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Thyroxine-Binding Globulin

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81. Asn347 Glycosylation of Corticosteroid-binding Globulin Fine-tunes the Host Immune Response by Modulating Proteolysis by Pseudomonas aeruginosa and Neutrophil Elastase (PubMed)

Asn347 Glycosylation of Corticosteroid-binding Globulin Fine-tunes the Host Immune Response by Modulating Proteolysis by Pseudomonas aeruginosa and Neutrophil Elastase Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues upon elastase-based proteolysis of the exposed reactive center loop (RCL). However, the molecular mechanisms that regulate the RCL proteolysis by co-existing host and bacterial elastases in inflamed/infected tissues remain unknown. We

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2016 The Journal of biological chemistry

82. Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. (PubMed)

Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Essentials Endogenous hormone levels' influence on hemostatic factor levels is not fully characterized. We tested for associations of endogenous hormone with hemostatic factor levels in postmenopause. Estrone levels were inversely associated with the natural anticoagulant, protein S antigen. Dehydroepiandrosterone sulfate (...) levels were inversely associated with thrombin generation.Background Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. Objectives Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), and androstenedione, and low levels of sex hormone-binding globulin

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2016 Journal of Thrombosis and Haemostasis

83. Associations of cortisol/testosterone and cortisol/sex hormone-binding globulin ratios with atherosclerosis in middle-age women. (PubMed)

Associations of cortisol/testosterone and cortisol/sex hormone-binding globulin ratios with atherosclerosis in middle-age women. The cortisol/testosterone (C/T) ratio has been hypothesized to be a better predictor of atherosclerosis than cortisol alone. No study has assessed whether the C/T and C/sex hormone-binding globulin (SHBG) ratios are associated with atherosclerosis in a U.S. population sample.This substudy included 367 women who had both cortisol from year 15 and testosterone and SHBG

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2016 Atherosclerosis

84. Effects of intraperitoneal insulin versus subcutaneous insulin administration on sex hormone-binding globulin concentrations in patients with type 1 diabetes mellitus. (PubMed)

Effects of intraperitoneal insulin versus subcutaneous insulin administration on sex hormone-binding globulin concentrations in patients with type 1 diabetes mellitus. Elevated sex hormone-binding globulin (SHBG) concentrations have been described in patients with type 1 diabetes mellitus (T1DM), probably due to low portal insulin concentrations. We aimed to investigate whether the route of insulin administration, continuous intraperitoneal insulin infusion (CIPII), or subcutaneous (SC

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2016 Endocrine connections Controlled trial quality: uncertain

85. Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates (PubMed)

Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates 1. A simple method is described for estimating the rate of thyroxine dissociation from binding sites in plasma.2. At tracer concentrations in human plasma thyroxine dissociates at two distinct exponential rates. These are due to the two thyroxine-binding proteins present in human plasma.3. The t((1/2)) for thyroxine dissociation from thyroxine-binding globulin is 8.1 +/- 0.7 (S.E.) min at room temperature (...) and 38.6 +/- 2.1 sec at 37 degrees C.4. The t((1/2)) for thyroxine dissociation from thyroxine-binding pre-albumin is 53 +/- 5.0 sec at room temperature and 7.9 +/- 0.3 sec at 37 degrees C.5. Dissociation of thyroxine from both proteins is a single exponential process, suggesting that each protein has only one type of specific binding site.6. These results indicate that the minute pool of free thyroxine in plasma is turning over about 100 times each second, with about two thirds of this flux being due

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1971 The Journal of physiology

86. The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin. (PubMed)

The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin. 4958064 1966 11 29 2018 11 13 0021-9738 45 6 1966 Jun The Journal of clinical investigation J. Clin. Invest. The kinetics of distribution between plasma and liver of 131-I-labeled L-thyroxine in man: observations of subjects with normal and decreased serum thyroxine-binding globulin. 939-49 Cavalieri R R RR Searle G L GL (...) eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Iodine Radioisotopes 0 Serum Globulins 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine AIM IM Adult Aged Blood Volume Humans Iodine Radioisotopes Kinetics Liver metabolism Male Middle Aged Serum Globulins metabolism Thyroxine metabolism Thyroxine-Binding Proteins metabolism 1966 6 1 1966 6 1 0 1 1966 6 1 0 0 ppublish 4958064 10.1172/JCI105409 PMC292773 Science. 1965 Aug 13;149(3685):748-50 14330531 J Clin Endocrinol Metab. 1952

