA interference (RNAi) and gene

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2018 Oncology letters

30. Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway (PubMed)

Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed that lncRNA AFAP1-AS1 was upregulated and acted as an oncogene in a variety of tumors. However, the expression (...) and biological functions of lncRNA AFAP1-AS1 in tongue squamous cell carcinoma (TSCC) are still unknown.The expression level of AFAP1-AS1 was measured in 103 pairs of human TSCC tissues and corresponding adjacent normal tongue mucous tissues. The correlation between AFAP1-AS1 and the clinicopathological features was evaluated using the chi-square test. The effects of AFAP1-AS1 on TSCC cells were determined via a CCK-8 assay, clone formation assay, flow cytometry, wound healing assay and transwell assay

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2018 Molecular Cancer

31. Tongue Squamous Cell Carcinoma in a European Lynx (Lynx Lynx): Papillomavirus Infection and Histologic Analysis (PubMed)

Tongue Squamous Cell Carcinoma in a European Lynx (Lynx Lynx): Papillomavirus Infection and Histologic Analysis Oral squamous cell carcinoma (SCC) is a common finding in domestic and wild felids. Only two cases of oral SCC have been reported in Lynx species (Lynx rufus and Lynx canadensis), at mandibular and gingival sites. In this study, we describe the first report of tongue SCC in a 15 years old female European lynx (Lynx lynx), along with viral investigations. Necropsy and histological (...) analysis were performed and the presence of papillomavirus (PV) infection was investigated by ultrastructural and molecular methods. The lardaceous mass at tongue level was histologically diagnosed as moderately differentiated SCC. Typical microscopical features of SCC were also found in the retropharyngeal lymph node and at the pulmonary level. Neither viral DNA by PCR, nor viral particles by transmission electron microscopy were found. Despite that PV infection is associated with Felidae, this work

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2018 Veterinary Sciences

32. Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27) (PubMed)

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27) Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts of propolis are chrysin, caffeic acid, p-coumaric acid, and ferulic acid (...) . Although their pro-apoptotic activity on human tongue squamous cell carcinoma cells (CAL-27) was established previously, the detailed mechanism of this process remains unclear. Considering the crucial role of proline metabolism and proline dehydrogenase/proline oxidase (PRODH/POX) in the regulation of cancer cell survival/apoptosis, we studied these processes in polyphenol-treated CAL-27 cells. All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active

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2018 Frontiers in pharmacology

33. Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma (PubMed)

Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma Oral malignancies remain to have higher morbidity and mortality rates owing to the poor understanding of the carcinogenesis and the lack of early detection and diagnosis. The lack of established biomarkers for oral tongue squamous cell carcinoma (OTSCC) resulted in aggressive multi-modality management less effective. Here, we report for the first time (...) that a panel of potential markers identified from tongue tumor samples using two-dimensional-differential-in-gel-electrophoresis (2D-DIGE). Our approach of combining 2D-DIGE with tandem mass spectrometry identified 24 candidate proteins including cofilins, myosin light chain family members, annexins, serpins, HSPs and tropomyosins, with significant differential expression in tongue carcinomas as compared with their matched adjacent normal tissues. The expression levels of the identified proteins were

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2018 Scientific reports

34. Digital metastasis of tongue squamous cell carcinoma (PubMed)

Digital metastasis of tongue squamous cell carcinoma 29892666 2019 02 26 2352-5126 4 2 2018 Mar JAAD case reports JAAD Case Rep Digital metastasis of tongue squamous cell carcinoma. 200-202 10.1016/j.jdcr.2017.09.009 Aiempanakit Kumpol K Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. eng Case Reports 2018 02 02 United States JAAD Case Rep 101665210 2352-5126 digit metastasis nail change oncologic patient squamous (...) cell carcinoma tongue 2018 6 13 6 0 2018 6 13 6 0 2018 6 13 6 1 epublish 29892666 10.1016/j.jdcr.2017.09.009 S2352-5126(17)30215-1 PMC5993555 Dermatol Surg. 2001 Mar;27(3):280-93 11277898 J Am Acad Dermatol. 2014 Aug;71(2):217.e1-217.e11; quiz 227-8 25037801 Br J Dermatol. 1998 Apr;138(4):708 9678955 Br J Dermatol. 2015 Sep;173(3):842-5 25704465 J Am Acad Dermatol. 2007 Mar;56(3):460-5 17147969 J Hand Surg Am. 2014 May;39(5):923-32.e17 24612837 J Am Acad Dermatol. 2014 Oct;71(4):787-94 24795111 J

