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Tongue Carcinoma

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181. Hypothyroidism in Carcinoma of the Tongue with Adjuvant Treatment Full Text available with Trip Pro

Hypothyroidism in Carcinoma of the Tongue with Adjuvant Treatment The objective of this study was to evaluate the incidence of hypothyroidism with adjuvant treatment in oral tongue carcinoma patients treated primarily with surgery.A retrospective review was carried out to analyze hypothyroidism incidence and its relation to adjuvant treatment (radiation/radio-chemotherapy) in oral tongue carcinoma after the primary surgical ablation and neck dissection. Hypothyroidism was analyzed in relation (...) with dose of radiation, gender, and adjuvant treatment modality.The study analyzed the patients who were treated between January 2012 and June 2015. Among 705 patients with carcinoma of the tongue treated primarily with wide local excision and neck dissection, 383 received adjuvant treatment. A total of 215 patients received radiation, and 168 received concurrent radio-chemotherapy. Of 378 patients, 78 developed hypothyroidism during follow-up: 27 patients received concurrent radio-chemotherapy

2017 Rambam Maimonides medical journal

182. miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma Full Text available with Trip Pro

miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC

2017 Biomarkers in cancer

183. Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways Full Text available with Trip Pro

Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways To investigate the effects and the possible underlying mechanisms of nicotine stimulation on tongue squamous cell carcinoma (TSCC) progression, a TSCC cell line Cal27 and 34 samples of paraffin-embedded TSCC were examined. Immunofluorescence, western blot analysis, and TOP/FOP flash, CCK-8, wound healing and Transwell invasion assays were used to evaluate Cal27 (...) , the expression levels of β-catenin, Wnt5a and Ror2 were higher in TSCC patients with a history of smoking than those without a history of smoking. Our results suggest nicotine may promote tongue squamous carcinoma cells progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways and may play a significant role in the progression and metastasis of smoking-related TSCC.

2017 Oncology letters

184. The effectiveness of elective neck dissection on early (stage I, II) squamous cell carcinoma of the oral tongue Full Text available with Trip Pro

The effectiveness of elective neck dissection on early (stage I, II) squamous cell carcinoma of the oral tongue The purpose of this study was to evaluate and compare the treatment outcomes of partial glossectomy with or without elective neck dissection in patients with tongue squamous cell carcinoma (SCCa).A total of 98 patients who were diagnosed with tongue SCCa and underwent partial glossectomy between 2005 and 2014 were evaluated. Only 14 patients received elective neck dissection, and 84 (...) patients received only partial glossectomy.There were 56 men and 42 women with a mean age of 57 years and mean follow-up period of 33.7 months. There were 70 patients graded as T1 and 28 as T2. The total occult metastasis rate was 17.3%. The 5-year overall survival rate was 83.3% with elective neck dissection and 92.4% with observation. The 5-year disease-free survival rate was in 70.7% in the elective neck dissection group and 65.3% in the observation group.We retrospectively reviewed the records

2017 Journal of the Korean Association of Oral and Maxillofacial Surgeons

185. Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation Full Text available with Trip Pro

Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation To establish a prognostic signature for locally advanced tongue squamous cell carcinoma (TSCC) patients treated with surgery.In the discovery study, unsupervised hierarchical clustering analysis identified two clusters which differentiated the Kaplan-Meier curves of RFS [median RFS, 111 days vs. not reached; log-rank test, P = 0.023]. The 30 genes identified were (...) , 0.333, P = 0.004).We conducted gene expression profiling of 26 clinicopathologically homogeneous advanced TSCC tissue samples using cDNA microarray as a discovery study. Candidate genes were screened using clustering analysis and univariate Cox regression analysis for relapse-free survival (RFS). These were combined into a prognostic index (PI), which was validated using three public microarray datasets of tongue and oral cancer (123 patients). Some genes identified in discovery were

2017 Oncotarget

186. The influence of marital status on survival in patients with oral tongue squamous cell carcinoma Full Text available with Trip Pro

