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Tissue Adhesive

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141. Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. (PubMed)

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor. Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage. Adhesion of erythrocytes to vascular endothelial cells has been described in multiple hemolytic disorders, especially in sickle cell disease, but the adhesion of normal erythrocytes to endothelial cells has hardly been described (...) . It was shown that calcium-loaded erythrocytes can adhere to endothelial cells. Because sickle erythrocyte adhesion to ECs can be enhanced by ultra-large von Willebrand factor multimers, we investigated whether calcium loading of erythrocytes could promote binding to endothelial cells via ultra-large von Willebrand factor multimers. We used (immunofluorescent) live-cell imaging of washed erythrocytes perfused over primary endothelial cells at venular flow rate. Using this approach, we show that calcium

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2017 PLoS ONE

142. On the adhesion-cohesion balance and oxygen consumption characteristics of liver organoids. (PubMed)

On the adhesion-cohesion balance and oxygen consumption characteristics of liver organoids. Liver organoids (LOs) are of interest in tissue replacement, hepatotoxicity and pathophysiological studies. However, it is still unclear what triggers LO self-assembly and what the optimal environment is for their culture. Hypothesizing that LO formation occurs as a result of a fine balance between cell-substrate adhesion and cell-cell cohesion, we used 3 cell types (hepatocytes, liver sinusoidal (...) sensor and used to model the O2 concentration gradient in the organoids. We show that no LO formation occurs on highly adhesive hepatic extra-cellular matrix-based substrates, suggesting that cellular aggregation requires an optimal trade-off between the adhesiveness of a substrate and the cohesive forces between cells and that this balance is modulated by substrate mechanics. Thus, in addition to substrate stiffness, physicochemical properties, which are also critical for cell adhesion, play a role

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2017 PLoS ONE

143. Weak Evidence Supports the Biocompatibility of Non-Zinc Containing Denture Adhesives?

on The Evidence Published evidence regarding the biocompatibility of denture adhesives is very limited. Possible negative outcomes of denture adhesive use include local tissue irritation, alteration of microflora of the oral cavity, and a condition called myelopolyneuropathy secondary to the hyperzincemia resulting from excessive use of zinc containing denture adhesives. When zinc containing adhesives are excluded, low level in vivo evidence suggests denture adhesive use to be safe. More investigation (...) in this topic is recommended. Applicability Denture adhesives are widely used and can improve the stability and retention of removable dental prostheses, especially when there are anatomical limitations for denture wear. There is little available evidence regarding the biocompatibility of denture adhesives. Both of these systemic reviews show that it is possible for denture adhesive to create some degree of local tissue irritation along with some more serious potential systemic side effects. Further studies

2015 UTHSCSA Dental School CAT Library

144. The effect of bone adhesives on tissue regeneration in animal models

The effect of bone adhesives on tissue regeneration in animal models Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures

2018 PROSPERO

145. Fibrin tissue adhesives versus nasal packing in the treatment of patients undergoing endoscopic nasal surgery: a systematic review

Fibrin tissue adhesives versus nasal packing in the treatment of patients undergoing endoscopic nasal surgery: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

146. Tissue adhesives for traumatic lacerations in children and adults

Tissue adhesives for traumatic lacerations in children and adults Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures

2018 PROSPERO

147. Histopathological Effects of Tissue Adhesives on Experimental Peripheral Nerve Transection Model in Rats (PubMed)

Histopathological Effects of Tissue Adhesives on Experimental Peripheral Nerve Transection Model in Rats Our aim was to evaluate the histopathological effects of tissue adhesives on peripheral nerve regeneration after experimental sciatic nerve transection in rats and to search whether these tissue adhesives may possess a therapeutic potential in peripheral nerve injuries.This experimental study was performed using 42 female Wistar-Albino rats distributed in 6 groups subsequent to transection (...) of right sciatic nerves. Group I underwent external circumferential neurolysis; Group II received suture repair; Group III had local polymeric hydrogel based tissue adhesive administration; Group IV received suture repair and polymeric hydrogel based tissue adhesive application together; Group V had gelatin based tissue adhesive application and Group VI had suture repair and gelatin based tissue adhesive together. After a 6-week follow-up period, biopsies were obtained from site of neural injury

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2015 Journal of Korean Neurosurgical Society

148. Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study (PubMed)

Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study With the significance of stable adhesion of alveolar bone and peri-implant soft tissue on the surface of titanium for successful dental implantation procedure, the purpose of this study was to apply microgrooves on the titanium surface and investigate their effects on peri-implant cells and tissues.Three types of commercially pure titanium discs were prepared; machined (...) microthreads design were inserted into the edentulous mandible of beagle dogs. After 2 weeks and 6 weeks of implant insertion, the animal subjects were euthanized to confirm peri-implant tissue healing pattern in histologic specimens.Group C presented the lowest water contact angle (62.89±5.66 θ), highest surface energy (45±1.2 mN/m), and highest surface roughness (Ra=22.351±2.766 µm). The expression of adhesion molecules of hGFs and MC3T30E1 cells was prominent in group C. Titanium implants

