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Thyroxine-Binding Globulin

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101. Goiter formation following prostaglandin administration in rats. (Full text)

Goiter formation following prostaglandin administration in rats. Prostaglandins (PGE1 and PGE2) induced a hyperplastic microfollicular goiter with a high radioiodine (131I) thyroid uptake, increased endocytosis, a heavy autoradiographic (125I) reaction, and a moderate increase of thyroid hormones (T4, T3), thyroxine-binding globulin (TGB), and thyrotropin (TSH) concentrations in adult rats. Ultrastructurally, both prostaglandins (E1 and E2) markedly stimulated the thyroid cell activity

1976 The American journal of pathology PubMed abstract

102. Thyrotrophin estimation in diagnosis and treatment of childhood thyroid disorders. (Full text)

raised TSH was found in 3 girls with thyroiditis, 2 brothers with goitres due to enzyme defect, and a girl with an ectopic thyroid. In one girl with a defect of iodine organification and in 3 boys with thyroxine binding globulin deficiency the TSH levels were normal despite very low serum thyroxine values. Serum TSH was also estimated in 20 children during treatment for primary hypothyroidism. 3 of these children showed slightly raised TSH levels despite apparently adequate replacement therapy with L

1975 Archives of Disease in Childhood PubMed abstract

103. The mechanism of thyroxine transfer from plasma to tissue binding sites (Full text)

The mechanism of thyroxine transfer from plasma to tissue binding sites 1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA).2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation for both TBG and TBPA.3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves

1971 The Journal of physiology PubMed abstract

104. Which test of thyroid function? (Full text)

Which test of thyroid function? 4131644 1974 05 17 2018 11 13 0007-1447 1 5907 1974 Mar 23 British medical journal Br Med J Which test of thyroid function? 553-6 Havard C W CW eng Comparative Study Journal Article Review England Br Med J 0372673 0007-1447 0 Resins, Plant 0 Serum Globulins 0 Thyroxine-Binding Proteins 06LU7C9H1V Triiodothyronine 9002-71-5 Thyrotropin Q51BO43MG4 Thyroxine AIM IM Humans Resins, Plant Serum Globulins Thyroid Diseases diagnosis Thyroid Function Tests Thyrotropin (...) blood Thyroxine blood metabolism Thyroxine-Binding Proteins Triiodothyronine blood 54 1974 3 23 1974 3 23 0 1 1974 3 23 0 0 ppublish 4131644 PMC1633686 J Clin Invest. 1964 May;43:931-42 14169522 Australas Ann Med. 1966 May;15(2):116-21 4162613 J Clin Endocrinol Metab. 1971 Nov;33(5):729-31 4331062 J Clin Invest. 1966 Jan;45(1):153-63 4158931 J Lab Clin Med. 1972 Nov;80(5):729-39 4628231 J Clin Endocrinol Metab. 1968 Feb;28(2):181-6 4965869 Clin Endocrinol (Oxf). 1973 Jul;2(3):193-9 4760544 JAMA

1974 British medical journal PubMed abstract

105. Interaction of gelatin with stereospecific binding proteins and its enhancement of competitive binding assays (Full text)

Interaction of gelatin with stereospecific binding proteins and its enhancement of competitive binding assays The effect of gelatin (0.5 g/l) on binding curves at high dilution of three classes of stereo-specific binding proteins was studied. These included two antibodies (to oestradiol and aldosterone), six transins (horse and dog transcortins, human thyroxine-binding globulin, human sex steroid-binding globulin, and guinea pig transprogestin), and one receptor (bovine adrenal protein kinase (...) ). Gelatin increased the apparent binding of all these proteins, particularly at the highest dilutions and sometimes in a striking manner. While much of this action can be attributed to its decreasing the adhesion of the dilute binding protein to glass, gelatin also increased the apparent uptake of some tracers by certain adsorbents. Similar findings were obtained using human gamma globulin (2 g/l). These effects resulted in increased sensitivity and improved reproducibility in the assays employing them.

1974 Journal of Clinical Pathology PubMed abstract

106. Measurement of Circulating Desialylated Glycoproteins and Correlation with Hepatocellular Damage (Full text)

Measurement of Circulating Desialylated Glycoproteins and Correlation with Hepatocellular Damage Addition of increasing amounts of (125)I-labeled desialylated thyroxine-binding globulin (DTBG) to hepatic cell membranes resulted in a progressive increase in binding. Saturability of membrane sites was indicated by a concentration beyond which further increases in [(125)I]DTBG resulted in no further binding. The binding curve for [(125)I]DTBG was similar to binding curves of desialylated

