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Thyroxine-Binding Globulin

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EVALUATION OF VAGINAL SMEAR, SERUM GONADOTROPIN, PROTEIN-BOUND IODINE, AND THYROXINE-BINDING AS MEASURES OF PLACENTAL ADEQUACY 13938457 1998 11 01 2018 12 01 0021-9738 41 1962 Nov The Journal of clinical investigation J. Clin. Invest. Evaluation of vaginal smear, serum gonadotropin, protein-bound iodine, and thyroxine-binding as measures of placental adequacy. 1998-2011 NICOLOFF J T JT NICOLOFF R R DOWLING J T JT eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Gonadotropins (...) 0 Ion Exchange Resins 0 Serum Globulins 9679TC07X4 Iodine Q51BO43MG4 Thyroxine OM Abortion, Induced Abortion, Spontaneous Female Gonadotropins Humans Iodine Ion Exchange Resins Placenta Pregnancy Serum Globulins Thyroid Function Tests Thyroxine Vaginal Smears ABORTION ION EXCHANGE RESINS PROTEIN-BOUND IODINE TEST SERUM GLOBULIN THYROXIN VAGINAL SMEARS 1962 11 1 1962 11 1 0 1 1962 11 1 0 0 ppublish 13938457 10.1172/JCI104658 PMC291130 J Am Med Assoc. 1953 Sep 26;153(4):271-4 13084385 Am J Obstet

1962 Journal of Clinical Investigation

42. Using changes in binding globulins to assess oral contraceptive compliance. Full Text available with Trip Pro

-hormone- and thyroxine-binding globulins (CBG, SHBG and TBG, respectively) as measures of OCP compliance.We used frozen serum from a trial that compared ovarian suppression between normal-weight and obese women randomized to one of two OCPs containing EE2 and levonorgestrel (LNG). Based on serial LNG measurements during the trial, 17% of participants were noncompliant. We matched noncompliant participants with compliant participants by age, body mass index, ethnicity and OCP formulation. We measured (...) Using changes in binding globulins to assess oral contraceptive compliance. Validity of oral contraceptive pill (OCP) clinical trial results depends on participant compliance. Ethinyl estradiol (EE2) induces increases in hepatic binding globulin (BG) levels. Measuring these BG increases may provide an effective and convenient approach to distinguish noncompliant from compliant OCP users in research settings. This analysis evaluated the usefulness of measuring increases in corticosteroid-, sex

2012 Contraception Controlled trial quality: uncertain

43. The Effects of Estradiol and Estriol on Plasma Levels of Cortisol and Thyroid Hormone-Binding Globulins and on Aldosterone and Cortisol Secretion Rates in Man Full Text available with Trip Pro

The Effects of Estradiol and Estriol on Plasma Levels of Cortisol and Thyroid Hormone-Binding Globulins and on Aldosterone and Cortisol Secretion Rates in Man The effects of estriol and estradiol on the plasma levels of cortisol- and thyroxine-binding globulin activity, and on the secretion rates of aldosterone and cortisol were studied in man. The metabolite estriol had no consistent or significant influence on plasma levels of the hormone-binding globulin activities; the hormone estradiol

1967 Journal of Clinical Investigation

44. Newborn Screening ACT Sheet [Low T4 and/or elevated TSH (Primary T4 followup TSH test)] Congenital Hypothyroidism

of the date this guideline was adopted, and to consider other medical and scientific information that become available after that date. © American College of Medical Genetics and Genomics, 2012 (Funded in part through MCHB/HRSA/HHS grant #U22MC03957) Newborn Screening ACT Sheet [Low T4 and/or elevated TSH (Primary T4 follow- up TSH test)] Congenital Hypothyroidism Differential Diagnosis: Primary and secondary congenital hypothyroidism (CH), transient CH, thyroxine binding globulin (TBG) deficiency

2018 American College of Medical Genetics and Genomics

47. Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment. Full Text available with Trip Pro

component analysis, cluster analysis and limma. Blood neutrophil counts were analysed using linear regression.Plasma analyte levels of HIV-infected individuals are markedly different from those of healthy controls and HIV-negative individuals receiving post-exposure prophylaxis. Viral reactivation following cART interruption also affects multiple analytes, but cART interruption itself only has only a minor effect. We find that Thyroxine-Binding Globulin (TBG) levels and late-stage neutrophil numbers

