How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

205 results for

Thyroxine-Binding Globulin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Fasting Study of Levothyroxine Sodium Tablets 300 Mcg to Synthroid® Tablets 300 Mcg

evaluation, blood chemistry, serum T4 (free and total), serum T3 (total only), serum thyroid-stimulating hormone (TSH), serum thyroxine-binding globulin (TBG), hepatitis B and hepatitis C tests, HIV test, 12-lead ECG, and urine drug screen including amphetamine, barbiturates, benzodiazepine, cannabinoid, cocaine, opiate screen, phencyclidine, and methadone) performed within 14 days of the initial dose of study medication. Exclusion Criteria: Institutionalized subjects will not be used. Social Habits: Use

2008 Clinical Trials

142. Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg

), as referenced by the Table of "Desirable Weights of Adults" Metropolitan Life Insurance Company, 1983 (See Part II Administrative Aspects of Bioequivalence Protocols). All subjects should be judged normal (euthyroid) and healthy during a prestudy medical evaluation (physical examination, laboratory evaluation, blood chemistry, serum T4 (free and total), serum T3 (total only), serum thyroid-stimulating hormone (TSH), serum thyroxine-binding globulin (TBG), hepatitis B and hepatitis C tests, HIV test, 12-lead

2008 Clinical Trials

143. Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)

or alcoholic beverages within 12 hours of serum sampling). Each cycle consists of 28 days. Serum Concentration of Free Thyroxine (T4) [ Time Frame: Baseline and Cycle 6 (between Days 15 and 21 of the cycle) ] Serum samples were obtained under fasting conditions (no food or alcoholic beverages within 12 hours of serum sampling). Each cycle consists of 28 days. Serum Concentration of Thyroxin Binding Globulin (TBG) [ Time Frame: Baseline and Cycle 6 (between Days 15 and 21 of the cycle) ] Serum samples were (...) in the ratio indicates a increased responsiveness to APC. Each cycle consists of 28 days. Serum Concentration of Sex Hormone Binding Globulin (SHBG) [ Time Frame: Baseline and Cycle 6 (between Days 15 and 21 of the cycle) ] Serum samples were obtained under fasting conditions (no food or alcoholic beverages within 12 hours of serum sampling). Each cycle consists of 28 days. Serum Concentration of C-Reactive Protein (CRP) [ Time Frame: Baseline and Cycle 6 (between Days 15 and 21 of the cycle) ] Serum

2007 Clinical Trials

144. Effect of thyroid hormone binding proteins on insulin receptor binding of B1-thyronine-insulin analogues Full Text available with Trip Pro

-insulin and NaB1-L-thyroxyl-aminolauroyl-insulin were compared with insulin for their capacity to inhibit the binding of [125I]TyrA14-insulin to rat liver plasma membrane in albumin-free buffer. Effective doses at 50% maximum inhibition of binding (ED50) were calculated with and without addition of the thyroid hormone binding proteins transthyretin, thyroxine binding globulin and human serum albumin. The binding of thyronine-insulin analogues to insulin receptors was inhibited in a dose-dependent

2004 Biochemical Journal

145. Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative Full Text available with Trip Pro

designed to increase both selectivity of binding to TTR and inhibitory potency in relation to TTR amyloid fibril formation. We found two diflunisal derivatives that, in contrast with diclofenac, flufenamic acid and diflunisal, displaced T4 from TTR in plasma preferentially over binding to albumin and thyroxine binding globulin. The same diflunisal derivatives also had a stabilizing effect on TTR tetramers in plasma, as studied by isoelectric focusing of whole plasma under semi-denaturing conditions (...) . Several small compounds, such as diclofenac, diflunisal and flufenamic acid, have been reported to bind to TTR in vitro, in the T4 (thyroxine) binding channel that runs through the TTR tetramer, and consequently are considered to stabilize TTR. However, if these agents bind plasma proteins other than TTR, decreased drug availability will occur, compromising their use as therapeutic agents for TTR amyloidosis. In the present work, we compared the action of these compounds and of new derivatives

2004 Biochemical Journal

146. A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. (Abstract)

A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. To compare the changes induced by oral versus transdermal estrogen therapy on the total and free serum concentrations of testosterone (T), thyroxine (T4), and cortisol (C) and the concentrations of their serum binding globulins sex hormone-binding globulin, thyroxine-binding globulin, and cortisol (...) treatment periods. The mean(SD) percentage changes from baseline of sex hormone-binding globulin, total T, and free T with oral CEE were +132.1% (74.5%), +16.4% (43.8%), and -32.7% (25.9%), respectively, versus +12.0% (25.1%), +1.2% (43.7%), and +1.0% (45.0%) with TD E2. The mean (SD) percentage changes of thyroxine-binding globulin, total T4, and free T4 with oral CEE were +39.9% (20.1%), +28.4% (29.2%), and -10.4% (22.3%), respectively, versus +0.4% (11.1%), -0.7% (16.5%), and +0.2% (26.6%) with TD E2

