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Tissue Donation

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1. Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy

Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy E604 CMAJ | JUNE 3, 2019 | VOLUME 191 | ISSUE 22 © 2019 Joule Inc. or its licensors I n Canada, organ donation from deceased donors is a com- mon practice that saves or improves the lives of more than nearly 2000 Canadians every year, accounting for more than 3 of 4 of all transplanted organs. 1 Deceased donation is permitted after either neurologic or circulatory (...) providers and policy-makers. This document is intended to inform policies related to offering organ and tissue donation to patients who have made a decision that will lead to imminent death. These are conscious, competent patients who have chosen to withdraw mechanical ventilation, including invasive or noninvasive GUIDELINE | GUIDANCE FOR POLICY CPD Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy James Downar MDCM MHSc

2019 CPG Infobase

2. Consent for organ and tissue donation after death

Consent for organ and tissue donation after death MEMBER BRIEFING Consent for organ and tissue donation after deathCONSENT FOR ORGAN AND TISSUE DONATION AFTER DEATH 2 Consent for organ and tissue donation after death This briefing is intended to provide background information to RCN members across the UK who wish to complete the RCN survey on consent for organ and tissue donation after death. The survey will be open from 15 January to 11 February 2018. Why is the RCN reviewing its UK position (...) ? The RCN produced a position on consent for organ and tissue donation in 2009. At that time, after gathering and discussing member views, the RCN Council decided to support the opt-in arrangements which were then in operation across the entire UK. They also agreed to review this position at a later date. Each of the four countries of the UK is able to make its own laws on consent for organ and tissue donation. In 2015, the law changed in Wales to introduce a “soft opt-out” system for organ and tissue

2018 Royal College of Nursing

3. Donated Reproductive Tissue: Safety

Donated Reproductive Tissue: Safety Music Therapy for Patients in the Hospital: Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Music Therapy for Patients in the Hospital: Clinical Effectiveness and Cost-Effectiveness Music Therapy for Patients in the Hospital: Clinical Effectiveness and Cost-Effectiveness Published on: February 8, 2017 Project Number: RA0890-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Clinical guidelines for organ and tissue donation

Clinical guidelines for organ and tissue donation application/vnd.openxmlformats-officedocument.wordprocessingml.document

2018 Great Ormond Street Hospital

5. Screening Donated Cells, Tissues, and Organs for West Nile Virus: Clinical Evidence, Cost-Effectiveness, and Guidelines

Screening Donated Cells, Tissues, and Organs for West Nile Virus: Clinical Evidence, Cost-Effectiveness, and Guidelines Screening Donated Cells, Tissues, and Organs for West Nile Virus: Clinical Evidence, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Screening Donated Cells, Tissues, and Organs for West Nile Virus: Clinical Evidence, Cost-Effectiveness, and Guidelines Screening Donated Cells, Tissues, and Organs for West Nile Virus: Clinical Evidence, Cost (...) -Effectiveness, and Guidelines Published on: February 2, 2016 Project Number: RA0828-000 Product Line: Research Type: Other Diagnostics Report Type: Reference List Result type: Report Question What is the clinical evidence regarding the risk of transmission of West Nile virus from donated cells, tissues, or organs to the donation recipient? What is the cost-effectiveness of screening donated cells, tissue, or organs for West Nile virus prior to transplantation? What are the evidence-based guidelines

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

6. Parents' experiences of requests for organ and tissue donation: the value of asking. (PubMed)

Parents' experiences of requests for organ and tissue donation: the value of asking. A proportion of children die, making them potentially eligible to be organ/tissue donors. Not all are approached for donation, and experiences of those parents are not well understood. The objective was to investigate to what extent organ and tissue donation (OTD) is discussed as part of end-of-life care and to explore parents' and healthcare professionals' (HCPs) experiences.A retrospective qualitative (...) study.Multicentre study with participants recruited through two neonatal intensive care units (ICUs), two paediatric ICUs, a cardiac ICU and a children's hospice.Bereaved parents, parents of a child with a long-term condition (LTC) and HCPs.None.Parents' and HCPs' views and experiences of discussions about OTD.24 parents of 20 children were interviewed: 21 bereaved parents and 3 parents of a child with a LTC. Seven parents were asked about donation (13 not asked), four agreed and two donated. 41 HCPs were

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2019 Archives of Disease in Childhood

7. Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice. (PubMed)

Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice. Islet transplantation is a treatment option that can help individuals with type 1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can hamper islet survival and engraftment due to the size of the islets and loss of the native microvasculature. We hypothesised that size-controlled pseudoislets engineered via