1974 Journal of Clinical Investigation PubMed abstract

107. A Radioimmunoassay for Measurement of 3,3′, 5′-Triiodothyronine (Reverse T3) (Full text)

subjects, 103+/-49 ng/100 ml in 22 hyperthyroid patients, 19+/-9 ng/100 ml in 12 hypothyroid patients, and 54+/-7 ng/100 ml in five subjects with elevated serum thyroxine-binding globulin: the values in each of the latter three groups of individuals were significantly different from normal. Reverse T(3) was detected regularly in normal or supranormal concentrations in serum of 12 hypothyroid patients rendered euthyroid or mildly hyperthyroid by treatment with synthetic T(4). It is suggested that serum

1974 Journal of Clinical Investigation PubMed abstract

108. Observations on the maturation of thyroid function in early fetal life (Full text)

and maintaining a linear correlation with crownrump length (r = 0.864, P < 0.001). Thyroxine-binding prealbumin binding capacity (TBPA) in fetuses 14-24 wk gestation was comparable with that seen at term. When examining the distribution of tracer amounts of thyroxine-(131)I (T4-(131)I) between the thyroxine-binding proteins, it was found that a major fraction was bound to TBPA and albumin during the early part of gestation. This decreased linearly with maturation of the fetus as the fraction bound to TBG (...) that seen in normal children. No correlation was demonstrated between the serum TSH levels and total thyroxine. TSH and FT4, however, increased in a parallel manner with a significant positive correlation. This suggested that fetal TSH secretion was responsive to FT4 levels from very early in gestation, possibly as early as 11 wk.Thyroxine-binding globulin (TBG) was detected in a fetus of 78 days gestation (1.4 mug/100 ml). Levels increased rapidly, paralleling the rise in serum thyroxine

1970 Journal of Clinical Investigation PubMed abstract

109. The effect of diphenylhydantoin on thyroxine metabolism in man (Full text)

was unchanged from the pretreatment values. Plasma ultrafiltration was used to estimate the free thyroxine fraction at regular intervals during the control and treatment periods. During diphenylhydantoin treatment, there was little or no change in this fraction and therefore, absolute free thyroxine decreased. Thyroxine-binding globulin and thyroxine-binding prealbumin capacities remained constant. These results indicate that thyroxine degradation can proceed at a normal rate in subjects receiving (...) diphenylhydantoin despite decreases in plasma free thyroxine concentration. If free thyroxine is the only portion of the hormone available for cellular utilization, then free thyroxine clearance must be increased in these subjects. This increase in clearance could represent either a direct stimulation of peripheral thyroxine metabolism by diphenylhydantoin, or it could reflect the response of intrinsic regulatory systems to a diphenylhydantoin-mediated displacement of thyroxine from thyroxine-binding globulin

1970 Journal of Clinical Investigation PubMed abstract

110. Detection of genetic variation with radioactive ligands. I. Electrophoretic screening of plasma proteins with a selected panel of compounds. (Full text)

. A majority bound to albumin and a smaller fraction to prealbumins and lipoproteins. Several vitamins and hormones bound to specific alpha and beta globulins. (1) Electrophoretic polymorphisms of vitamin D-binding protein (group-specific component), a vitamin B12-binding protein (transcobalamin II), and thyroxine-binding alpha-globulin are described elsewhere. (2) Testosterone-binding beta-globulin (TeBG) showed an electrophoretic polymorphism in Caucasians and a possible deficiency allele. (3

1977 American Journal of Human Genetics PubMed abstract

111. Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. (Full text)

Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. Reverse triiodothyronine (rT3), triiodothyronine (T3), thyroxine (T4), thyroxine binding globulin (TBG), and thyrotrophin (TSH) were measured in sera from placental cord blood in an unselected series of 272 deliveries. In this series the concentrations of rT3 (mean 3.33 nmol/l, 95% confidence limits 1.6--7.0 nmol/l), were log normally distributed and did not overlap the adult normal range (0.11

1978 Archives of Disease in Childhood PubMed abstract

112. Birmingham Medical Research Expeditionary Society 1977 Expediton: thyroid function and acute mountain sickenss. (Full text)

Birmingham Medical Research Expeditionary Society 1977 Expediton: thyroid function and acute mountain sickenss. In a study of 17 subjects plasma-thyroxine-binding globulin and plasma thyroxine concentrations rose during a high altitude trek. An early and sustained rise in plasma reverse triiodothyronine occurred independently of changes in plasma thyroxine and was probably related to physical exertion. Similar changes in thyroid function were found in subjects most affected and least affected

1979 Postgraduate medical journal PubMed abstract

113. Effects of Oestrogen on Urinary Thyroxine Excretion (Full text)

in women. A similar effect was seen in men after three days' treatment with 20 mug/day of ethinyloestradiol. The increased urinary T-4 excretion on oestrogen withdrawal reached a maximum in one to three days. This response contrasted with that produced by phenytoin, a drug known to bind to thyroxine binding globulin, and which resulted in increased urinary T-4 excretion during the period that it was being administered.

