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Thyroxine-Binding Globulin

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141. RADIOCHROMATOGRAPHIC IDENTIFICATION OF THYROXIN IN AN ALPHA GLOBULIN FRACTION OF SERUM SEPARATED BY STARCH ZONE ELECTROPHORESIS (PubMed)

RADIOCHROMATOGRAPHIC IDENTIFICATION OF THYROXIN IN AN ALPHA GLOBULIN FRACTION OF SERUM SEPARATED BY STARCH ZONE ELECTROPHORESIS 13130690 2003 05 01 2018 12 01 0021-9738 33 2 1954 Feb The Journal of clinical investigation J. Clin. Invest. Radiochromatographic identification of thyroxin in an alpha globulin fraction of serum separated by starch zone electrophoresis. 230-4 LARSON F C FC DEISS W P WP ALBRIGHT E C EC eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Alpha-Globulins (...) 0 Serum Globulins 9005-25-8 Starch Q51BO43MG4 Thyroxine OM Alpha-Globulins Chromatography Electrophoresis Humans Serum Globulins Starch Thyroxine analysis 5425:50906:110:155:421:464 CHROMATOGRAPHY ELECTROPHORESIS SERUM GLOBULIN THYROXIN/determination 1954 2 1 1954 2 1 0 1 1954 2 1 0 0 ppublish 13130690 10.1172/JCI102889 PMC438493 Blood. 1950 Aug;5(8):764-6 15426658 Proc Soc Exp Biol Med. 1952 May;80(1):42-4 14930066 Lancet. 1952 Mar 1;1(6705):439-41 14898765 Nature. 1952 Jan 5;169(4288):19-20

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1954 Journal of Clinical Investigation

142. Effects of Toremifene, a Selective Estrogen Receptor Modulator, on Spontaneous and Stimulated GH Secretion, IGF-I, and IGF-Binding Proteins in Healthy Elderly Subjects (PubMed)

endocrine effects of tamoxifen are known, few data are available for toremifene.To explore sex-dependent effects of toremifene on spontaneous 10-hour overnight GH secretion, followed by GH-releasing hormone-ghrelin stimulation. Additionally, effects on IGF-I, its binding proteins, and sex hormone-binding globulin (SHBG) were quantified.Twenty men and 20 women, within an allowable age range of 50 to 80 years, volunteered for this double-blind, placebo-controlled prospective crossover study. Ten-minute (...) Effects of Toremifene, a Selective Estrogen Receptor Modulator, on Spontaneous and Stimulated GH Secretion, IGF-I, and IGF-Binding Proteins in Healthy Elderly Subjects Estrogens amplify spontaneous and stimulated growth hormone (GH) secretion, whereas they diminish GH-dependent insulin-like growth factor (IGF)-I in a dose-dependent manner. Selective estrogen receptor modulators (SERMs), including tamoxifen and toremifene, are widely adjunctively used in breast and prostate cancer. Although some

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2017 Journal of the Endocrine Society Controlled trial quality: uncertain

143. STUDIES ON THE METABOLISM OF PLASMA PROTEINS IN THE NEPHROTIC SYNDROME. I. ALBUMIN, γ-GLOBULIN AND IRON-BINDING GLOBULIN (PubMed)

STUDIES ON THE METABOLISM OF PLASMA PROTEINS IN THE NEPHROTIC SYNDROME. I. ALBUMIN, γ-GLOBULIN AND IRON-BINDING GLOBULIN 13278400 2003 05 01 2018 12 01 0021-9738 35 1 1956 Jan The Journal of clinical investigation J. Clin. Invest. Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. 44-56 GITLIN D D JANEWAY C A CA FARR L E LE eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Blood Proteins 0 Globulins 0 (...) Serum Albumin 0 Serum Globulins 0 gamma-Globulins E1UOL152H7 Iron OM Blood Proteins Globulins Humans Iron Nephrosis blood Nephrotic Syndrome Serum Albumin metabolism Serum Globulins gamma-Globulins 5629:30541 GAMMA GLOBULIN NEPHROSIS/blood in SERUM ALBUMIN/metabolism SERUM GLOBULIN 1956 1 1 1956 1 1 0 1 1956 1 1 0 0 ppublish 13278400 10.1172/JCI103251 PMC438777 J Biol Chem. 1955 Feb;212(2):633-9 14353864 Fed Proc. 1951 Jun;10(2):562-3 14849615 Science. 1954 Sep 17;120(3116):461-3 13195675 J Exp Med

