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Tongue Carcinoma

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1. Preliminary Results Suggest miR-139-5p Is a Viable Salivary Biomarker for Diagnosis of Tongue Squamous Cell Carcinoma (TSCC)

Preliminary Results Suggest miR-139-5p Is a Viable Salivary Biomarker for Diagnosis of Tongue Squamous Cell Carcinoma (TSCC) UTCAT3049, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Preliminary Results Suggest miR-139-5p Is a Viable Salivary Biomarker for Diagnosis of Tongue Squamous Cell Carcinoma (TSCC) Clinical Question In patients with undiagnosed tongue squamous cell carcinoma, can a salivary test conducted (...) in the dental office effectively detect tongue squamous cell carcinoma through the identification of a microRNA biomarker? Clinical Bottom Line The cohort study conducted by Duz et. al. concludes that miR-139-5p is a feasible salivary biomarker for detection of tongue squamous cell carcinoma (TSCC). This study found that expression levels of miR-139-5p in saliva of TSCC patients were significantly decreased compared to control samples. With future studies validating sensitivity and specificity, salivary

2016 UTHSCSA Dental School CAT Library

2. Nomograms to estimate long‐term overall survival and tongue cancer‐specific survival of patients with tongue squamous cell carcinoma (PubMed)

Nomograms to estimate long‐term overall survival and tongue cancer‐specific survival of patients with tongue squamous cell carcinoma The aim of this study was to construct nomograms to predict long-term overall survival (OS) and tongue cancer-specific survival (TCSS) of tongue squamous cell carcinoma (TSCC) patients based on clinical and tumor characteristics. Clinical, tumor, and treatment characteristics of 12,674 patients diagnosed with TSCC between 2004 and 2013 were collected from

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2017 Cancer medicine

3. Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space (PubMed)

Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space The lingual position of the mandibular second molar and narrow tongue space are associated with oral tongue squamous cell carcinoma (OTSCC) development in young mature patients. The present study aimed to assess the role of the mandibular second molar position and tongue space in young mature patients with OTSCC (...) second molar on the affected side and area of the tongue space were determined using coronal and axial CT images. Mann-Whitney U test analysis revealed that the location of the mandibular second molar and the area of the tongue space differed significantly between young mature patients with OTSCC and the controls. The present study thus revealed that the lingual position of the mandibular second molar and the narrow tongue space may be potential factors influencing OTSCC development in young maturity.

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2017 Oncology letters

4. Prognostic value of tumor microenvironment biomarkers in oral tongue squamous cell carcinoma (OTSCC): a systematic review

Prognostic value of tumor microenvironment biomarkers in oral tongue squamous cell carcinoma (OTSCC): a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

5. The influence of lymph node ratio on survival and disease recurrence in squamous cell carcinoma of the tongue. (PubMed)

The influence of lymph node ratio on survival and disease recurrence in squamous cell carcinoma of the tongue. This study was performed to report the outcomes of patients with oral squamous cell carcinoma (OSCC) of the tongue over a 10-year period with the aim of testing the hypothesis that the lymph node ratio (LNR) has a significant influence on loco-regional recurrence. The charts of 227 patients with OSCC of the mobile tongue treated at the University Hospital of Zurich from 2003 to 2012 (...) was diagnosed in 25 patients (28%). The overall and disease-specific survival rates for the study population were 72% and 80%, respectively. Perineural invasion was identified as an independent risk factor for decreased disease-specific survival, whereas LNR was not. LNR did not show an influence on disease recurrence. Thus, its prognostic value in patients with tongue cancer remains uncertain and the decision regarding adjuvant therapy should not be made solely on the basis of LNR.Copyright © 2019

2019 International Journal of Oral and Maxillofacial Surgery

6. Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. (PubMed)

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. To investigate the role of lingual lymph node (LLN) metastasis on locoregional control (LRC) in patients with locally advanced tongue squamous cell carcinoma (SCC).A total of 231 patients were prospectively enrolled. Analyses focused on the association between the LLN metastasis and clinical pathologic variables as well as the significance of LLN metastasis in predicting prognosis.LLNs were noted (...) in 58 patients, 33 of whom were positive for LLN metastasis. LLN metastasis was significantly related to adverse pathologic characteristics. In patients with LLN metastasis, the 5-year LRC rate was 45%. In patients without LLN metastasis, the 5-year LRC rate was 65% and the difference was significant (P = 0.013). Further, Cox model analysis confirmed the independence of LLN metastasis from prognosis prediction.LLN metastasis in locally advanced tongue SCC is relatively uncommon; however, LLNs should

2019 Laryngoscope

7. Treatment of adenoid cystic carcinoma of the mobile tongue with anterolateral thigh flap reconstruction: A case report. (PubMed)

