How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,682 results for

Thyroxine-Binding Globulin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy. (PubMed)

Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy. To investigate the significance of preoperative serum sex hormone-binding globulin (SHBG) level regarding the postoperative biochemical outcome in patients who were followed up for relative longer periods after undergoing radical prostatectomy (RP). Preoperative serum levels of testosterone (T), free T, and SHBG level were prospectively analyzed in 307

Full Text available with Trip Pro

2015 Medicine

122. Sex Hormone Binding Globulin and Risk of Breast Cancer in Postmenopausal Women: A Meta-Analysis of Prospective Studies. (PubMed)

Sex Hormone Binding Globulin and Risk of Breast Cancer in Postmenopausal Women: A Meta-Analysis of Prospective Studies. Previous studies on the association between sex hormone binding globulin (SHBG) level and risk of breast cancer in postmenopausal women reported conflicting results. A meta-analysis of prospective studies was performed to evaluate the association between SHBG level and risk of breast cancer in postmenopausal women. Pubmed (1980 to July 2014) and EMBASE (1988 to July 2014) were

2015 Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

123. Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program. (PubMed)

Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program. Steroid sex hormones and SHBG may modify metabolism and diabetes risk, with implications for sex-specific diabetes risk and effects of prevention interventions.This study aimed to evaluate the relationships of steroid sex hormones, SHBG and SHBG single-nucleotide polymorphisms (SNPs) with diabetes risk factors and with progression to diabetes in the Diabetes Prevention Program (DPP

Full Text available with Trip Pro

2015 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

124. A cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women. (PubMed)

A cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women. To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women.Cross-sectional study.University general clinical research center.A total of 319 young healthy women with ovulatory menstrual cycles.None.Midfollicular serum SHBG concentrations.In our final linear regression model, SHBG

Full Text available with Trip Pro

2015 Fertility and Sterility Controlled trial quality: uncertain

125. Alcohol consumption in relation to plasma sex hormones, prolactin and sex hormone-binding globulin in premenopausal women. (PubMed)

Alcohol consumption in relation to plasma sex hormones, prolactin and sex hormone-binding globulin in premenopausal women. Alcohol consumption is a consistent risk factor for breast cancer, and evidence suggests premenopausal plasma hormones are associated with breast cancer.Plasma concentrations of estradiol, estrone, estrone sulfate, testosterone, androstenedione, progesterone, prolactin, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin

Full Text available with Trip Pro

2014 Cancer Epidemiology & Biomarkers and Prevention

126. ADIPOSITY, CHRONIC INFLAMMATION AND THE PREPUBERTAL DECLINE OF SEX HORMONE BINDING GLOBULIN IN CHILDREN: EVIDENCE FOR ASSOCIATIONS WITH THE TIMING OF PUBERTY (Earlybird 58). (PubMed)

ADIPOSITY, CHRONIC INFLAMMATION AND THE PREPUBERTAL DECLINE OF SEX HORMONE BINDING GLOBULIN IN CHILDREN: EVIDENCE FOR ASSOCIATIONS WITH THE TIMING OF PUBERTY (Earlybird 58). The regulation and role of SHBG in children are poorly defined. Here we investigated whether adiposity-related mechanisms regulate SHBG and whether SHBG levels are associated with the age of puberty.Longitudinal modelling of annual physiological and endocrine measurements from age 5 to 15 years in a cohort of 347 Plymouth

Full Text available with Trip Pro

2014 Journal of Clinical Endocrinology and Metabolism

127. Naturally Occurring Mutants Inform Sex Hormone-binding Globulin Structure and Function. (PubMed)

Naturally Occurring Mutants Inform Sex Hormone-binding Globulin Structure and Function. SHBG transports and regulates the activities of androgens and estrogens. Several single nucleotide polymorphisms in the human SHBG gene have been linked to sex steroid-dependent diseases, including those associated with the metabolic syndrome. The N-terminal laminin G-like domain of SHBG includes binding sites for calcium, sex steroids, and fibulin family members, as well as a dimerization domain. We have (...) found that 8 of 18 uncharacterized nonsynonymous single nucleotide polymorphisms within this domain alter the production or biochemical properties of SHBG in ways not previously recognized. O-Linked glycosylation at Thr7 is disrupted in SHBG T7N, whereas abnormal glycosylation of SHBG G195E limits its secretion. Three SHBG mutants (R135C, L165M, and E176K) bind estradiol with abnormally high affinity. SHBG R135C also has an increased interaction with fibulin-2. Two different substitutions within