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2018 Diabetologia

8. A multicentre investigation of organ and tissue donation education for critical care residents. (PubMed)

A multicentre investigation of organ and tissue donation education for critical care residents. To describe critical care medicine residents' training, expertise, and skills regarding organ and tissue donation processes and procedures.We undertook a qualitative multicentre study and employed a purposive sample of program directors, physicians, nurses, residents, and organ donation leaders from all nine academic intensive care unit (ICU) training centres (five adult, four pediatric) in Ontario (...) (n = 71). Interviews, conducted by telephone between December 2015 and March 2016, were audio-recorded and transcribed verbatim. Data collection and analysis were performed using an iterative process and continued until saturation was achieved.Five main themes were identified: 1) gaps in residents' knowledge for both neurologic determination of death (NDD) and circulatory determination of death (DCD) cases; 2) commitment to the provision of organ and tissue donation training; 3) limited

2018 Canadian Journal Of Anaesthesia

9. Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect” (PubMed)

Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect” 29491148 2018 04 01 1521-0103 365 1 2018 Apr The Journal of pharmacology and experimental therapeutics J. Pharmacol. Exp. Ther. Correction to "Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect". 139

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2018 The Journal of pharmacology and experimental therapeutics

10. Lessons learned from a student-driven initiative to design and implement an Organ and Tissue Donation course across Canadian medical schools (PubMed)

Lessons learned from a student-driven initiative to design and implement an Organ and Tissue Donation course across Canadian medical schools The competencies required of the well-trained physician are constantly evolving, and medical education must adapt accordingly. In response, a growing number of influential medical education licensing and accreditation bodies have proposed frameworks that outline society's expectations of physician competencies. In Canada, undergraduate and graduate (...) how organ and tissue donation is taught in Canadian medical schools. Citing relevant medical education literature where applicable, we include a detailed description of our approach as a roadmap for students contemplating their own curricular innovations. By outlining the factors influencing this project's implementation, as well as the benefits and limitations of student participation in curriculum reform, we offer educators a fresh perspective on optimizing the student role in this important

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2018 Perspectives on medical education

11. Organ donation for transplantation: improving donor identification and consent rates for deceased organ donation

' . The Human Tissue Authority has produced codes of practice for consent and for donation of solid organs for transplantation, and the NHS has produced a code of practice on confidentiality [1] . Good communication between healthcare professionals and people is essential. It should be supported by evidence-based written information tailored to the person's needs. The information people are given about their care should be culturally appropriate. It should also be accessible to people with additional needs (...) are potential organ donors communication skills and knowledge necessary to improve consent ratios for organ donation. More information You can also see this guideline in the NICE pathway on organ donation for transplantation. T o find out what NICE has said on topics related to this guideline, see our web page on organ and tissue transplantation. See also the guideline committee's discussion and the evidence reviews (in the full guideline), and information about how the guideline was developed, including

2011 National Institute for Health and Clinical Excellence - Clinical Guidelines

12. Canadian guidelines for controlled pediatric donation after circulatory determination of death-summary report

individuals within the healthcare team may have differing views on the meaning and permissibility of deceased organ and tissue donation (OTD) based on societal, cultural, religious, and other personal beliefs ( ). These concerns justify the above recommendation to allow conscientious objection by healthcare professionals to not participate in pDCD, consistent with other policy and position statements ( , , ). However, considering the important role donation can play in the lives of donor families (...) that these practices conform to accepted medical and legal standards, c) Which organs are potentially eligible for recovery, d) That consenting for pDCD does not guarantee organ recovery or transplantation, e) If organ recovery is not possible, tissue donation may remain an option, f) How EOL care would proceed if they decline organ donation or if recovery does not occur after attempted donation, g) That the treating team has no influence over allocation, which may include allocation to adult or pediatric

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2017 CPG Infobase

13. COMmunication with Families regarding ORgan and Tissue donation after death in intensive care (COMFORT): protocol for an intervention study. (PubMed)

COMmunication with Families regarding ORgan and Tissue donation after death in intensive care (COMFORT): protocol for an intervention study. Discussing deceased organ donation can be difficult not only for families but for health professionals who initiate and manage the conversations. It is well recognised that the methods of communication and communication skills of health professionals are key influences on decisions made by families regarding organ donation.This multicentre study is being (...) performed in nine intensive care units with follow-up conducted by the Organ and Tissue Donation Service in New South Wales (NSW) Australia. The control condition is pre-intervention usual practice for at least six months before each site implements the intervention. The COMFORT intervention consists of six elements: family conversations regarding offers for organ donation to be led by a "designated requester"; family offers for donation are deferred to the designated requester; the offer of donation

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2017 BMC health services research

14. Fresh osteochondral allografts-procurement and tissue donation in Europe. (PubMed)

Fresh osteochondral allografts-procurement and tissue donation in Europe. Fresh osteochondral allografts are a well-established treatment for large, full-thickness cartilage defects. The clinical outcome for carefully selected patients is very favorable, especially for the young and active and graft survival up to 25 years has been described in the literature. Furthermore, a high patient satisfaction rate has been reported, but the biggest obstacle to overcome is the availability of tissue (...) for transplantation. Large fresh bone allografts for cartilage damage repair only can be harvested from organ donors following organ removal or cadaveric donors, preferably in the setting of an operation room to minimize possible contamination of the tissue. Apart from the logistic challenges this entails, an experienced recovery team is needed. Furthermore, the public as well as medical staff is much less aware of the possibility and requirements of tissue donation than organ donation and families of deceased

