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Tocolytic

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21. The combination tocolytic effect of MgSO<sub>4</sub> and an oxytocin receptor antagonist in myometrium from singleton and twin pregnancies. (PubMed)

The combination tocolytic effect of MgSO4 and an oxytocin receptor antagonist in myometrium from singleton and twin pregnancies. Preterm birth at <37 weeks of gestation is the most common and costly complication of pregnancy and remains the leading cause of neonatal morbidity, death, and reduced achievement in surviving infants. Magnesium sulfate is 1 class of tocolytics for threatened preterm labor; however, its clinical efficacy has been questioned. Twin pregnancies (...) reversed in twins (P<.01).Magnesium sulfate is equipotent in suppressing contractions in singleton and twin myometrium. Oxytocin (0.5 nmol/L) significantly reduces the tocolytic potency of magnesium sulfate, which may explain, in part, magnesium sulfate's poor efficacy in vivo; however, this can be reversed partially by the use of an oxytocin receptor antagonist. Combination tocolysis that involves oxytocin receptor antagonists requires further investigation.Copyright © 2016 Elsevier Inc. All rights

2016 American Journal of Obstetrics and Gynecology

22. Success rate in preterm uterine contraction inhibition with tocolytic agents in a tertiary care center (PubMed)

Success rate in preterm uterine contraction inhibition with tocolytic agents in a tertiary care center This study aims to assess the success rate of inhibiting preterm uterine contraction with tocolytic agents to delay delivery for at least 48 hours and risk factors of failure inhibition.Between January 2013 and July 2014, medical records of all singleton pregnant women between 24 0/7 and 33 6/7 weeks of gestation with the diagnosis of preterm labor (with cervical dilatation) or threatened (...) preterm labor (without cervical dilatation) who received tocolytic agents were reviewed. The success rate of preterm uterine contraction inhibition was accounted in patients with 48 hours delayed delivery. The risk factors of the inhibition failure and neonatal outcomes were also investigated in this study.Among 424 pregnant women diagnosed of preterm labor or threatened preterm labor, 103 singleton pregnant women met the study criteria. Overall success rate of preterm uterine contraction inhibition

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2016 International journal of women's health

23. Maternal plasma nitric oxide metabolites and cervical length assessment in predicting the tocolytic therapy in preterm labor in Isfahan (PubMed)

Maternal plasma nitric oxide metabolites and cervical length assessment in predicting the tocolytic therapy in preterm labor in Isfahan Preterm labor (PTL) is the main challenge in prenatal health care, leads to high rate of mortality and increases cost of health services. To evaluate the preterm delivery (PTD)-related risk factors, we decided to measure nitrite oxide metabolites and cervical length (CL) as the diagnostic and predictive tools for PTD in women and response to tocolytic

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2016 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

24. A comparison of the effects of the most commonly used tocolytic agents on maternal and fetal blood flow (PubMed)

A comparison of the effects of the most commonly used tocolytic agents on maternal and fetal blood flow To investigate the effects of two tocolytics, nifedipine and magnesium sulfate, on Doppler indices in maternal and fetal vessels.We recruited 100 pregnant women with preterm birth between 24-36 gestational weeks who were admitted to our tertiary center over a two-year period. Patients were allocated to nifedipine (n=49) and magnesium sulfate (n=51) groups and Doppler indices of umbilical (...) sulfate increased resistance. Despite the proposed neuroprotective benefits of magnesium sulfate, nifedipine seems to be a better and safer tocolytic agent than magnesium sulfate due to its positive beneficial effects on maternal and fetal vessels.

