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Tissue Adhesive

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141. Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. (Abstract)

Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis.We first performed colectomy 7 days after 10 mg trinitrobenzene sulfonic acid (TNBS (...) )-induced colitis to validate a rat TNBS-colitis-colectomy model. Subsequently, this TNBS-colitis-colectomy model was used in 73 Wistar rats that were stratified into a colitis group (CG, no adhesive), a TissuCol group (TG), a Histoacryl group (HG), and a Duraseal group (DG). Anastomotic sealant was applied with one adhesive after constructing an end-to-end hand-sewn anastomosis. Clinical manifestations, anastomotic bursting pressure, and immunohistochemistry of macrophage type-one (M1) and type-two (M2

2015 Inflammatory Bowel Diseases

142. Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report (Full text)

Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report Patients with stage III and IV pressure ulcers requiring surgical reconstruction remain a challenge. Extended hospitalization, and high costs of care per patient episode due to high rates of complications and recurrence, make efforts to reduce these rates of utmost importance to the medical community in general. We report a case in which two prior attempts at surgical resolution had failed, and which (...) was successfully resolved with the aid of a new tissue adhesive designed for the closure of dead space. To the best of our knowledge, this is the first reported example of the use of this adhesive in flap surgery for pressure ulcers.We report the case of a 42-year-old Caucasian wheelchair-bound paraplegic man with history of spina bifida, urinary catheter, colostomy, and a history of pressure ulcers. He presented to our institution with a stage IV, methicillin-resistant Staphylococcus aureus-contaminated

2015 Journal of medical case reports PubMed abstract

143. The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. (Full text)

The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used in the management of severe trauma and/or intraoperative bleeding. As a first step (...) in demonstrating the potential utility of this approach, our objective was to ascertain the ability of the PEG-LysNH2 to adhere to and seal injured tissues, as well as to maintain the seal under physiological conditions.The efficacy of the PEG-LysNH2 in sealing injured tissues was evaluated using an ex-vivo pressure testing system. A 2.5 mm incision was made on intact ex-vivo tissues and then sealed with the PEG-LysNH2. Application of the PEG-LysNH2 was followed by 1) step-wise pressure increase to a maximum

2015 BMC Musculoskeletal Disorders PubMed abstract

144. Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study (Full text)

Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study With the significance of stable adhesion of alveolar bone and peri-implant soft tissue on the surface of titanium for successful dental implantation procedure, the purpose of this study was to apply microgrooves on the titanium surface and investigate their effects on peri-implant cells and tissues.Three types of commercially pure titanium discs were prepared; machined (...) microthreads design were inserted into the edentulous mandible of beagle dogs. After 2 weeks and 6 weeks of implant insertion, the animal subjects were euthanized to confirm peri-implant tissue healing pattern in histologic specimens.Group C presented the lowest water contact angle (62.89±5.66 θ), highest surface energy (45±1.2 mN/m), and highest surface roughness (Ra=22.351±2.766 µm). The expression of adhesion molecules of hGFs and MC3T30E1 cells was prominent in group C. Titanium implants

2015 Journal of periodontal & implant science PubMed abstract

145. Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of

Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology Scientific Impact Paper No. 39 May 2013The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology 1. Introduction Adhesions are fibrinous bands between and within organs that develop after aberrant healing; they are formed commonly after surgery and/or infection as a consequence of inflammation. The clinical burden on the NHS of adhesions can (...) be estimated from data extrapolated from the Surgical and Clinical Adhesions Research (SCAR) Study. 1 Following open gynaecological surgery, 2931 (34.5%) women had a total of 5433 readmissions over 10 years with 245 (4.5%) admitted for adhesion related disease. It is estimated that the direct cost of readmissions related to adhesions in the first year after lower abdominal surgery is £24.2 million, which increases to £95.2 million 10 years after the initial surgery. 2 Surgical techniques

2013 Royal College of Obstetricians and Gynaecologists

146. A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications (Full text)

similar hyaluronic acid-based hydrogels, and to support cell implantation in terms of viability, metabolic activity, adhesion and migration. The specific case of pure Col-III fibrils in a glycol-chitosan matrix was investigated. The proposed hydrogels meet many essential requirements for soft tissue engineering applications, particularly for mechanically challenged tissues such as vocal folds and heart valves. (...) A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III

2018 Scientific reports PubMed abstract

147. Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients (Full text)

Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients.This study was conducted on 39 patients who underwent discoplasty (...) grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance.MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1

2018 Journal of the Korean Association of Oral and Maxillofacial Surgeons PubMed abstract

148. Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. (Full text)

ligands that promote adhesion under shear flow conditions. Recently our lab developed a method, termed dynamic biochemical tissue analysis (DBTA), to detect functional selectin ligands in situ by probing tissues with L-selectin-coated microspheres under hemodynamic flow conditions. In this investigation, DBTA was used to probe human colon tissues for L-selectin ligand activity. The detection of L-selectin ligands using DBTA was highly specific. Furthermore, DBTA reproducibly detected functional L (...) Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining, are performed under static, no-flow conditions. However, such analysis does not assay for functional L-selectin ligands, specifically those