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2018 JAAD Case Reports

35. A Prognostic Nomogram Incorporating Depth of Tumor Invasion to Predict Long-term Overall Survival for Tongue Squamous Cell Carcinoma With R0 Resection (PubMed)

A Prognostic Nomogram Incorporating Depth of Tumor Invasion to Predict Long-term Overall Survival for Tongue Squamous Cell Carcinoma With R0 Resection Purpose: To establish a useful prognostic nomogram to predict long-term overall survival for patients with tongue squamous cell carcinoma (TSCC) after R0 resection. Patients and Methods: The nomogram was developed using a retrospective cohort of 235 TSCC patients from Sun Yat-sen University Cancer Center between 1 January 2000 and 31 December

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2018 Journal of Cancer

36. miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7 (PubMed)

miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7 The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR

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2018 Oncology letters

37. Tongue carcinoma in young adults: a review of the literature (PubMed)

Tongue carcinoma in young adults: a review of the literature A recent reduction in the number of smoke-related tumours has been observed thanks to the diffusion of anti-tobacco campaigns carried out in the majority of developed countries. Nevertheless, as demonstrated by recent global epidemiologic studies, squamous cell carcinoma of the mobile tongue appears to be progressively increasing in incidence, particularly among young adults and especially in females. The driving mechanism responsible (...) for such changes is still to be precisely defined. Several genetic studies have compared the mutational pattern of tongue squamous cell carcinoma in young adults to that of more elderly patients, without identifying significant differences that may help in better characterising this subgroup of subjects. Tongue squamous cell carcinomas in young adults have been historically considered as particularly aggressive clinical entities, with a high risk of loco-regional relapse, survival rates inferior to those

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2018 Acta Otorhinolaryngologica Italica

38. miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targeting RDX (PubMed)

miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targeting RDX The aim of the present study is to investigate the role of microRNA (miRNA/miR)-409-3p in the proliferation, invasion and migration of tongue squamous cell carcinoma (TSCC) cells via targeting radixin (RDX) gene. The expression of miR-409-3p was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in TSCC tissue and cell lines. The binding of miR-409 (...) the effects of miR-409-3p on the tumor growth and lymphatic metastasis in nude mice. A significant downregulation was detected in miR-409-3p expression in TSCC tissues and cells (all P<0.05) compared with normal tongue mucosa tissues and cell line, which was associated with lymph node metastasis and tumor-node metastasis staging (both P<0.05). The results from the dual-luciferase reporter gene assay indicated that RDX is a potential target gene of miR-409-3p. Compared with the blank group, a marked

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2018 Oncology letters

39. IRX5 promotes NF‐κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma (PubMed)

IRX5 promotes NF‐κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma Iroquois homeobox gene 5 (Irx5) is a highly conserved member of the Iroquois homeobox gene family. Members of this family play distinct and overlapping roles in normal embryonic cell patterning and development of malignancies. In this study, we observed that IRX5 was abnormally abundant in tongue squamous cell carcinoma (TSCC) tissues and cell lines. We used gain

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2018 Journal of cellular and molecular medicine

40. Effect of Ferula persica plant methanol extract on the level of Cox-2 in induced squamous cell carcinoma (SCC) in rat tongue (PubMed)

Effect of Ferula persica plant methanol extract on the level of Cox-2 in induced squamous cell carcinoma (SCC) in rat tongue Background: More than 90% of oral cancers are cases of squamous cell carcinoma. Standard treatment of cancer includes a combination of surgery, chemotherapy and radiotherapy. Each of these treatments, however, brings about certain problems and side effects. Today herbal medicine, has become a more preferable option in dealing with health problems or preventing them (...) because this type of medicine has better compatibility with the body and does not cause undesirable side effects. In this study , the effect of Ferula persica plant methanol extraction on Cox-2 levels in SCC induced rat tongue is conducted in vivo. Methods: In this lab research, 75 rats from SD race in the age - range of 2/5 - 3 months were selected and put in five groups. In order to induce tongue carcinoma, 4- Nitroquinoline 1 (4 NQO) powder was used 3 times a week for each rat. Furthermore, Ferula

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2018 Journal of dental research, dental clinics, dental prospects

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