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2016 Turkish Journal of Obstetrics and Gynecology

25. Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. (PubMed)

Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. Despite the global burden of morbidity and mortality associated with preterm birth, little evidence is available for use of antenatal corticosteroids and tocolytic drugs in preterm births in low-income and middle-income countries. We analysed data from the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS) to assess (...) antenatal corticosteroids are known to be most beneficial. We also calculated use in women at 22-25 weeks' and 34-36 weeks' gestation. We assessed tocolytic drug use, with and without antenatal corticosteroids, in spontaneous, uncomplicated preterm deliveries at 26-34 weeks' gestation.Of 303,842 recorded deliveries after 22 weeks' gestation, 17,705 (6%) were preterm. 3900 (52%) of 7547 women who gave birth at 26-34 weeks' gestation, 94 (19%) of 497 women who gave birth at 22-25 weeks' gestation

2014 Lancet

26. Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor

Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02538718 Recruitment Status : Recruiting First Posted : September 2, 2015 Last

2015 Clinical Trials

27. ATP-sensitive potassium channels modulate in vitro tocolytic effects of β2-AR agonists on uterine muscle rings in rats in early but not in late pregnancy (PubMed)

ATP-sensitive potassium channels modulate in vitro tocolytic effects of β2-AR agonists on uterine muscle rings in rats in early but not in late pregnancy To investigate whether ATP-sensitive potassium (K(ATP)) channels modulate the tocolytic effect of β2-adrenergic receptor (β2-AR) agonists (ritodrine and salmeterol) in early-pregnant (day 6) and late-pregnant (day 22) rat uterus in vitro, in order to examine the relation between the K(ATP) channel sulphonylurea-binding regulatory subunit (SUR (...) ) expression and pharmacological reactivity of β2-AR agonists.The tocolytic effects of ritodrine and salmeterol (10(-10)-10(-5) M) on spontaneous rhythmic contractions were investigated cumulatively, alone, or in the presence of the K(ATP) channel blocker glibenclamide (10(-6) M) and the K(ATP) channel opener pinacidil (10(-9)-10(-7) M) after 5-min preincubation.β2-AR agonist induced myometrial relaxation was inhibited by glibenclamide and enhanced by pinacidil on day 6, when SUR1 expression levels were

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2015 Croatian medical journal

28. Tocolytics used as adjunctive therapy at the time of cerclage placement: a systematic review. (PubMed)

Tocolytics used as adjunctive therapy at the time of cerclage placement: a systematic review. To review the published literature on whether the use of empiric perioperative tocolytic medications could provide additional benefit when used in combination with cerclage.Systematic review of published medical literature reporting the efficacy of empiric tocolytics used as a perioperative adjunct to vaginal cerclage in high-risk patients. A PubMed search without date criteria of various tocolytics (...) and cerclage yielded 42 studies. Review articles were excluded, as were reports of abdominal cerclage, emergent cerclage, or cerclage for the purpose of delayed interval delivery in twin gestations.Only five publications on the topic of perioperative tocolytic use at the time of history or ultrasound-indicated vaginal cerclage placement were identified. These included zero clinical trials, three retrospective cohort studies, one case series and one case report. Only one cohort study compared cerclage

2015 Journal of perinatology : official journal of the California Perinatal Association

29. Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. (PubMed)

Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. To determine the most effective tocolytic agent at delaying delivery.Systematic review and network meta-analysis.Cochrane Central Register of Controlled Trials, Medline, Medline In-Process, Embase, and CINAHL up to 17 February 2012.Randomised controlled trials of tocolytic therapy in women at risk of preterm delivery.At least two reviewers extracted data on study design, characteristics, number of participants (...) , and outcomes reported (neonatal and maternal). A network meta-analysis was done using a random effects model with drug class effect. Two sensitivity analyses were carried out for the primary outcome; restricted to studies at low risk of bias and restricted to studies excluding women at high risk of preterm delivery (those with multiple gestation and ruptured membranes).Of the 3263 titles initially identified, 95 randomized controlled trials of tocolytic therapy were reviewed. Compared with placebo

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2012 BMJ

30. Tocolytic therapy: a meta-analysis and decision analysis

Tocolytic therapy: a meta-analysis and decision analysis Tocolytic therapy: a meta-analysis and decision analysis Tocolytic therapy: a meta-analysis and decision analysis Haas DM, Imperiale TF, Kirkpatrick PR, Klein RW, Zollinger TW, Golichowski AM CRD summary The review concluded that all current tocolytic agents were superior to no treatment at delaying delivery of newborns for both 48 hours and seven days. In light of the limited assessment of study quality, questionable statistical (...) techniques used and an absence of any statistical investigation into variation between studies, the authors' conclusions are not likely to be reliable. Authors' objectives To determine the optimal first-line tocolytic agent for treatment of premature labour. Searching MEDLINE, EMBASE, CINAHL and Cochrane Database of Clinical Trials were searched (without language restrictions) for full published papers with dates that ranged from 1950 to January 2008; search terms were reported. Cochrane reviews were

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2009 DARE.