2017 PLoS ONE PubMed abstract

149. Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia. (Abstract)

Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia. The aim of this study is to compare the diagnostic values of plasma levels of vascular adhesion protein-1 (VAP-1) and intestinal fatty acid-binding protein (I-FABP) for diagnosing acute mesenteric ischemia (AMI).The study used a randomized, controlled experimental design. Forty-two female Sprague-Dawley rats were divided into three control (...) groups and three ischemia groups. Plasma VAP-1 and I-FABP levels were measured, and the extent of ischemic damage was determined using a histopathological damage score in terminal ileum tissue samples.In the early phase of AMI (i.e. at the 30-min time point), VAP-1 levels did not differ between the control and ischemia groups (p > 0.05), but I-FABP levels were significantly higher in the ischaemia groups (p = 0.017). Although both VAP-1 and I-FABP levels increased in the ischaemia groups, only VAP-1

2018 European journal of trauma and emergency surgery : official publication of the European Trauma Society Controlled trial quality: uncertain

150. The role of oral fluvastatin on postoperative peritoneal adhesion formation in an experimental rat model. (Abstract)

, and tissue samples were taken to measure MMP-9 protein.There were significant differences between the groups on adhesion grade (p < .05), IL-1β content of the plasma and t-PA activity of the adhesions (p < .05). The grading of adhesion demonstrated significant differences between all groups. The levels of the IL-1β content of plasma, t-PA activity and MMP-9 of adhesion showed pivotal changes in Group B compared with Group A and C, while the difference between Group A and C was not statistically (...) The role of oral fluvastatin on postoperative peritoneal adhesion formation in an experimental rat model. Postoperative peritoneal adhesions are a momentousness complication after abdominal surgery. Although varied means have been used to prevent and treat adhesions, the effects have not been satisfactory. Fluvastatin, a HMG-CoA reductase inhibitors, exhibits a variety of pharmacological effects. Aim of this study was to evaluate the effect of fluvastatin on postoperative peritoneal adhesion

2018 Acta chirurgica Belgica

151. Evaluation of bioflavonoids on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin. (Full text)

ground after removal of the excess tissues, to expose the middle dentin. The dentin specimens were randomly allocated into four groups, each consisting of 24 teeth (n = 24) according to the application of the enzyme inhibitor. The adhesive system used in this study was Adper easy bond, a self-etch adhesive system, and Adper Single Bond 2, a total-etch adhesive system. Microtensile bond strength testing was conducted using thermocycler 2000, Heto-Holten A/S.All the three enzyme inhibitors increase (...) Evaluation of bioflavonoids on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin. This study aims to evaluate the effect of two bioflavonoids (epigallocatechin-3-gallate [EGCG] and catechin) and a protein inhibitor (chlorhexidine [CHX]) on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin.The occlusal surfaces of 96 mandibular human third molar teeth specimens were

2018 Indian journal of dental research : official publication of Indian Society for Dental Research Controlled trial quality: uncertain PubMed abstract

152. Response to the Letter to the Editor-Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model. (Abstract)

Hyaluronic Acid IM Arch Gynecol Obstet. 2016 Sep;294(3):665 27262726 Arch Gynecol Obstet. 2016 Sep;294(3):533-40 27022935 Animals Female Humans Hyaluronic Acid Platelet-Rich Plasma Postoperative Complications Rats Tissue Adhesions Uterine Diseases Uterus 2016 05 18 2016 05 30 2016 6 22 6 0 2016 6 22 6 0 2018 8 11 6 0 ppublish 27324784 10.1007/s00404-016-4132-8 10.1007/s00404-016-4132-8 (...) Response to the Letter to the Editor-Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model. 27324784 2018 08 10 2018 12 02 1432-0711 294 3 2016 09 Archives of gynecology and obstetrics Arch. Gynecol. Obstet. Response to the Letter to the Editor-Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention

2018 Archives of gynecology and obstetrics Controlled trial quality: uncertain

153. Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model. (Full text)

;294(3):533-40 27022935 Arch Gynecol Obstet. 2016 Sep;294(3):667 27324784 Animals Female Humans Hyaluronic Acid Platelet-Rich Plasma Postoperative Complications Rats Tissue Adhesions Uterine Diseases Uterus 2016 04 08 2016 05 30 2016 6 6 6 0 2016 6 6 6 0 2018 8 11 6 0 ppublish 27262726 10.1007/s00404-016-4131-9 10.1007/s00404-016-4131-9 (...) Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model. 27262726 2018 08 10 2018 12 02 1432-0711 294 3 2016 09 Archives of gynecology and obstetrics Arch. Gynecol. Obstet. Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model. 665 10.1007/s00404-016-4131-9

2018 Archives of gynecology and obstetrics Controlled trial quality: uncertain PubMed abstract

154. Cyanoacrylate Adhesive Reduces Seroma Production After Modified Radical Mastectomy or Quadrantectomy With Lymph Node Dissection-A Prospective Randomized Clinical Trial. (Abstract)

