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Tissue Adhesive

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101. Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after general abdominal surgery

involves a number of liquid- and solid-phase agents (membranes, sheets) that primarily act as barriers between two adjacent peritoneal surfaces. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Abdomen; Postoperative Complicationss; Tissue Adhesions Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200 (...) Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after general abdominal surgery Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after general abdominal surgery Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after general abdominal surgery Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made

2012 Health Technology Assessment (HTA) Database.

102. Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery

as barriers between two adjacent peritoneal surfaces. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Abdomen; Gynecologic Surgical Procedures; Humans; Postoperative Complications; Tissue Adhesions Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 (...) Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database

2012 Health Technology Assessment (HTA) Database.

103. Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix. (PubMed)

Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix. Postoperative adhesion is a natural phenomenon that occurs in damaged tissue cells. Several anti-adhesion agents are currently used, but there is no leading-edge product with excellent adhesion-preventive effects. The purpose of this study was to develop ideal anti-adhesive agents using human-derived acellular dermal matrix (ADM). We developed 5 new biocompatible thermosensitive (...) anti-adhesion barriers (AABs) using micronized human-derived ADM, hyaluronic acid, and temperature-sensitive and biocompatible synthesized polymers. The biocompatibility, anti-adhesion effect, and biodegradability of these AABs were compared with those of commercial thermosensitive anti-adhesion agents. No cytotoxic effects were observed in vitro and in vivo. Animal testing of adhesion resistance confirmed that the adhesion area, strength, and grade of AAB03 were statistically superior to those

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2019 PLoS ONE

104. Amino acids disrupt calcium-dependent adhesion of stratum corneum. (PubMed)

Amino acids disrupt calcium-dependent adhesion of stratum corneum. In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca2+ ions are known to play a key role in maintaining this junction. In this study, we hypothesized that Ca2+ chelation in stratum corneum will weaken the bond of the tissue and consequently promote exfoliation. Amino acids, ubiquitously existing as metabolites and building blocks of the body, have

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2019 PLoS ONE

105. Tissue adhesives vs sutures for upper eyelid blepharoplasty wound closure

Tissue adhesives vs sutures for upper eyelid blepharoplasty wound closure Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2019 PROSPERO

106. Comparison of tissue adhesive and suturing in the repair of lacerations in the emergency department.

Comparison of tissue adhesive and suturing in the repair of lacerations in the emergency department. Comparison of tissue adhesive and suturing in the repair of lacerations in the emergency department. – Less Is More Search for: Simpler & Better Medicine Menu / Summary: For adults with lacerations 5 cm or shorter, use of a tissue adhesive (in this case, Histoacryl Blue [HAB]) may be associated with lower costs and improved physician and patient satisfaction compared to suturing

2015 Less Is More Blog

107. Gynecare interceed absorbable adhesion barrier (Ethicon Inc.) for prevention of adhesions following gynecologic surgery

has been made for the HTA database. Citation Gynecare interceed absorbable adhesion barrier (Ethicon Inc.) for prevention of adhesions following gynecologic surgery . Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication Dates. 2011 Authors' conclusions Postoperative adhesions result from tissue trauma and healing; their incidence ranges from 60% to 90% after pelvic and gynecological surgery. Diseases such as endometriosis and pelvic inflammatory disease, and therapies (...) peritoneal surfaces. A variety of synthetic barriers have been developed as adjuncts to optimal surgical techniques for the prevention and reduction of adhesions. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Equipment Design; Gynecologic Surgical Procedures; Postoperative Complicationss; Tissue Adhesions Language Published English Country of organisation United States English summary An English language summary is available. Address