31. The Effects of Progesterone Therapy on the Gestation Length and Reduction of Neonatal Complications in Patients who had Received Tocolytic Therapy for Acute Phase of Preterm Labor. (PubMed)

The Effects of Progesterone Therapy on the Gestation Length and Reduction of Neonatal Complications in Patients who had Received Tocolytic Therapy for Acute Phase of Preterm Labor. While tocolytic therapy can halt the process of delivery, some patients return before the 37th week of pregnancy with recurrence of preterm labor signs.This study was designed to evaluate the efficacy of progesterone in the prolonging of gestation and reduction of neonatal complications.In a clinical trial in 2010 (...) that progesterone can significant reduce the rate of recurrent preterm labor and the several possible neonatal complications among women who had treated with tocolytics to suppress the acute phase.

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2014 Iranian Red Crescent medical journal

32. Nanovectors to Prevent Placental Passage of Tocolytic Agents

Nanovectors to Prevent Placental Passage of Tocolytic Agents Nanovectors to Prevent Placental Passage of Tocolytic Agents - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nanovectors to Prevent Placental (...) Passage of Tocolytic Agents The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02199756 Recruitment Status : Recruiting First Posted : July 24, 2014 Last Update Posted : November 2, 2018 See Sponsor: The University of Texas

2014 Clinical Trials

33. Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour

Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02068404 Recruitment Status : Unknown Verified July 2015 by Chantal Csajka, Centre

2014 Clinical Trials

34. Nifedipine versus Terbutaline, Tocolytic Effectiveness and Maternal and Neonatal Adverse Effects: a Randomized, Controlled Pilot Trial. (PubMed)

Nifedipine versus Terbutaline, Tocolytic Effectiveness and Maternal and Neonatal Adverse Effects: a Randomized, Controlled Pilot Trial. Although previous evidence suggests advantages of nifedipine over terbutaline as tocolytic agents, in some jurisdictions, terbutaline is approved for use and nifedipine is not. In women in preterm labour, we compared the impact of terbutaline versus nifedipine on inhibition of uterine contractions, preterm birth, neonatal sepsis, intracranial haemorrhage (...) of terbutaline increased tremor (76.4% versus 0%), nausea (58.8% versus 9.4%) and dizziness (29.4% versus 6.25%). The total number of side effects, and the proportion of women experiencing one or more side effects, proved greater with terbutaline. In this study, terbutaline and nifedipine performed similarly in their tocolytic effects. Each drug has specific side effects, although overall, nifedipine was associated with fewer adverse effects. © 2014 Nordic Association for the Publication of BCPT (former

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2014 Basic & clinical pharmacology & toxicology

35. Tocolytics for preterm premature rupture of membranes. (PubMed)

Tocolytics for preterm premature rupture of membranes. In women with preterm labor, tocolysis has not been shown to improve perinatal mortality; however, it is often given for 48 hours to allow for the corticosteroid effect for fetal maturation. In women with preterm premature rupture of membranes (PPROM), the use of tocolysis is still controversial. In theory, tocolysis may prolong pregnancy in women with PPROM, thereby allowing for the corticosteroid benefit and reducing the morbidity (...) and mortality associated with prematurity.To assess the potential benefits and harms of tocolysis in women with preterm premature rupture of membranes.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (15 January 2014).We included pregnant women with singleton pregnancies and PPROM (23 weeks to 36 weeks and six days). We included any tocolytic therapy compared to no tocolytic, placebo, or another tocolytic.All review authors assessed the studies for inclusion. We extracted

