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Tocolytic

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2. Combination of tocolytic agents for inhibiting preterm labour. (PubMed)

Combination of tocolytic agents for inhibiting preterm labour. Preterm birth represents the single largest cause of mortality and morbidity for newborns and a major cause of morbidity for pregnant women. Tocolytic agents include a wide range of drugs that can inhibit labour to prolong pregnancy. This may gain time to allow the fetus to mature further before being born, permit antenatal corticosteroid administration for lung maturation, and allow time for intra-uterine transfer to a hospital (...) with neonatal intensive care facilities. However, some tocolytic drugs are associated with severe side effects. Combinations of tocolytic drugs may be more effective over single tocolytic agents or no intervention, without adversely affecting the mother or neonate.To assess the effects on maternal, fetal and neonatal outcomes of any combination of tocolytic drugs for the treatment of preterm labour when compared with any other treatment, no treatment or placebo.We searched the Cochrane Pregnancy

2014 Cochrane

3. Antenatal corticosteroid administration in women undergoing tocolytic treatment who delivered before 34 weeks of gestation: a retrospective cohort study using a national inpatient database. (PubMed)

Antenatal corticosteroid administration in women undergoing tocolytic treatment who delivered before 34 weeks of gestation: a retrospective cohort study using a national inpatient database. Antenatal corticosteroid treatment is globally recommended for women at risk of giving birth before 34 weeks of gestation. In Japan, data on the rate of completing recommended antenatal corticosteroid treatment are lacking. This study aimed to: (i) determine the proportion of patients treated for threatened (...) preterm birth with tocolysis who received antenatal glucocorticoids; and (ii) analyze the association between long-term tocolysis and antenatal glucocorticoids treatment as recommended.This was a retrospective cohort study using a national inpatient database in Japan. We selected pregnant women who had undergone treatment in hospitals due to threatened preterm birth and received the tocolytic ritodrine hydrochloride by infusion from July 2010 to March 2016, and delivered at < 34 weeks of gestation

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2019 BMC Pregnancy and Childbirth

4. Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo-controlled randomized trial. (PubMed)

Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo-controlled randomized trial. Our aim was to investigate the effect of the prophylactic use of vaginal progesterone on the latency period from the initiation of tocolytic therapy to delivery in twin pregnancies with preterm labor.This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies in mothers who were exposed

2018 The journal of obstetrics and gynaecology research

5. Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first-in-human trial in healthy postmenopausal women. (PubMed)

Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first-in-human trial in healthy postmenopausal women. Preterm birth remains a significant risk for later disability. The selective inhibition of the prostaglandin F2α receptor has significant advantages for a tocolytic. The prodrug OBE022 and its metabolite OBE002 are novel prostaglandin F2α receptor antagonists under development for treating preterm labour.We performed

2018 British journal of clinical pharmacology

6. Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment

Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment - GOV.UK GOV.UK uses cookies to make the site simpler. Search Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment Monitor (...) patients closely and remove the vaginal delivery system immediately in cases of excessive or prolonged uterine contractions, at the onset of labour, or if there is clinical concern for mother or baby. Published 6 February 2018 From: Therapeutic area: Contents Advice for healthcare professionals: Mysodelle can cause uterine tachysystole that may not respond to tocolytic treatment monitor patients closely and remove the vaginal delivery system immediately if any of the following apply: tachysystole: more

2018 MHRA Drug Safety Update

7. Atrial Fibrillation as a Rare Complication of the Use of Nifedipine as a Tocolytic Agent: A Case Report and Review of the Literature (PubMed)

Atrial Fibrillation as a Rare Complication of the Use of Nifedipine as a Tocolytic Agent: A Case Report and Review of the Literature Calcium channel blockers are commonly used tocolytic agents on Labor and Delivery units worldwide as part of the management of preterm labor. Despite their overall reassuring safety profile, rare cardiovascular complications have been reported. In this report, we describe the case of threatened preterm labor managed with nifedipine with subsequent development

