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Tissue Adhesive

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1. Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA

Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA Prolonged wound drainage after TKA is associated with increased risk of infection. To decrease wound drainage, tissue adhesive has been suggested as an adjunct to wound closure after TKA; however, no studies of which we are aware have investigated the effect of tissue adhesive in a modern fast-track TKA setting.The purpose (...) of this study was to evaluate the effect of wound closure using a high-viscosity tissue adhesive in simultaneous bilateral TKA with respect to (1) postoperative wound drainage, measured as number of dressing changes in the first 72 hours postoperatively; and (2) wound healing assessed using the ASEPSIS score.Thirty patients undergoing simultaneous bilateral TKA were included in the study. The left knee was randomized to receive either standard three-layer closure with staples or the same closure

2019 EvidenceUpdates

2. Tissue Adhesive Compared With Sterile Strips After Cesarean Delivery: A Randomized Controlled Trial

Tissue Adhesive Compared With Sterile Strips After Cesarean Delivery: A Randomized Controlled Trial To assess whether tissue adhesive after closure of Pfannenstiel incision for cesarean delivery lowers the risk of wound complications when compared with sterile strips.In this multicenter randomized controlled trial, women undergoing cesarean delivery using Pfannenstiel skin incision were randomized to receive tissue adhesive (2-octyl cyanoacrylate) compared with sterile strips after closure (...) . A planned interim analysis was performed after 500 patients delivered. A conditional power analysis revealed that the probability of showing a benefit with tissue adhesive was extremely low (6.2%), and the study was halted owing to futility.Between November 2016 and April 2018, 504 patients were randomized, and follow-up was achieved in 479 (95%). Wound complications occurred in 18 out of 238 patients (7.6%) in the tissue adhesive group and 19 out of 241 patients (7.9%) in the sterile strips group

2019 EvidenceUpdates

3. Lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to orbital roof: A case report (PubMed)

Lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to orbital roof: A case report To report a case of lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to the orbital roof.A 23-year-old female was presented with right lagophthalmos. Five months prior to consult at our clinic, she suffered from a penetrating trauma to the frontal lobe of the brain through the right orbital roof with cerebrospinal fluid leakage. Decompressive craniectomy was performed (...) assistance was achieved after sharp dissection of the cicatrized adipose tissue from the orbital roof. An autogenous dermis-fat was grafted on the orbital roof and superior orbital rim to avoid adhesion of orbital adipose tissue onto the bone again.Cicatricial adhesion of an orbital adipose tissue to the orbital roof is one of the possible causes of posttraumatic lagophthalmos in patients with an orbital roof fracture. Surgeons need to be aware of this condition in planning of surgical repair when

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2018 American journal of ophthalmology case reports

4. Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity. (PubMed)

Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity. The goal of the study was to assess calcium alone and Aquamin, a multi-mineral natural product that contains magnesium and detectable levels of 72 trace elements in addition to calcium, for capacity to affect growth and differentiation in colonoid cultures derived from histologically-normal human colon tissue.Colonoid cultures were maintained in a low (...) to 3.0 mM calcium). In spite of this, proteomic analysis and immunohistochemistry revealed that both interventions induced strong up-regulation of proteins that promote cell-cell and cell-matrix adhesive functions, barrier formation and tissue integrity. Transmission electron microscopy revealed an increase in desmosomes in response to intervention.These findings demonstrate that colonoids derived from histologically normal human tissue can undergo differentiation in the presence of a low ambient

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2019 PLoS ONE

5. Tendon Adhesions: A Novel Method of Objectively Measuring Adhesions by Assessing Tendon Glide Through a Soft Tissue Envelope in a Rat Model. (PubMed)

Tendon Adhesions: A Novel Method of Objectively Measuring Adhesions by Assessing Tendon Glide Through a Soft Tissue Envelope in a Rat Model. To develop a rat model of extra-synovial tendon adhesions that will enable accurate testing of scar barriers and adhesion inhibiting treatments to facilitate future research.Thirty-six 6-month-old male Sprague-Dawley rats were randomized to one of the 3 groups of 12. In Group A, the middle one-third portion of the left Achilles tendon was excised. In Group (...) B, the tendon and soft tissue bed was abraded with steel wool. In Group C, a silk suture was sewn along the tendon. The right hind limbs served as controls. At 4 weeks, biomechanical testing was performed on the bilateral hind limbs. The Achilles tendon was cut at the gastrocnemius-tendon junction proximal to the "adhesion zone" (or analogous level in the control limb). The calcaneal insertion of the Achilles was attached to a tensiometer. The force needed to pull the tendon out of its soft

