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Tocolytic

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121. Trimbow (beclometasone / formoterol / glycopyrronium bromide) - chronic obstructive pulmonary disease (COPD)

with Foster (BDP+FF – ratio 100+6) in the rat pre-postnatal development study. Also, it cannot be excluded that antimuscarinic effects of GB such as dry mouth or tachycardia could have compounded the tocolytic effects of FF and contributed to worsening the general health of the dams. The exposure levels at the NOAEL for FF and GB were below the human exposure levels at the recommended therapeutic dose of Trimbow in COPD patients and thus these effects may be of clinical relevance. Adequate information has

2017 European Medicines Agency - EPARs

122. WHO recommendations on interventions to improve preterm birth outcomes

not occur within 7 days after the initial dose, and a subsequent clinical assessment demonstrates that there is a high risk of preterm birth in the next 7 days. Conditional recommendation based on moderate-quality evidence for newborn outcomes and low-quality evidence for maternal outcomes Tocolytics for inhibiting preterm labour 2.0. Tocolytic treatments (acute and maintenance treatments) are not recommended for women at risk of imminent preterm birth for the purpose of improving newborn outcomes

2015 World Health Organisation Guidelines

124. Oral betamimetics for maintenance therapy after threatened preterm labour. (PubMed)

Oral betamimetics for maintenance therapy after threatened preterm labour. Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation.To assess the effects of oral betamimetic maintenance therapy after threatened preterm labour for preventing preterm birth.We updated the search of the Cochrane Pregnancy and Childbirth Group's Trials Register on 9 November 2012.Randomised (...) controlled trials comparing oral betamimetic with alternative tocolytic therapy, placebo or no therapy, for maintenance following treatment of threatened preterm labour.Two review authors independently applied the selection criteria and carried out data extraction and quality assessment of studies.We did not identify any new trials from the updated search so the results remain unchanged as follows.We included 13 randomised controlled trials (RCTs) with a total of 1551 women. We found no differences

2012 Cochrane

125. Systematic review: Calcium channel blockers are effective as first line for tocolysis in the management of preterm labour

blockers are effective as first line for tocolysis in the management of preterm labour Richard G Brown , David A MacIntyre Statistics from Altmetric.com Commentary on : Flenady V , Wojcieszek AM , Papatsonis DN , et al . Calcium channel blockers for inhibiting preterm birth . Context Preterm birth remains as the leading cause of neonatal morbidity and mortality. Although tocolytics do not reduce the risk of preterm birth, they effectively delay delivery by 48 h. 1 This creates a window of opportunity (...) for corticosteroid administration and transfer to units with neonatal intensive care unit (NICU) facilities, which improves neonatal mortality and morbidity. 2 However, a consensus on the most effective tocolytic does not exist. This study aimed to assess the effects of calcium channel blockers (CCBs) on maternal, fetal and neonatal outcomes when administered to women in preterm labour. Methods This was an updated review of randomised trials using CCBs as tocolytics for management of preterm birth. Maternal

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2014 Evidence-Based Medicine (Requires free registration)

126. Safe Prevention of the Primary Cesarean Delivery

bolus ( ), and tocolytic agents ( ) are routine components of intrauterine resuscitation ( ) that have extremely limited data for effectiveness or safety. Performance of these interventions without a subsequent change in fetal heart rate pattern is not necessarily an indication for cesarean delivery. Medication exposure, regional analgesia, rapid labor progress, cervical examination, infection, maternal hypotension, and maternal fever all can affect the fetal heart rate pattern (48). Attention

2014 American College of Obstetricians and Gynecologists

127. Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study. (PubMed)

(75.9%) with fetoscopic surgery. There were no significant differences in maternal doses of opioids or neuromuscular blocking agents. Open surgery was associated with higher dose of halogenated anaesthetic agents [maximum medium alveolar concentration (MAC) sevoflurane 1.90 vs. 1.50%, P = 0.01], higher need for intra-operative tocolytic drugs [five of seven (71.4%) and two of 22 (9.1%) required nitroglycerine, P = 0.001], higher volume of colloids (500 vs. 300 ml, P = 0.036) and more postoperative (...) tocolytic drugs (three drugs in all seven cases (100%) of open and in one of 21 (4.76%) of fetoscopic surgery, P < 0.001). Median mean arterial pressure was lower in open than in fetoscopic surgery. SBP, DBP and mean blood pressure decreased during uterine exposure, and this descent was more acute in open surgery. Use of vasoconstrictor drugs was related to the time of uterine exposure, but not to surgical technique. Blood gas analysis was not affected by CO2 insufflation during fetoscopic surgery.Open

2018 European Journal of Anaesthesiology

128. Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal

Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

129. Caudal Dexmetedomedine Versus Magnesium in Orthopedic Pediatric Surgeries

: No Additional relevant MeSH terms: Layout table for MeSH terms Bupivacaine Magnesium Sulfate Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Analgesics Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

130. Risk Analysis of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia

Hypertension Toxemia Hypertension, Pregnancy-Induced Pregnancy Complications Vascular Diseases Cardiovascular Diseases Infection Magnesium Sulfate Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control

2018 Clinical Trials

131. Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children`s Long-Term Outcome

: enrollment till birth, maximum 21 weeks ] recording of days of hospitalisation for threatened preterm labour before 31 +6 weeks of gestation and recording tocolytic treatment (type/ days/dose) premature rupture of membranes (ProM) before 31 +6 weeks of gestation [ Time Frame: enrollment till birth, maximum 21 weeks ] rate of women with premature rupture of membranes (ProM) before 31 +6 weeks of gestation Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate

2018 Clinical Trials

132. Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB

of cervical pessary at enrollment till removal of cervical pessary at WoG 37, maximum 25 weeks ] rate of maternal physical or psychological intolerance to pessary during pregnancy Hospitalisation for threatened preterm labour before 31+6 weeks [ Time Frame: randomization till birth, maximum 20 weeks ] Hospitalisation for threatened preterm labour before 31+6 weeks: recording of days of hospitalisation and tocolytic treatment: type / days / dose premature rupture of membranes (PRoM) before 31+6 weeks

2018 Clinical Trials

133. Magnesium for Shivering in Epidural Lidocaine Deliveries

-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

134. Safety and Efficacy of Intrathecally Administered Magnesium Sulfate

Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Analgesics, Opioid Narcotics Analgesics Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents Antipsychotic Agents

2018 Clinical Trials

135. Management of the PDA Trial

Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Gout Suppressants Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

136. Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers

Tissue Diseases Skin Diseases Nifedipine Iloprost Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Physiological Effects of Drugs Vasodilator Agents Tocolytic Agents Reproductive Control Agents Platelet Aggregation Inhibitors

2018 Clinical Trials

137. Effects of Noninvasive Ventilation Compared to Salbutamol

Respiratory System Agents Tocolytic Agents Reproductive Control Agents Adrenergic beta-2 Receptor Agonists Adrenergic beta-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

138. Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty

Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control Agents Anesthetics, Local

2018 Clinical Trials

139. Clinical Study on the Effect of PTH on CYP3A4 Activity

Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Physiological Effects of Drugs Vasodilator Agents Tocolytic Agents Reproductive Control Agents

2018 Clinical Trials

140. Pharmacological Prophylaxis of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis

-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Tocolytic Agents Reproductive Control Agents Cyclooxygenase Inhibitors Enzyme Inhibitors

2018 Clinical Trials

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