2011 Health Technology Assessment (HTA) Database.

108. SprayShield adhesion barrier system (Covidien Inc.) for prevention of postoperative adhesions

system (Covidien Inc.) for prevention of postoperative adhesions. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2011 Authors' objectives Adhesions are abnormal fibrous bands that form between tissues, organs, and the abdominal wall. Adhesions form due to an abnormal wound-healing process following tissue injury or local inflammation, and they are a frequent sequelae of abdominal or pelvic surgery. Medical conditions such as endometriosis, radiation therapy, pelvic inflammatory (...) of peritoneal adhesions, and often requires surgical intervention. Given the extent of adhesion-related morbidity, antiadhesion barriers have been developed as adjuncts to meticulous surgical technique to prevent and reduce their occurrence. These barriers, which are solid or fluid, are designed to prevent the formation of fibrin bridges - an early step in adhesiogenesis - by physically separating the traumatized areas from the surrounding tissues. Final publication URL The report may be purchased from

2011 Health Technology Assessment (HTA) Database.

109. Amniotic tissue-derived allografts for treatment of plantar fasciitis

and regeneration of damaged tissue and limit inflammation and formation of scar tissue. The fetal membranes have been used to treat chronic wounds, prevent adhesions, and promote healing and regeneration of nerves and bone. Amniotic tissues may be obtained when performing elective cesarean sections for healthy pregnancies, then cleansed, sterilized, and processed. Patient Population: The focus of this health technology assessment is on amniotic tissue–derived allografts for the treatment of patients (...) Amniotic tissue-derived allografts for treatment of plantar fasciitis Amniotic tissue–derived allografts for treatment of plantar fasciitis Amniotic tissue–derived allografts for treatment of plantar fasciitis HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Amniotic tissue–derived allografts for treatment of plantar fasciitis. Lansdale

2017 Health Technology Assessment (HTA) Database.

110. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial (PubMed)

Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial Some children feel pain during wound closures using tissue adhesives. We sought to determine whether a topically applied analgesic solution of lidocaine-epinephrine-tetracaine would decrease pain during tissue adhesive repair.We conducted a randomized, placebo-controlled, blinded trial involving 221 children between the ages of 3 months (...) and 17 years. Patients were enrolled between March 2011 and January 2012 when presenting to a tertiary-care pediatric emergency department with lacerations requiring closure with tissue adhesive. Patients received either lidocaine-epinephrine-tetracaine or placebo before undergoing wound closure. Our primary outcome was the pain rating of adhesive application according to the colour Visual Analogue Scale and the Faces Pain Scale--Revised. Our secondary outcomes were physician ratings of difficulty

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2013 EvidenceUpdates Controlled trial quality: predicted high

111. The Effect of Extensor Tendon Adhesions on Finger Motion. (PubMed)

of these findings to clinical relevance remains unclear, the ability to predict the level of adhesion by the pattern of motion restriction may allow for a targeted tenolysis procedure. This would reduce the amount of soft tissue dissection required, which in turn, could be expected to reduce the degree of repeat adhesion formation.Copyright © 2018 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved. (...) The Effect of Extensor Tendon Adhesions on Finger Motion. To quantify the amount and pattern of finger range of motion loss at the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints with a simulated extensor tendon adhesion at the level of the proximal phalanx or metacarpal.In 10 cadaveric specimens, traction sutures were placed in the forearm extensor digitorum communis and flexor digitorum profundus tendons of the middle and ring fingers. Active

2019 Journal of Hand Surgery - American

112. Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. (PubMed)

and hepatocyte.NOD1 WT and KO mice were treated with NOD1 agonists and submitted to liver IR. Expression of adhesion molecules were analyzed in total liver, isolated hepatocytes and endothelial cells. Interaction between PMN and hepatocyte was studied in ex vivo co-culture model using electron microscopy (EM) and LDH levels. We generated NOD1 antagonist-loaded nanoparticles (np ALINO).NOD1 agonist treatment increased liver injury, PMN tissue infiltration and up-regulated ICAM-1 and VCAM-1 expression 20 hours (...) Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules. In liver transplantation, organ shortage leads to use marginal grafts that are more susceptible to ischemia reperfusion (IR). We identified nucleotide-binding oligomerization domain 1 (NOD1) as an important modulator of polymorphonuclear (PMN)-induced liver injury such as in IR. Here we aimed at elucidating its role in the liver IR, especially on the endothelium

