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Thyroxine-Binding Globulin

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82. Euthyroid Hyperthyroxinemia (Treatment)

. Effects of clofibrate (Atromid S) on the thyroxine-binding capacity of thyroxine-binding globulin and free thyroxine. J Clin Endocrinol Metab . 1969 Jul. 29(7):957-61. . Beex LV, Ross A, Smals AG, Kloppenborg PW. Letter: 5-fluorouracil and the thyroid. Lancet . 1976 Apr 17. 1(7964):866-7. . Chekuri L, Lange JR, Thapa PB. Lithium-induced transient euthyroid hyperthyroxinemia: a case report. Prim Care Companion CNS Disord . 2014. 16(2): . . Azizi F, Vagenakis AG, Portnay GI, Braverman LE, Ingbar SH (...) ):886-9. . Magalhães PK, Rodrigues Dare GL, Rodrigues Dos Santos S, et al. Clinical features and genetic analysis of four Brazilian kindreds with resistance to thyroid hormone. Clin Endocrinol (Oxf) . 2007 Nov. 67(5):748-53. . Tucker WS Jr. Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. South Med J . 1989 Mar. 82(3):368-71. . Maye P, Bisetti A, Burger A, et al. Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism

2014 eMedicine.com

84. Anabolic Steroid Use and Abuse (Overview)

that AASs bind to glucocorticoid, progesterone, and estrogen receptors and exert multiple effects. Discussions exist as to how the endogenous testosterone and spermatogenic functions of the testes are inhibited by the use of testosterone and AASs. By suppressing FSH, spermatogenic function should be reduced. AASs have also been shown to alter fasting blood glucose levels and decrease glucose tolerance, presumably due to either a hepatic effect or changes in the insulin receptor. Thyroxine-binding (...) globulin (TBG) may also be lowered by AASs and result in lowered total T4 levels, with free T4 levels remaining normal. An up-regulation of sex-hormone binding globulin, with a concomitant decrease in TBG, is thought to cause the changes in total T4 levels. Genitourinary effects The male prostate is very sensitive to androgens, especially those that are reduced in prostatic tissue to dihydrotestosterone (DHT) or DHT analogues. In response to this stimulation, the prostate grows in size, potentially

2014 eMedicine.com

85. Hashimoto Thyroiditis (Follow-up)

, increased use by the fetus, and increased metabolism of thyroxine by the fetoplacental unit. The increase usually resolves and levothyroxine requirements return to prepregnancy levels 6-8 weeks postpartum. Note that total T4 and T3 levels may actually be increased in pregnancy. This phenomenon is thought to be due to the estrogen-induced sialylation (increased sialic acid content) of the thyroxine-binding globulin (TBG). This leads to decreased clearance of the TBG by the liver and to increased levels

2014 eMedicine.com

86. Euthyroid Hyperthyroxinemia (Follow-up)

):2193-5. . McKerron CG, Scott RL, Asper SP, Levy RI. Effects of clofibrate (Atromid S) on the thyroxine-binding capacity of thyroxine-binding globulin and free thyroxine. J Clin Endocrinol Metab . 1969 Jul. 29(7):957-61. . Beex LV, Ross A, Smals AG, Kloppenborg PW. Letter: 5-fluorouracil and the thyroid. Lancet . 1976 Apr 17. 1(7964):866-7. . Chekuri L, Lange JR, Thapa PB. Lithium-induced transient euthyroid hyperthyroxinemia: a case report. Prim Care Companion CNS Disord . 2014. 16(2): . . Azizi F (...) mutations of transthyretin]. Nippon Rinsho . 1994 Apr. 52(4):886-9. . Magalhães PK, Rodrigues Dare GL, Rodrigues Dos Santos S, et al. Clinical features and genetic analysis of four Brazilian kindreds with resistance to thyroid hormone. Clin Endocrinol (Oxf) . 2007 Nov. 67(5):748-53. . Tucker WS Jr. Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. South Med J . 1989 Mar. 82(3):368-71. . Maye P, Bisetti A, Burger A, et al. Hyperprealbuminemia, euthyroid hyperthyroxinemia