2018 Journal of Hand Surgery - American

6. Tissue adhesives for closure of surgical incisions. (PubMed)

Tissue adhesives for closure of surgical incisions. Sutures (stitches), staples and adhesive tapes have been used for many years as methods of wound closure, but tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables the closure to be meticulous, but the sutures may show tissue reactivity and can require removal. Tissue adhesives offer the advantages of an absence of risk of needlestick injury and no requirement to remove sutures later. Initially (...) , tissue adhesives were used primarily in emergency room settings, but this review looks at the use of tissue adhesives in the operating room/theatre where surgeons are using them increasingly for the closure of surgical skin incisions.To determine the effects of various tissue adhesives compared with conventional skin closure techniques for the closure of surgical wounds.In March 2014 for this second update we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register

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2014 Cochrane

7. A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts. (PubMed)

A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts. The purpose was to compare patient-centered outcomes, early wound healing, and postoperative complications at palatal donor area of subepithelial connective tissue grafts (CTG) between cyanoacrylates tissue adhesives and polytetrafluoroethylene (PTFE) sutures.Thirty-six patients who required harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two groups

2018 Journal of periodontology Controlled trial quality: uncertain

8. Effect of cyanocrylate tissue adhesive in the post-operative palatal wound healing and pain management: a systematic review

Effect of cyanocrylate tissue adhesive in the post-operative palatal wound healing and pain management: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

9. n-Butyl-2-cyanoacrylate tissue adhesive (Histoacryl) vs. subcuticular sutures for skin closure of Pfannenstiel incisions following cesarean delivery. (PubMed)

n-Butyl-2-cyanoacrylate tissue adhesive (Histoacryl) vs. subcuticular sutures for skin closure of Pfannenstiel incisions following cesarean delivery. Tissue adhesives are now routinely used for skin closure in various surgeries. This study aimed to evaluate the safety and efficacy of n-butyl-2-cyanoacrylate (NBCA) tissue adhesive in cesarean delivery by comparing it with the safety and efficacy of subcuticular suture closure.A retrospective chart review was undertaken of all patients who

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2018 PLoS ONE

10. No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis. (PubMed)

No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis. An example of aggressive eosinophilic polyposis can be found in eosinophilic granulomatosis with polyangiitis (EGPA). Intercellular adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule-1 (vCAM-1) play a part in mediating the recruitment and adhesion of leukocytes to the vessel wall, and their blood-to-tissue (...) migration under inflammatory conditions.This prospective study compared 3 groups-patients with a definite diagnosis EGPA, non-EGPA patients with phenotypic features suggestive of EGPA, and patients with non-eosinophilic nasal polyposis (controls)-in terms of nasal tissue histology, iCAM-1 and vCAM-1 expression, and blood inflammatory cells.A total of 58 adults underwent sinus surgery (13 patients with EGPA, 23 suspected of having EGPA, and 22 controls).Mean tissue eosinophil counts were significantly

2019 American journal of rhinology & allergy

11. Complications following chin laceration reparation using tissue adhesive compared to suture in children. (PubMed)

Complications following chin laceration reparation using tissue adhesive compared to suture in children. Tissue adhesive is widely used in the emergency department to repair minor lacerations but there exists a debate as to whether it should be used for chin lacerations. The main objective of this study was to evaluate the rate of wound dehiscence of chin lacerations repaired with tissue adhesive in comparison to sutures.This was a retrospective chart review including all children requiring (...) a facial laceration reparation in a single tertiary care paediatric hospital. The primary outcome was wound dehiscence in the 30 days following reparation, comparing the use of tissue adhesive and sutures. The independent variable of interest was the use of tissue adhesive vs suture. A random sample of charts was reviewed in duplicate to insure reliability of the chart review.Among the 2044 children presenting with a facial laceration requiring an intervention, 1804 (88%) were repaired using tissue