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2015 Journal of periodontal & implant science

149. Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. (PubMed)

Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis.We first performed colectomy 7 days after 10 mg trinitrobenzene sulfonic acid (TNBS (...) )-induced colitis to validate a rat TNBS-colitis-colectomy model. Subsequently, this TNBS-colitis-colectomy model was used in 73 Wistar rats that were stratified into a colitis group (CG, no adhesive), a TissuCol group (TG), a Histoacryl group (HG), and a Duraseal group (DG). Anastomotic sealant was applied with one adhesive after constructing an end-to-end hand-sewn anastomosis. Clinical manifestations, anastomotic bursting pressure, and immunohistochemistry of macrophage type-one (M1) and type-two (M2

2015 Inflammatory Bowel Diseases

150. Exploiting cell-mediated contraction and adhesion to structure tissues in vitro (PubMed)

Exploiting cell-mediated contraction and adhesion to structure tissues in vitro Progress in tissue engineering is now impacting beyond the field of regenerative medicine. Engineered tissues are now used as tools to evaluate the toxicity of compounds or even to enable the modelling of disease. While many of the materials that are used to facilitate tissue growth are designed to enable cell attachment, many researchers consider that the contraction and modification of these matrices by attached (...) cells is not desirable and take measures to prevent this from occurring. Where substantial alignment of the molecules within tissues, however, is a feature of structure the process of contraction can be exploited to guide new matrix deposition. In this paper, we will demonstrate how we have used the cell contraction process to generate tissues with high levels of organization. The tissues that have been grown in the laboratory have been characterized using a suite of analytical techniques

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2015 Philosophical Transactions of the Royal Society B: Biological Sciences

151. Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report (PubMed)

Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report Patients with stage III and IV pressure ulcers requiring surgical reconstruction remain a challenge. Extended hospitalization, and high costs of care per patient episode due to high rates of complications and recurrence, make efforts to reduce these rates of utmost importance to the medical community in general. We report a case in which two prior attempts at surgical resolution had failed, and which (...) was successfully resolved with the aid of a new tissue adhesive designed for the closure of dead space. To the best of our knowledge, this is the first reported example of the use of this adhesive in flap surgery for pressure ulcers.We report the case of a 42-year-old Caucasian wheelchair-bound paraplegic man with history of spina bifida, urinary catheter, colostomy, and a history of pressure ulcers. He presented to our institution with a stage IV, methicillin-resistant Staphylococcus aureus-contaminated

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2015 Journal of medical case reports

152. The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. (PubMed)

The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used in the management of severe trauma and/or intraoperative bleeding. As a first step (...) in demonstrating the potential utility of this approach, our objective was to ascertain the ability of the PEG-LysNH2 to adhere to and seal injured tissues, as well as to maintain the seal under physiological conditions.The efficacy of the PEG-LysNH2 in sealing injured tissues was evaluated using an ex-vivo pressure testing system. A 2.5 mm incision was made on intact ex-vivo tissues and then sealed with the PEG-LysNH2. Application of the PEG-LysNH2 was followed by 1) step-wise pressure increase to a maximum

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2015 BMC Musculoskeletal Disorders

153. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. (PubMed)

Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. Cyanoacrylate topical adhesives and fast absorbing gut sutures are increasingly utilized by dermatologic surgeons as they provide satisfactory surgical outcomes while eliminating an additional patient visit for suture removal. To date, no head-to-head studies have compared the wound healing characteristics of these epidermal closure techniques (...) selected for closure with cyanoacrylate and the contralateral side with fast absorbing gut suture. Using photographs from the three-month postoperative visit, six blinded individuals rated the overall cosmetic outcome.The present study shows no significant difference in cosmetic outcomes between cyanoacrylate and fast absorbing gut suture for closure of linear facial wounds resulting from Mohs micrographic surgery. Cyanoacrylate tissue adhesive may not be as effective in achieving optimal cosmesis

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

154. Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E62 (PubMed)

Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E62 24800307 2015 03 30 2018 12 02 1878-0369 99 4 2014 Apr AORN journal AORN J Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair (...) with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E629-E634. 549-54 Girard Nancy N eng Journal Article Comment United States AORN J 0372403 0001-2092 0 Anesthetics, Local 0619F35CGV Tetracaine 98PI200987 Lidocaine YKH834O4BH Epinephrine IM N CMAJ. 2013 Sep 17;185(13):E629-34 23897942 Anesthetics, Local therapeutic use Epinephrine therapeutic use Female Humans Lidocaine therapeutic use Male Pain drug therapy Tetracaine therapeutic use 2014 5 8 6 0 2014 5 8 6 0 2015 3 31 6

2015 AORN journal Controlled trial quality: uncertain

155. Bene?ts and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis

; Postoperative Complications /prevention & Randomized Controlled Trials as Topic /methods; Tissue Adhesions /prevention & Treatment Outcome; control; control AccessionNumber 12013055949 Date bibliographic record published 27/09/2013 Date abstract record published 03/10/2013 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods, results and conclusions followed by a detailed critical (...) Bene?ts and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis ten Broek RP, Stommel MW, Strik C, van Laarhoven CJ, Keus F, van Goor H CRD summary This review assessed the benefits and harms of four adhesion barriers for abdominal surgery and concluded