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2014 Cochrane database of systematic reviews (Online)

36. A comparison of three tocolytics for preterm labor: a randomized clinical trial. (PubMed)

A comparison of three tocolytics for preterm labor: a randomized clinical trial. To compare the efficacy and maternal side effects of nifedipine (N), magnesium sulfate (M), and indomethacin (I) for acute tocolysis.In this single center randomized trial, women in preterm labor 24-32 weeks' gestation received intravenous M, oral N, or I suppositories. The primary outcomes of interest were arrest of preterm labor (>48 h, ≥7 days), gestational age at delivery, and maternal side effects.Over a 38 (...) of pulmonary edema in the M group and one with plural effusion in the N group.There were no differences in efficacy or in major maternal safety issues between the three tocolytic agents. Since there is no FDA approved tocolytic to treat preterm labor, clinicians should use the tocolytic that has afforded them the best results with the least maternal/neonatal side effects.

2014 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

37. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. (PubMed)

Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Abstract Objective. To examine the epidemiology, effectiveness, and safety of tocolytics, and the variation in use of standard treatments and predictive testing for women in preterm labor (PTL) transported to tertiary care. Methods. This was a health record review of consecutive PTL patients (<38 weeks gestation) transported to a tertiary care facility by Ontario's air and land critical care transport service between (...) January 1, 2006 and January 1, 2011. The primary outcome was the effectiveness of tocolytics in decreasing the frequency of contractions and incidence of delivery. Secondary outcomes included the type of tocolytics used, adverse events (defined a priori), use of standard treatments (corticosteroid, antibiotic), and use of predictive tests (cervical length measurement, fetal fibronectin). We report descriptive statistics and relative risk of contractions decreasing with tocolytics with 95% confidence

2014 Prehospital emergency care

38. The use of tocolytic therapy in a pregnant trauma patient

The use of tocolytic therapy in a pregnant trauma patient BestBets: The use of tocolytic therapy in a pregnant trauma patient The use of tocolytic therapy in a pregnant trauma patient Report By: Helene Svinos - Medical Student Search checked by Anna O' Malley - Medical Student Institution: University of Manchester Date Submitted: 9th June 2008 Date Completed: 11th March 2009 Last Modified: 11th March 2009 Status: Green (complete) Three Part Question In a [pregnant trauma patient] does (...) [tocolytic therapy] improve [outcome for mother and foetus]? Clinical Scenario A pregnant woman of 32 weeks gestation is admitted to the ED after a fall. She has blunt abdominal trauma and is having what seem to be uterine contractions. You wonder whether you start tocolytic therapy to try to prevent or delay a premature delivery and so prevent some of the possible complications for both mother and baby. Search Strategy Medline 1950 to November week 1 2008 using Ovid Interface EMBASE 1980-2008 Week 1

2009 BestBETS

39. Calcium Channel Blockers as Tocolytics: Principles of Their Actions, Adverse Effects and Therapeutic Combinations (PubMed)

Calcium Channel Blockers as Tocolytics: Principles of Their Actions, Adverse Effects and Therapeutic Combinations Dihydropyridine Ca2+ channel blockers (CCBs) are widely accepted in the treatment of premature labour. Their mechanism of action in tocolysis involves the blockade of L-type Ca2+ channels, influenced by the Ca2+-activated K+ channels, beta-adrenergic receptors (β-ARs) and sexual hormones. In clinical practice, most experience has been gained with the use of nifedipine, whose (...) efficacy is superior or comparable to those of β-agonists and oxytocin antagonists. Additionally, it has a favourable adverse effect profile as compared with the majority of other tocolytics. The most frequent and well-tolerated side-effects of CCBs are tachycardia, headache and hypotension. In tocolytic therapy efforts are currently being made to find combinations of tocolytic agents that yield better therapeutic action. The available human and animal studies suggest that the combination of CCBs

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2013 Pharmaceuticals

40. Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery

Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery (UTM/2012) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01796522 Recruitment Status : Withdrawn (have been published new studies

2013 Clinical Trials

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