How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,676 results for

Thyroxine-Binding Globulin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Effects of aerobic exercise training on serum sex hormone binding globulin, body fat index, and metabolic syndrome factors in obese postmenopausal women. (PubMed)

Effects of aerobic exercise training on serum sex hormone binding globulin, body fat index, and metabolic syndrome factors in obese postmenopausal women. The percentage of obese postmenopausal women with metabolic syndrome is rising, and physical factors associated with the metabolic syndrome prevalence or incidence are also rising, including high body mass index (BMI), visceral fat area (VFA), low plasma sex hormone-binding globulin (SHBG) levels, and low cardiorespiratory fitness. Therefore

2012 Metabolic syndrome and related disorders Controlled trial quality: uncertain

182. The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial. (PubMed)

The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial. Findings from observational studies suggest that sex hormone-binding globulin (SHBG) and endogenous sex hormones may be mediators of the putative relation between coffee consumption and lower risk of type 2 diabetes. The objective of this study was to evaluate the effects of caffeinated and decaffeinated coffee on SHBG and sex hormone levels.After

Full Text available with Trip Pro

2012 Nutrition journal Controlled trial quality: uncertain

183. The effects of bed-rest and countermeasure exercise on the endocrine system in male adults: evidence for immobilization-induced reduction in sex hormone-binding globulin levels. (PubMed)

The effects of bed-rest and countermeasure exercise on the endocrine system in male adults: evidence for immobilization-induced reduction in sex hormone-binding globulin levels. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56- day) bed-rest in male adults.Twenty healthy male subjects underwent 8 weeks of strict bed-rest and 12 months

2012 Journal of endocrinological investigation Controlled trial quality: uncertain

184. Using changes in binding globulins to assess oral contraceptive compliance. (PubMed)

-hormone- and thyroxine-binding globulins (CBG, SHBG and TBG, respectively) as measures of OCP compliance.We used frozen serum from a trial that compared ovarian suppression between normal-weight and obese women randomized to one of two OCPs containing EE2 and levonorgestrel (LNG). Based on serial LNG measurements during the trial, 17% of participants were noncompliant. We matched noncompliant participants with compliant participants by age, body mass index, ethnicity and OCP formulation. We measured (...) Using changes in binding globulins to assess oral contraceptive compliance. Validity of oral contraceptive pill (OCP) clinical trial results depends on participant compliance. Ethinyl estradiol (EE2) induces increases in hepatic binding globulin (BG) levels. Measuring these BG increases may provide an effective and convenient approach to distinguish noncompliant from compliant OCP users in research settings. This analysis evaluated the usefulness of measuring increases in corticosteroid-, sex

Full Text available with Trip Pro

2012 Contraception Controlled trial quality: uncertain

185. Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: Cross sectional study. (PubMed)

).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays. Analyzed single nucleotide polymorphisms (SNPs) were: VDR-rs7975232 (ApaI) C>A, rs731236 A>G (TaqI), rs1544410 C>T (BsmI), rs10735810 T>C (FokI) and carrier globulin/binding protein (GC)-rs4588 and rs7041 and the haplotype bAt [CCA]. Hepatic fibrosis (...) Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: Cross sectional study. Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC

Full Text available with Trip Pro

2018 Medicine

186. Bioavailability of Oral Hydrocortisone Corrected for Binding Proteins and Measured by LC-MS/MS Using Serum Cortisol and Salivary Cortisone (PubMed)

Bioavailability of Oral Hydrocortisone Corrected for Binding Proteins and Measured by LC-MS/MS Using Serum Cortisol and Salivary Cortisone The assessment absolute bioavailability of oral hydrocortisone is complicated by its saturable binding to cortisol binding globulin (CBG). Previous assessment of bioavailability used a cortisol radioimmunoassay which has cross reactivity with other steroids. Salivary cortisone is a measure of free cortisol and LC-MS/MS is the gold standard method (...) for measuring steroids. We here report the absolute bioavailability of hydrocortisone calculated using serum cortisol and salivary cortisone measured by LC-MS/MS.14 healthy male dexamethasone suppressed volunteers were administered 20 mg hydrocortisone either intravenously or orally by tablet. Samples of serum and saliva were taken and measured for cortisol and cortisone by LC-MS/MS. Serum cortisol was corrected for saturable binding using published data and pharmacokinetic parameters derived using

Full Text available with Trip Pro

2018 Journal of bioequivalence & bioavailability

187. Enrichment and Identification of the Most Abundant Zinc Binding Proteins in Developing Barley Grains by Zinc-IMAC Capture and Nano LC-MS/MS (PubMed)

