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Tissue Adhesive

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161. Biocompatibility of a Self-adhesive Gutta-percha-based Material in Subcutaneous Tissue of Mice. (PubMed)

Biocompatibility of a Self-adhesive Gutta-percha-based Material in Subcutaneous Tissue of Mice. The purpose of this study was to evaluate the biocompatibility of a self-adhesive gutta-percha material and compare it with that of conventional gutta-percha.Standard quantities of bioactive gutta-percha and conventional gutta-percha were directly inserted subcutaneously into the dorsal connective tissue of 30 BALB/c mice according to ISO 10993-6. After 7, 21, and 63 days each, 10 animals were (...) euthanized, and the materials and surrounding tissue were removed. Tissue samples were subjected to histological processing resulting in 5-μm-thick slices stained with hematoxylin-eosin and Gomori trichrome stain. A grade ranging from I-IV was used to classify the inflammatory reaction. The Mann-Whitney U test with Bonferroni correction was used to compare the grade of inflammation induced by the materials at each time point. Qualitative evaluation of biocompatibility over time was also

2014 Journal of Endodontics

162. Sutures, needles, and tissue adhesives: a review for dermatologic surgery. (PubMed)

Sutures, needles, and tissue adhesives: a review for dermatologic surgery. Dermatologic surgery generally requires the removal of offending or excessive tissue followed by repair of the resultant defect. The functional and cosmetic outcome is increasingly important as patients' expectations grow and physicians become increasingly aware of surgical materials and techniques that enable them to repair defects in a functionally and cosmetically appealing manner.To perform an updated and thorough (...) review of the literature regarding sutures, surgical tape, tissue adhesives and stitching techniques.A comprehensive literature review was conducted on-line via multiple search engines and sites using the keywords suture, suture techniques, suturing techniques, surgical techniques, surgical tapes, surgical adhesives, and tissue adhesives.There are numerous articles on sutures, surgical tape, and tissue adhesives, but there are no current articles that review them together in a comprehensive manner

2014 Dermatologic Surgery

163. Phase 4 Field Trial of the Unicirc Instrument With Tissue Adhesive

Phase 4 Field Trial of the Unicirc Instrument With Tissue Adhesive Phase 4 Field Trial of the Unicirc Instrument With Tissue Adhesive - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Phase 4 Field Trial (...) of the Unicirc Instrument With Tissue Adhesive (Unicirc003) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02091726 Recruitment Status : Completed First Posted : March 19, 2014 Results First Posted : December 11, 2014 Last Update Posted : September 6, 2018 Sponsor: Simunye Primary Health Care Information

2014 Clinical Trials

164. Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion. (PubMed)

Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion. Connective tissue growth factor (CTGF) plays important roles in normal and pathological conditions. The aim of this study was to investigate the role of CTGF in peritoneal metastasis as well as the underlying mechanism in gastric cancer progression.CTGF expression levels for wild-type and stable overexpression clones were determined by Western blotting and quantitative (...) polymerase chain reaction (Q-PCR). Univariate and multivariate analyses, immunohistochemistry, and survival probability analyses were performed on gastric cancer patients. The extracellular matrix components involved in CTGF-regulated adhesion were determined. Recombinant CTGF was added to cells or coinoculated with gastric cancer cells into mice to evaluate its therapeutic potential.CTGF overexpression and treatment with the recombinant protein significantly inhibited cell adhesion. In vivo peritoneal

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2014 Gastric Cancer

165. Prognostic and diagnostic implications of epithelial cell adhesion/activating molecule (EpCAM) expression in renal tumours: a retrospective clinicopathological study of 948 cases using tissue microarrays. (PubMed)

Prognostic and diagnostic implications of epithelial cell adhesion/activating molecule (EpCAM) expression in renal tumours: a retrospective clinicopathological study of 948 cases using tissue microarrays. To evaluate the expression and prognostic value of epithelial cell adhesion/activating molecule (EpCAM) in a large set of renal cell carcinomas (RCCs) using a tissue microarray (TMA) approach.We studied the immunohistochemical expression and overexpression of EpCAM on TMAs containing formalin

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2014 BJU international

166. A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage (PubMed)

A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage The architecture and morphogenetic properties of tissues are founded in the tissue-specific regulation of cell behaviors. In endochondral bones, the growth plate cartilage promotes bone elongation via regulated chondrocyte maturation within an ordered, three-dimensional cell array. A key event in the process that generates this cell array is the transformation of disordered resting chondrocytes into clonal (...) polarity, such as cell body alignment, are not prerequisites for oriented cell behavior. Our results support a model in which regulation of adhesive surface dynamics and cortical tension by extrinsic signaling modifies the thermodynamic landscape to promote organization of daughter cells in the context of the three-dimensional growth plate tissue.