The influence of marital status on survival in patients with oral tongue squamous cell carcinoma Marital status was found to be an independent prognostic factor for survival in several cancers. However related researches of oral tongue squamous cell carcinoma (OTSCC) are still rare. We explored the Surveillance, Epidemiology, and End Results (SEER) program and finally identified 14,194 patients with OTSCC. Kaplan-Meier analysis and multivariate Cox regression models were used to distinguish (...) risk factors for overall survival (OS) and tumor cause-specific survival (TCSS). Widowed patients had the highest percentage of female, highest average ages and more prevalence with localized SEER Stage significantly, while patients in the single group were younger than other groups. After univariate analysis and multivariate analysis, marital status was demonstrated to be an independent prognostic factor of OS and TCSS. Married patients showed better 5-year OS (65.6%) and 5-year TCSS (89.9%) than

2017 Oncotarget

187. Suppression of MAGE-A10 alters the metastatic phenotype of tongue squamous cell carcinoma cells Full Text available with Trip Pro

Suppression of MAGE-A10 alters the metastatic phenotype of tongue squamous cell carcinoma cells MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2 (...) ). These cell lines were transduced with lentivirus particles coding for short hairpin against MAGE-A10 mRNA. Repression of MAGE-A10 expression in LN2 cells altered their morphology and impaired growth of LN1 and LN2 cell lines. Furthermore, repression of MAGE-A10 expression increased cell-cell and cell matrix adhesion. Furthermore shMAGEA10 cells were shown to assemble aberrantly on a 3D culture system (microspheroids) when compared to cells transduced with the control scrambled construct. Cell migration

2017 Biochemistry and Biophysics Reports

188. miR-19a and miR-424 target TGFBR3 to promote epithelial-to-mesenchymal transition and migration of tongue squamous cell carcinoma cells Full Text available with Trip Pro

miR-19a and miR-424 target TGFBR3 to promote epithelial-to-mesenchymal transition and migration of tongue squamous cell carcinoma cells Previous studies indicate that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), a novel suppressor of progression in certain cancers, is down-regulated in tongue squamous cell carcinoma (TSCC). However, the role of this factor as an upstream regulator in TSCC cells remains to be elucidated. The present study was designed

2017 Cell adhesion & migration

189. Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. Condition or disease Intervention/treatment Phase Tongue Neoplasms Carcinoma Drug: luteolin Drug: nano-luteolin Early Phase 1 Detailed Description: This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell (...) for MeSH terms Carcinoma Carcinoma, Squamous Cell Tongue Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Neoplasms, Squamous Cell Mouth Neoplasms Head and Neck Neoplasms Neoplasms by Site Mouth Diseases Stomatognathic Diseases Tongue Diseases

2017 Clinical Trials

190. A systematic review of the correlation between blood and lymphatic vessel markers and patient survival of tongue squamous cell carcinoma

A systematic review of the correlation between blood and lymphatic vessel markers and patient survival of tongue squamous cell carcinoma Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6

2019 PROSPERO

191. Radiotherapy alone or combined with chemotherapy for base of tongue squamous cell carcinoma. (Abstract)

Radiotherapy alone or combined with chemotherapy for base of tongue squamous cell carcinoma. To evaluate the long-term disease control, survival, and complications after definitive radiotherapy (RT) alone or combined with adjuvant chemotherapy with or without planned neck dissection for base of tongue squamous cell carcinoma (SCC).We retrospectively reviewed the medical records of 467 patients treated at the University of Florida with definitive RT alone or combined with adjuvant chemotherapy (...) between 1964 and 2011 for base of tongue SCC.Median follow-up was 5.6 years. Median total dose to the primary site was 74.4 Gy. Eighty-seven patients (19%) were treated with once-daily fractionation, and 380 (81%) received altered fractionation schedules. Intensity-modulated RT was used in 128 patients (27%). Chemotherapy was administered to 173 (37%) patients. Planned neck dissection after RT was performed in 226 patients (48%). Data regarding p16 pathway activation were available for 25 patients.At

