How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,552 results for

Tocolytic

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Magnesium Sulfate in the Prevention of Post-ERCP Pancreatitis.

Pancreatitis Pancreatic Diseases Digestive System Diseases Magnesium Sulfate Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

142. Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial

Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Analgesics Anticonvulsants Calcium Channel Blockers Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

143. Delayed interval delivery of the second twin in a woman with altered markers of inflammation. (PubMed)

Delayed interval delivery of the second twin in a woman with altered markers of inflammation. Delayed interval intertwin delivery rates are expected to rise during the next years as potent and targeted tocolytic agents are employed and antenatal surveillance methods become more sophisticated and specific in predicting the critical delivery timepoint of optimal perinatal outcome.We present a case of delayed intertwin delivery after delivery of the first twin due to premature prelabor rupture

Full Text available with Trip Pro

2018 BMC Pregnancy and Childbirth

144. S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor (PubMed)

S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor Tocolytics show limited efficacy to prevent preterm delivery. In uterine smooth muscle cGMP accumulation following addition of nitric oxide (NO) has little effect on relaxation suggesting a role for protein S-nitrosation. In human myometrial tissues from women in labor at term (TL), or spontaneously in labor preterm (sPTL), direct stimulation of soluble guanylyl cyclase (sGC) fails to relax (...) contraction can reveal new tocolytic targets.

Full Text available with Trip Pro

2018 Scientific reports

145. Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects (PubMed)

Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects Ritodrine is a commonly used tocolytic to prevent preterm labour. However, it can cause unexpected serious adverse reactions, such as pulmonary oedema, pulmonary congestion, and tachycardia. It is unknown whether such adverse reactions are associated with pharmacogenomic variants in patients.Whole-exome sequencing of 13 subjects with serious ritodrine-induced cardiac

Full Text available with Trip Pro

2018 BMC medical genomics

146. Rupture of a myomectomy site in the third trimester of pregnancy after myomectomy, septoplasty and cesarean section: A case report (PubMed)

, septoplasty and cesarean section. The 39-year-old woman (gravida 2, para 2) presented at 29 weeks' gestation with uterine contractions. She was successfully treated with tocolytics. At 32 weeks of pregnancy, in the absence of contractions, the patient complained of severe abdominal pain and she became hypotensive. Emergency laparotomy and cesarean section were performed, resulting in the delivery of a live infant. The myomectomy site was found to have ruptured but the cesarean and septoplasty scars were

Full Text available with Trip Pro

2018 Case Reports in Women's Health

147. Effectiveness of nifedipine in threatened preterm labor: a randomized trial (PubMed)

Effectiveness of nifedipine in threatened preterm labor: a randomized trial Threatened preterm labor is a condition in which regular uterine contractions occur at least 1 time in 10 minutes and persist for more than 30 minutes before completion of 37 weeks of gestation without dilatation of the cervix. In preterm labor with cervical dilatation, the efficacy of tocolytics was proven for prolonging pregnancy. However, in threatened preterm labor, the efficacy of tocolytics has not yet been well (...) of treatment, 88.3% of the nifedipine group and 69.9% of the placebo group had no uterine contraction (P<0.001). Nifedipine led to successful treatment outcomes in 77.6% of the total participants compared with 49.5% in the placebo group (P<0.001). The remainder of the participants from both groups needed a second-line tocolytic drug. Of these, 9.7% in the nifedipine group delivered within 48 hours compared with 12.6% in the placebo group (P>0.05). Mean gestation age at delivery and neonatal complications

Full Text available with Trip Pro

2018 International journal of women's health

148. Functional comparison of anoctamin 1 antagonists on human uterine smooth muscle contractility and excitability (PubMed)