Cyanoacrylate Adhesive Reduces Seroma Production After Modified Radical Mastectomy or Quadrantectomy With Lymph Node Dissection-A Prospective Randomized Clinical Trial. The accumulation of fluid, a seroma, is a frequent complication after modified radical mastectomy or quadrantectomy with lymph node dissection. The aim of the present study was to examine whether a new adhesive material made of cyanoacrylate can effectively provide a sealing coat to tissues and thus reduce the incidence (...) of seroma significantly.The present prospective, randomized case-control study included 128 women with a breast cancer diagnosis and scheduled for modified radical mastectomy or quadrantectomy with lymph node dissection in Thessaloniki, Greece. In 64 patients (cases), a cyanoacrylate adhesive was applied at the operative field after removal of the tumor and lymph nodes; the remaining 64 patients served as the controls.Seroma production (P = .001), drainage duration (P = .001), and drainage amount (P

2018 Clinical breast cancer Controlled trial quality: uncertain

155. Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. (Abstract)

Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. Is Rab11a GTPase, a regulator of intracellular trafficking, of significance in endometrial functions?Rab11a is an important component of the cascades involved in equipping the endometrial epithelium (EE) with 'adhesiveness' and 'cohesiveness'.Cell adhesion molecules (CAMs) have been investigated extensively for modulation in their endometrial expression during the peri-implantation phase. However, the mechanisms (...) knockdown (Rab-kd) and control clones of Ishikawa were generated. JAr (human trophoblastic cell line) cells were used to form multicellular spheroids. Pre-receptive (n = 6) and receptive (n = 6) phase endometrial tissues from women with proven fertility and receptive phase (n = 6) endometrial tissues from women with unexplained infertility were used.Rab-kd and control clones were used for in-vitro assays. Live cells were used for biotinylation, JAr spheroid assays, flow cytometry, trans-epithelial

2018 Human Reproduction

156. Inflammation by Activated Macrophage-Like THP-1 Cells Increases Human Dura Mater Cell Adhesion with Alteration of Integrin α<sub>2</sub> β<sub>1</sub> and Matrix Metalloproteinase. (Abstract)

. The hDMC was cultured from human dura mater tissue, and the studies were performed with hDMC after co-culturing with macrophage like THP-1 cells (Mϕ). The adhesion of co-cultured hDMC through collagen I increased 6.4-fold and through collagen IV increased 5.0-fold compared with the adhesion of naïve cells (p < 0.001). Integrin subtype α2 β1 expression was increased 6.3-fold (p < 0.001) and α1 expression was decreased 2.0-fold (p < 0.001) in the co-cultured cells compared with the naïve cells. Co (...) Inflammation by Activated Macrophage-Like THP-1 Cells Increases Human Dura Mater Cell Adhesion with Alteration of Integrin α2 β1 and Matrix Metalloproteinase. This study was designed to investigate (i) extracellular matrix to specify adhesive substrates to human dura mater cell (hDMC); (ii) the alteration on adhesion-related molecules in hDMC; and (iii) secreted matrix metalloproteinases (MMPs) linked with extracellular matrix remodeling after exposure to inflammation

2018 Journal of Orthopaedic Research

157. Floraseal Versus Iodine Impregnated Adhesive Drapes

Floraseal Versus Iodine Impregnated Adhesive Drapes Floraseal Versus Iodine Impregnated Adhesive Drapes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Floraseal Versus Iodine Impregnated Adhesive Drapes (...) : Osteoremedies Information provided by (Responsible Party): Victor Hugo Hernandez, University of Miami Study Details Study Description Go to Brief Summary: Infection after total joint arthroplasty can have devastating consequences. Adhesive drapes have been traditionally used at our institution to help reduce the risk of wound contamination and infection by superficial skin flora. Our primary objective is to determine if a cyanoacrylate-based sealant (FloraSeal microbial sealant) is superior to conventional

2018 Clinical Trials

158. Safety and Efficacy of Actamaxâ„¢Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy

to the Actamax™Adhesion Barrier Arm will have up to 30mL of product applied to all sites of surgery (area of treatment/trauma). Device: Actamax™Adhesion Barrier Actamax™Adhesion Barrier is a degradable hydrogel to be sprayed directly on surgically traumatized tissue. The aim of using the Actamax™ Adhesion Barrier (AB) in this way is to allow damaged and apposing tissue surfaces the opportunity to heal separately without becoming abnormally attached. No Intervention: Surgical Control Myomectomy (...) Safety and Efficacy of Actamaxâ„¢Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy Safety and Efficacy of Actamax™Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

159. Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora

table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Yuqing Chen, First Affiliated Hospital, Sun Yat-Sen University: intrauterine lavage therapy hysteroscopy microbiome uterine endometrial repair intrauterine gel-injection therapy Additional relevant MeSH terms: Layout table for MeSH terms Tissue Adhesions Cicatrix Fibrosis Pathologic Processes (...) Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

160. A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers

A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03709810 Recruitment Status : Completed First Posted : October 17, 2018 Last Update Posted : February 11, 2019 Sponsor: GlaxoSmithKline

2018 Clinical Trials

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