2017 Laryngoscope

192. Adenoid cystic carcinoma of the base of tongue: A population-based study. (Abstract)

Adenoid cystic carcinoma of the base of tongue: A population-based study. The objective was to assess demographic and survival patterns in patients with adenoid cystic carcinoma of the base of tongue.Patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1973 through 2012 and were categorized by age, gender, race, historical stage A, and treatment. Incidence and survival were compared with Kaplan Meier curves and mortality hazard ratios.A total of 216 (...) patients were included. After adjusting for age, gender, race and tumor-directed treatment, patients over the age of 70years had a significantly increased mortality [HR=2.847, 95% CI (1.499, 5.404) p=0.0014]. Furthermore mortality among patients with distant disease was significantly increased [HR=2.474 95% CI (1.459, 4.195) p=0.00008].By examining the largest collection of patients we have demonstrated that there is a significant difference in mortality based on both the age at diagnosis

2017 American Journal of Otolaryngology

193. Using 3 Tesla magnetic resonance imaging in the pre-operative evaluation of tongue carcinoma. (Abstract)

Using 3 Tesla magnetic resonance imaging in the pre-operative evaluation of tongue carcinoma. This study aimed to evaluate the role of 3 Tesla magnetic resonance imaging in predicting tongue tumour thickness via direct and reconstructed measures, and their correlations with corresponding histological measures, nodal metastasis and extracapsular spread.A prospective study was conducted of 25 patients with histologically proven squamous cell carcinoma of the tongue and pre-operative 3 Tesla (...) magnetic resonance imaging from 2009 to 2012.Correlations between 3 Tesla magnetic resonance imaging and histological measures of tongue tumour thickness were assessed using the Pearson correlation coefficient: r values were 0.84 (p < 0.0001) and 0.81 (p < 0.0001) for direct and reconstructed measurements, respectively. For magnetic resonance imaging, direct measures of tumour thickness (mean ± standard deviation, 18.2 ± 7.3 mm) did not significantly differ from the reconstructed measures (mean

2017 Journal of Laryngology & Otology

194. Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma. (Abstract)

Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma. Natriuretic peptide receptor A (NPRA) is one of the natriuretic peptide receptors. NPRA has been reported to play a role in the carcinogenesis of various tumours, as well as functional roles in renal, cardiovascular, endocrine, and skeletal homeostasis. The clinicopathological significance of NPRA in tongue (...) squamous cell carcinoma (TSCC) was examined in this study. The overexpression of NPRA was more frequent in TSCC (21/58, 36.2%) than in the normal oral epithelium (0/10, 0%) (P<0.05). It was also more frequently observed in cancers with higher grades according to the pattern of invasion (grades 1-2 vs. grades 3-4, P<0.01). Additionally, there was a tendency towards an association between the N classification and NPRA expression (N0 vs. N1-2, P=0.06). Significant correlations were also observed between

2017 International Journal of Oral and Maxillofacial Surgery

195. Clinical Outcomes in pT4 Tongue Carcinoma are Worse than in pT3 Disease: How Extrinsic Muscle Invasion Should be Considered? (Abstract)

Clinical Outcomes in pT4 Tongue Carcinoma are Worse than in pT3 Disease: How Extrinsic Muscle Invasion Should be Considered? The identification of extrinsic tongue muscle invasion in oral cavity cancer remains challenging. Notably, the most recent American Joint Committee on Cancer (AJCC 2017, 8th edition) staging manual indicates that extrinsic muscle invasion does not lead to the diagnosis of a T4 tumor. Because this approach carries the risk of tumor downstaging, we compared the clinical (...) outcomes of patients with oral tongue squamous cell carcinoma (SCC) staged as pT3 vs. pT4 according to the AJCC 2010, 7th edition criteria.We retrospectively examined the records of consecutive patients with pT3 (n = 135) and pT4 (n = 68) tongue SCC who underwent radical surgery. Of the 68 pT4 tongue SCC, 63 (93%) had extrinsic muscle involvement alone. The 5-year locoregional control (LRC), distant metastasis (DM), and disease-free survival (DFS) rates served as outcome measures.Compared with pT3

2017 Annals of Surgical Oncology

196. A Proposal to Redefine Close Surgical Margins in Squamous Cell Carcinoma of the Oral Tongue. Full Text available with Trip Pro

A Proposal to Redefine Close Surgical Margins in Squamous Cell Carcinoma of the Oral Tongue. Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close (...) . The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear.To determine whether the arbitrarily defined close margin (<5.0 mm) would portend as high a risk for local recurrence as a positive margin after resection of SCCOT.In this retrospective study, head and neck pathologists reviewed archived tumor specimens from 381 patients with SCCOT who underwent primary surgical resection at a tertiary care center from