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1966 Journal of Clinical Investigation

87. Raised free thyroxine values in patients with familial elevation of thyroxine-binding globulin. (PubMed)

Raised free thyroxine values in patients with familial elevation of thyroxine-binding globulin. 4623425 1972 07 11 2013 11 21 1468-2044 47 252 1972 Apr Archives of disease in childhood Arch. Dis. Child. Raised free thyroxine values in patients with familial elevation of thyroxine-binding globulin. 315 Hutchison J H JH eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Serum Globulins 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine IM Blood Protein Disorders genetics Genes (...) , Dominant Humans Serum Globulins Thyroxine blood Thyroxine-Binding Proteins 1972 4 1 1972 4 1 0 1 1972 4 1 0 0 ppublish 4623425 PMC1648026

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1972 Archives of Disease in Childhood

88. Filgrastim enhances T-cell clearance by antithymocyte globulin exposure after unrelated cord blood transplantation (PubMed)

Filgrastim enhances T-cell clearance by antithymocyte globulin exposure after unrelated cord blood transplantation Residual antithymocyte globulin (ATG; Thymoglobulin) exposure after allogeneic hematopoietic (stem) cell transplantation (HCT) delays CD4+ T-cell immune reconstitution (CD4+ IR), subsequently increasing morbidity and mortality. This effect seems particularly present after cord blood transplantation (CBT) compared to bone marrow transplantation (BMT). The reason (...) CD4+ IR after CBT (P < .001), but not after BMT (P = .74). To decipher these differences, we performed ATG-binding and ATG-cytotoxicity experiments using cord blood- and bone marrow graft-derived T-cell subsets, B cells, natural killer cells, and monocytes. No differences were observed. Nevertheless, a major covariate in our cohort was Filgrastim treatment (only given after CBT). We found that Filgrastim (granulocyte colony-stimulating factor [G-CSF]) exposure highly increased neutrophil-mediated

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2018 Blood advances

89. Thyroxine-Binding Globulin

Thyroxine-Binding Globulin Thyroxine-Binding Globulin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thyroxine-Binding Globulin (...) Thyroxine-Binding Globulin Aka: Thyroxine-Binding Globulin , Thyroxine Binding Globulin , Thyroid Binding Globulin , TBG II. Physiology Radioimmunoassay of major storage of hormone TBG binds hormone in circulation (T4) is 99.97% protein bound (T3) is 99.7% protein bound III. Interpretation: General TBG effects measurement of total T4 and T3 Increased TBG increases total T4 and T3 measurements Decreased percent and T3 No change in and Decreased TBG decreases total T4 and T3 measurements Increased percent

2015 FP Notebook

90. Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine. (PubMed)

Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine. 4958993 1967 02 05 2018 11 13 0021-9738 45 8 1966 Aug The Journal of clinical investigation J. Clin. Invest. Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine. 1290-301 Zaninovich A A AA Farach H H Ezrin C C Volpé R R eng (...) Journal Article United States J Clin Invest 7802877 0021-9738 0 Estrogens 0 Iodine Isotopes 0 Thyroxine-Binding Proteins 06LU7C9H1V Triiodothyronine 6158TKW0C5 Phenytoin AIM IM Adolescent Adult Aged Epilepsy metabolism Estrogens pharmacology Female Hepatitis metabolism Humans Hyperthyroidism metabolism Hypothyroidism metabolism Iodine Isotopes Liver Cirrhosis metabolism Male Middle Aged Myxedema metabolism Phenytoin pharmacology Prostatic Neoplasms metabolism Thyroxine-Binding Proteins

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1966 Journal of Clinical Investigation

91. Cytotoxic Effects of Rabbit Anti-Thymocyte Globulin preparations on Primary Human Thymic Epithelial Cells. (PubMed)

Cytotoxic Effects of Rabbit Anti-Thymocyte Globulin preparations on Primary Human Thymic Epithelial Cells. Graft-versus-host disease (GvHD) presents a major cause for morbidity and mortality after allogeneic hematopoietic stem cell transplantation (alloHSCT). Rabbit anti-thymocyte globulin (rATG) treatment reduces the incidence of GvHD after alloHSCT. However, delayed immune reconstitution following rATG treatment, partly due to hampered thymic function, is being discussed. The present study (...) aimed at elucidating possible cytotoxic effects of two commonly used rATG preparations on cultured human thymic stroma, especially thymic epithelial cells (TECs).A primary thymic epithelial cell culture was established and the binding and cytotoxicity of two rATG preparations to the aforementioned cells were assessed by flow cytometry and immunofluorescence analyses. The release of several cytokines by cultured TSCs in response to rATG was analyzed via multiplex ELISA.Both preparations showed