Treatment of adenoid cystic carcinoma of the mobile tongue with anterolateral thigh flap reconstruction: A case report. Adenoid cystic carcinoma (ACC) is an infrequent malignant neoplasm of the salivary glands. The clinical and pathological characteristics include slow growth, perineural invasion, and local recurrence. ACC of the mobile tongue is rarely reported in the literature.We describe a case of a 43-year-old man patient with numbness and growth in the tongue for 1 month duration (...) . The patient reported a long-term smoking and drinking habit.A biopsy was carried out and histopathological analysis confirmed as diagnosis of adenoid cystic carcinoma. Computed tomography (CT) of the head and neck enhanced scanning revealed an ill-defined high density mass with altered enhanced signal entities involving the anterior 2/3rd of the tongue.The patient was treated with surgery and adjuvant radiotherapy. Incision was placed over the anteriorly till 2/3rd of tongue and then the femoral

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2019 Medicine

8. Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report (PubMed)

Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report Spindle cell carcinoma (SpCC), which predominantly arises in the oral, pharyngeal and laryngeal mucosal tissues, is composed of a mixture of squamous and sarcomatoid components. The present study describes the case of a 62-year-old woman with SpCC recurrence 4 years after an initial surgery to remove a well-differentiated (...) primary squamous cell carcinoma (SCC) of the tongue. The recurrent tumor was spherical and located deep within the tongue tissue, which differs from the typical manifestation of ulcerated masses of the mucosa. The majority of cases of recurrence involving SpCC are associated with radiotherapeutic treatment of the primary malignancy; however, the patient in the present study had not received postoperative radiotherapy for SCC. Furthermore, the recurrent tumor in the present case exhibited marked

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2017 Molecular and clinical oncology

9. Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue

Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02985255 Recruitment Status : Unknown Verified December 2016

2016 Clinical Trials

10. Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma (PubMed)

Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated (...) genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.

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2016 Oncotarget

11. Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial. (PubMed)

Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial. Although perineural invasion (PNI) has been recognized as a poor prognostic factor for oral cancer, few studies have focused on tongue squamous cell carcinoma (TSCC). Using a prospective randomized trial, this study investigated the role of PNI in the regional control and survival of the patients with cT1-2N0 TSCC, and clarified the benefit of neck management

2018 Surgical oncology

12. A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. (PubMed)

A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer.Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year (...)  = 0.0335).This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.

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2018 Annals of Surgical Oncology

13. miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma (PubMed)

miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortality. However, the therapeutic benefits of chemotherapy are usually attenuated due to intrinsic and/or acquired drug resistance, and a large proportion of TSCC

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2018 Journal of experimental & clinical cancer research : CR

14. Depth of invasion in superficial oral tongue carcinoma quantified using intraoral ultrasonography. (PubMed)

Depth of invasion in superficial oral tongue carcinoma quantified using intraoral ultrasonography. Depth of invasion (DOI) in oral carcinoma has been integrated into the primary tumor categories in the current tumor-node-metastasis staging (8th edition). However, there is no standard modality to determine DOI preoperatively. The aims of the present study were to evaluate the accuracy of a preoperative measurement of DOI using ultrasonography (US) for superficial oral tongue carcinomas (...) , and to correlate the values obtained with histologically determined DOI measurements.We retrospectively analyzed the records of 56 patients with oral tongue carcinoma who underwent intraoral US preoperatively, followed by curative surgery at the Shizuoka Cancer Center Hospital in Japan. For the measurement of DOI with US, our unique technique (water balloon method) was evaluated.The histologically measured tumor size (maximum diameter) showed a distribution of 7.0 to 40.0 mm (mean, 18.6 mm). The correlation

2018 Laryngoscope

15. Squamous-Cell Carcinoma of the Tongue. (PubMed)

Squamous-Cell Carcinoma of the Tongue. 27332922 2016 07 13 2016 06 23 1533-4406 374 25 2016 Jun 23 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma of the Tongue. e32 10.1056/NEJMicm1513456 Albuquerque Rui P P RP University of Birmingham, Birmingham, United Kingdom r.p.p.d.albuquerque@bham.ac.uk. Richards Andrea A University of Birmingham, Birmingham, United Kingdom r.p.p.d.albuquerque@bham.ac.uk. eng Case Reports Journal Article United (...) States N Engl J Med 0255562 0028-4793 AIM IM Aged Biopsy Carcinoma, Squamous Cell pathology Female Humans Tongue pathology Tongue Neoplasms pathology 2016 6 23 6 0 2016 6 23 6 0 2016 7 14 6 0 ppublish 27332922 10.1056/NEJMicm1513456

