How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,676 results for

Thyroxine-Binding Globulin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies. (PubMed)

Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies. We conducted a meta-analysis of observational study to clarify the association between sex hormone-binding globulin (SHBG) levels and the risk of fracture in older adults. We found that higher SHBG levels were associated with an increased risk of fracture in older adults.The association between SHBG levels and the risk of fracture in older adults remains elusive. We

2018 Osteoporosis International

22. Sex Hormone-Binding Globulin Expression Correlates with Acetyl-CoA Carboxylase and Triglyceride Content in Human Liver. (PubMed)

Sex Hormone-Binding Globulin Expression Correlates with Acetyl-CoA Carboxylase and Triglyceride Content in Human Liver. There is emerging evidence that sex hormone binding globulin (SHBG) is significantly reduced in chronic metabolic diseases, including obesity and non-alcoholic fatty liver disease (NAFLD). We have recently reported using in vitro (HepG2 cells) and in vivo models (SHBG-C57BL/ksJ-db/db mice) that SHBG could play a role in arresting the progression of NAFLD by downregulating

2018 Journal of Clinical Endocrinology and Metabolism

23. Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche: a prospective cohort study. (PubMed)

Relationship between umbilical cord sex hormone binding globulin, sex steroids, and age at menarche: a prospective cohort study. To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche.Prospective population-based cohort.Not applicable.In 286 female members

2018 Fertility and Sterility

24. Sex hormone-binding globulin is a biomarker associated with nonvertebral fracture in men on dialysis therapy. (PubMed)

Sex hormone-binding globulin is a biomarker associated with nonvertebral fracture in men on dialysis therapy. Gonadal hormones impact bone health and higher values of sex hormone-binding globulin (SHBG) have been independently associated with fracture risk in men without chronic kidney disease. People with chronic kidney disease have a greatly increased fracture risk, and gonadal dysfunction is common in men receiving dialysis treatment. Nevertheless, in these men the effect of gonadal steroids

2018 Kidney International

25. Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial. (PubMed)

Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial. Testosterone and its binding protein sex hormone-binding globulin have been associated with cardiovascular disease and dysglycaemia. However, information on the prognostic implication in patients at high cardiovascular risk with dysglycaemia is inconsistent. The study objective was to determine whether testosterone and/or sex hormone (...) -binding globulin predict cardiovascular events or death in dysglycaemic patients.Dysglycaemic males at high cardiovascular risk ( n = 5553) who participated in the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial and provided baseline blood samples were studied. Testosterone and sex hormone-binding globulin were measured at baseline and used to estimate free testosterone. Low levels of total and free testosterone were defined as ≤300 ng/dl and ≤7 ng/dl, respectively. Patients

2018 European journal of preventive cardiology Controlled trial quality: uncertain

26. Relationship between dietary carbohydrates intake and circulating sex hormone-binding globulin levels in postmenopausal women. (PubMed)

Relationship between dietary carbohydrates intake and circulating sex hormone-binding globulin levels in postmenopausal women. Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relationship between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies.Among postmenopausal women with available SHBG

Full Text available with Trip Pro

2018 Journal of diabetes Controlled trial quality: uncertain

27. Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin. (PubMed)

Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin. We tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obese women 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial.From 2005 to 2008, 439 overweight/obese, postmenopausal women (BMI >25 kg/m), 50 to 75 years, were randomized to a year-long intervention: diet

2018 Menopause Controlled trial quality: uncertain

28. Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein (PubMed)

Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein Corticosteroid-binding globulin (CBG) was isolated from chicken serum and identified by mass spectrometry and genomic analysis. This revealed that the organization and synteny of avian and mammalian SerpinA6 genes are conserved. Recombinant zebra finch CBG steroid-binding properties reflect those of the natural (...) protein in plasma and confirm its identity. Zebra finch and rat CBG crystal structures in complex with cortisol resemble each other, but their primary structures share only ∼40% identity, and their steroid-binding site topographies differ in several unexpected ways. Remarkably, a tryptophan that anchors ligands in mammalian CBG steroid-binding sites is replaced by an asparagine. Phylogenetic comparisons show that reptilian CBG orthologs share this unexpected property. Glycosylation of this asparagine

Full Text available with Trip Pro

2016 The Journal of biological chemistry

29. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. (PubMed)

Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. The undercarboxylated form of osteocalcin (ucOC) regulates male fertility and energy metabolism, acting through the G protein-coupled receptor (GPRC)6A, thus forming a new pancreas-bone-testis axis. Recently, GPRC6A has also been suggested to mediate the nongenomic responses of free testosterone (T). However, these data did not consider the physiological scenario, where circulating T is mainly bound (...) to sex hormone-binding globulin (SHBG) and only a small percentage circulates freely in the blood. Here, by the use of computational modelling, we document the existence of similar structural moieties between ucOC and SHBG that are predicted to bind to GPRC6A at docking analysis. This hypothesis of competition was assessed by binding experiments on human embryonic kidney-293 cells transfected with human GPRC6A gene. Unliganded SHBG specifically bound the membrane of human embryonic kidney-293 cells

Full Text available with Trip Pro

2016 Endocrinology

30. Thyroxine-Binding Globulin Deficiency (Treatment)

Thyroxine-Binding Globulin Deficiency (Treatment) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