Full Text available with Trip Pro

2014 Molecular Endocrinology

129. Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study. (PubMed)

Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study. Reduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear. We examined the association between SHBG and cardiovascular risk factors, independently of total testosterone (TT), in young men.Observational, cross-sectional study.General

Full Text available with Trip Pro

2014 European Journal of Endocrinology

130. Sex hormone-binding globulin (SHBG) gene expression and insulin resistance. (PubMed)

Sex hormone-binding globulin (SHBG) gene expression and insulin resistance. The plasma level of sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes, is subject to genetic, hormonal, metabolic, and nutritional regulation, and is a marker for the development of the metabolic syndrome and diabetes.Because the mechanism for these associations is unclear, and no studies of SHBG gene expression in humans have been published, SHBG mRNA was measured in human liver samples

Full Text available with Trip Pro

2014 Journal of Clinical Endocrinology and Metabolism

131. Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production and Corticosterone Levels in Mice. (PubMed)

Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production and Corticosterone Levels in Mice. Distinct male and female patterns of pituitary GH secretion produce sexually differentiated hepatic gene expression profiles, thereby influencing steroid and xenobiotic metabolism. We used a fully automated system to obtain serial nocturnal blood samples every 15 minutes from cannulated wild-type (WT) and somatostatin knockout (Sst-KO) mice (...) -KO mice exhibited a globally feminized pattern of GH-dependent mRNA levels, but female Sst-KO mice were largely unaffected. Among the differentially expressed female-predominant genes was Serpina6, which encodes corticosteroid-binding globulin (CBG). Increased CBG was associated with elevated diurnal peak plasma corticosterone in unstressed WT females and both sexes of Sst-KO mice compared with WT males. Sst-KO mice also had exaggerated ACTH and corticosterone responses to acute restraint stress

Full Text available with Trip Pro

2014 Endocrinology

132. Naturally Occurring Mutations of Human Corticosteroid-binding Globulin. (PubMed)

Naturally Occurring Mutations of Human Corticosteroid-binding Globulin. Corticosteroid-binding globulin (CBG) is encoded by SERPINA6. It is the major plasma binding protein of glucocorticoids and regulates plasma cortisol levels and bioavailability in humans. Several proteases target CBG and disrupt its steroid-binding properties. To date, most genetic deficiencies that alter plasma CBG levels or function have been identified in patients presenting with a variety of clinical conditions.The (...) objective of the study was to test 32 previously uncharacterized nonsynonymous, single-nucleotide polymorphisms in SERPINA6 for their ability to alter CBG production and/or function.Human CBG mutants were produced in Chinese hamster ovary cells for ELISA, cortisol-binding activity measurements, and Western blotting as well as assays of their protease sensitivities.Eight naturally occurring CBG mutants with abnormal production and/or function were identified. Cortisol-binding affinity was markedly

Full Text available with Trip Pro

2014 Journal of Clinical Endocrinology and Metabolism

133. Sex hormone binding globulin deficiency due to a homozygous missense mutation. (PubMed)

Sex hormone binding globulin deficiency due to a homozygous missense mutation. SHBG is known as the major sex steroid binding protein in plasma, and it regulates the bioavailability of both T and estradiol levels required for effects on target tissues. We identified a man with an undetectable SHBG concentration in combination with low total T. He presented with a 7-year history of muscle weakness, fatigue, and a low libido.To determine the cause of the SHBG deficiency, we employed both genetic

Full Text available with Trip Pro

2014 Journal of Clinical Endocrinology and Metabolism

134. Reproductive endocrinology: functional effects of sex hormone-binding globulin variants. (PubMed)

Reproductive endocrinology: functional effects of sex hormone-binding globulin variants. A new study has found eight single nucleotide polymorphisms in sex hormone-binding globulin that functionally affect its affinity for androgens or estrogens and other biochemical properties. This finding adds to growing concern about the ‘one size fits all’ approach in formulas to calculate free or bioavailable concentrations of estradiol and testosterone.

