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Thyroxine-Binding Globulin

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101. CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA (PubMed)

CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA 16695872 2006 05 31 2018 11 13 0021-9738 40 11 1961 Nov The Journal of clinical investigation J. Clin. Invest. CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA. 2053-63 Ingbar S H SH Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital

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1961 Journal of Clinical Investigation

102. The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine-binding globulin and patients with Graves' disease (PubMed)

The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine-binding globulin and patients with Graves' disease The kinetics of distribution of 3,3',5-triiodo-L-thyronine (T(3)) have been studied employing both a single-injection and a continuous infusion of T(3-) (131)I. External monitoring of radioactivity in the liver during the infusion permitted estimation of the hepatic distribution volume (V(H)) and the one-way hepatic clearance (C(H (...) )) of the hormone. Among 10 euthyroid control subjects, V(H) averaged 2.07 liters +/-0.50 (SD), and the mean value for C(H), 231 ml of plasma per min (+/-64). In three euthyroid men whose plasma showed decreased binding capacity by thyroxine-binding globulin (TBG) abnormally high V(H) and C(H) values were found, the increase in C(H) being proportional to the decrease in binding activity by plasma proteins. Among all 13 subjects, there was a high correlation (+ 0.86) between C(H) and the proportion of free

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1970 Journal of Clinical Investigation

103. Familial Thyroxine-binding Globulin Deficiency (PubMed)

Familial Thyroxine-binding Globulin Deficiency Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemical results disclosed the diagnosis and emphasize

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1970 British medical journal

104. Studies on human thyroxine-binding globulin (TBG): I. Purification of TBG and immunologic studies on the relationship between TBG from normal persons and those with TBG “deficiency” (PubMed)

Studies on human thyroxine-binding globulin (TBG): I. Purification of TBG and immunologic studies on the relationship between TBG from normal persons and those with TBG “deficiency” A method for obtaining highly purified thyroxine-binding globulin (TBG) from whole human serum is presented. The method employs relatively simple procedures of step-wise ammonium sulfate precipitation followed by column chromatography on DEAE cellulose and DEAE Sephadex. The final product produces a single (...) low a concentration to be detectable by disc gel electrophoresis. It is concluded that some persons with TBG "deficiency" have a circulating protein, immunologically indistinguishable from TBG, which is defective in its ability to bind thyroxine.

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1969 Journal of Clinical Investigation

105. Preparation and Properties of Thyroxine-Binding Alpha Globulin (TBG) (PubMed)

Preparation and Properties of Thyroxine-Binding Alpha Globulin (TBG) Thyroxine-binding alpha globulin (TBG) in human serum was isolated from Cohn fractions IV-5,6 and IV-4 by (1) chromatography on carboxymethyl (CM) cellulose, (2) gel filtration on Sephadex G-200, (3) chromatography on diethylaminoethyl-Sephadex, (4) a novel procedure of "double-gel" electrophoresis, and (5) preparative polyacrylamide gel electrophoresis. The protein was homogeneous by analytical disc gel electrophoresis (...) as that of native TBG in serum, apparently excluding the possibility of a subunit of the native protein. Chemical composition was ascertained by amino acid and carbohydrate analyses. The maximal thyroxine (T4)-binding capacity measured by reverse flow paper electrophoresis was 15,000 mug per g of protein, representing more than 2100 times that of the starting material, or about 5000 times that of whole serum. Based on the molecular weight obtained, the TBG preparation could bind 0.7 mole T4 per mole of protein

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1971 Journal of Clinical Investigation

