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Tocolytic

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2. Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment Full Text available with Trip Pro

Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment - GOV.UK GOV.UK uses cookies to make the site simpler. Search Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment Monitor (...) patients closely and remove the vaginal delivery system immediately in cases of excessive or prolonged uterine contractions, at the onset of labour, or if there is clinical concern for mother or baby. Published 6 February 2018 From: Therapeutic area: Contents Advice for healthcare professionals: Mysodelle can cause uterine tachysystole that may not respond to tocolytic treatment monitor patients closely and remove the vaginal delivery system immediately if any of the following apply: tachysystole: more

2018 MHRA Drug Safety Update

3. Antenatal corticosteroid administration in women undergoing tocolytic treatment who delivered before 34 weeks of gestation: a retrospective cohort study using a national inpatient database. Full Text available with Trip Pro

Antenatal corticosteroid administration in women undergoing tocolytic treatment who delivered before 34 weeks of gestation: a retrospective cohort study using a national inpatient database. Antenatal corticosteroid treatment is globally recommended for women at risk of giving birth before 34 weeks of gestation. In Japan, data on the rate of completing recommended antenatal corticosteroid treatment are lacking. This study aimed to: (i) determine the proportion of patients treated for threatened (...) preterm birth with tocolysis who received antenatal glucocorticoids; and (ii) analyze the association between long-term tocolysis and antenatal glucocorticoids treatment as recommended.This was a retrospective cohort study using a national inpatient database in Japan. We selected pregnant women who had undergone treatment in hospitals due to threatened preterm birth and received the tocolytic ritodrine hydrochloride by infusion from July 2010 to March 2016, and delivered at < 34 weeks of gestation

2019 BMC Pregnancy and Childbirth

4. Tocolytic therapy for preterm delivery: systematic review and network meta-analysis

Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Haas DM, Caldwell DM, Kirkpatrick P, McIntosh JJ, Welton NJ CRD summary This review concluded that prostaglandin inhibitors and calcium channel blockers had the highest probability of delaying delivery and improving neonatal and maternal outcomes (...) . This was a generally well-conducted review and the conclusions are likely to be reliable based on the information available. Authors' objectives To determine the most effective tocolytic agent at delaying delivery in women at risk of preterm delivery. Searching MEDLINE, EMBASE, CINAHL and Cochrane Central Register of Controlled Trials (CENTRAL) were searched without language restrictions to 2012; search terms were reported. Bibliographies of Cochrane reviews were searched for additional studies. Abstracts

2012 DARE.

5. Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first-in-human trial in healthy postmenopausal women. Full Text available with Trip Pro

Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first-in-human trial in healthy postmenopausal women. Preterm birth remains a significant risk for later disability. The selective inhibition of the prostaglandin F2α receptor has significant advantages for a tocolytic. The prodrug OBE022 and its metabolite OBE002 are novel prostaglandin F2α receptor antagonists under development for treating preterm labour.We performed

2018 British journal of clinical pharmacology Controlled trial quality: uncertain

6. Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo-controlled randomized trial. (Abstract)

Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo-controlled randomized trial. Our aim was to investigate the effect of the prophylactic use of vaginal progesterone on the latency period from the initiation of tocolytic therapy to delivery in twin pregnancies with preterm labor.This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies in mothers who were exposed

2018 The journal of obstetrics and gynaecology research Controlled trial quality: predicted high

7. Atrial Fibrillation as a Rare Complication of the Use of Nifedipine as a Tocolytic Agent: A Case Report and Review of the Literature Full Text available with Trip Pro

Atrial Fibrillation as a Rare Complication of the Use of Nifedipine as a Tocolytic Agent: A Case Report and Review of the Literature Calcium channel blockers are commonly used tocolytic agents on Labor and Delivery units worldwide as part of the management of preterm labor. Despite their overall reassuring safety profile, rare cardiovascular complications have been reported. In this report, we describe the case of threatened preterm labor managed with nifedipine with subsequent development

2018 Case reports in obstetrics and gynecology

8. Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties Full Text available with Trip Pro

Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA-approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S-nitrosation. The recent discovery