2007 Menopause Controlled trial quality: uncertain

147. Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins. (Abstract)

and norgestimate 250 microg. Blood samples were taken at baseline and at the end of Cycle 3. Serum levels of sex-hormone-binding globulin (SHBG), thyroxine-binding globulin (TBG), corticosteroid-binding globulin (CBG) and C-reactive protein (CRP) were quantified by immunoassay methods. EE and LNG levels in patch users were measured by radioimmunoassay (RIA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. The paired t test and Student's t test were used for statistical analysis.Nineteen

2006 Contraception Controlled trial quality: uncertain

148. Effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters: conventional vs. extended-cycle use. (Abstract)

of thyroxine-binding globulin were elevated by about 65% in both treatment regimens. Likewise, both groups showed an increase in total triiodothyronine (T3) and total thyroxine (T4) by 30-40%, and no change in free T4. Until the 12th month of conventional treatment, the level of free T3 remained unchanged but decreased slightly during the extended-cycle regimen. In both groups there was a rise of sex hormone-binding globulin by 210-230% after 3 months and by 220-250% after 12 months. The levels of total

2008 Contraception Controlled trial quality: uncertain

149. Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder. (Abstract)

thyroxine-binding globulin concentrations compared with the group without PMDD. Women with PMDD with abuse had greater mean concentrations of total T3 and thyroxine-binding globulin, greater total T3/free T4 and free T3/free T4 ratios, and lower ratios of free T3/total T3 and free T4/total T4 than either of the other 2 nonabused groups. Greater total T3 concentrations and histories of major depression independently predicted premenstrual symptoms in all women with PMDD, together accounting for 31% to 38

2004 Psychosomatic Medicine

150. A novel mutation (del 1711 G) in the TBG gene as a cause of complete TBG deficiency. (Abstract)

A novel mutation (del 1711 G) in the TBG gene as a cause of complete TBG deficiency. Inherited thyroxine-binding globulin (TBG) deficiency is caused by mutations in the TBG gene (locus: Xq22.2), which result in defective synthesis or changes in the physical properties or biological function of a protein.We report a novel mutation of the TBG gene causing a complete TBG deficiency in three brothers of Polish origin. DNA was extracted from all of the family members and subjected to sequence

2007 Thyroid

151. Hypothalamic-pituitary axis and peripheral tissue responses to TRH stimulation and liothyronine suppression tests in normal subjects evaluated by current methods. (Abstract)

, and sex hormone-binding globulin (SHBG) were also measured at basal and after the oral administration of L-T(3).TRH administration resulted in an increase of 4- to 14-fold rise in serum TSH (8.3 +/- 2.5-fold), and in a slight rise in serum PRL concentrations (3.8 +/- 1.5-fold). Administration of graded doses of triiodothyronine (T(3)) resulted in a dose-dependent suppression of TSH and PRL. Basal thyroxine-binding globulin (TBG) and cholesterol levels decreased, and ferritin and SHBG increased after L

2008 Thyroid

152. A one-year follow-up on the effects of raloxifene on thyroid function in postmenopausal women. (Abstract)

A one-year follow-up on the effects of raloxifene on thyroid function in postmenopausal women. Estrogens increase serum thyroxine-binding globulin (TBG) and total thyroxine (TT4) concentrations. Serum free thyroxine (FT4) concentrations, however, remain normal. Raloxifene (RAL) is a selective estrogen receptor modulator used to treat postmenopausal osteoporosis. Data on the long-term effects of RAL on thyroid physiology are scanty. We evaluated the effects of RAL administration for 1 year

2004 Menopause Controlled trial quality: uncertain

153. A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women. Full Text available with Trip Pro

, thyroxine-binding globulin (TBG), and cortisol-binding globulin (CBG) in naturally menopausal women.This was a randomized, open-label crossover clinical trial. A 6-wk withdrawal from prior hormone therapy (baseline) was followed in randomized order by 12-wk oral conjugated equine estrogens (CEEs) (0.625 mg/d) and 12-wk transdermal estradiol (E2) (0.05 mg/d), with oral micronized progesterone (100 mg/d) given continuously during both regimens.A total of 27 women enrolled, and 25 completed both treatment