2014 eMedicine.com

87. Anabolic Steroid Use and Abuse (Follow-up)

that AASs bind to glucocorticoid, progesterone, and estrogen receptors and exert multiple effects. Discussions exist as to how the endogenous testosterone and spermatogenic functions of the testes are inhibited by the use of testosterone and AASs. By suppressing FSH, spermatogenic function should be reduced. AASs have also been shown to alter fasting blood glucose levels and decrease glucose tolerance, presumably due to either a hepatic effect or changes in the insulin receptor. Thyroxine-binding (...) globulin (TBG) may also be lowered by AASs and result in lowered total T4 levels, with free T4 levels remaining normal. An up-regulation of sex-hormone binding globulin, with a concomitant decrease in TBG, is thought to cause the changes in total T4 levels. Genitourinary effects The male prostate is very sensitive to androgens, especially those that are reduced in prostatic tissue to dihydrotestosterone (DHT) or DHT analogues. In response to this stimulation, the prostate grows in size, potentially

2014 eMedicine.com

89. Anabolic Steroid Use and Abuse (Diagnosis)

that AASs bind to glucocorticoid, progesterone, and estrogen receptors and exert multiple effects. Discussions exist as to how the endogenous testosterone and spermatogenic functions of the testes are inhibited by the use of testosterone and AASs. By suppressing FSH, spermatogenic function should be reduced. AASs have also been shown to alter fasting blood glucose levels and decrease glucose tolerance, presumably due to either a hepatic effect or changes in the insulin receptor. Thyroxine-binding (...) globulin (TBG) may also be lowered by AASs and result in lowered total T4 levels, with free T4 levels remaining normal. An up-regulation of sex-hormone binding globulin, with a concomitant decrease in TBG, is thought to cause the changes in total T4 levels. Genitourinary effects The male prostate is very sensitive to androgens, especially those that are reduced in prostatic tissue to dihydrotestosterone (DHT) or DHT analogues. In response to this stimulation, the prostate grows in size, potentially

2014 eMedicine.com

91. Euthyroid Hyperthyroxinemia (Diagnosis)

) and triiodothyronine (T3) circulate in the blood bound to the following three different binding proteins: Thyroxine-binding globulin (TBG) Thyroxine-binding prealbumin (TBPA), or transthyretin (TTR) Albumin Approximately 99.97% of circulating T4 and 99.7% of circulating T3 are bound to these proteins. TBG carries 75% of the circulating T4 and T3, owing to its high affinity. TBPA binds to only approximately 15% of the hormones (mostly T4), and albumin binds to the remaining 10%. In comparison, T3 is less avidly (...) vs. extended-cycle use. Contraception . 2008 Jun. 77(6):420-5. . Mooradian A, Morley JE, Simon G, et al. Propranolol-induced hyperthyroxinemia. Arch Intern Med . 1983 Nov. 143(11):2193-5. . McKerron CG, Scott RL, Asper SP, Levy RI. Effects of clofibrate (Atromid S) on the thyroxine-binding capacity of thyroxine-binding globulin and free thyroxine. J Clin Endocrinol Metab . 1969 Jul. 29(7):957-61. . Beex LV, Ross A, Smals AG, Kloppenborg PW. Letter: 5-fluorouracil and the thyroid. Lancet . 1976

2014 eMedicine.com

92. Euthyroid Sick Syndrome (Diagnosis)

, and leptin, as well as changes in brain thyroid hormone metabolism, affect inhibition and secretion of TRH and TSH. Inhibition of plasma membrane transport of iodothyronines Serum factors, such as bilirubin, NEFA, furanoic acid, hippuric acid, and indoxyl sulphate, which are present in various NTIs, have been shown to inhibit transport of thyroid hormones. Thyroxine-binding globulin decrease and desialation T4-binding globulin (TBG) is a member of the serine protease inhibitors. Diminished T4 in NTI has (...) are thought to play a role in NTI—particularly interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-alpha, and interferon-beta. Cytokines are thought to affect the hypothalamus, the pituitary, or other tissues, inhibiting production of TSH, thyroid-releasing hormone (TRH), thyroglobulin, T3, and thyroid-binding globulins. Cytokines are also thought to decrease the activity of type 1 deiodinase and to decrease the binding capacity of T3 nuclear receptors. It has been proposed that several components

2014 eMedicine.com

93. Coexistence of THRB and TBG Gene Mutations in a Turkish Family. (Full text)

Coexistence of THRB and TBG Gene Mutations in a Turkish Family. Resistance to thyroid hormone is a syndrome characterized by high serum free T4 levels and unsuppressed serum TSH concentration. Thyroxine-binding globulin complete deficiency manifests with low serum total T4 and T3 levels and normal serum TSH concentration. Our objective is to describe a family with the coexistence of resistance to thyroid hormone and thyroxine-binding globulin complete deficiency.We conducted clinical studies