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2014 Development (Cambridge, England)

167. The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders. (PubMed)

The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders. The aim of this study was to evaluate the efficiency of two local hemostatic agents administered with apreoperative dose of replacement therapy in patients with bleeding disorders undergoing oral surgery.The study included 21 patients that were randomly divided into 3 groups. Patients in Group1 (n = 7) received preoperative replacement therapy and postoperative fibrin sealant applied (...) to the surgical site. Patientsin Group 2 (n = 7) received preoperative replacement therapy and postoperative tissue adhesive applied to the surgicalsite. Patients in Group 3 (n = 7) were given replacement therapy pre- and postoperatively.Postoperative bleeding was not observed in 17 of the 21 patients, including 5 in Group 1 (71.42%), 6 in Group2 (85.71%), and 6 in Group 3 (85.71%). Hemorrhagic complications occurred in only 4 of the 21 patients.The use of fibrin sealant and tissue adhesive was beneficial

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2014 Turkish journal of haematology : official journal of Turkish Society of Haematology Controlled trial quality: uncertain

168. A pilot trial of bordered polyurethane dressings, tissue adhesive and sutureless devices compared with standard polyurethane dressings for securing short-term arterial catheters. (PubMed)

A pilot trial of bordered polyurethane dressings, tissue adhesive and sutureless devices compared with standard polyurethane dressings for securing short-term arterial catheters. To improve arterial catheter (AC) securement and reduce AC failure; to assess feasibility of a large randomised controlled trial.A four-arm, parallel, randomised, controlled, non-blinded pilot trial with 195 intensive care patients taking part, in a tertiary referral hospital in Brisbane, Australia from May to November (...) 2012.Standard polyurethane (SPU) dressing (controls); bordered polyurethane (BPU) + SPU dressing; tissue adhesive (TA) + SPU dressing; and sutureless securement device (SSD) + SPU dressing (no sutures used).AC failure, ie, complete dislodgement, occlusion (monitor failure, inability to infuse or fluid leaking), pain or infection (local or blood).Median AC dwell time was 26.2 hours and was comparable between groups. AC failure occurred in 26/195 patients (13%). AC failure was significantly worse

2014 Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Controlled trial quality: predicted high

169. Is It Possible to Eliminate Sutures in Open (Lichtenstein Technique) and Laparoscopic (Totally Extraperitoneal Endoscopic) Inguinal Hernia Repair? A Randomized Controlled Trial With Tissue Adhesive (n-Hexyl-α-Cyanoacrylate). (PubMed)

Is It Possible to Eliminate Sutures in Open (Lichtenstein Technique) and Laparoscopic (Totally Extraperitoneal Endoscopic) Inguinal Hernia Repair? A Randomized Controlled Trial With Tissue Adhesive (n-Hexyl-α-Cyanoacrylate). The morbidity linked to the use of sutures in inguinal hernioplasty is well known. Tissue adhesives may be an alternative, so as to be able to improve levels of postoperative comfort, but clinical experience using them is limited. The aim of this study is to evaluate (...) to receive either tackers (n = 54) or glue (n = 52).The primary endpoints were pain and recurrence. Secondary endpoints were operating time, postoperative morbidity, pain, and analgesic consumption.No morbidity associated with the use of the glue existed. The use of glue significantly reduced the mean of surgical time (12 minutes in open surgery, 13 minutes in laparoscopic surgery), pain, and analgesics consumption, both via the open and laparoscopic approaches (P < .001). After 1 year the adhesive did

2014 Surgical innovation Controlled trial quality: uncertain

170. Soft tissue cell adhesion to titanium abutments after different cleaning procedures: Preliminary results of a randomized clinical trial. (PubMed)

Soft tissue cell adhesion to titanium abutments after different cleaning procedures: Preliminary results of a randomized clinical trial. A randomized controlled trial was performed to assess soft tissue cell adhesion to implant titanium abutments subjected to different cleaning procedures and test if plasma cleaning can enhance cell adhesion at an early healing time.Eighteen patients with osseointegrated and submerged implants were included. Before re-opening, 18 abutments were divided in 3 (...) contamination with cocobacteria.Within the limits of the present study, plasma of Argon may enhance cell adhesion to titanium abutments, even at the early stage of soft tissue healing. Further studies with greater samples are necessary to confirm these findings.