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2016 NEJM

16. C-reactive Protein is an independent prognostic marker in Patients with Tongue Carcinoma - a retrospective Study. (PubMed)

C-reactive Protein is an independent prognostic marker in Patients with Tongue Carcinoma - a retrospective Study. Reliable prognostic markers are lacking for tongue carcinoma. C-reactive protein (CRP) and a ratio from neutrophils/lymphocytes (NLR) are biomarkers, associated with prognosis in solid cancers. Aim of this work was to investigate the role of CRP and NLR in prognosis of patients with tongue carcinoma.Retrospective cohort study.We retrospectively analysed data of patients treated (...) for tongue carcinoma at our institution. Levels of CRP, Neutrophils and Lymphocytes were measured pretherapeutic.197 patients treated for squamous cell carcinoma of the tongue between 2002 and 2015.Overall survival, disease-free survival.Elevated CRP was significantly associated with shorter overall survival in our cohort in uni- and multivariate analysis. NLR was not associated with prognosis.In the present study we could confirm the role of CRP as an independent prognostic marker in patients

2018 Clinical Otolaryngology

17. Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis".

Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". 29449674 2019 01 21 2019 03 06 1532-1827 118 5 2018 03 06 British journal of cancer Br. J. Cancer Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". e12 10.1038/bjc.2017.491 Almangush Alhadi A Department of Pathology, University of Helsinki, Helsinki, Finland. Department of Oral and Maxillofacial (...) , Finland. Medical Research Center, Oulu University Hospital, Oulu, Finland. eng Letter Comment 2018 02 15 England Br J Cancer 0370635 0007-0920 0 Biomarkers IM Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Br J Cancer. 2018 Mar 6;118(5):e11 29449675 Biomarkers Humans Prognosis Squamous Cell Carcinoma of Head and Neck Tongue Neoplasms 2018 2 17 6 0 2019 1 22 6 0 2018 2 17 6 0 ppublish 29449674 bjc2017491 10.1038/bjc.2017.491 PMC5846078 Neoplasma. 2011;58(3):217-26 21391738 Br J Cancer. 2017 Sep 5;117

2018 British journal of cancer

18. Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'.

Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. 29449675 2019 01 21 2019 03 06 1532-1827 118 5 2018 03 06 British journal of cancer Br. J. Cancer Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. e11 10.1038/bjc.2017.482 Jayaraj Rama R Charles Darwin University, Darwin, NT 0909, Australia. Kumarasamy Chellan C Charles Darwin University, Darwin, NT 0909, Australia (...) . eng Letter Comment 2018 02 15 England Br J Cancer 0370635 0007-0920 0 Biomarkers IM Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Br J Cancer. 2018 Mar 6;118(5):e12 29449674 Biomarkers Humans Prognosis Squamous Cell Carcinoma of Head and Neck Tongue Neoplasms 2018 2 17 6 0 2019 1 22 6 0 2018 2 17 6 0 ppublish 29449675 bjc2017482 10.1038/bjc.2017.482 PMC5846075 Oncogene. 1997 Jul 31;15(5):579-84 9247311 Br J Cancer. 2017 Sep 5;117(6):856-866 28751758 Anticancer Res. 2000 May-Jun;20(3A):1343-51

2018 British journal of cancer

19. Utilizing the nanosecond pulse technique to improve antigen intracellular delivery and presentation to treat tongue squamous cell carcinoma (PubMed)

Utilizing the nanosecond pulse technique to improve antigen intracellular delivery and presentation to treat tongue squamous cell carcinoma Tongue squamous cell carcinoma is the most common squamous cell carcinoma of the head and neck. Immunotherapy has great potential in the treatment of tongue squamous cell carcinoma because of its unique advantages. However, the efficacy of immunotherapy is limited by the efficiency of antigen phagocytosis by immune cells.We extracted dendritic cells (DCs (...) of DCs to tumour lysing proteins and have good biosafety. The tumour cell killing rate of the nsPEF group was higher than the other group (p < 0.05).Utilizing nsPEF to improve the phagocytic and presenting ability of DCs could greatly activate the adaptive immune cells to enhance the immunotherapeutic effect on tongue squamous cell carcinoma.

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2018 Medicina oral, patología oral y cirugía bucal

20. CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma (PubMed)

CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma The present study evaluated the expression and potential role of CD63 in the migration and invasion of tongue squamous cell carcinoma (TSCC) cells. Immunohistochemistry (IHC) was used to investigate the association between the expression level of CD63 protein and the histological differentiation of samples from 40 patients with TSCC and four normal tongue tissue specimens. RNA interference (RNAi) and gene

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2018 Oncology letters

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