2018 Journal of cellular and molecular medicine

9. Tocolytic action and underlying mechanism of galetin 3,6-dimethyl ether on rat uterus. Full Text available with Trip Pro

Tocolytic action and underlying mechanism of galetin 3,6-dimethyl ether on rat uterus. Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from aerial parts of Piptadenia stipulacea. Previously, FGAL was shown to inhibit both carbachol- and oxytocin-induced phasic contractions in the rat uterus, which was more potent with oxytocin. Thus, in this study, we aimed to investigate the tocolytic action mechanism of FGAL on the rat uterus.Segments of rat uterus ileum were suspended in organ bath

2017 BMC Complementary and Alternative Medicine

10. Bitter taste receptors as targets for tocolytics in preterm labor therapy Full Text available with Trip Pro

Bitter taste receptors as targets for tocolytics in preterm labor therapy Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently identifying novel targets for tocolytics are essential for more successful management of PTB. Here we report that myometrial cells from human and mouse express bitter taste (...) myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca2+]i Finally, ChQ prevents mouse PTBs induced by bacterial endotoxin LPS or progesterone receptor antagonist mifepristone more often than current commonly used tocolytics, and this prevention is largely lost in α-gustducin-knockout mice. Collectively, our results reveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometrium

2017 The FASEB Journal

11. The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial Full Text available with Trip Pro

The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic effects of MgSO4 and another drug (...) M. However, one-minute Apgar scores for newborns were higher in women treated with MgSO4 compared to that of phenytoin (P = 0.001). Five-minute Apgar was not significantly different. Conclusion: Although MgSO4 is more effective than phenytoin for prevention of convulsion in eclampsia and severe preeclampsia, phenytoin may be considered for treatment of special conditions such as mild preeclampsia. Due to the tocolytic effects of MgSO4 on increasing the duration of labor, the increased risk

2017 Iranian journal of neurology Controlled trial quality: uncertain

12. Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor

Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03040752 Recruitment Status : Completed First Posted : February 2, 2017 Last Update Posted : February 2

2017 Clinical Trials

13. Tocolytic

Tocolytic Tocolytic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tocolytic Tocolytic Aka: Tocolytic , Tocolysis II. Indications III (...) . Contraindications (See specific medications) or lethal fetal anomaly <100 >180 or Maternal bleeding with hemodynamic instability Maternal Systolic <90 mmHg Maternal cardiopulmonary symptoms (e.g. , ) IV. Preparations: Preferred Tocolytics ral Indications Stops labor for 24-48 hours Allows maternal transport and doses Load: 6 grams bolus IV over 20 min (Very high dose!, some protocols use 4 g load) Maintenance: 2 grams/hour IV infusion (max: 3 g/h) Must follow protocols for patient safety Tocolytic

2018 FP Notebook

14. Tocolytic Drugs Preterm Labour

Tocolytic Drugs Preterm Labour Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Search Search Toggle navigation Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Back to guidelines homepage Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Published: 22/02/2011 This guideline has been archived. Please see the . share this Royal College of Obstetricians and Gynaecologists © 2019 Registered charity no. 213280 27 Sussex Place Regent's Park London NW1 4RG UK Tel

2011 Royal College of Obstetricians and Gynaecologists

15. Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. (Abstract)

Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. Despite the global burden of morbidity and mortality associated with preterm birth, little evidence is available for use of antenatal corticosteroids and tocolytic drugs in preterm births in low-income and middle-income countries. We analysed data from the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS) to assess (...) antenatal corticosteroids are known to be most beneficial. We also calculated use in women at 22-25 weeks' and 34-36 weeks' gestation. We assessed tocolytic drug use, with and without antenatal corticosteroids, in spontaneous, uncomplicated preterm deliveries at 26-34 weeks' gestation.Of 303,842 recorded deliveries after 22 weeks' gestation, 17,705 (6%) were preterm. 3900 (52%) of 7547 women who gave birth at 26-34 weeks' gestation, 94 (19%) of 497 women who gave birth at 22-25 weeks' gestation