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2014 Medicina oral, patología oral y cirugía bucal Controlled trial quality: uncertain

171. The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration. (PubMed)

The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration. Tetraspanins are cell membrane-spanning proteins that transduce extracellular signals and control cell adhesion via interactions with multiple molecules, including the protein immunoglobulin superfamily, member 3 (IGSF3). Exhibiting a large extracellular domain, and anchored in tetraspanin-enriched microdomains within the plasma membrane, the function of IGSF3 is unknown.Building on our finding that IGSF3 knockdown in lung (...) epithelial cells increases glucosylceramides, sphingolipids that are known to enhance the stability of tetraspanin complexes, we hypothesized that IGSF3 is critical for cell adhesion. Further, because we found that IGSF3 expression was consistently decreased after cigarette smoke exposure we investigated whether genomic alterations (single-nucleotide polymorphisms [SNPs]) within IGSF3 are present in chronic obstructive pulmonary disease (COPD).To knock down IGSF3, human bronchial epithelial cells (Beas2b

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2018 Annals of the American Thoracic Society

172. Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. (PubMed)

Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. Is Rab11a GTPase, a regulator of intracellular trafficking, of significance in endometrial functions?Rab11a is an important component of the cascades involved in equipping the endometrial epithelium (EE) with 'adhesiveness' and 'cohesiveness'.Cell adhesion molecules (CAMs) have been investigated extensively for modulation in their endometrial expression during the peri-implantation phase. However, the mechanisms (...) knockdown (Rab-kd) and control clones of Ishikawa were generated. JAr (human trophoblastic cell line) cells were used to form multicellular spheroids. Pre-receptive (n = 6) and receptive (n = 6) phase endometrial tissues from women with proven fertility and receptive phase (n = 6) endometrial tissues from women with unexplained infertility were used.Rab-kd and control clones were used for in-vitro assays. Live cells were used for biotinylation, JAr spheroid assays, flow cytometry, trans-epithelial

2018 Human Reproduction

173. A general model of focal adhesion orientation dynamics in response to static and cyclic stretch (PubMed)

in tissues. Here I present a simple theoretical model based on, to my knowledge, a novel approach in the understanding of stretch-sensitive bond association and dissociation processes together with the elasticity of the cell-substrate system to predict the growth, stability, and the orientation of focal adhesions in the presence of static as well as cyclically varying stretches. The model agrees well with several experimental observations; most importantly, it explains the puzzling observations (...) A general model of focal adhesion orientation dynamics in response to static and cyclic stretch Understanding cellular response to mechanical forces is immensely important for a plethora of biological processes. Focal adhesions are multimolecular protein assemblies that connect the cell to the extracellular matrix and play a pivotal role in cell mechanosensing. Under time-varying stretches, focal adhesions dynamically reorganize and reorient and as a result, regulate the response of cells

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2018 Communications Biology

174. Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway (PubMed)

Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway Extracellular matrix (ECM) creates the tissue microenvironment and serves a role in airway wall remodeling in chronic obstructive pulmonary disease (COPD). However, the biological function of ECM in COPD remains to be elucidated. In the present study, 24 healthy Sprague Dawley rats were (...) proliferation, cell cycle progression, migration and adhesion ability, respectively. Furthermore, as demonstrated by ELISA, treatment with ECM components increased levels of C‑X‑C motif chemokine ligand 1 (CXCL1), CXCL8 and interleukin‑6 in ASMCs. Expression of transforming growth factor β1 (TGFβ1), fibroblast growth factor‑1 (FGF‑1) and tissue inhibitor of metalloproteinase 1 (TIMP1) was increased, and expression of matrix metalloproteinase‑9 (MMP‑9) was decreased following treatment with ECM components

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2018 Molecular medicine reports

175. Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer (PubMed)