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2018 Case reports in obstetrics and gynecology

8. Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties (PubMed)

Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA-approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S-nitrosation. The recent discovery

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2018 Journal of cellular and molecular medicine

9. Tocolytic therapy for preterm delivery: systematic review and network meta-analysis

Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Tocolytic therapy for preterm delivery: systematic review and network meta-analysis Haas DM, Caldwell DM, Kirkpatrick P, McIntosh JJ, Welton NJ CRD summary This review concluded that prostaglandin inhibitors and calcium channel blockers had the highest probability of delaying delivery and improving neonatal and maternal outcomes (...) . This was a generally well-conducted review and the conclusions are likely to be reliable based on the information available. Authors' objectives To determine the most effective tocolytic agent at delaying delivery in women at risk of preterm delivery. Searching MEDLINE, EMBASE, CINAHL and Cochrane Central Register of Controlled Trials (CENTRAL) were searched without language restrictions to 2012; search terms were reported. Bibliographies of Cochrane reviews were searched for additional studies. Abstracts

2012 DARE.

10. Tocolytic Drugs Preterm Labour

Tocolytic Drugs Preterm Labour Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Search Search Toggle navigation Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Back to guidelines homepage Preterm Labour, Tocolytic Drugs (Green-top Guideline No. 1B) Published: 22/02/2011 This guideline has been archived. Please see the . share this Royal College of Obstetricians and Gynaecologists © 2019 Registered charity no. 213280 27 Sussex Place Regent's Park London NW1 4RG UK Tel

2011 Royal College of Obstetricians and Gynaecologists

11. Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor

Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03040752 Recruitment Status : Completed First Posted : February 2, 2017 Last Update Posted : February 2

2017 Clinical Trials

12. Tocolytic action and underlying mechanism of galetin 3,6-dimethyl ether on rat uterus. (PubMed)

Tocolytic action and underlying mechanism of galetin 3,6-dimethyl ether on rat uterus. Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from aerial parts of Piptadenia stipulacea. Previously, FGAL was shown to inhibit both carbachol- and oxytocin-induced phasic contractions in the rat uterus, which was more potent with oxytocin. Thus, in this study, we aimed to investigate the tocolytic action mechanism of FGAL on the rat uterus.Segments of rat uterus ileum were suspended in organ bath

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2017 BMC Complementary and Alternative Medicine

13. Bitter taste receptors as targets for tocolytics in preterm labor therapy (PubMed)

Bitter taste receptors as targets for tocolytics in preterm labor therapy Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently identifying novel targets for tocolytics are essential for more successful management of PTB. Here we report that myometrial cells from human and mouse express bitter taste (...) myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca2+]i Finally, ChQ prevents mouse PTBs induced by bacterial endotoxin LPS or progesterone receptor antagonist mifepristone more often than current commonly used tocolytics, and this prevention is largely lost in α-gustducin-knockout mice. Collectively, our results reveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometrium

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2017 The FASEB Journal

14. The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial (PubMed)

The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic effects of MgSO4 and another drug (...) M. However, one-minute Apgar scores for newborns were higher in women treated with MgSO4 compared to that of phenytoin (P = 0.001). Five-minute Apgar was not significantly different. Conclusion: Although MgSO4 is more effective than phenytoin for prevention of convulsion in eclampsia and severe preeclampsia, phenytoin may be considered for treatment of special conditions such as mild preeclampsia. Due to the tocolytic effects of MgSO4 on increasing the duration of labor, the increased risk

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2017 Iranian journal of neurology

15. Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor

Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02989519 Recruitment Status : Completed First Posted : December 12, 2016 Last Update Posted

2016 Clinical Trials

16. Tocolytic Therapy for Preterm Labor in Multiple Gestation

Tocolytic Therapy for Preterm Labor in Multiple Gestation Tocolytic Therapy for Preterm Labor in Multiple Gestation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tocolytic Therapy for Preterm Labor (...) Center Information provided by (Responsible Party): Tel-Aviv Sourasky Medical Center Study Details Study Description Go to Brief Summary: To compare the tocolytic efficacy oxytocin receptor antagonist (Atosiban) with that of calcium channel blockers (Nifedipine) among women with multiple gestation who present with threatened preterm labor. Condition or disease Intervention/treatment Phase Labor Preterm Multiple Drug: Atosiban Drug: Nifedipine Phase 3 Detailed Description: Preterm birth remains