2013 Journal of Clinical Endocrinology and Metabolism PubMed abstract

94. MEASUREMENT OF TOTAL RATHER THAN FREE THYROXINE IN PREGNANCY: THE DIAGNOSTIC IMPLICATIONS. (Abstract)

of employing T4 for diagnostic discrimination in both pregnant and nonpregnant patient panels. Use of T4 assays has significant drawbacks in this regard, and we believe that the suggestion is a retrograde step in thyroid function testing.Analysis of the interplay between the concentrations of T4 and thyroxine-binding globulin (TBG), typifying their respective reference ranges in either the nonpregnant or pregnant euthyroid state, shows that the effective T4 range is widened significantly

2013 Thyroid

95. Subclinical Hypothyroidism

be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased. Concepts Disease or Syndrome ( T047 ) MSH ICD9 790.94 ICD10 SnomedCT 237542005 English Euthyroid Sick Syndrome , Euthyroid Sick Syndromes , EUTHYROID SICK SYNDROME , Euthyroid sick syndrome , euthyroid sick syndrome , euthyroid sick syndrome (diagnosis) , EUTHYROID SICK SYNDROME LOW T3 LOW T4 SYNDROME , Euthyroid sick-syndrome , Euthyroid Sick Syndromes [Disease/Finding] , sick

2015 FP Notebook

96. T3 Resin Uptake

Biliary Drugs s Perphenazine Fluorouracil Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "T3 Resin Uptake." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: T3 uptake measurement (C0202224) Definition (NCI) The determination of the binding of triiodothyonine to thyroxine binding globulin protein in a sample. Definition (NCI_CDISC) A measurement (...) of the binding of triiodothyonine to thyroxine binding globulin protein in a biological specimen. Concepts Laboratory Procedure ( T059 ) SnomedCT 166340002 , 143695002 , 250669007 , 17130003 , 275756004 CPT 84479 English T3RU , Tri-iodothyronine uptake , T3 uptake , T3U , Triiodothyronine Uptake Measurement , triiodothyronine uptake measurement (lab test) , triiodothyronine uptake measurement , T3 resin uptake , resin t3 uptake , t3 uptake , t3u , t3 uptake test , t3 resin uptake , Measurement

2015 FP Notebook

97. Thyroid hormone metabolism and environmental chemical exposure (Full text)

serum thyroid hormone tests (- TSH and T4) were again normal by 2 years of age and were still normal at 8-12 years, adolescence is a period with extra stress on thyroid hormone metabolism. Therefore we measured serum levels of TSH, T4, 3,3',5- triiodothyronine (T3), free T4 (FT4), antibodies and thyroxine-binding globulin (TBG) in our adolescent cohort.Vena puncture was performed to obtain samples for the measurement of thyroid hormone metabolism related parameters and the current serum dioxin (PCDD

2012 Environmental Health PubMed abstract

98. Thyroid disorders in pregnancy. (Abstract)

Thyroid disorders in pregnancy. The thyroid gland is substantially challenged during pregnancy. Total T(3) and T(4) levels increase by 50% during pregnancy owing to a 50% increase in thyroxine-binding globulin levels. Serum TSH levels decrease in the first trimester and increase in the second and third trimesters; however, not to prepregnancy levels. Hypothyroidism is present in up to 3% of all pregnant women. Subclinical hypothyroidism during pregnancy is associated with an increased rate

2012 Nature reviews. Endocrinology

99. Thyroid hormones in the elderly sick: "T4 euthyroidism". (Full text)

Thyroid hormones in the elderly sick: "T4 euthyroidism". Thyroid function and serum levels of triiodothyronine (T3) and thyroxine (T4) were investigated in 79 euthyroid geriatric patients. Of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low T3 levels. In contrast, 7 (12%) and 6 (30%), respectively, had raised T4 levels. Two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. Thyroxine-binding globulin was greatly

1975 British medical journal PubMed abstract

100. Stability of thyroxine and triiodothyronine in biological fluids. (Full text)

Stability of thyroxine and triiodothyronine in biological fluids. The stability of thyroxine and triiodothyronine in serum has been investigated. Apparent levels of total thryroxine, as determined by two different protein-binding assays employing thyroxine-binding globulin as the binding protein, increased significantly in serum and plasma samples stored at room temperature and were signficantly lower in haemolysed samples. Values did not change significantly in samples stored at 4 degrees C

1975 Journal of Clinical Pathology PubMed abstract

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