2019 Injury

12. Prophylactic use of antibiotics in endoscopic injection of tissue adhesive for the elective treatment of gastric varices: A randomized controlled study. (PubMed)

Prophylactic use of antibiotics in endoscopic injection of tissue adhesive for the elective treatment of gastric varices: A randomized controlled study. Tissue adhesive injection is the first-line treatment for gastric varices re-bleeding. Available studies are focused on antibiotic usage in emergency endoscopy, while the use of antibiotics in selective endoscopic tissue adhesive treatment remains controversial.This is a randomized, controlled study conducted in a tertiary referral hospital (...) . Consecutive patients were enrolled from February 16, 2016 to November 19, 2016 and blindly randomized into two treatment groups. Patients in the prophylactic group received 2g of cefotiam during endoscopic injection of tissue adhesive. All the subjects were observed for rebleeding, fever and laboratory indicators change in hospital and post discharge.One hundred and seven patients who received endoscopic therapy for gastroesophageal varices were included. Fifty-three patients were allocated

2019 Journal of gastroenterology and hepatology Controlled trial quality: uncertain

13. Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. (PubMed)

Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. Prolonged wound drainage after TKA is associated with increased risk of infection. To decrease wound drainage, tissue adhesive has been suggested as an adjunct to wound closure after TKA; however, no studies of which we are aware have investigated the effect of tissue adhesive in a modern fast-track TKA setting.The purpose (...) of this study was to evaluate the effect of wound closure using a high-viscosity tissue adhesive in simultaneous bilateral TKA with respect to (1) postoperative wound drainage, measured as number of dressing changes in the first 72 hours postoperatively; and (2) wound healing assessed using the ASEPSIS score.Thirty patients undergoing simultaneous bilateral TKA were included in the study. The left knee was randomized to receive either standard three-layer closure with staples or the same closure

2019 Clinical Orthopaedics and Related Research Controlled trial quality: uncertain

14. Cyanoacrylate tissue adhesive or silk suture for closure of surgical wound following removal of an impacted mandibular third molar: A randomized controlled study. (PubMed)

Cyanoacrylate tissue adhesive or silk suture for closure of surgical wound following removal of an impacted mandibular third molar: A randomized controlled study. The aim of the study was to compare postoperative sequelae and wound healing outcome following closure of surgical wound with either cyanoacrylate tissue adhesive or silk suture.Subjects with mesio-angularly impacted mandibular third molar were allocated randomly into 2 equal groups. The control group had wound closure with silk (...) suture and study group with cyanoacrylate tissue adhesive. Subjects were followed up for 7 postoperative days. Postoperative pain, swelling, trismus, bleeding, wound dehiscence and wound infection were evaluated.Sixty subjects in each group completed the study. No significant difference was observed in the mean postoperative pain, swelling, trismus, wound dehiscence and infection between the 2 groups. There was a statistically significant difference in postoperative bleeding between the 2 groups

2019 Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery Controlled trial quality: uncertain

15. Tissue Adhesive Compared With Sterile Strips After Cesarean Delivery: A Randomized Controlled Trial. (PubMed)

Tissue Adhesive Compared With Sterile Strips After Cesarean Delivery: A Randomized Controlled Trial. To assess whether tissue adhesive after closure of Pfannenstiel incision for cesarean delivery lowers the risk of wound complications when compared with sterile strips.In this multicenter randomized controlled trial, women undergoing cesarean delivery using Pfannenstiel skin incision were randomized to receive tissue adhesive (2-octyl cyanoacrylate) compared with sterile strips after closure (...) . A planned interim analysis was performed after 500 patients delivered. A conditional power analysis revealed that the probability of showing a benefit with tissue adhesive was extremely low (6.2%), and the study was halted owing to futility.Between November 2016 and April 2018, 504 patients were randomized, and follow-up was achieved in 479 (95%). Wound complications occurred in 18 out of 238 patients (7.6%) in the tissue adhesive group and 19 out of 241 patients (7.9%) in the sterile strips group

2019 Obstetrics and Gynecology Controlled trial quality: predicted high

16. Comparison between N-butyl cyanoacrylate tissue adhesive and Ethilon nylon sutures in extraoral maxillofacial incisions: A randomized prospective study. (PubMed)