1972 British medical journal PubMed abstract

114. Effects of Replacement Doses of Sodium-L-Thyroxine on the Peripheral Metabolism of Thyroxine and Triiodothyronine in Man (Full text)

were marginally elevated and, as in frank thyrotoxicosis, T(4)-binding capacities of thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA) reduced, suggesting that subclinical thyrotoxicosis was present. Thus, the often recommended replacement dose of 0.3 mg L-thyroxine daily may be greater than that required to achieve the euthyroid state. The studies have also provided additional evidence of the peripheral conversion of T(4) to T(3) in man and have permitted the calculation

1973 Journal of Clinical Investigation PubMed abstract

115. Simultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man (Full text)

-life = 1.38 days). The mean T(3) equilibration time averaged 22 hr except in hypothyroid and high thyroxine-binding globulin (TBG) patients where the equilibration period was delayed by 10 hr. The mean T(3) distribution space in normal subjects was 38.4 liters. This was reduced in subjects with high TBG levels (26 liters) and increased in patients with low TBG and in all hyperthyroid states (53-55 liters). The normal serum T(3) concentration was estimated by radioimmunoassay to be 0.106 mug/100 ml (...) (125)I-T(3) and (131)I-T(4) kinetics were performed in 31 subjects from the clinical categories of euthyroid, primary hypothyroid, thyrotoxic and posttreatment hypothyroid Graves' disease, factitial thyrotoxic, and idiopathically high and low thyroxinebinding globulin states. The normal mean T(3) fractional turnover rate (kT(3)) was 0.68 (half-life = 1.0 days), increased in toxic Graves' disease patients to 1.10 (half-life = 0.63 days), and decreased in primary hypothyroid patients to 0.50 (half

1972 Journal of Clinical Investigation PubMed abstract

116. Thyroid Hormone Binding by Human Serum Prealbumin (TBPA). ELECTROPHORETIC STUDIES OF TRIIODOTHYRONINE-TBPA INTERACTION (Full text)

Thyroid Hormone Binding by Human Serum Prealbumin (TBPA). ELECTROPHORETIC STUDIES OF TRIIODOTHYRONINE-TBPA INTERACTION Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG). The T3-TBPA interaction has been confirmed at pH 9.0 and pH 7.4 in this electrophoretic demonstration of TBPA

1972 Journal of Clinical Investigation PubMed abstract

117. Effect of epinephrine on the peripheral metabolism of thyroxine (Full text)

unchanged. Beginning on day 2 of epinephrine and persisting at least 1 day after epinephrine was discontinued, serum thyroxine-binding globulin (TBG) maximal binding capacity increased, thyroxine-binding prealbumin (TBPA) maximal binding capacity decreased, and free T4 iodine decreased. Stable serum T4 iodine decreased during the experiment. Three indexes, namely the free T4 iodine, the reciprocal of TBG capacity, and the urinary radio-T4 "clearance" changed in parallel, suggesting that the increase

1969 Journal of Clinical Investigation PubMed abstract

118. The effects of an acute load of thyroxine on the transport and peripheral metabolism of triiodothyronine in man (Full text)

The effects of an acute load of thyroxine on the transport and peripheral metabolism of triiodothyronine in man In order to examine the question of whether thyroxine-binding globulin (TBG) influences significantly the peripheral metabolism of 3,3',5-triiodo-L-thyronine (T(3)) in vivo, paired studies of the effects of a large intravenous load of L-thyroxine (T(4)) on the kinetics of (131)I-labeled T(3) metabolism were carried out in five normal subjects. After the T(4) load, both the early

1970 Journal of Clinical Investigation PubMed abstract

119. Assessment of the combined usefulness in thyroid function testing of the triiodothyronine resin-sponge and 24-hour iodine uptakes (Full text)

of patients with changes in body iodine pools or thyroxine-binding globulin levels. Reasons are given for regarding this pair of tests as being more generally useful than any of the other possible combinations at present available. The resin sponge test kit was found to be satisfactory both technically and in respect of cost.

1966 Journal of Clinical Pathology PubMed abstract

120. Thyroxine Transport in Thyrotoxicosis and Hypothyroidism (Full text)

Thyroxine Transport in Thyrotoxicosis and Hypothyroidism (a) The thyroxine-binding proteins were investigated in 23 cases of untreated thyrotoxicosis and 16 cases of untreated hypothyroidism, employing reverse flow paper electrophoresis with the glycine acetate system at pH 8.6 in the Durrum type cell.(b) In active thyrotoxicosis, all sera exhibited diminished thyroxine-binding prealbumin (TBPA) capacities. however, 17 of the 23 sera also had diminished thryroxine-binding alpha globulin (TBG

1967 Journal of Clinical Investigation PubMed abstract

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