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1956 Journal of Clinical Investigation

144. Transcholesterin, a cholesterol-binding globulin: serological demonstration of a specific interaction between cholesterol and serum globulin. (PubMed)

Transcholesterin, a cholesterol-binding globulin: serological demonstration of a specific interaction between cholesterol and serum globulin. 4958033 1966 11 28 2018 11 13 0027-8424 53 5 1965 May Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. Transcholesterin, a cholesterol-binding globulin: serological demonstration of a specific interaction between cholesterol and serum globulin. 1061-9 Francis T T Jr Ling N S NS Krasteff T T eng (...) Journal Article United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 Serum Globulins 0 Surface-Active Agents 97C5T2UQ7J Cholesterol IM Biological Transport Cholesterol Humans Immunodiffusion Immunoelectrophoresis In Vitro Techniques Serum Globulins Surface-Active Agents 1965 5 1 2001 3 28 10 1 1965 5 1 0 0 ppublish 4958033 PMC301373 Proc Soc Exp Biol Med. 1951 Oct;78(1):329-32 14892010 Endocrinology. 1952 Mar;50(3):366-73 14926704 Science. 1952 Oct 17;116(3016):428-30 12984139 Am J Physiol. 1952

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1965 Proceedings of the National Academy of Sciences of the United States of America

145. Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. (PubMed)

Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population.The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according

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2013 BMC Cardiovascular Disorders

146. Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. (PubMed)

Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population.The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according

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2013 BMC cardiovascular disorders

147. Age, Body Mass, Usage of Exogenous Estrogen, and Lifestyle Factors in Relation to Circulating Sex Hormone-Binding Globulin Concentrations in Postmenopausal Women. (PubMed)

Age, Body Mass, Usage of Exogenous Estrogen, and Lifestyle Factors in Relation to Circulating Sex Hormone-Binding Globulin Concentrations in Postmenopausal Women. Circulating concentrations of sex hormone-binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood.We comprehensively investigated correlates of SHBG concentrations among 13 547 women

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2013 Clinical Chemistry

148. How Changes in Affinity of Corticosteroid-binding Globulin Modulate Free Cortisol Concentration. (PubMed)

How Changes in Affinity of Corticosteroid-binding Globulin Modulate Free Cortisol Concentration. Recent studies of corticosteroid-binding globulin (CBG) indicate that it does not merely transport cortisol passively but also actively regulates its release in the circulation. We show how CBG binding affinity can vary to give changes in free cortisol concentration in a physiologically relevant range.The objective was to determine how the binding affinity of plasma CBG is affected by glycosylation (...) , changes in body temperature, and the conformational change induced by proteases at sites of inflammation.Binding assays were performed over a range of temperatures with plasma and recombinant CBG to determine the contribution of glycosylation. The role of conformational change was assessed by measuring binding affinities of plasma CBG before and after reactive loop cleavage by neutrophil elastase.Determination of binding constants allows calculation of clinically relevant changes in CBG saturation

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2013 Journal of Clinical Endocrinology and Metabolism

149. Sex Hormone Binding Globulin and Verbal Memory in Older Men. (PubMed)

Sex Hormone Binding Globulin and Verbal Memory in Older Men. Cognitive function in older adults may be affected by multiple factors, such as sex hormone levels, metabolic disturbances, and neuropsychiatric illness. However, relatively few studies have tested the associations between these factors and cognitive function in a single sample. A cross-sectional analysis was conducted to examine the association between sex hormones, metabolic parameters, and psychiatric diagnoses with verbal memory (...) in nondemented older men.Participants were 112 men (mean age: 61.3 years) from the Baltimore Epidemiologic Catchment Area Follow-Up Study who completed measures of blood sex hormone levels, metabolic parameters (e.g., lipid profiles), and verbal memory.Higher levels of serum sex hormone binding globulin (SHBG) were associated with lower delayed verbal memory scores (standardized coefficients [beta]=-0.19, t=-2.07, df=1, 105, p=0.04), and higher body mass index (BMI) was associated with better immediate (beta

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2013 The American Journal of Geriatric Psychiatry

150. Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. (PubMed)

Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Regulators of adipose tissue hormones remain incompletely understood, but may include sex hormones. As adipose tissue hormones have been shown to contribute to numerous metabolic and cardiovascular disorders, understanding their regulation in midlife women is of clinical importance. Therefore, we assessed the associations between testosterone (T) and sex hormone binding globulin (SHBG

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2013 Obesity

151. Low androstenedione/sex hormone binding globulin ratio increases fracture risk in postmenopausal women. The Women's Health in the Lund Area study. (PubMed)

Low androstenedione/sex hormone binding globulin ratio increases fracture risk in postmenopausal women. The Women's Health in the Lund Area study. The Women's Health in the Lund Area (WHILA) project (n=6917) is a cohort study that started in 1995 and includes a postal questionnaire, physical examination, bone density measurement and blood laboratory analyses. Fracture data have been added, and in this report fracture risk and its association with sex hormones was analysed in postmenopausal (...) women without current hormone therapy (HT). A total of 409 women (median age 56.8 years) with 489 fractures were identified from the postmenopausal women without HT during a median follow-up time of 8.4 years. Lower serum levels of androstenedione (p<0.001), testosterone (p=0.008), androstenedione/sex hormone binding globulin (SHBG) ratio (p<0.001), testosterone/SHBG ratio (p=0.003) and higher levels of SHBG (p=0.005) were observed in women with fractures compared to no fracture. No difference

2013 Maturitas

152. Total testosterone and sex hormone-binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men. (PubMed)

Total testosterone and sex hormone-binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men. The purpose of this study is to investigate the relationship between sex hormones and metabolic syndrome independent of age and BMI in Korean men.We conducted a cross-sectional study with data from a health promotion center during the period from March 2007 to February 2010. 2172 Korean men aged 21-79 were enrolled. Total testosterone, sex hormone (...) -binding globulin (SHBG), high density lipoprotein (HDL) cholesterol, triglyceride (TG), and glucose were assessed with overnight fasting serum samples.Sex hormones were divided into quartiles; odds ratios for metabolic syndrome and each component were analyzed.Total testosterone showed negative associations with waist circumference (WC), fasting glucose, TG, blood pressure and body mass index (BMI), and a positive relationship with HDL cholesterol (P for trend <0.001, respectively). SHBG

2013 Maturitas

153. The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome

The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting (...) registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor

2013 Clinical Trials

154. Associations Between Body Size and Serum Estradiol and Sex Hormone-Binding Globulin Levels in Premenopausal African American Women. (PubMed)

Associations Between Body Size and Serum Estradiol and Sex Hormone-Binding Globulin Levels in Premenopausal African American Women. African American (AA) women have the highest rates of premenopausal breast cancer; however, it is unclear whether body size contributes to the hormonal patterns potentially associated with increased breast cancer risk in these women.To characterize the association between body size and serum levels of estradiol and sex hormone-binding globulin (SHBG) levels

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2013 Journal of Clinical Endocrinology and Metabolism

155. Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. (PubMed)

Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. It is unknown whether intensive lifestyle modification (ILS) or metformin changes sex steroids among premenopausal women without a history of polycystic ovarian syndrome (PCOS).We examined 1-year intervention impact on sex steroids (estradiol, testosterone, dehydroepiandrosterone, and androstenedione [A4]) and SHBG and differences by race/ethnicity.A subgroup of Diabetes Prevention

2013 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

156. Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. (PubMed)

Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. It is unknown whether intensive lifestyle modification (ILS) or metformin changes sex steroids among premenopausal women without a history of polycystic ovarian syndrome (PCOS).We examined 1-year intervention impact on sex steroids (estradiol, testosterone, dehydroepiandrosterone, and androstenedione [A4]) and SHBG and differences by race/ethnicity.A subgroup of Diabetes Prevention

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2013 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

157. Intensive Insulin Therapy Increases Sex Hormone Binding Globulin in Newly Diagnosed Type 2 Diabetic Patients. (PubMed)

Intensive Insulin Therapy Increases Sex Hormone Binding Globulin in Newly Diagnosed Type 2 Diabetic Patients. Many studies have shown that low sex hormone-binding globulin (SHBG) is associated with insulin resistance, but only few studies have examined how serum SHBG is regulated by insulin in humans. This interventional study aimed to investigate the effect of insulin therapy (IT) on serum SHBG levels in newly diagnosed type 2 diabetic patients.A total of 80 newly diagnosed type 2 diabetic