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion regulation in breast cancer remains unexplored.Tissue microarray was used to evaluate YAP expression in clinical breast cancer specimens (...) by immunohistochemical staining. Cell migration and invasion abilities were measured by Transwell assay. A cell adhesion assay was used to measure the ability of cell adhesion to gelatin. The focal adhesion was visualized through immunofluorescence. Phosphorylated FAK and other proteins were detected by Western blot analysis. Gene expression profiling was used to screen differently expressed genes, and gene ontology enrichment was performed using DAVID software. The gene mRNA levels were measured by quantitative

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2018 Journal of experimental & clinical cancer research : CR

176. Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase (PubMed)

Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase The cytokines secreted by immune cells have a large impact on the tissue, surrounding a fracture, e.g., by attraction of osteoprogenitor cells. However, the underlying mechanisms are not yet fully understood. Thus, this study aims at investigating molecular mechanisms of the immune cell-mediated migration of immature primary human osteoblasts (phOBs (...) ), with transforming growth factor beta (TGF-β), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) and focal adhesion kinase (FAK) as possible regulators. Monocyte- and macrophage (THP-1 cells ± phorbol 12-myristate 13-acetate (PMA) treatment)-conditioned media, other than the granulocyte-conditioned medium (HL-60 cells + dimethyl sulfoxide (DMSO) treatment), induce migration of phOBs. Monocyte- and macrophage (THP-1 cells)-conditioned media activate Smad3-dependent TGF-β signaling in the phOBs

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2018 International journal of molecular sciences

177. ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion (PubMed)

the correlation between ADAM-17 and disease activity score 28 (DAS28) in RA. To determine expression of ADAM-17 in RA synovial tissues (STs) and RA FLS, we performed immunofluorescence analyses. To determine the role of ADAM-17 in RA, we transfected RA FLSs with small interfering RNA (siRNA) against ADAM-17. THP-1 adhesion to ADAM-17 siRNA-transfected RA FLSs was measured. Finally, adhesion molecules on ADAM-17 siRNA-transfected RA FLSs were measured using cell surface ELISAs.ADAM-17 in RA serum (...) ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion To examine the expression of ADAM-17 in rheumatoid arthritis (RA) biological fluids and the role it plays in monocyte adhesion to RA fibroblast-like synoviocytes (FLSs).ADAM-17 expression was measured by enzyme-linked immunosorbent assays (ELISAs) in serum from normal (NL) subjects, osteoarthritis (OA) patients, and RA patients. We also analyzed

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2018 Arthritis research & therapy

178. Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)

-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Tissue Adhesions Cicatrix Fibrosis Pathologic Processes (...) Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR) Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Use

2018 Clinical Trials

179. Safety and Efficacy of Actamaxâ„¢Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy

to the Actamax™Adhesion Barrier Arm will have up to 30mL of product applied to all sites of surgery (area of treatment/trauma). Device: Actamax™Adhesion Barrier Actamax™Adhesion Barrier is a degradable hydrogel to be sprayed directly on surgically traumatized tissue. The aim of using the Actamax™ Adhesion Barrier (AB) in this way is to allow damaged and apposing tissue surfaces the opportunity to heal separately without becoming abnormally attached. No Intervention: Surgical Control Myomectomy (...) Safety and Efficacy of Actamaxâ„¢Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy Safety and Efficacy of Actamax™Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

180. Human-Derived Amniotic Membrane Is Associated With Decreased Postoperative Intraperitoneal Adhesions in a Rat Model. (PubMed)

of adhesions were analyzed between groups by using adhesion scoring and microscopy. Scoring was based on the percentage of the cecum involved (0-4), vascularity of adhesions (0-3), strength (0-3), inflammation (0-3), and fibrosis (0-3). Adhered tissue was harvested for polymerase chain reaction analysis for gene regulation activity.All rats survived 14 days. Adhesions were observed in all animals. There were significantly fewer adhesions in the amniotic membrane group (2) versus hyaluronic acid (3) group (...) (p = 0.01). The percentage of adhesion to the cecum was lower in the amniotic membrane group (29%) than in the hyaluronic acid group (47%, p = 0.04). Histological examination showed no significant difference between or within the 3 groups for inflammation or fibrosis. Genetic analysis of adhered tissues supported high rates of epithelialization and inhibition of fibrosis in the amniotic membrane group.We are limited by the small sample size and the preclinical nature of the study.Human-derived

2018 Diseases of the Colon & Rectum

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