106. Growth retardation and thyroxine-binding globulin deficiency. (PubMed)

Growth retardation and thyroxine-binding globulin deficiency. 4995345 1971 06 18 2018 11 13 1468-2044 46 245 1971 Feb Archives of disease in childhood Arch. Dis. Child. Growth retardation and thyroxine-binding globulin deficiency. 115-7 Penfold J L JL Kneebone G M GM Wellby M M Oldfield R K RK eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Thyroxine-Binding Proteins IM Blood Protein Disorders complications Child Growth Growth Disorders complications Humans Male Thyroid Function (...) Tests Thyroxine-Binding Proteins analysis 1971 2 1 1971 2 1 0 1 1971 2 1 0 0 ppublish 4995345 PMC1647577 J Clin Endocrinol Metab. 1966 Aug;26(8):835-41 4958593 Metabolism. 1968 Mar;17(3):260-2 4966620 N Engl J Med. 1968 May 16;278(20):1081-7 4171474 J Clin Invest. 1969 Mar;48(3):508-15 4975158 J Pediatr. 1969 Jul;75(1):130-2 4182951 Pediatrics. 1969 Oct;44(4):518-25 4981400 J Clin Endocrinol Metab. 1970 Jan;30(1):131-3 4982597 Nature. 1952 Jan 5;169(4288):19-20 14910673 Am J Clin Pathol. 1961 Aug;36

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1971 Archives of Disease in Childhood

107. Growth pattern in a boy with thyroxine-binding globulin deficiency. (PubMed)

Growth pattern in a boy with thyroxine-binding globulin deficiency. 4623427 1972 07 11 2018 11 13 1468-2044 47 252 1972 Apr Archives of disease in childhood Arch. Dis. Child. Growth pattern in a boy with thyroxine-binding globulin deficiency. 322-3 Raiti S S Newns G H GH eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Serum Globulins 0 Thyroxine-Binding Proteins IM Blood Protein Disorders physiopathology Blood Protein Electrophoresis Body Height Body Weight Bone Development Child (...) Growth Humans Male Serum Globulins Thyroxine-Binding Proteins 1972 4 1 1972 4 1 0 1 1972 4 1 0 0 ppublish 4623427 PMC1648035 Arch Dis Child. 1971 Feb;46(245):115-7 4995345

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1972 Archives of Disease in Childhood

108. Study of Four New Kindreds with Inherited Thyroxine-Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS (PubMed)

Study of Four New Kindreds with Inherited Thyroxine-Binding Globulin Abnormalities POSSIBLE MUTATIONS OF A SINGLE GENE LOCUS Five families with inherited thyroxine-binding globulin (TBG) abnormalities were studied. On the basis of serum thyroxine (T(4))- binding capacity of TBG in affected males, three family types were identified: TBG deficiency, low TBG, and high TBG capacity. In all families evidence for X-linked inheritance was obtained and in one family all criteria establishing this mode (...) of inheritance were met. Only females were heterozygous, exhibiting values intermediate between affected males and normals. Overlap in heterozygotes was most commonly encountered in families with low TBG. QUANTITATIVE VARIATION IN THE SERUM CONCENTRATION OF FUNCTIONALLY NORMAL TBG WAS DEMONSTRATED BY: (a) failure of serum from TBG-deficient subjects to react with anti-TBG antibodies; (b) normal kinetics of T(4) and triiodothyronine-binding to TBG in sera from subjects with low TBG and high TBG capacity; (c

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1972 Journal of Clinical Investigation

109. X-Chromosome Linked Inheritance of Decreased Thyroxine-binding Globulin (PubMed)

X-Chromosome Linked Inheritance of Decreased Thyroxine-binding Globulin 4625785 1972 09 21 2018 11 13 1468-2044 47 254 1972 Aug Archives of disease in childhood Arch. Dis. Child. X-chromosome linked inheritance of decreased thyroxine-binding globulin. 635-8 Malvaux P P De Nayer P P eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Globulins 0 Iodine Isotopes 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine IM Adolescent Adult Aged Autoradiography Blood Protein Disorders genetics (...) Child Child, Preschool Dialysis Electrophoresis, Paper Female Genetic Linkage Globulins Humans Iodine Isotopes Male Middle Aged Pedigree Sex Chromosomes Sex Factors Thyroxine blood Thyroxine-Binding Proteins 1972 8 1 1972 8 1 0 1 1972 8 1 0 0 ppublish 4625785 PMC1648253 Ann Endocrinol (Paris). 1965 May-Jun;26(3):360-2 4954617 J Clin Endocrinol Metab. 1966 Apr;26(4):459-62 4956313 N Engl J Med. 1966 Jun 30;274(26):1469-73 4957281 J Clin Endocrinol Metab. 1966 Aug;26(8):835-41 4958593 J Clin