Functional comparison of anoctamin 1 antagonists on human uterine smooth muscle contractility and excitability Pre-term birth is a major health care challenge throughout the world, and preterm labor represents a potentially reversible component of this problem. Current tocolytics do not improve preterm labor beyond 48 h. We have previously shown that anoctamin 1 (ANO1) channel blockade results in relaxation of pre-contracted human uterine smooth muscle (USM). Three drug classes with reported (...) -induced calcium flux (in vitro human USM cells) and 3) Membrane potential assay (in vitro human USM cells).Benzbromarone (BB) demonstrated the greatest potency among the compounds tested with respect to force, frequency inhibition, reducing calcium elevation and depolarizing membrane potential.While all 3 ANO1 antagonists attenuate pregnant human uterine tissue contractility and excitability, BB is the most potent tocolytic drug. Our findings may serve as a foundation for future structure-function

Full Text available with Trip Pro

2018 Journal of Smooth Muscle Research

149. A computational model of excitation and contraction in uterine myocytes from the pregnant rat (PubMed)

in intracellular calcium release) and the tocolytic nifedipine (via a block of L-type calcium channels currents) on action potentials and contractions are also reproduced, which quantitatively match to experimental data. All of these results validated the cell model development. In conclusion, the developed model provides a computational platform for further investigations of the ionic mechanism underlying the genesis and control of electrical and mechanical activities in the rat uterine myocytes.

Full Text available with Trip Pro

2018 Scientific reports

150. Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma

Anti-Asthmatic Agents Respiratory System Agents Tocolytic Agents Reproductive Control Agents Adrenergic beta-2 Receptor Agonists Adrenergic beta-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Diuretics, Osmotic

2018 Clinical Trials

151. The Effect of Dehydration on Intestinal Permeability

Imbalance Metabolic Diseases Pathologic Processes Indomethacin Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Tocolytic Agents Reproductive Control Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

152. Efficacy of Magnesium Sulfate on Reducing Renal Colic in the Emergency Department

Renal Colic Disease Attributes Pathologic Processes Infant, Newborn, Diseases Pain Neurologic Manifestations Signs and Symptoms Magnesium Sulfate Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive

2018 Clinical Trials

153. Magnesium and Vascular Stiffness

of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents Cathartics Gastrointestinal Agents Antacids

2018 Clinical Trials

154. Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth

antagonist of the oxytocin receptor in the treatment of preterm labor and its impact on the level of oxidative stress after 48 hours of tocolytic treatment. Condition or disease Intervention/treatment Phase Premature Birth Drug: Atosiban Not Applicable Detailed Description: Atosiban (1-(3-mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine-oxytocin) is licensed for clinical use in women suffering from threatened premature birth and is widely used in clinical practice in Europe (...) Status of Pregnant Women Suffering From Threatened Preterm Birth During Tocolytic Treatment With Atosiban Actual Study Start Date : February 1, 2014 Actual Primary Completion Date : June 10, 2018 Estimated Study Completion Date : December 30, 2018 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Atosiban Total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values as well as 3

2018 Clinical Trials

155. Acetaminophen vs Indomethacin in Treating hsPDA

Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Tocolytic Agents Reproductive Control Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

156. Magnesium and Intraoperative Blood Loss in Meningioma Surgery

Diseases Magnesium Sulfate Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

157. Postoperative Analgesia of Magnesium Sulfate in Suprascapular Nerve Block Following Shoulder Arthroscopy

Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

158. TAP Block in Laparoscopic Cholecystectomy.

Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Analgesics Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

159. Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis

: Layout table for MeSH terms Pancreatitis Pancreatic Diseases Digestive System Diseases Indomethacin Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Tocolytic Agents Reproductive Control Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

160. Verify the Safety and Effectiveness of the Cerclage Pessary in Prevention and Treatment of High-risk Preterm Pregnancy

of chorioamnionitis Hospitalisation for threatened preterm labour before 32 weeks(Case Report Form) [ Time Frame: before 37+0 weeks ] requirement of hospitalisation due to preterm contractions that need medical treatment to try to stop them before 31+6 weeks Mean hospital stay duration: number of days of admittance at the hospital Use of tocolytic treatment: Type of tocolytic, days of treatment, dose Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2018 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>