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2013 European Journal of Endocrinology Controlled trial quality: uncertain

158. Interaction of beta1H globulin with cell-bound C3b: quantitative analysis of binding and influence of alternative pathway components on binding (PubMed)

Interaction of beta1H globulin with cell-bound C3b: quantitative analysis of binding and influence of alternative pathway components on binding Purified beta1H globulin (beta1H) was shown to bind to C3b coated cells by both immunofluorescent and radioactive tracer techniques. With EAC43, the amount of beta1H bound was directly proportional to the amount of C3 used to prepare the cells; EA, EAC14 and EAC14oxy2 bound very small amounts of beta1H. The C3b binding site on beta1H was labile (...) in that not all of the purified 125I-beta1H was capable of binding to C3b, even when an excess of cell-bound C3b was present. Scatchard analysis of binding of beta1H to C3b-coated cells indicated an equilibrium constant of 10(9) L/M. Deviations from linearity were regularly found on Scatchard analyses. This was consistent with the hypothesis that the beta1H binding sites exhibit negative cooperativity in that as more sites become occupied, it becomes more difficult to fill the remaining sites

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1978 The Journal of experimental medicine

159. An Androgen Binding Protein in the Testicular Cytosol of Human Testis: COMPARISON WITH HUMAN PLASMA TESTOSTERONE-ESTROGEN BINDING GLOBULIN (PubMed)

An Androgen Binding Protein in the Testicular Cytosol of Human Testis: COMPARISON WITH HUMAN PLASMA TESTOSTERONE-ESTROGEN BINDING GLOBULIN After removal of plasma contamination, an androgen binding protein (hABP) was detected in a 105,000-g supernate of human testicular homogenate. The physicochemical properties of hABP have been compared with a similar androgen binding protein in human plasma, testosterone-estrogen binding globulin (TeBG). hABP had high affinity (K(d) = 7.8 nM) and low (...) capacity (0.27 pmol/mg protein) for 5alpha-dihydrotestosterone (DHT). Binding affinity of human TeBG for DHT was greater (K(d) = 0.66 nM, binding capacity 0.68 pmol/mg protein). On the basis of sedimentation rates and Einstein Stokes radii of hABP and TeBG, the mol wt of the two proteins were similar in the range of 87,000-92,000. The ligand specificities of hABP and TeBG were the same. The binding of [(3)H]DHT to hABP and TeBG were reversible processes at 0 degrees C. The half-lives

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1978 Journal of Clinical Investigation

160. BINDING OF CORTICOSTEROIDS BY PLASMA PROTEINS. IV. THE ELECTROPHORETIC DEMONSTRATION OF CORTICOSTEROID BINDING GLOBULIN (PubMed)

BINDING OF CORTICOSTEROIDS BY PLASMA PROTEINS. IV. THE ELECTROPHORETIC DEMONSTRATION OF CORTICOSTEROID BINDING GLOBULIN 13539190 2000 07 01 2018 12 01 0021-9738 37 4 1958 Apr The Journal of clinical investigation J. Clin. Invest. Binding of corticosteroids by plasma proteins. IV. The electrophoretic demonstration of corticosteroid binding globulin. 519-23 DAUGHADAY W H WH eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Adrenal Cortex Hormones 0 Blood Proteins 0 (...) Glucocorticoids 0 Serum Globulins 9010-38-2 Transcortin OM Adrenal Cortex Hormones blood Blood Proteins Glucocorticoids Humans Serum Globulins Transcortin 5834:31730:14:542 ADRENAL CORTEX HORMONES/in blood SERUM GLOBULIN 1958 4 1 1958 4 1 0 1 1958 4 1 0 0 ppublish 13539190 10.1172/JCI103633 PMC293116 J Biol Chem. 1951 Nov;193(1):265-75 14907713 J Biol Chem. 1954 Jan;206(1):411-9 13130562 Science. 1955 Apr 22;121(3147):601-2 14372963 Proc Soc Exp Biol Med. 1949 Oct;72(1):110-4 15391689 Arch Biochem Biophys

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1958 Journal of Clinical Investigation

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