2018 PLoS ONE

49. Screening, diagnosis and management of congenital hypothyroidism Full Text available with Trip Pro

for congenital hypothyroidism? J Clin Endo- crinol Metab 2005; 90: 3797–3799. 23 Lanting CI, van Tijn DA, Loeber JG, Vulsma T, de Vijlder JJ, Verkerk PH: Clinical effective- ness and cost-effectiveness of the use of the thyroxine/thyroxine-binding globulin ratio to detect congenital hypothyroidism of thyroidal and central origin in a neonatal screening pro- gram. Pediatrics 2005; 116: 168–173. 24 Nebesio TD, McKenna MP, Nabhan ZM, Eugster EA: Newborn screening results in children with central hypothyroidism

2015 Pediatric Endocrine Society

50. Effect of Albumin Polymorphism on Thyroid Hormones: A Case Report and Literature Review Full Text available with Trip Pro

to human serum albumin, 75% is bound to thyroxine-binding globulin, 15% to transthyretin, and 0.03% is free. The disorder is characterized by a greater elevation of serum thyroxine than triiodothyronine (T3). The high serum concentration of T4 is due to the modification of a binding site located in the N-terminal half of HSA (in subdomain IIA). Arg218 or Arg222 gets replaced with smaller amino acids, such as histidine, proline, or serine, due to missense mutation; this reduces the steric hindrances

2018 Cureus

51. Increased Requirement of Replacement Doses of Levothyroxine Caused by Liver Cirrhosis Full Text available with Trip Pro

cirrhosis is mentioned as causing L-T4 malabsorption.In this study, we report increased requirement of daily doses of l-thyroxine in two patients with the atrophic variant of Hashimoto's thyroiditis and liver cirrhosis. In one patient, this increased requirement could have been contributed by the increased serum levels of the estrogen-dependent thyroxine-binding globulin (TBG), which is the major plasma carrier of thyroid hormones. In the other patient, we switched from tablet L-T4 to liquid L-T4

2018 Frontiers in endocrinology

52. A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome Full Text available with Trip Pro

cohort. Suitable assays were found for 9 of the 13 markers identified by iTRAQ and were used in a 25 SRNS × 25 SSNS validation cohort. Vitamin D-binding protein (VDBP), alpha-1 acid glycoprotein 1 (AGP1), alpha-1 acid glycoprotein 2 (AGP2), alpha-1-B glycoprotein (A1BG), fetuin-A, prealbumin, thyroxine-binding globulin and hemopexin, and alpha-2 macroglobulin were measured and combined with urine neutrophil gelatinase-associated lipocalin (NGAL), which had been previously shown to distinguish

2017 Biomarker insights

53. Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins Full Text available with Trip Pro

. We identified immune reactivity between dietary proteins and target sites on the thyroid axis that includes thyroid hormones, thyroid receptors, enzymes, and transport proteins. We also measured immune reactivity of either target specific monoclonal or polyclonal antibodies for thyroid-stimulating hormone (TSH) receptor, 5'deiodinase, thyroid peroxidase, thyroglobulin, thyroxine-binding globulin, thyroxine, and triiodothyronine against 204 purified dietary proteins commonly consumed in cooked (...) and raw forms. Dietary protein determinants included unmodified (raw) and modified (cooked and roasted) foods, herbs, spices, food gums, brewed beverages, and additives. There were no dietary protein immune reactions with TSH receptor, thyroid peroxidase, and thyroxine-binding globulin. However, specific antigen-antibody immune reactivity was identified with several purified food proteins with triiodothyronine, thyroxine, thyroglobulin, and 5'deiodinase. Laboratory analysis of immunological cross

2017 Journal of thyroid research

54. N-glycoproteomic analysis of human follicular fluid during natural and stimulated cycles in patients undergoing in vitro fertilization Full Text available with Trip Pro

and glycoproteomes. N-GPs were validated by the consensus sequence N-X-S/T (92.2% specificity for the N-glycomotif at p<0.05). All data were compared between natural versus hyperstimulated hFF samples.We detected 41 and 44 N-GPs in the natural and stimulated hFF samples, respectively. Importantly, we identified 11 N-GPs with greater than two-fold upregulation in stimulated hFF samples compared to natural hFF samples. We also validated the novel N-GPs thyroxine-binding globulin, vitamin D-binding protein