2019 Journal of Hepatology

113. Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells Via Interleukin 6. (PubMed)

Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells Via Interleukin 6. In temporal arteries (TAs) from giant cell arteritis patients, varicella zoster virus (VZV) is seen in perineurial cells that surround adventitial nerve bundles and form the peripheral nerve-extrafascicular tissue barrier (perineurium). We hypothesized that during VZV reactivation from ganglia, virus travels transaxonally and disrupts the perineurium to infect surrounding cells.Mock

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2019 Journal of Infectious Diseases

114. L1 Cell Adhesion Molecule (L1CAM) expression in endometrioid endometrial carcinomas: A possible pre-operative surrogate of lymph vascular space invasion. (PubMed)

L1 Cell Adhesion Molecule (L1CAM) expression in endometrioid endometrial carcinomas: A possible pre-operative surrogate of lymph vascular space invasion. Risk stratification of endometrial carcinomas is primarily based on surgical staging that requires extensive retroperitoneal lymph node dissection. One of the most powerful predictor of lymph node involvement is the lymph vascular space invasion (LVSI). The objective of this study was to determine the potential of L1 Cell Adhesion Molecule (...) embedded whole tumor tissue sections.LVSI was identified in 26/41 (63,4%) of the cases. L1CAM was positive in 8/47 (17%) cases, all of them positive for LVSI and within the high-risk category of ESMO-ESGO-ESTRO. L1CAM-positive cases were associated with high histological grade and p53 aberrant immunohistochemical profile. Besides, it showed a trend to larger tumors, greater depth of myometrial infiltration, and with a higher frequency of the MELF pattern of myoinvasion. LVSI was also associated

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2018 PLoS ONE

115. Identification of myocilin as a blood plasma protein and analysis of its role in leukocyte adhesion to endothelial cell monolayers. (PubMed)

Identification of myocilin as a blood plasma protein and analysis of its role in leukocyte adhesion to endothelial cell monolayers. Myocilin is an extracellular glycoprotein with a poorly understood biological function and typically known because of its association with glaucoma. In this study, we analyzed the expression and biological activity of human myocilin in some non-ocular tissues. Western immunoblot showed the presence of myocilin in blood plasma as well as in liver and lymphoid (...) tissues (thymus and lymph node). Quantitative PCR confirmed the expression of MYOC in these lymphoid organs and revealed that its mRNA is also present in T-lymphocytes and leukocytes. In addition, detection of 30 kDa C-terminal myocilin fragments in thymus and liver suggested that myocilin undergoes an in vivo proteolytic processing that might regulate its biological activity. The presence of myocilin in blood was further corroborated by peptide mass fingerprinting of the HPLC-isolated protein

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2018 PLoS ONE

116. Regulation and function of IL-22 in peritoneal adhesion formation after abdominal surgery. (PubMed)

Regulation and function of IL-22 in peritoneal adhesion formation after abdominal surgery. Peritoneal adhesion occurs frequently after gastrointestinal/gynecological surgery. Tissue repair and regeneration are very important during this process. IL-22 is an important cytokine that is secreted from immune cells but functions on mesenchymal cells, such as mesothelial cells. The objective of this study was to investigate the roles of IL-22 and its regulators during adhesion formation. Postsurgical (...) peritoneal drainage fluid from patients and rodent models was examined by enzyme-linked immunosorbent assay and fluorescence-activated cell sorting. It was observed that IL-22 expression in the abdominal cavity was rapidly induced 12 hours after surgery and then slowly decreased to a lower, steady level for up to 7 days after surgery. However, neutralizing IL-22 at the time point at which the highest level of expression was observed failed to reduce adhesion, but neutralizing IL-22 at a later time point