Comparison between N-butyl cyanoacrylate tissue adhesive and Ethilon nylon sutures in extraoral maxillofacial incisions: A randomized prospective study. Wound closure is a part of any surgical procedure. Wound care and healing process are concepts, which are usually reliant upon sutures. The suture and non-suture repair of the tissues has been a major concern to surgeons for over four thousand years. The objective of this study is to compare the rates of infection, wound dehiscence, necrosis (...) and time required by N-butyl cyanoacrylate tissue adhesive and nylon sutures in extraoral maxillofacial wound closer.24 patients requiring external wound closing were included in this study. Patients were divided in two groups, in one group wound closer was done by N-butyl cyanoacrylate tissue adhesive and by conventional nylon suture in the other group. The software STATA® of StataCorp was used in statistical analysis if this study.Wound infection, dehiscence, necrosis of tissue edges, time taken

2019 Journal of oral biology and craniofacial research Controlled trial quality: uncertain

17. Tissue adhesives to secure peripheral intravenous catheters: A randomized controlled trial in patients over 65 years. (PubMed)

Tissue adhesives to secure peripheral intravenous catheters: A randomized controlled trial in patients over 65 years. Peripheral venous catheterization is one of the most used medical procedures in hospitals worldwide. Recent researches state that using intravascular devices is a risk factor for both local and systemic complications. In this study, we aimed to test that addition of tissue adhesive to the insertion site of peripheral intravenous catheters (PIVC) in the emergency department (ED (...) ) would reduce the device failure rate at 6 h and 24 h following insertion.We designed a single-site, two-arm, randomized, controlled trial. We inserted 115 PIVCs into 115 adult patients.PIVC device failure for the 6th hour follow up was 15.4% in the tissue adhesive group (95% CI: 4.1-26.7) vs. 25.6% with standard care group (95% CI: 11.9-39.3). There was no statistically significant difference between two groups (p = 0.33).The number of patients for 24 h follow-up was not enough and the obtained data

2019 Turkish journal of emergency medicine Controlled trial quality: uncertain

18. CORR Insights®: Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. (PubMed)

CORR Insights®: Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. 31107335 2019 11 20 1528-1132 2019 Apr 27 Clinical orthopaedics and related research Clin. Orthop. Relat. Res. CORR Insights®: Tissue Adhesive for Wound Closure Reduces Immediate Postoperative Wound Dressing Changes After Primary TKA: A Randomized Controlled Study in Simultaneous Bilateral TKA. 10.1097/CORR

2019 Clinical Orthopaedics and Related Research Controlled trial quality: uncertain

19. Effect of Replacing Buried Sutures With Tissue Adhesive on Aesthetic Outcome of Surgical Wounds.

Effect of Replacing Buried Sutures With Tissue Adhesive on Aesthetic Outcome of Surgical Wounds. Effect of Replacing Buried Sutures With Tissue Adhesive on Aesthetic Outcome of Surgical Wounds. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Effect of Replacing Buried Sutures With Tissue Adhesive on Aesthetic Outcome of Surgical Wounds. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03425370 Recruitment Status : Terminated (Wound dehiscence on tissue adhesive side of 1 wound which developed an infection

2018 Clinical Trials

20. Comprehensive Review of Tissue Adhesives. (PubMed)

Comprehensive Review of Tissue Adhesives. Cyanoacrylates, also known as tissue adhesives or skin glues, are commonly used as sealants for lacerations and incisions and have found utility in excisional and cosmetic surgeries in both outpatient and operating room settings.To review the surgical literature on the utilities, advantages, disadvantages, and special uses of cyanoacrylates applicable to dermatology.PubMed was reviewed for relevant articles related to cyanoacrylates and their use (...) in skin closures. Articles unrelated to cutaneous closures were excluded.Tissue adhesives polymerize to a water resistant, pliable film after application to approximated wound edges and have antibacterial properties. Adhesives slowly slough off as the wound heals, typically after 5 days. Compared with 5-0 nonabsorbable suture, adhesives provide similar tensile strength and similar patient and surgeon satisfaction. Although slightly more expensive than sutures, tissue adhesives obviate the need

2018 Dermatologic Surgery

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