2019 Transplantation

92. Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin. (PubMed)

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin. The serine protease inhibitor (SERPIN) family member corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in plasma. Human CBG mediates the targeted release of cortisol at sites of inflammation through cleavage of its reactive center loop (RCL) by neutrophil elastase. The RCLs of SERPIN family members are targeted by diverse endogenous and exogenous proteases (...) , including several bacterial proteases. We tested different bacteria for their ability to secrete proteases that disrupt CBG cortisol-binding activity, and characterized the responsible protease and site of CBG cleavage. Serum CBG integrity was assessed by Western blotting and cortisol-binding capacity assay. Effects of time, pH, temperature, and protease inhibitors were tested. Proteolytically active proteins from bacterial media were purified by fast protein liquid chromatography, and the active

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2014 Endocrinology

93. Preparation of 125-I-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. (PubMed)

Preparation of 125-I-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. A protein with the electrophoretic, immunologic, and hormone-binding properties of thyroxine-binding globulin (TBG) has been prepared from human plasma and labeled with radioiodine (125-I) by an enzymatic method of iodination. The [125-I]TBG retained the electrophoretic and immunologic characteristics of unlabeled TBG but exhibited a partial loss of thyroxine-binding activity (...) , as assessed by affinity chromatography. The in vivo behavior of [125I]TBG was studied in six euthyroid subjects (controls) with normal serum levels of TBG as measured both by radioimmunoassay and by determination of maximal T4-binding capacity and in four male patients with untreated primary hyperthyroidism, three of whom had elevated serum TBG. The half-time of the final slope of the plasma disappearance curve averaged 5.0 days plus or minus 1.2 (SD) in the controls and ranged from 3.9 to 109 days

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1975 Journal of Clinical Investigation

94. Studies on human thyroxine-binding globulin (TBG). IX. Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG. (PubMed)

Studies on human thyroxine-binding globulin (TBG). IX. Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG. Thyroxine-binding globulin (TBG) and partially desialylated or slow TBG (STBG) were purified from human serum by affinity chromatography. Purified TBG was identical to TBG present in serum by the criteria of electrophoretic mobility, affinity for thyroxine (T4), and heat-inactivation response. Purified STBG had slower electrophoretic (...) T4-binding, precipitation by antiserum, or the heat-inactivation properties. "Heavily" and "lightly" iodinated TBG had identical disappearance half-times from serum in the rabbit. 15 min after the intravenous administration of [131-I]-STBG and [125-I]TBG mixture to rats, more than 90% of the injected 131-I dose was in the liver, and the liver 131-I/125-I ratio was 32-fold that of serum. Selective uptake of STBG by the liver was also observed in the rabbit and in man. The serum [125-I]STBG/[131-I

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1975 Journal of Clinical Investigation

95. Growth retardation and familial thyroxine-binding globulin deficiency. (PubMed)

Growth retardation and familial thyroxine-binding globulin deficiency. 71932 1977 12 29 2018 11 13 0007-1447 2 6089 1977 Sep 17 British medical journal Br Med J Growth retardation and familial thyroxine-binding globulin deficiency. 742 Barragry J M JM Burr W A WA eng Case Reports Journal Article England Br Med J 0372673 0007-1447 0 Alpha-Globulins 0 Thyroxine-Binding Proteins AIM IM Alpha-Globulins deficiency genetics Child Growth Disorders genetics Humans Male Thyroxine-Binding Proteins

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1977 British medical journal

96. Concentration of thyroxine-binding globulin and the Thyopac-3 test. (PubMed)

Concentration of thyroxine-binding globulin and the Thyopac-3 test. 406006 1977 09 02 2008 11 20 0007-1447 2 6079 1977 Jul 09 British medical journal Br Med J Concentration of thyroxine-binding globulin and the Thyopac-3 test. 128 Davies M C MC Allison H H eng Letter England Br Med J 0372673 0007-1447 0 Serum Globulins 0 Thyroxine-Binding Proteins AIM IM Female Humans Pregnancy Serum Globulins analysis Thyroid Function Tests Thyroid Gland metabolism Thyroxine-Binding Proteins analysis 1977 7 9