31. Thyroxine-Binding Globulin Deficiency (Overview)

Thyroxine-Binding Globulin Deficiency (Overview) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

32. Thyroxine-Binding Globulin Deficiency (Follow-up)

Thyroxine-Binding Globulin Deficiency (Follow-up) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

33. Thyroxine-Binding Globulin Deficiency (Diagnosis)

Thyroxine-Binding Globulin Deficiency (Diagnosis) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

34. Comment on Muka et al. Associations of Steroid Sex Hormones and Sex Hormone-Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis. Diabetes 2017;66:577-586. (PubMed)

Comment on Muka et al. Associations of Steroid Sex Hormones and Sex Hormone-Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis. Diabetes 2017;66:577-586. 28733310 2018 01 09 2018 12 02 1939-327X 66 8 2017 08 Diabetes Diabetes Comment on Muka et al. Associations of Steroid Sex Hormones and Sex Hormone-Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis. Diabetes 2017;66:577-586 (...) . e7 10.2337/db17-0269 Abbasi Ali A 0000-0002-6452-4765 Department of Primary Care & Public Health Sciences, King's College London, London, U.K., and Department of Epidemiology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands ali.abbasi@kcl.ac.uk a.abbasi@umcg.nl. eng Letter Comment United States Diabetes 0372763 0012-1797 0 Gonadal Steroid Hormones 0 Sex Hormone-Binding Globulin 3XMK78S47O Testosterone AIM IM Diabetes. 2017 Mar;66(3):577-586 28223343

Full Text available with Trip Pro

2017 Diabetes

35. The Utility of Sex Hormone Binding Globulin in Hypogonadism and Infertile Males. (PubMed)

The Utility of Sex Hormone Binding Globulin in Hypogonadism and Infertile Males. We sought to determine the role of sex hormone-binding globulin in patients with male infertility.We retrospectively reviewed the records of 168 males seen at a fertility clinic from 2012 to 2014 to investigate the accuracy of total testosterone in the biochemical diagnosis of hypogonadism using calculated bioavailable testosterone as the reference value. We used multivariable analysis to assess sex hormone-binding (...) low bioavailable testosterone less than 210 ng/dl and only 48% could be considered biochemically eugonadal according to calculated bioavailable testosterone. Of the 80 patients with total testosterone less than 300 ng/dl, 19% had free testosterone levels greater than 6.5 ng/dl and, thus, could be considered to be eugonadal. By a magnitude similar to that of follicle-stimulating hormone, sex hormone-binding globulin independently predicted decreased sperm concentration (p = 0.0027) and motility (p

2017 Journal of Urology

36. Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program. (PubMed)

Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program. The relationship between hyperinsulinemia and decreased sex hormone-binding globulin (SHBG) levels has been observed in obese adults and children. Weight reduction not only increased insulin sensitivity but also elevated serum SHBG levels in obese adults and children. However, the correlation between the changes in insulin resistance indices and serum SHBG

Full Text available with Trip Pro

2017 Medicine

37. Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk. (PubMed)

Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk. Use of ethinylestradiol, one of the active ingredients in combined oral contraceptives, affects the incidence of venous thrombosis. To explain why some women develop thrombosis when using oral contraceptives and others do not, we hypothesized a role for the first-pass metabolism of ethinylestradiol in the liver. We set out to determine the association between (...) genetic variation in the first-pass metabolism of ethinylestradiol, venous thrombosis risk and the effect on Sex-hormone-binding-globulin (SHBG) levels.Premenopausal women were included from two case-control studies: LETS (103 cases; 159 controls) and MEGA (397 cases; 796 controls). Haplotype-tagging SNPs were selected in 11 candidate genes; COMT, CYP1A2, CYP2C9, CYP3A4, CYP3A5, SULT1A1, SULT1E1, UGT1A1, UGT1A3, UGT1A9, UGT2B7. Venous thrombosis risk was expressed as odds ratios (OR) with 95

2017 European journal of internal medicine

38. Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis. (PubMed)

Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis. Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD.A comprehensive search of the databases of the MEDLINE (...) and EMBASE was performed from inception through April 2016. The inclusion criterion was the observational studies that assessed the association of serum total testosterone (TT) and sex-hormone binding globulin (SHBG) and NAFLD. We calculated pooled effect estimates of TT and SHBG with 95% confidence intervals (CI) comparing between subjects with and without NAFLD by using random-effects model.Sixteen trials comprising 13,721 men and 5,840 women met the inclusion criteria. TT levels were lower in men

2017 Annals of hepatology

39. Associations of Vitamin D-Binding Globulin and Bioavailable Vitamin D Concentrations with Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA). (PubMed)

Associations of Vitamin D-Binding Globulin and Bioavailable Vitamin D Concentrations with Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Low 25-hydroxyvitamin D [25(OH)D] is associated with coronary heart disease (CHD) in people who are white and Chinese but not black or Hispanic. Vitamin D binding globulin (VDBG) avidly binds 25(OH)D, reducing its bioavailability, and differs in isoform and concentration by race.Evaluate associations of VDBG with CHD

Full Text available with Trip Pro

2017 Journal of Clinical Endocrinology and Metabolism

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>