2016 Clinical Trials

17. Progesterone as a tocolytic agent for preterm labor: a systematic review. (PubMed)

Progesterone as a tocolytic agent for preterm labor: a systematic review. Tocolytic agents have been used for over 60 years in the fight against preterm labor, which ultimately can lead to preterm birth. Currently, clinicians can choose from a variety of drug classes to achieve the primary goal of delaying delivery by 48 h, thereby allowing time for administration of corticosteroids for fetal lung maturity, and if appropriate, starting magnesium sulfate for fetal neuroprotection. However (...) , there are currently no known therapies to maintain the tocolytic effect beyond those initial 48 h.Progesterone, which has been used in the prevention of preterm birth for over 10 years, has long been known to have the effect of uterine quiescence. It was first studied as a tocolytic agent in the 1960s. In the last several years, more studies have been done that suggest a potential use for maintenance tocolysis after the successful arrest of preterm labor. Although the studies are conflicting, the meta-analyses

2016 Current opinion in obstetrics & gynecology

18. Effect of Tocolytic Drugs on Fetal Heart Rate Variability: a Systematic Review. (PubMed)

Effect of Tocolytic Drugs on Fetal Heart Rate Variability: a Systematic Review. Tocolytics may cause changes in fetal heart rate (HR) pattern, while fetal heart rate variability (HRV) is an important marker of fetal well-being. We aim to systematically review the literature on how tocolytic drugs affect fetal HRV.We searched CENTRAL, PubMed and EMBASE up to June 2016. Studies published in English, using computerized or visual analysis to describe the effect of tocolytics on HRV in human fetuses (...) were included. Studies describing tocolytics during labor, external cephalic version, pre-eclampsia and infection were excluded. Eventually, we included six studies, describing 169 pregnant women.Nifedipine, atosiban and indomethacin administration show no clinically important effect on fetal HRV. Following administration of magnesium sulfate decreased variability and cases of bradycardia are described. Fenoterol administration results in a slight increase in fetal HR with no changes in variability

2016 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

19. Uterotonics and tocolytics for anesthesiologists. (PubMed)

Uterotonics and tocolytics for anesthesiologists. Obstetric anesthesiologists are supposed to understand the uterotonics and tocolytics used in the perinatal period to provide a better clinical practice. This review describes current consensus of uterotonics and tocolytics used in the perinatal period that an obstetric anesthesiologist should know.Rational use of uterotonics for cesarean section has been well studied in the past decades. Oxytocin remained as a first line uterotonics (...) , and it has been reported that methylergonovine is a superior second-line uterotonic to carboprost. On the other hand, the role of tocolytic agents in obstetric anesthesia has not been well studied.Anesthesiologists involved in obstetric anesthesia should be able to determine the appropriate uterotonic for cesarean section and know the indication of tocolytics in perinatal period.

2016 Current Opinion in Anaesthesiology

20. Tocolytic

Tocolytic Tocolytic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tocolytic Tocolytic Aka: Tocolytic , Tocolysis II. Indications III (...) . Contraindications (See specific medications) or lethal fetal anomaly <100 >180 or Maternal bleeding with hemodynamic instability Maternal Systolic <90 mmHg Maternal cardiopulmonary symptoms (e.g. , ) IV. Preparations: Preferred Tocolytics ral Indications Stops labor for 24-48 hours Allows maternal transport and doses Load: 6 grams bolus IV over 20 min (Very high dose!, some protocols use 4 g load) Maintenance: 2 grams/hour IV infusion (max: 3 g/h) Must follow protocols for patient safety Tocolytic

2018 FP Notebook

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