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1977 British medical journal

97. Concentration of thyroxine-binding globulin: value of direct assay. (PubMed)

Concentration of thyroxine-binding globulin: value of direct assay. The concentration of thyroxine-binding globulin (TBG) in the serum can now be measured by direct assays that are simple and inexpensive. Comparison of a direct measurement of TBG concentration with a widely used indirect method (Thyopac-3) showed that the indirect method was inaccurate when TBG concentrations were high. This will result in an increase in the derived free thyroxine index (FTI), so that euthyroid patients (...) with a raised TBG concentration may be at risk of being labelled thyrotoxic. Correction of serum total thyroxine (T4) concentration according to the actual TBG concentration (T4:TBG ratio) provided a better correlation with thyroid state than FTI.

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1977 British medical journal

98. Concentration of thyroxine-binding globulin. (PubMed)

Concentration of thyroxine-binding globulin. 67870 1977 07 18 2008 11 20 0007-1447 1 6071 1977 May 14 British medical journal Br Med J Concentration of thyroxine-binding globulin. 1282-3 Mardell R R eng Letter England Br Med J 0372673 0007-1447 0 Alpha-Globulins 0 Thyroxine-Binding Proteins AIM IM Alpha-Globulins analysis Humans Thyroxine-Binding Proteins analysis 1977 5 14 1977 5 14 0 1 1977 5 14 0 0 ppublish 67870 PMC1607059

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1977 British medical journal

99. THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS (PubMed)

THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS 13221653 2003 05 01 2018 12 01 0021-9738 34 1 1955 Jan The Journal of clinical investigation J. Clin. Invest. Thyroxine binding capacity of serum alpha globulin in hypothyroid, euthyroid, and hyperthyroid subjects. 44-7 ALBRIGHT E C EC LARSON F C FC DEISS W P WP eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Alpha-Globulins 0 Serum Globulins Q51BO43MG4 Thyroxine OM Alpha (...) -Globulins Humans Hyperthyroidism blood Hypothyroidism blood Serum Globulins Thyroxine 5527:33585:230:232:417:459 HYPERTHYROIDISM/blood in HYPOTHYROIDISM/blood in SERUM GLOBULIN THYROXIN 1955 1 1 1955 1 1 0 1 1955 1 1 0 0 ppublish 13221653 10.1172/JCI103061 PMC438579 Nature. 1952 Jan 5;169(4288):19-20 14910673 Science. 1952 Jun 6;115(2997):626-7 17841620 Proc Soc Exp Biol Med. 1953 Nov;84(2):513-6 13121091 J Clin Invest. 1954 Feb;33(2):230-4 13130690 Klin Wochenschr. 1953 Jan 1;31(1-2):13-7 13062550 J

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1955 Journal of Clinical Investigation

100. FAMILIAL INCREASE IN THE THYROXINE-BINDING SITES IN SERUM ALPHA GLOBULIN (PubMed)

FAMILIAL INCREASE IN THE THYROXINE-BINDING SITES IN SERUM ALPHA GLOBULIN 13798328 1998 11 01 2018 12 01 0021-9738 38 1959 Oct The Journal of clinical investigation J. Clin. Invest. Familial increase in the thyroxine-binding sites in serum alpha globulin. 1683-8 BEIERWALTES W H WH ROBBINS J J eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Alpha-Globulins 0 Serum Globulins Q51BO43MG4 Thyroxine OM Alpha-Globulins Binding Sites Humans Serum Globulins chemistry Thyroxine blood (...) Transcription, Genetic SERUM GLOBULIN/chemistry THYROXIN/blood 1959 10 1 1959 10 1 0 1 1959 10 1 0 0 ppublish 13798328 10.1172/JCI103946 PMC444135 J Biol Chem. 1950 Nov;187(1):97-106 14794694 J Clin Invest. 1958 Feb;37(2):153-9 13513745 Nature. 1952 Jan 5;169(4288):19-20 14910673 Ann Intern Med. 1956 Jan;44(1):40-51 13275849 J Clin Invest. 1937 Sep;16(5):695-703 16694514 J Clin Endocrinol Metab. 1957 Jan;17(1):33-43 13385316 J Clin Invest. 1958 Jul;37(7):1024-30 13563631 Endocrinology. 1958 Aug;63(2):256-9

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1959 Journal of Clinical Investigation

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