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Tissue Adhesive

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121. Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. (Abstract)

and hepatocyte.NOD1 WT and KO mice were treated with NOD1 agonists and submitted to liver IR. Expression of adhesion molecules were analyzed in total liver, isolated hepatocytes and endothelial cells. Interaction between PMN and hepatocyte was studied in ex vivo co-culture model using electron microscopy (EM) and LDH levels. We generated NOD1 antagonist-loaded nanoparticles (np ALINO).NOD1 agonist treatment increased liver injury, PMN tissue infiltration and up-regulated ICAM-1 and VCAM-1 expression 20 hours (...) Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. In liver transplantation, organ shortage leads to use marginal grafts that are more susceptible to ischemia reperfusion (IR). We identified nucleotide-binding oligomerization domain 1 (NOD1) as an important modulator of polymorphonuclear (PMN)-induced liver injury such as in IR. Here we aimed at elucidating its role in the liver IR, especially on the endothelium

2019 Journal of Hepatology

122. The Effect of Extensor Tendon Adhesions on Finger Motion. (Abstract)

of these findings to clinical relevance remains unclear, the ability to predict the level of adhesion by the pattern of motion restriction may allow for a targeted tenolysis procedure. This would reduce the amount of soft tissue dissection required, which in turn, could be expected to reduce the degree of repeat adhesion formation.Copyright © 2018 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved. (...) The Effect of Extensor Tendon Adhesions on Finger Motion. To quantify the amount and pattern of finger range of motion loss at the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints with a simulated extensor tendon adhesion at the level of the proximal phalanx or metacarpal.In 10 cadaveric specimens, traction sutures were placed in the forearm extensor digitorum communis and flexor digitorum profundus tendons of the middle and ring fingers. Active

2019 Journal of Hand Surgery - American

123. Regulation and function of IL-22 in peritoneal adhesion formation after abdominal surgery. (Abstract)

Regulation and function of IL-22 in peritoneal adhesion formation after abdominal surgery. Peritoneal adhesion occurs frequently after gastrointestinal/gynecological surgery. Tissue repair and regeneration are very important during this process. IL-22 is an important cytokine that is secreted from immune cells but functions on mesenchymal cells, such as mesothelial cells. The objective of this study was to investigate the roles of IL-22 and its regulators during adhesion formation. Postsurgical (...) peritoneal drainage fluid from patients and rodent models was examined by enzyme-linked immunosorbent assay and fluorescence-activated cell sorting. It was observed that IL-22 expression in the abdominal cavity was rapidly induced 12 hours after surgery and then slowly decreased to a lower, steady level for up to 7 days after surgery. However, neutralizing IL-22 at the time point at which the highest level of expression was observed failed to reduce adhesion, but neutralizing IL-22 at a later time point

2019 Wound Repair and Regeneration

124. The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study. (Abstract)

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study. To study the effect of chronic endometritis (CE) diagnosed by CD138 immunohistochemical (IHC) staining on endometrial fibrosis and reproductive prognosis in patients with moderate or severe intrauterine adhesions (IUAs).Prospective cohort study (Canadian Task Force classification II-2).University-affiliated hospital.One (...) hundred sixty-seven women with moderate to severe IUAs.Transcervical resection of adhesions (TCRA) and endometrial biopsy were performed in all patients. According to results of IHC staining with anti-syndecan-1 antibodies to identify CD138 cells, participants were classified into two groups: 78 patients with CE (CE group) and 89 women without CE (NCE group). IHC staining for fibrosis markers transforming growth factor beta 1, anti-fibrosis markers matrix metalloproteinase 9, and endometrial

2019 Fertility and Sterility

125. Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells Via Interleukin 6. (Abstract)

Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells Via Interleukin 6. In temporal arteries (TAs) from giant cell arteritis patients, varicella zoster virus (VZV) is seen in perineurial cells that surround adventitial nerve bundles and form the peripheral nerve-extrafascicular tissue barrier (perineurium). We hypothesized that during VZV reactivation from ganglia, virus travels transaxonally and disrupts the perineurium to infect surrounding cells.Mock

2019 Journal of Infectious Diseases

126. Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer. (Abstract)

Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer. L1 cell adhesion molecule (L1CAM) is highly expressed in malignant tumours and might play a pivotal role in tumour progression.We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients. We performed propensity score matching (PSM) analysis to clarify the prognostic impact of L1CAM in GC patients. We evaluated L1CAM gene expression (...) in fresh frozen specimens from another group of 131 GC patients to establish its clinical relevance. The effects of changes in L1CAM were investigated in vitro and in vivo.L1CAM was mainly expressed in tumour cells of GC tissues. Elevated L1CAM expression was an independent prognostic factor for overall and disease-free survival, and an independent risk factor for distant metastasis in GC patients. PSM analysis showed that high L1CAM expression was significantly associated with poor prognosis. L1CAM

2019 British Journal of Cancer

127. Depot-medroxyprogesterone acetate reduces genital cell-cell adhesion molecule expression and increases genital herpes simplex virus type 2 infection susceptibility in a dose-dependent fashion. (Abstract)

Depot-medroxyprogesterone acetate reduces genital cell-cell adhesion molecule expression and increases genital herpes simplex virus type 2 infection susceptibility in a dose-dependent fashion. Analyzing ectocervical biopsy tissue from women before and after they initiated use of depot-medroxyprogesterone acetate (DMPA), we previously reported this progestin reduces levels of the cell-cell adhesion molecule (CCAM) desmoglein-1 and increases genital mucosal permeability. We likewise saw treating

2019 Contraception

128. Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E62 (Abstract)

Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E62 24800307 2015 03 30 2018 12 02 1878-0369 99 4 2014 Apr AORN journal AORN J Evidence appraisal of Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair (...) with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E629-E634. 549-54 Girard Nancy N eng Journal Article Comment United States AORN J 0372403 0001-2092 0 Anesthetics, Local 0619F35CGV Tetracaine 98PI200987 Lidocaine YKH834O4BH Epinephrine IM N CMAJ. 2013 Sep 17;185(13):E629-34 23897942 Anesthetics, Local therapeutic use Epinephrine therapeutic use Female Humans Lidocaine therapeutic use Male Pain drug therapy Tetracaine therapeutic use 2014 5 8 6 0 2014 5 8 6 0 2015 3 31 6

2015 AORN journal Controlled trial quality: uncertain

129. Histopathological Effects of Tissue Adhesives on Experimental Peripheral Nerve Transection Model in Rats Full Text available with Trip Pro

Histopathological Effects of Tissue Adhesives on Experimental Peripheral Nerve Transection Model in Rats Our aim was to evaluate the histopathological effects of tissue adhesives on peripheral nerve regeneration after experimental sciatic nerve transection in rats and to search whether these tissue adhesives may possess a therapeutic potential in peripheral nerve injuries.This experimental study was performed using 42 female Wistar-Albino rats distributed in 6 groups subsequent to transection (...) of right sciatic nerves. Group I underwent external circumferential neurolysis; Group II received suture repair; Group III had local polymeric hydrogel based tissue adhesive administration; Group IV received suture repair and polymeric hydrogel based tissue adhesive application together; Group V had gelatin based tissue adhesive application and Group VI had suture repair and gelatin based tissue adhesive together. After a 6-week follow-up period, biopsies were obtained from site of neural injury

2015 Journal of Korean Neurosurgical Society

130. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. (Abstract)

Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. Cyanoacrylate topical adhesives and fast absorbing gut sutures are increasingly utilized by dermatologic surgeons as they provide satisfactory surgical outcomes while eliminating an additional patient visit for suture removal. To date, no head-to-head studies have compared the wound healing characteristics of these epidermal closure techniques (...) selected for closure with cyanoacrylate and the contralateral side with fast absorbing gut suture. Using photographs from the three-month postoperative visit, six blinded individuals rated the overall cosmetic outcome.The present study shows no significant difference in cosmetic outcomes between cyanoacrylate and fast absorbing gut suture for closure of linear facial wounds resulting from Mohs micrographic surgery. Cyanoacrylate tissue adhesive may not be as effective in achieving optimal cosmesis

2015 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

131. Exploiting cell-mediated contraction and adhesion to structure tissues in vitro Full Text available with Trip Pro

Exploiting cell-mediated contraction and adhesion to structure tissues in vitro Progress in tissue engineering is now impacting beyond the field of regenerative medicine. Engineered tissues are now used as tools to evaluate the toxicity of compounds or even to enable the modelling of disease. While many of the materials that are used to facilitate tissue growth are designed to enable cell attachment, many researchers consider that the contraction and modification of these matrices by attached (...) cells is not desirable and take measures to prevent this from occurring. Where substantial alignment of the molecules within tissues, however, is a feature of structure the process of contraction can be exploited to guide new matrix deposition. In this paper, we will demonstrate how we have used the cell contraction process to generate tissues with high levels of organization. The tissues that have been grown in the laboratory have been characterized using a suite of analytical techniques

2015 Philosophical Transactions of the Royal Society B: Biological Sciences

132. Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. (Abstract)

Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease. Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis.We first performed colectomy 7 days after 10 mg trinitrobenzene sulfonic acid (TNBS (...) )-induced colitis to validate a rat TNBS-colitis-colectomy model. Subsequently, this TNBS-colitis-colectomy model was used in 73 Wistar rats that were stratified into a colitis group (CG, no adhesive), a TissuCol group (TG), a Histoacryl group (HG), and a Duraseal group (DG). Anastomotic sealant was applied with one adhesive after constructing an end-to-end hand-sewn anastomosis. Clinical manifestations, anastomotic bursting pressure, and immunohistochemistry of macrophage type-one (M1) and type-two (M2

2015 Inflammatory Bowel Diseases

133. Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report Full Text available with Trip Pro

Recurrent ischial pressure ulcer resolved with a novel tissue adhesive: a case report Patients with stage III and IV pressure ulcers requiring surgical reconstruction remain a challenge. Extended hospitalization, and high costs of care per patient episode due to high rates of complications and recurrence, make efforts to reduce these rates of utmost importance to the medical community in general. We report a case in which two prior attempts at surgical resolution had failed, and which (...) was successfully resolved with the aid of a new tissue adhesive designed for the closure of dead space. To the best of our knowledge, this is the first reported example of the use of this adhesive in flap surgery for pressure ulcers.We report the case of a 42-year-old Caucasian wheelchair-bound paraplegic man with history of spina bifida, urinary catheter, colostomy, and a history of pressure ulcers. He presented to our institution with a stage IV, methicillin-resistant Staphylococcus aureus-contaminated

2015 Journal of medical case reports

134. The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. Full Text available with Trip Pro

The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study. Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used in the management of severe trauma and/or intraoperative bleeding. As a first step (...) in demonstrating the potential utility of this approach, our objective was to ascertain the ability of the PEG-LysNH2 to adhere to and seal injured tissues, as well as to maintain the seal under physiological conditions.The efficacy of the PEG-LysNH2 in sealing injured tissues was evaluated using an ex-vivo pressure testing system. A 2.5 mm incision was made on intact ex-vivo tissues and then sealed with the PEG-LysNH2. Application of the PEG-LysNH2 was followed by 1) step-wise pressure increase to a maximum

2015 BMC Musculoskeletal Disorders

135. Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study Full Text available with Trip Pro

Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an in vitro and in vivo study With the significance of stable adhesion of alveolar bone and peri-implant soft tissue on the surface of titanium for successful dental implantation procedure, the purpose of this study was to apply microgrooves on the titanium surface and investigate their effects on peri-implant cells and tissues.Three types of commercially pure titanium discs were prepared; machined (...) microthreads design were inserted into the edentulous mandible of beagle dogs. After 2 weeks and 6 weeks of implant insertion, the animal subjects were euthanized to confirm peri-implant tissue healing pattern in histologic specimens.Group C presented the lowest water contact angle (62.89±5.66 θ), highest surface energy (45±1.2 mN/m), and highest surface roughness (Ra=22.351±2.766 µm). The expression of adhesion molecules of hGFs and MC3T30E1 cells was prominent in group C. Titanium implants

2015 Journal of periodontal & implant science

136. Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of

Adhesion Prevention Agents in Obstetrics and Gynaecology, The Use of The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology Scientific Impact Paper No. 39 May 2013The Use of Adhesion Prevention Agents in Obstetrics and Gynaecology 1. Introduction Adhesions are fibrinous bands between and within organs that develop after aberrant healing; they are formed commonly after surgery and/or infection as a consequence of inflammation. The clinical burden on the NHS of adhesions can (...) be estimated from data extrapolated from the Surgical and Clinical Adhesions Research (SCAR) Study. 1 Following open gynaecological surgery, 2931 (34.5%) women had a total of 5433 readmissions over 10 years with 245 (4.5%) admitted for adhesion related disease. It is estimated that the direct cost of readmissions related to adhesions in the first year after lower abdominal surgery is £24.2 million, which increases to £95.2 million 10 years after the initial surgery. 2 Surgical techniques

2013 Royal College of Obstetricians and Gynaecologists

137. A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications Full Text available with Trip Pro

similar hyaluronic acid-based hydrogels, and to support cell implantation in terms of viability, metabolic activity, adhesion and migration. The specific case of pure Col-III fibrils in a glycol-chitosan matrix was investigated. The proposed hydrogels meet many essential requirements for soft tissue engineering applications, particularly for mechanically challenged tissues such as vocal folds and heart valves. (...) A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III

2018 Scientific reports

138. Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients Full Text available with Trip Pro

Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients.This study was conducted on 39 patients who underwent discoplasty (...) grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance.MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1

2018 Journal of the Korean Association of Oral and Maxillofacial Surgeons

139. Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. Full Text available with Trip Pro

ligands that promote adhesion under shear flow conditions. Recently our lab developed a method, termed dynamic biochemical tissue analysis (DBTA), to detect functional selectin ligands in situ by probing tissues with L-selectin-coated microspheres under hemodynamic flow conditions. In this investigation, DBTA was used to probe human colon tissues for L-selectin ligand activity. The detection of L-selectin ligands using DBTA was highly specific. Furthermore, DBTA reproducibly detected functional L (...) Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining, are performed under static, no-flow conditions. However, such analysis does not assay for functional L-selectin ligands, specifically those

2017 PLoS ONE

140. Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia. (Abstract)

Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia. The aim of this study is to compare the diagnostic values of plasma levels of vascular adhesion protein-1 (VAP-1) and intestinal fatty acid-binding protein (I-FABP) for diagnosing acute mesenteric ischemia (AMI).The study used a randomized, controlled experimental design. Forty-two female Sprague-Dawley rats were divided into three control (...) groups and three ischemia groups. Plasma VAP-1 and I-FABP levels were measured, and the extent of ischemic damage was determined using a histopathological damage score in terminal ileum tissue samples.In the early phase of AMI (i.e. at the 30-min time point), VAP-1 levels did not differ between the control and ischemia groups (p > 0.05), but I-FABP levels were significantly higher in the ischaemia groups (p = 0.017). Although both VAP-1 and I-FABP levels increased in the ischaemia groups, only VAP-1

2018 European journal of trauma and emergency surgery : official publication of the European Trauma Society Controlled trial quality: uncertain

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