2013 DARE.

156. Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of

Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology Scientific Impact Paper No. 39 May 2013The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology 1. Introduction Adhesions are fibrinous bands between and within organs that develop after aberrant healing; they are formed commonly after surgery and/or infection as a consequence of inflammation. The clinical burden on the NHS of adhesions can (...) be estimated from data extrapolated from the Surgical and Clinical Adhesions Research (SCAR) Study. 1 Following open gynaecological surgery, 2931 (34.5%) women had a total of 5433 readmissions over 10 years with 245 (4.5%) admitted for adhesion related disease. It is estimated that the direct cost of readmissions related to adhesions in the first year after lower abdominal surgery is £24.2 million, which increases to £95.2 million 10 years after the initial surgery. 2 Surgical techniques

2013 Royal College of Obstetricians and Gynaecologists

157. Intercellular adhesion molecule-1 expression in massive chronic intervillositis: Implications for the invasion of maternal cells into fetal tissues. (PubMed)

Intercellular adhesion molecule-1 expression in massive chronic intervillositis: Implications for the invasion of maternal cells into fetal tissues. Massive chronic intervillositis (MCI), also known as chronic intervillositis of unknown etiology, is a placental lesion associated with massive infiltration of mononuclear cells in the intervillous space, poor perinatal outcome, and high rate of recurrence. Our previous demonstration of increased syncytiotrophoblast (st) intercellular adhesion

2014 Placenta

158. Cyanoacrylate tissue adhesive on a polyglactin scaffold in strabismus surgery: a laboratory study. (PubMed)

Cyanoacrylate tissue adhesive on a polyglactin scaffold in strabismus surgery: a laboratory study. The use of cyanoacrylate tissue adhesives in strabismus surgery has been variously successful, depending primarily on achieving adequate bond strength and minimizing extraocular muscle slippage. We investigate a novel approach to this problem, involving cyanoacrylate tissue adhesive on a polyglactin 910 scaffold as a means to secure extraocular muscle to the sclera for strabismus surgery.In (...) this experimental laboratory study, butyl-cyanoacrylate was used to fix a polyglactin 910 scaffold to the sclera of cadaver eyes. After allowing for polymerization, a force was applied to the mesh until the polyglactin-sclera bond failed. The maximum load (g) required for bond failure was recorded. The effects of surface area of the polyglactin 910 mesh as well as time required for cyanoacrylate tissue adhesive polymerization on bond strength were investigated.All combination of variables tested, except

2014 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

159. Comparative study of nJ- and μJ-energy level femtosecond lasers: Evaluation of flap adhesion strength, stromal bed quality and tissue responses. (PubMed)

Comparative study of nJ- and μJ-energy level femtosecond lasers: Evaluation of flap adhesion strength, stromal bed quality and tissue responses. To compare flap adhesion strength, stromal bed quality, and tissue responses after flap preparation using nJ- and μJ-energy level femtosecond lasers.All corneal flaps were created by either VisuMax laser (μJ-energy level) or femto-LDV (nJ-energy level). Flap adhesion strength in the rabbits was measured with a tension meter 1 and 2 months (...) postoperatively. To investigate tissue responses to laser delivery, immunofluorescence staining and TUNEL assay were performed 4 and 24 hours postoperatively. To assess flap bed smoothness, human donor corneas were used. Surface irregularities were graded based on scanning electron microscopy results.The flap adhesion strength in the VisuMax group at month 1 and 2 was 16.95 ± 1.45 kPa and 18.33 ± 1.81 kPa, respectively; and 12.31 ± 4.15 kPa and 13.85 ± 4.78 kPa in the LDV group, respectively. No significant

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2014 Investigative Ophthalmology & Visual Science

160. Mechanical Strength and Rheological Properties of Tissue Adhesives With Regard to Colorectal Anastomosis: An Ex vivo Study. (PubMed)

Mechanical Strength and Rheological Properties of Tissue Adhesives With Regard to Colorectal Anastomosis: An Ex vivo Study. To compare mechanical strength and rheology of existing tissue adhesives in a clinically relevant test setup with regard to colorectal anastomosis.Little is known on the mechanical strength of tissue adhesives directly after application. Furthermore, rheological profiling may be important in understanding mechanical performance and explaining differences between adhesives (...) . This study provides new data on the mechanical strength and rheology of a comprehensive list of tissue adhesives with regard to colorectal adhesiveness.Twelve surgical tissue adhesives were included: 4 cyanoacrylate adhesives (CA), 2 fibrin glues (FG), 3 polyethylene glycol (PEG) adhesives, and 3 albumin-based (AB) adhesives. Tubular rat colonic segments were glued together. Tensile (T), shear (S), and peel (P) strength were measured. Shear storage (G') and shear loss (G″) moduli were also evaluated.CA

2014 Annals of Surgery

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