2017 Injury

15. "Effective" Requesting: A Scoping Review of the Literature on Asking Families to Consent to Organ and Tissue Donation. (PubMed)

"Effective" Requesting: A Scoping Review of the Literature on Asking Families to Consent to Organ and Tissue Donation. Families are often asked to consent to the donation of their deceased relative's organs or tissues. These end-of-life conversations are important because they affect consent rates as well as the psychological impact of the decision for families. This scoping review of the literature on requesting family consent was prepared to support of the development of leading practice (...) and the process. This review includes a final set of 168 articles addressing (a) whether, when, and how to ask families for consent to donation or (b) characteristics of families or decedents that affect families' decisions or family satisfaction with their decisions.Six main themes were identified: (1) the objectives of requesting and encouraging family consent to donation, (2) the effect of the donation decision on family well-being, (3) the process of requesting family consent, (4) the impact

2017 Transplantation

16. Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry (PubMed)

Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry There is a worldwide shortage of organs available for transplant, leading to preventable mortality associated with end-stage organ disease. While most citizens in many countries with an intent-to-donate "opt-in" system support organ donation, registration rates remain low. In Canada, most (...) Canadians support organ donation but less than 25% in most provinces have registered their desire to donate their organs when they die. The family physician office is a promising yet underused setting in which to promote organ donor registration and address known barriers and enablers to registering for deceased organ and tissue donation. We developed a protocol to evaluate an intervention to promote registration for organ and tissue donation in family physician waiting rooms.This protocol describes

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2017 Trials

17. Donation of Post Mortem Tumor Tissues

Donation of Post Mortem Tumor Tissues Donation of Post Mortem Tumor Tissues - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Donation of Post Mortem Tumor Tissues (DONUM) The safety and scientific validity (...) l'Oncologia Information provided by (Responsible Party): Niguarda Hospital Study Details Study Description Go to Brief Summary: DONUM is an observational prospective independent protocol for patients with advanced lung cancer, colorectal cancer or cancer of unknown primary, willing to donate their tumor tissue samples post mortem for biomedical research purposes. All patients who fulfill the inclusion criteria will be eligible for the study after giving their Informed consent. Informed Consent

2017 Clinical Trials

18. Patient, Caregiver and Physician Perspectives on Participating in a Thoracic Rapid Tissue Donation Program (PubMed)

Patient, Caregiver and Physician Perspectives on Participating in a Thoracic Rapid Tissue Donation Program The collection of posthumous tissue from advanced stage lung cancer patients is beneficial to medical science. Recruiting living patients to a Rapid Tissue Donation Program (RTD) poses several psychosocial challenges and little is known about perceptions of joining this type of program. This study qualitatively examined perceptions of advanced stage lung cancer patients (n=14 (...) ) participating in a lung cancer RTD program, their NoK (n=11), and physicians (n=6) at the Thoracic Oncology Clinic at H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida USA.Semi-structured interviews were conducted with participants and interview transcripts were analyzed using the constant comparison method.Majority of patients joined to give back to research, discussed participation with family members, and desired for family to receive information about the use of the tissue after

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2017 Patient education and counseling

19. Development of national system performance metrics for tissue donation, production, and distribution activity (PubMed)

Development of national system performance metrics for tissue donation, production, and distribution activity Canada's federal, provincial, and territorial governments gave Canadian Blood Services a mandate for organ and tissue donation and transplantation, including system performance, data and analytics. In 2012 Canadian Blood Services facilitated an eye and tissue banking workshop focused on standardized specifications and practices. At the workshop, the Canadian tissue community directed (...) Canadian Blood Services to facilitate the development and implementation of a national data stream and analytics. Prior to this no national data was prospectively collected or collated on tissue donation, production or distribution activity. An eye and tissue data committee was formed with representation from eye and tissue banks in all Canadian jurisdictions. A minimum data set, standardized definitions, a data submission form and a quality assurance process was developed. Training was provided

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2017 Cell and tissue banking

20. Registration for deceased organ and tissue donation among Ontario immigrants: a population-based cross-sectional study (PubMed)

Registration for deceased organ and tissue donation among Ontario immigrants: a population-based cross-sectional study Canada has low rates of deceased organ and tissue donation. Immigrants to Canada may differ in their registered support for deceased organ donation based on their country of origin.We used linked administrative databases in Ontario (about 11 million residents aged ≥ 16 yr) to study the proportion of immigrants and long-term residents registered for deceased organ and tissue (...) donation as of October 2013. We used modified Poisson regression to identify and quantify predictors of donor registration.Compared with long-term residents (n = 9 244 570), immigrants (n = 1 947 646) were much less likely to register for deceased organ and tissue donation (11.9% v. 26.5%). Immigrants from the United States, Australia and New Zealand had the highest registration rate (40.0%), whereas immigrants with the lowest registration rates were from Eastern Europe and Central Asia (9.4%), East

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2016 CMAJ open

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