2008 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

154. Thyroid function and ioduria in infants after cardiac surgery: comparison of patients with primary and delayed sternal closure. (Abstract)

cardiac surgery with primary sternal closure and immediately after DSC. In both groups of patients, low total triiodothyronine, total thyroxine, thyroxine-binding globulin levels, high reverse triiodothyronine levels, and normal free triiodothyronine, free thyroxine, and thyroid-stimulating hormone levels were recorded immediately after surgery. Concentrations of total triiodothyronine and thyroid-stimulating hormone were lower in the patients with DSC. Five days after primary sternal closure and 2

2005 Pediatric Critical Care Medicine

155. The hypothalamic-pituitary-thyroid axis in preterm infants; changes in the first 24 hours of postnatal life. Full Text available with Trip Pro

The hypothalamic-pituitary-thyroid axis in preterm infants; changes in the first 24 hours of postnatal life. The purpose of this study was to measure serum T4, free T4, TSH, T3, rT3, T4 sulfate, and thyroxine binding globulin at four time points within the first 24 h of life (cord and 1, 7, and 24 h) in infants between 24 and 34 wk gestation. The infants were subdivided into gestational age groups: 24-27 wk (n = 22); 28-30 wk (n = 26); and 31-34 wk (n = 24). The TSH surge in the first hour

2004 Journal of Clinical Endocrinology and Metabolism

156. Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. Full Text available with Trip Pro

Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. Thyroid hormone is essential for fetal and neonatal development in particular of the brain, but little is known about regulation of fetal thyroid hormone levels throughout human gestation. The purpose of this study was to clarify developmental trends and interrelationships among T(4), free T(4) (FT4), thyroxine-binding globulin (TBG), TSH, T(3), rT(3), and T(4) sulfate (T4S) levels in cord and fetal blood

2004 Journal of Clinical Endocrinology and Metabolism

157. Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1. (Abstract)

terminal repeats from AAV serotype 2 have been used for liver-directed gene transfers. We hypothesized that liver-directed gene transfer of apoA-l using vectors based on AAV serotypes 1 and 5 would result in higher-level, prolonged expression of apoA-l and increased HDL-C. To test this hypothesis we injected apoA-l-/- mice via the tail vein with either AAV2, AAV1 or AAV5 vectors encoding the murine apoA-l cDNA driven by the liver-specific thyroxine binding globulin promoter. Plasma levels of murine

2006 Atherosclerosis

158. Physiological Changes In Pregnancy

levels increase due to placental production. Oxytocin levels increase to a peak at term. ADH levels are unchanged. Thyroid and parathyroid gland Thyroxine-binding globulin (TBG) concentrations rise due to increased oestrogen levels. T4 and T3 increase over the first half of pregnancy but there is a normal to slightly decreased amount of free hormone due to increased TBG-binding. Normal ranges are slightly reduced in the second and third trimester. TSH production is stimulated after the first

2008 Mentor

159. Thyroid Function Tests

. Once released, T4 and T3 then exert a negative feedback mechanism on TSH production. T4 is the main hormone produced by the thyroid. T3 is mainly produced by peripheral conversion of T4. T3 and T4 are largely protein bound in the plasma, mainly to thyroxine-binding globulin (TBG). Only the unbound, or 'free', portion (FT3, FT4) is active. T3 and T4 both act via nuclear receptors to increase cell metabolism. Reverse T3 (rT3): rT3 is a product of T4 degradation in peripheral tissues. It is also

2008 Mentor

160. Thyroid function tests in chronic liver disease: evidence for multiple abnormalities despite clinical euthyroidism. Full Text available with Trip Pro

Thyroid function tests in chronic liver disease: evidence for multiple abnormalities despite clinical euthyroidism. To further evaluate thyroid function in patients with liver disease, we have measured total and free T3 and T4, thyroxine binding globulin, basal and thyrotropin releasing hormone-stimulated thyrotropin and thyroglobulin antibodies in 33 patients with liver cirrhosis, in 22 with chronic hepatitis and in 30 healthy controls. All the patients but one were clinically euthyroid. T3 (...) , FT3, T3/thyroxine binding globulin and T4/thyroxine binding globulin ratios and thyrotropin after thyrotropin releasing hormone were significantly reduced, while FT4, thyroxine binding globulin and thyrotropin were significantly increased in liver cirrhosis. In chronic hepatitis group, FT3 and T3/thyroxine binding globulin ratio were significantly lower and thyroxine binding globulin and FT4 were higher than in healthy controls. The between patients comparison revealed a significantly lower T3

1983 Gut

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>