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1972 Archives of Disease in Childhood

110. Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups (PubMed)

Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups 4214930 1975 02 18 2018 11 13 0022-2593 11 3 1974 Sep Journal of medical genetics J. Med. Genet. Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups. 271-4 Grant D B DB Clarke H G HG Putman D D eng Journal Article England J Med Genet 2985087R 0022-2593 0 Blood Group Antigens 0 Isoantigens 0 Thyroxine-Binding Proteins 9002-71-5 Thyrotropin Q51BO43MG4 Thyroxine IM Adult (...) Blood Group Antigens Blood Protein Electrophoresis Child Female Genetic Linkage Heterozygote Humans Isoantigens Male Pedigree Sex Chromosomes Thyrotropin blood Thyroxine blood Thyroxine-Binding Proteins blood deficiency 1974 9 1 1974 9 1 0 1 1974 9 1 0 0 ppublish 4214930 PMC1013141 N Engl J Med. 1966 Jun 30;274(26):1469-73 4957281 J Clin Endocrinol Metab. 1966 Aug;26(8):835-41 4958593 J Clin Endocrinol Metab. 1967 Nov;27(11):1515-20 4965464 J Clin Endocrinol Metab. 1967 Nov;27(11):1521-8 4169433 J

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1974 Journal of Medical Genetics

111. Observations on the Nature of the Underlying Disorder and the Occurrence of Associated Plasma Transport Abnormalities in a Patient with an Idiopathic Increase in the Plasma Thyroxine-binding Globulin (PubMed)

Observations on the Nature of the Underlying Disorder and the Occurrence of Associated Plasma Transport Abnormalities in a Patient with an Idiopathic Increase in the Plasma Thyroxine-binding Globulin 14234822 1996 12 01 2018 12 01 0021-9738 43 1964 Dec The Journal of clinical investigation J. Clin. Invest. OBSERVATIONS ON THE NATURE OF THE UNDERLYING DISORDER AND THE OCCURRENCE OF ASSOCIATED PLASMA TRANSPORT ABNORMALITIES IN A PATIENT WITH AN IDIOPATHIC INCREASE IN THE PLASMA THYROXINE-BINDING (...) GLOBULIN. 2266-71 INGBAR S H SH WATERHOUSE C C CUSHMAN P P eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Proteins 0 Serum Globulins 0 Thyroxine-Binding Globulin 0 Transferrin 731DCA35BT Diethylstilbestrol 789U1901C5 Copper 9010-38-2 Transcortin E1UOL152H7 Iron EC 1.16.3.1 Ceruloplasmin P7W01638W6 Norethandrolone Q51BO43MG4 Thyroxine WI4X0X7BPJ Hydrocortisone OM Blood Protein Disorders Ceruloplasmin Copper Diethylstilbestrol Geriatrics Humans Hydrocortisone Iron Norethandrolone

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1964 Journal of Clinical Investigation

112. A subset of walnut allergic adults is sensitized to walnut 11S globulin Jug r 4. (PubMed)

A subset of walnut allergic adults is sensitized to walnut 11S globulin Jug r 4. The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain all cases of walnut allergy.Identify recognized walnut allergens, other than the ones previously investigated (Jug r 1-3), in walnut allergic adults and determine the sensitization frequency (...) and diagnostic value.Three different in-house walnut extracts were prepared and analysed on SDS-PAGE blots to identify allergenic walnut proteins. Immunoblots and immunoprecipitation, followed by LC-MS analysis, were performed to screen for, and confirm, IgE binding to walnut allergens in selected walnut allergic adults. In a cohort of 55 walnut challenged adults, including 33 allergic and 22 tolerant, sensitization to native and recombinant walnut allergen Jug r 4 was assessed using immunoblotting

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2018 Clinical and Experimental Allergy

113. Potential Confounding of Diagnosis of Rabies in Patients with Recent Receipt of Intravenous Immune Globulin (PubMed)