2017 JAMA otolaryngology-- head & neck surgery

197. Malignant Tumors of the Palate

geographic variations, with the highest rate reported in India, accounting for 50% of all cancer cases in that country. The histologic distribution of hard palate malignant neoplasms is as follows: Squamous cell carcinoma - 53% Adenoid cystic carcinoma - 15% Mucoepidermoid carcinoma - 10% Adenocarcinoma - 4% Anaplastic carcinoma - 4% Other - 14% The histologic types and frequencies of minor salivary gland neoplasms of the palate is as follows: Benign - 26% Malignant - 74% overall Adenoid cystic carcinoma (...) - 30% Mucoepidermoid carcinoma - 16% Adenocarcinoma - 18% Malignant mixed tumor - 8% Other - 2% Next: Etiology Although a strong correlation is established between tobacco and alcohol consumption and SCC of the oral cavity and soft palate, the relationship to hard palate cancer is not as clear. Reverse smoking is a specific etiologic factor for SCC of the hard palate. In reverse smoking, the lit end of the cigarette is placed in the mouth so that an intense heat is generated during smoking. Other

2014 eMedicine Surgery

198. Malignant Tumors of the Tonsil

Surgery Updated: Aug 06, 2018 Author: Niels Kokot, MD; Chief Editor: Arlen D Meyers, MD, MBA Share Email Print Feedback Close Sections Sections Malignant Tonsil Tumor Surgery Overview Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, with over 40,000 new cases per year in the US. Of all primary HNSCCs, oropharyngeal carcinomas are the third most common, with the tonsil being the most common site of malignancy within the oropharynx. Historically (...) from 1945-1976 determined that more than 70% of malignancies in this region are squamous cell carcinoma. Squamous cell carcinomas are about 3-4 times more common in men than in women, and they are largely tumors that develop in the fifth decade of life or later. Lymphomas of the tonsil are the second most frequent malignancy in this area. Other more uncommon malignancies include minor salivary gland tumors and metastatic lesions. A study by Weatherspoon et al reported that approximately 75,468

2014 eMedicine Surgery

199. Malignant Tumors of the Floor of the Mouth

and neck cancers constitute 15% of all cancers of the body, with an incidence of 9.5 cases per 100,000 in the general population. Malignant tumors of the oral cavity account for approximately 30% of all head and neck cancers and for 5% of all cancers in the United States. Cancer of the floor of the mouth accounts for 28-35% of all oral cancers. The worldwide incidence varies greatly. Although cancer of the floor of the mouth accounts for 5% of all cancers in the United States, it accounts for 50 (...) % of all cancers in India. This difference is the result of cultural variations and habits (eg, excellent oral hygiene in the United States and betel chewing in India). Oral cavity cancers are more common in males, with a male-to-female ratio of 3-4:1. Although malignant tumors of the floor of the mouth develop most commonly after the fifth decade of life, they are not uncommon in younger persons. Previous Next: Etiology Tobacco and alcohol have additive effects on oral cancer. Tobacco includes

2014 eMedicine Surgery

200. Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Patient Version

regularly and updated as needed, by the PDQ Pediatric Treatment Editorial Board. General Information About Wilms Tumor and Other Childhood Kidney Tumors Key Points for This Section Childhood kidney tumors are diseases in which malignant (cancer) cells form in the tissues of the kidney. There are two , one on each side of the , above the waist. Tiny tubules in the kidneys and clean the . They take out waste products and make . The urine passes from each kidney through a long tube called (...) may also be called renal cell carcinoma. Rhabdoid Tumor of the Kidney is a type of kidney cancer that occurs mostly in infants and young children. It is often at the time of diagnosis. Rhabdoid tumor of the kidney grows and spreads quickly, often to the lungs or brain. Children with a certain change in the SMARCB1 are checked regularly to see if a rhabdoid tumor has formed in the kidney or has spread to the brain: Children younger than one year old have an every two to three months

2018 PDQ - NCI's Comprehensive Cancer Database

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