2014 Lancet

16. Uterotonics and tocolytics for anesthesiologists. Full Text available with Trip Pro

Uterotonics and tocolytics for anesthesiologists. Obstetric anesthesiologists are supposed to understand the uterotonics and tocolytics used in the perinatal period to provide a better clinical practice. This review describes current consensus of uterotonics and tocolytics used in the perinatal period that an obstetric anesthesiologist should know.Rational use of uterotonics for cesarean section has been well studied in the past decades. Oxytocin remained as a first line uterotonics (...) , and it has been reported that methylergonovine is a superior second-line uterotonic to carboprost. On the other hand, the role of tocolytic agents in obstetric anesthesia has not been well studied.Anesthesiologists involved in obstetric anesthesia should be able to determine the appropriate uterotonic for cesarean section and know the indication of tocolytics in perinatal period.

2016 Current Opinion in Anaesthesiology

17. Success rate in preterm uterine contraction inhibition with tocolytic agents in a tertiary care center Full Text available with Trip Pro

Success rate in preterm uterine contraction inhibition with tocolytic agents in a tertiary care center This study aims to assess the success rate of inhibiting preterm uterine contraction with tocolytic agents to delay delivery for at least 48 hours and risk factors of failure inhibition.Between January 2013 and July 2014, medical records of all singleton pregnant women between 24 0/7 and 33 6/7 weeks of gestation with the diagnosis of preterm labor (with cervical dilatation) or threatened (...) preterm labor (without cervical dilatation) who received tocolytic agents were reviewed. The success rate of preterm uterine contraction inhibition was accounted in patients with 48 hours delayed delivery. The risk factors of the inhibition failure and neonatal outcomes were also investigated in this study.Among 424 pregnant women diagnosed of preterm labor or threatened preterm labor, 103 singleton pregnant women met the study criteria. Overall success rate of preterm uterine contraction inhibition

2016 International journal of women's health

18. A comparison of the effects of the most commonly used tocolytic agents on maternal and fetal blood flow Full Text available with Trip Pro

A comparison of the effects of the most commonly used tocolytic agents on maternal and fetal blood flow To investigate the effects of two tocolytics, nifedipine and magnesium sulfate, on Doppler indices in maternal and fetal vessels.We recruited 100 pregnant women with preterm birth between 24-36 gestational weeks who were admitted to our tertiary center over a two-year period. Patients were allocated to nifedipine (n=49) and magnesium sulfate (n=51) groups and Doppler indices of umbilical (...) sulfate increased resistance. Despite the proposed neuroprotective benefits of magnesium sulfate, nifedipine seems to be a better and safer tocolytic agent than magnesium sulfate due to its positive beneficial effects on maternal and fetal vessels.

2016 Turkish Journal of Obstetrics and Gynecology

19. Maternal plasma nitric oxide metabolites and cervical length assessment in predicting the tocolytic therapy in preterm labor in Isfahan Full Text available with Trip Pro

Maternal plasma nitric oxide metabolites and cervical length assessment in predicting the tocolytic therapy in preterm labor in Isfahan Preterm labor (PTL) is the main challenge in prenatal health care, leads to high rate of mortality and increases cost of health services. To evaluate the preterm delivery (PTD)-related risk factors, we decided to measure nitrite oxide metabolites and cervical length (CL) as the diagnostic and predictive tools for PTD in women and response to tocolytic

2016 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

20. Tocolytic Therapy for Preterm Labor in Multiple Gestation

Tocolytic Therapy for Preterm Labor in Multiple Gestation Tocolytic Therapy for Preterm Labor in Multiple Gestation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tocolytic Therapy for Preterm Labor (...) Center Information provided by (Responsible Party): Tel-Aviv Sourasky Medical Center Study Details Study Description Go to Brief Summary: To compare the tocolytic efficacy oxytocin receptor antagonist (Atosiban) with that of calcium channel blockers (Nifedipine) among women with multiple gestation who present with threatened preterm labor. Condition or disease Intervention/treatment Phase Labor Preterm Multiple Drug: Atosiban Drug: Nifedipine Phase 3 Detailed Description: Preterm birth remains

2016 Clinical Trials

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