2017 Clinical and experimental reproductive medicine

55. Subclinical Hypothyroidism

be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased. Concepts Disease or Syndrome ( T047 ) MSH ICD9 790.94 ICD10 SnomedCT 237542005 English Euthyroid Sick Syndrome , Euthyroid Sick Syndromes , EUTHYROID SICK SYNDROME , Euthyroid sick syndrome , euthyroid sick syndrome , euthyroid sick syndrome (diagnosis) , EUTHYROID SICK SYNDROME LOW T3 LOW T4 SYNDROME , Euthyroid sick-syndrome , Euthyroid Sick Syndromes [Disease/Finding] , sick

2018 FP Notebook

56. T3 Resin Uptake

Biliary Drugs s Perphenazine Fluorouracil Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "T3 Resin Uptake." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: T3 uptake measurement (C0202224) Definition (NCI) The determination of the binding of triiodothyonine to thyroxine binding globulin protein in a sample. Definition (NCI_CDISC) A measurement (...) of the binding of triiodothyonine to thyroxine binding globulin protein in a biological specimen. Concepts Laboratory Procedure ( T059 ) SnomedCT 166340002 , 143695002 , 250669007 , 17130003 , 275756004 CPT 84479 English T3RU , Tri-iodothyronine uptake , T3 uptake , T3U , Triiodothyronine Uptake Measurement , triiodothyronine uptake measurement (lab test) , triiodothyronine uptake measurement , T3 resin uptake , resin t3 uptake , t3 uptake , t3u , t3 uptake test , t3 resin uptake , Measurement

2018 FP Notebook

58. Trobalt - retigabine

of thyroid proliferative lesions in response to chronic TSH stimulation than is the case for the human thyroid. The sensitivity of the rodent thyroid is to a great extent related to the shorter plasma half-life of T4 compared to that of humans, due to major differences in the transport proteins for the thyroid hormones, including the lack of thyroxine-binding globulin (TBG). TBG is found in humans and dogs (Casarett & Doull’s, 2001; Greaves, 2007). There is no evidence from the clinical studies performed

2011 European Medicines Agency - EPARs

59. Vyndaqel - tafamidis

for guidance. Primary and secondary pharmacodynamics was performed in vitro, by non-GLP assays. Critical safety pharmacology and pharmacokinetic assays complied with GLP, although repeated dose pharmacokinetics was not performed. 2.3.2. Pharmacology Primary pharmacodynamic studies The pharmacologic activity of tafamidis was demonstrated only in vitro, through its binding to TTR at the thyroxine binding sites and stabilisation of the TTR tetramer under non-physiologic (acid and urea denaturation conditions (...) through an interaction with the d-opioid receptor would not be expected at the mean human steady-state C max of 7.4 mM (2.28 µg/ml). Non-GLP assays for cyclooxygenase (COX-1 and COX-2) inhibition by tafamidis were performed on recombinant enzymes and in human whole blood, demonstrating absence of inhibitory effects. Although tafamidis binds to TTR at the thyroxine binding sites, the applicant maintained that treatment with tafamidis is not anticipated to result in an impact on thyroid function

2011 European Medicines Agency - EPARs

60. A double-blind, randomized, ascending, multiple-dose study of bazedoxifene in healthy postmenopausal women. (Abstract)

) administered orally once daily for 30 days. Bazedoxifene demonstrated a half-life of 25 to 30 hours, reached steady state within 7 days, and exhibited linear pharmacokinetics over a dose range of 5-80 mg. Fibrinogen levels decreased with bazedoxifene doses of 5 mg and greater; these changes were significant for bazedoxifene 20, 40, and 80 mg (P ≤ .05 vs placebo), but were not dose dependent. Bazedoxifene was associated with increased levels of sex hormone-binding globulin, thyroxine-binding globulin (...) , and cortisol-binding globulin (CBG); only increases in the levels of CBG appeared to be dose related. Bazedoxifene was safe and well tolerated within the tested dose range. Bazedoxifene showed no differences from placebo in adverse event reports, vital sign measurements, or electrocardiogram findings.© 2014, The American College of Clinical Pharmacology.

2016 Clinical pharmacology in drug development Controlled trial quality: uncertain

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