2014 Nature reviews. Endocrinology

135. Comments on ‘Low serum sex hormone binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients*’ (PubMed)

Comments on ‘Low serum sex hormone binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients*’ 24533679 2014 12 15 2018 12 02 1365-2265 80 6 2014 Jun Clinical endocrinology Clin. Endocrinol. (Oxf) Comments on 'low serum sex hormone binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients'. 874-6 10.1111/cen.12430 Wang Christina C Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center (...) , Torrance, CA, USA; The Clinical and Translational Science Institute, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA. Swerdloff Ronald S RS eng UL1 TR000124 TR NCATS NIH HHS United States UL1TR000124 TR NCATS NIH HHS United States Journal Article Research Support, N.I.H., Extramural Comment 2014 03 15 England Clin Endocrinol (Oxf) 0346653 0300-0664 0 Sex Hormone-Binding Globulin IM Clin Endocrinol (Oxf). 2014 Jun;80(6):877-83 24303796 Diabetes Complications

Full Text available with Trip Pro

2014 Clinical endocrinology

136. Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. (PubMed)

Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET (...) ) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that <1% of variance in plasma cortisol is accounted for by genetic variation in a single region of chromosome 14. This locus spans SERPINA6, encoding corticosteroid binding globulin (CBG, the major cortisol-binding protein in plasma), and SERPINA1, encoding α1-antitrypsin (which inhibits cleavage of the reactive centre loop that releases

Full Text available with Trip Pro

2014 PLoS genetics

137. Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. (PubMed)

Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably.We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS

Full Text available with Trip Pro

2014 PloS one

138. The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption (PubMed)

The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption An immunoadsorption technique employing a rabbit antiserum specific for human serum prealbumin has been devised to remove thyroxine (T(4))-binding prealbumin (TBPA) from serum completely without affecting the T(4)-binding activity of thyroxine-binding globulin (TBG) or the concentration of the other major proteins in serum. As judged from the proportion of T(4) associated (...) with the antigen-antibody precipitate, only about 15% of the endogenous T(4) is bound by TBPA, a value considerably less than that indicated by electrophoretic methods. As judged from the increase in the proportion of free T(4) that followed immunoadsorption of TBPA, TBPA does act as one determinant of the proportion of free T(4) but is far less important than TBG in this respect. A decrease in the T(4)-binding capacity of TBPA cannot solely account for the increase in the proportion of free T(4) in the sera

Full Text available with Trip Pro

1968 Journal of Clinical Investigation

139. Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease (PubMed)

epitope homologs and the presence of peptide regions with strong HLA-DQ8 and DQ2 binding capabilities. These results highlight that both MHC-II presentation and B cell response may be developed not only to prolamins but also to seed storage globulins. This is the first study of the non-prolamin type seed storage proteins of Brachypodium from the aspect of the celiac disease. (...) Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease Brachypodium distachyon, a small annual grass with seed storage globulins as primary protein reserves was used in our study to analyse the toxic nature of non-prolamin seed storage proteins related to celiac disease. The main storage proteins of B. distachyon are the 7S globulin type proteins and the 11S, 12S seed storage globulins similar to oat and rice. Immunoblot analyses using serum

Full Text available with Trip Pro

2017 Scientific reports

140. Two Different Corticosteroid-Binding Globulin Variants that Lack Cortisol-Binding Activity in a Greek Woman. (PubMed)

Two Different Corticosteroid-Binding Globulin Variants that Lack Cortisol-Binding Activity in a Greek Woman. Corticosteroid-binding globulin (CBG), encoded by SERPINA6, is the principal plasma binding protein for cortisol. Most nonsynonymous single-nucleotide polymorphisms that alter the production or function of CBG occur rarely, and their clinical significance remains obscure.Serum and DNA were obtained from a Greek woman with low morning cortisol levels and from family members. SERPINA6 (...) exons were sequenced, and serum CBG was measured by ELISA and cortisol-binding capacity assay. Recombinant CBG variants were produced for detailed functional studies.A novel heterozygous c.1282G>C transversion in exon 5 of SERPINA6, resulting in a p.Trp393Ser (W371S) substitution, was identified in the proband, who was also heterozygous for single-nucleotide polymorphisms encoding the CBG Lyon (D367N) and CBG A224S variants. The proband had no measurable plasma cortisol-binding activity despite

Full Text available with Trip Pro

2012 Journal of Clinical Endocrinology and Metabolism

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>