Potential Confounding of Diagnosis of Rabies in Patients with Recent Receipt of Intravenous Immune Globulin Rabies is an acute encephalitis that is nearly always fatal. It is caused by infection with viruses of the genus Lyssavirus, the most common of which is Rabies lyssavirus. The Council of State and Territorial Epidemiologists (CSTE) defines a confirmed human rabies case as an illness compatible with rabies that meets at least one of five different laboratory criteria.* Four (...) of these criteria do not depend on the patient's rabies vaccination status; however, the remaining criterion, "identification of Lyssavirus-specific antibody (i.e. by indirect fluorescent antibody…test or complete [Rabies lyssavirus] neutralization at 1:5 dilution) in the serum," is only considered diagnostic in unvaccinated patients. Lyssavirus-specific antibodies include Rabies lyssavirus-specific binding immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies and Rabies lyssavirus neutralizing

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2018 Morbidity and Mortality Weekly Report

114. Association of Central Obesity with Sex Hormonebinding Globulin: A Cross-sectional Study of 1166 Chinese Men (PubMed)

Association of Central Obesity with Sex Hormonebinding Globulin: A Cross-sectional Study of 1166 Chinese Men Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each (...) participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level. Results The mean serum level of sex hormone-binding globulin was increased in old-aged men

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2018 Open Medicine

115. Sex hormone binding globulin for prediction of gestational diabetes mellitus in pre-pregnant and pregnant women. a systematic review and meta-analysis

Sex hormone binding globulin for prediction of gestational diabetes mellitus in pre-pregnant and pregnant women. a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2018 PROSPERO

116. Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer's Disease: A Meta-Analysis. (PubMed)

Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer's Disease: A Meta-Analysis. Previous studies suggested that plasma sex hormones may be implicated in the pathogenesis of Alzheimer's disease (AD). However, the relationship between sex hormones and AD remains unclear.To systematically review and quantitatively analyze studies observing plasma total testosterone (TT), estradiol (E2), and sex hormone-binding globulin (SHBG) levels among AD patients.Medline, EMBASE

2015 Current Alzheimer research

117. Association of Sex Hormone Binding Globulin and Free Testosterone with Mortality in Men with Type 2 Diabetes Mellitus. (PubMed)

Association of Sex Hormone Binding Globulin and Free Testosterone with Mortality in Men with Type 2 Diabetes Mellitus. Low circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prognostic role of testosterone in men with type 2 diabetes mellitus (T2DM) is influenced by its carrier protein sex hormone-binding globulin (SHBG).We conducted a prospective cohort study at a tertiary referral centre.In total, 531 men with T2DM presenting

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2015 European Journal of Endocrinology

118. Endogenous androgens and sex hormone-binding globulin in women and risk of metabolic syndrome and type 2 diabetes. (PubMed)

Endogenous androgens and sex hormone-binding globulin in women and risk of metabolic syndrome and type 2 diabetes. The association of endogenous androgens and sex hormone-binding globulin (SHBG) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) mostly 23562 refers to small and selected study samples with immunoassay-based measurements. Thus, we investigated the association of hormone levels with MetS and T2DM in women from a large population-based sample.A total of 2077 women

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2015 Journal of Clinical Endocrinology and Metabolism

119. Late Pregnancy Thyroid-Binding Globulin Predicts Perinatal Depression (PubMed)

Late Pregnancy Thyroid-Binding Globulin Predicts Perinatal Depression Previously we found that late pregnancy total and free thyroxine (TT4, FT4) concentrations were negatively related to greater pre and/or postpartum depressive symptoms. In a much larger cohort, the current study examined whether these thyroid indices measured earlier in the third trimester (31-33 weeks) predict subsequent perinatal depression and anxiety ratings as well as syndromal depression. Thyroid-binding globulin (TBG

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2015 Psychoneuroendocrinology

120. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. (PubMed)

Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. Plasma corticosteroid-binding globulin (CBG) transports cortisol but high progesterone levels at the maternal-fetal interface can displace cortisol from its steroid-binding site. A secretion-deficient CBG mutant (A51V) in ∼1 of 36 Chinese causes low circulating CBG levels.Assess the implications of a CBG deficiency on pregnancy outcomes.From 1978 Chinese women screened at 12-16 weeks' gestation, 50 A51V carriers

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2015 Journal of Clinical Endocrinology and Metabolism

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