2019 Wound Repair and Regeneration

117. Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma. (PubMed)

Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma. There is an urgent need to understand the molecular signaling pathways that drive or mediate the development of hepatocellular carcinoma (HCC). The focal adhesion kinase (FAK) gene protein tyrosine kinase 2 is amplified in 16.4% of The Cancer Genome Atlas HCC specimens, and its amplification leads to increased FAK mRNA expression. It is not known whether the overexpression of FAK alone is sufficient to induce HCC (...) -induced HCC formation. Conclusion: FAK overexpression and β-catenin mutations often co-occur in human HCC tissues. Co-overexpression of FAK and CAT leads to HCC formation in mice through increased expression of AR; this mouse model may be useful for further studies of the molecular mechanisms in the pathogenesis of HCC and could lead to the identification of therapeutic targets.© 2019 by the American Association for the Study of Liver Diseases.

2019 Hepatology

118. Mesh fixation using novel bio-adhesive coating compared to tack fixation for IPOM hernia repair: in vivo evaluation in a porcine model. (PubMed)

strength, shrinkage, adhesion scores, and histopathology in all samples.Measurements at both time points revealed that LifeMesh had fully conformed to the abdominal wall, and that its fixation strength was superior to that of the tack-fixated Symbotex and comparable to that of the tack-fixated PP. Shrinkage in all groups was similar. Adhesion scores with LifeMesh were lower than with PP and comparable with Symbotex at both time points. Histology demonstrated similar tissue responses in LifeMesh (...) and Symbotex. Lack of necrosis, mineralization, or exuberant inflammatory reaction in all three groups pointed to their good progressive integration of the mesh to the abdominal wall. By 28 days the bio-adhesive layer in LifeMesh was substantially degraded, allowing a gradual tissue ingrowth that became the main fixation mode of this mesh to the abdominal wall.The excellent incorporation of LifeMesh to the abdominal wall and its superior fixation strength, together with its low adhesion score, suggest

2019 Surgical endoscopy

119. The differentiation-associated keratinocyte protein cornifelin contributes to cell-cell adhesion of epidermal and mucosal keratinocytes. (PubMed)

The differentiation-associated keratinocyte protein cornifelin contributes to cell-cell adhesion of epidermal and mucosal keratinocytes. Cornifelin (CNFN) has been identified as protein component of epidermal corneocytes. Here, we investigated the tissue distribution of CNFN and potential consequences of CNFN-deficiency on epithelial function in in vitro models of human skin and oral mucosa. Our detailed bioinformatics and immunostaining analysis revealed that CNFN is not only expressed (...) of corneodesmosomes as detected by electron-microscopy. Using dispase treatment followed by mechanical stress, epithelial sheets of CNFN-deficient epidermal keratinocytes were easily disrupted whereas their CNFN-competent counterparts remained intact. In contrast to epidermal keratinocytes, CNFN knock-down in oral keratinocytes had a more severe effect and caused pronounced acantholysis in organotypic models of oral mucosa. Together, these findings indicate that CNFN is a structural component of the cell-adhesion

2019 Journal of Investigative Dermatology

120. The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study. (PubMed)

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study. To study the effect of chronic endometritis (CE) diagnosed by CD138 immunohistochemical (IHC) staining on endometrial fibrosis and reproductive prognosis in patients with moderate or severe intrauterine adhesions (IUAs).Prospective cohort study (Canadian Task Force classification II-2).University-affiliated hospital.One (...) hundred sixty-seven women with moderate to severe IUAs.Transcervical resection of adhesions (TCRA) and endometrial biopsy were performed in all patients. According to results of IHC staining with anti-syndecan-1 antibodies to identify CD138 cells, participants were classified into two groups: 78 patients with CE (CE group) and 89 women without CE (NCE group). IHC staining for fibrosis markers transforming growth factor beta 1, anti-fibrosis markers matrix metalloproteinase 9, and endometrial

2019 Fertility and Sterility

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