+-immobilized metal ion affinity chromatography, and the captured proteins were identified using nanoscale liquid chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS). Results: In the endosperm, the most abundant zinc binding proteins were the storage protein B-hordeins, gamma-, and D-hordeins, while in the embryo, 7S globulins storage proteins exhibited zinc binding. In the aleurone/subaleurone, zinc affinity captured proteins were late abundant embryogenesis proteins, dehydrins, many isoforms (...) Enrichment and Identification of the Most Abundant Zinc Binding Proteins in Developing Barley Grains by Zinc-IMAC Capture and Nano LC-MS/MS Background: Zinc accumulates in the embryo, aleurone, and subaleurone layers at different amounts in cereal grains. Our hypothesis is that zinc could be stored bound, not only to low MW metabolites/proteins, but also to high MW proteins as well. Methods: In order to identify the most abundant zinc binding proteins in different grain tissues, we

Full Text available with Trip Pro

2018 Proteomes

188. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein (PubMed)

computational design algorithms enabled the introduction of doxycycline- and doxorubicin-binding sites into the serine proteinase inhibitor (serpin) family member α1-antichymotrypsin. Further engineering allowed exploitation of the proteinase-triggered serpin-typical S-to-R transition to modulate the ligand affinities. These design variants follow strategies observed in naturally occurring plasma globulins that allow for the targeted delivery of hormones in the blood. By analogy, we propose (...) Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory mechanisms in biological systems. While the design of ligand-binding sites into proteins remains challenging, this holds even truer for the coupling of a newly engineered binding site to an allosteric mechanism that regulates the ligand affinity. Here it is shown how

Full Text available with Trip Pro

2018 Proceedings of the National Academy of Sciences of the United States of America

189. EVALUATION OF VAGINAL SMEAR, SERUM GONADOTROPIN, PROTEIN-BOUND IODINE, AND THYROXINE-BINDING AS MEASURES OF PLACENTAL ADEQUACY (PubMed)

EVALUATION OF VAGINAL SMEAR, SERUM GONADOTROPIN, PROTEIN-BOUND IODINE, AND THYROXINE-BINDING AS MEASURES OF PLACENTAL ADEQUACY 13938457 1998 11 01 2018 12 01 0021-9738 41 1962 Nov The Journal of clinical investigation J. Clin. Invest. Evaluation of vaginal smear, serum gonadotropin, protein-bound iodine, and thyroxine-binding as measures of placental adequacy. 1998-2011 NICOLOFF J T JT NICOLOFF R R DOWLING J T JT eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Gonadotropins (...) 0 Ion Exchange Resins 0 Serum Globulins 9679TC07X4 Iodine Q51BO43MG4 Thyroxine OM Abortion, Induced Abortion, Spontaneous Female Gonadotropins Humans Iodine Ion Exchange Resins Placenta Pregnancy Serum Globulins Thyroid Function Tests Thyroxine Vaginal Smears ABORTION ION EXCHANGE RESINS PROTEIN-BOUND IODINE TEST SERUM GLOBULIN THYROXIN VAGINAL SMEARS 1962 11 1 1962 11 1 0 1 1962 11 1 0 0 ppublish 13938457 10.1172/JCI104658 PMC291130 J Am Med Assoc. 1953 Sep 26;153(4):271-4 13084385 Am J Obstet

Full Text available with Trip Pro

1962 Journal of Clinical Investigation

190. Effect of physiological variations in free fatty acid concentration on the binding of thyroxine in the serum of euthyroid and thyrotoxic subjects (PubMed)

the marked increases in FFA which followed the administration of nicotinic acid or 2-deoxyglucose were accompanied by significant changes in the per cent of free thyroxine (T(4)), the protein-bound iodine (PBI), the per cent of endogenous T(4) bound by the T(4)-binding globulin (TBG) or T(4)-binding prealbumin (TBPA), or the resin sponge uptake of triiodothyronine (T(3)). In the thyrotoxic group, the decline in FFA concentration which followed glucose administration was accompanied by slight (...) Effect of physiological variations in free fatty acid concentration on the binding of thyroxine in the serum of euthyroid and thyrotoxic subjects The effect of variations in the concentration of free fatty acids (FFA) on the binding of thyroid hormones in serum has been studied in 20 euthyroid subjects and 19 thyrotoxic patients. In the euthyroid group, neither the pronounced decreases in FFA induced by the oral administration of glucose or the intravenous administration of nicotinic acid, nor

Full Text available with Trip Pro

1969 Journal of Clinical Investigation

191. The mechanism of thyroxine transfer from plasma to tissue binding sites (PubMed)

The mechanism of thyroxine transfer from plasma to tissue binding sites 1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA).2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation for both TBG and TBPA.3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves

Full Text available with Trip Pro

1971 The Journal of physiology

192. Conventional and dual competitive binding analyses of thyroxine using the Thyopac-4 kit (PubMed)

) was correlated significantly (gamma = + 0.961) with the free Thyopac index (y), representing a regression equation of y = 71.7x(2) - 88.4x + 24.2. Thyopac ETR was shown to be useful in differentiating normal thyroid states from abnormal, irrespective of changes in T(4)-binding globulin (TBG). Further, the T(4) value obtained simultaneously made it possible to detect changes in the TBG level by noting an inconsistent value for the effective thyroxine ratio. (...) Conventional and dual competitive binding analyses of thyroxine using the Thyopac-4 kit A simple method is described for the simultaneous determinations of thyroxine and the effective thyroxine ratio (ETR) using a single kit of Thyopac-4. Thyopac ETR values obtained were 1.00 +/- 0.03 for normal subjects; 1.22 +/- 0.11 for hyperthyroid; 0.87 +/- 0.04 for hypothyroid; and 1.02 +/- 0.05 for pregnant women. Cases with TBG deficiency and the nephrotic syndrome indicated normal values. The value (x

Full Text available with Trip Pro

1974 Journal of Clinical Pathology

193. N-Glycans Modulate the Function of Human Corticosteroid-Binding Globulin (PubMed)

N-Glycans Modulate the Function of Human Corticosteroid-Binding Globulin Human corticosteroid-binding globulin (CBG), a heavily glycosylated protein containing six N-linked glycosylation sites, transports cortisol and other corticosteroids in blood circulation. Here, we investigate the biological importance of the N-glycans of CBG derived from human serum by performing a structural and functional characterization of CBG N-glycosylation. Liquid chromatography-tandem MS-based glycoproteomics (...) glycosylation and the site-to-site differences in core-fucosylation and branching could be in silico correlated with the accessibility to the individual glycosylation sites on the maturely folded protein. Deglycosylated and desialylated CBG analogs were generated to investigate the biological importance of CBG N-glycans. As a functional assay, MCF-7 cells were challenged with native and glycan-modified CBG and the amount of cAMP, which is produced as a quantitative response upon CBG binding to its cell

Full Text available with Trip Pro

2011 Molecular & cellular proteomics : MCP

194. Diverse Roles for Sex Hormone-Binding Globulin in Reproduction (PubMed)

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction Sex hormone-binding globulin (SHBG) transports androgens and estrogens in blood and regulates their access to target tissues. Hepatic production of SHBG fluctuates throughout the life cycle and is influenced primarily by metabolic and hormonal factors. Genetic differences also contribute to interindividual variations in plasma SHBG levels. In addition to controlling the plasma distribution, metabolic clearance, and bioavailability (...) of sex steroids, SHBG accumulates in the extravascular compartments of some tissues and in the cytoplasm of specific epithelial cells, where it exerts novel effects on androgen and estrogen action. In mammals, the gene-encoding SHBG is expressed primarily in the liver but also at low levels in other tissues, including the testis. In subprimate species, Shbg expression in Sertoli cells is under the control of follicle-stimulating hormone and produces the androgen-binding protein that influences

Full Text available with Trip Pro

2011 Biology of reproduction

195. Sex hormone-binding globulin and risk of hyperglycemia in patients with androgenetic alopecia. (PubMed)

Sex hormone-binding globulin and risk of hyperglycemia in patients with androgenetic alopecia. Low circulating levels of sex hormone-binding globulin (SHBG) are a strong predictor of the risk of type 2 diabetes. Androgenetic alopecia (AGA) has been related to an increase in cardiovascular risk, but the mechanism of this association has not been elucidated. AGA can be associated with low levels of SHBG and insulin resistance, which could be related to hyperglycemia and type 2 diabetes.The

2011 Journal of American Academy of Dermatology

196. Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone-Binding Globulin. (PubMed)

Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone-Binding Globulin. Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explore whether tumor necrosis factor-α (TNF-α) rather than insulin could be the main factor

Full Text available with Trip Pro

2011 Diabetes

197. Sex Hormone-Binding Globulin, Oligomenorrhea, Polycystic Ovary Syndrome, and Childhood Insulin at Age 14 Years Predict Metabolic Syndrome and Class III Obesity at Age 24 Years. (PubMed)

Sex Hormone-Binding Globulin, Oligomenorrhea, Polycystic Ovary Syndrome, and Childhood Insulin at Age 14 Years Predict Metabolic Syndrome and Class III Obesity at Age 24 Years. We hypothesized that oligomenorrhea (menstrual cyclicity ≥42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III obesity (body mass index ≥40 kg/m(2)) at age 24 years.In this prospective study

Full Text available with Trip Pro

2011 Journal of Pediatrics

198. Polymorphisms in the Sex Hormone-Binding Globulin (SHBG) Gene Influence Serum SHBG Levels in Women with Polycystic Ovary Syndrome. (PubMed)

Polymorphisms in the Sex Hormone-Binding Globulin (SHBG) Gene Influence Serum SHBG Levels in Women with Polycystic Ovary Syndrome. Single-nucleotide polymorphisms (SNPs) in the SHBG gene are associated with type 2 diabetes mellitus. SHBG has also been proposed as a candidate gene for the polycystic ovary syndrome (PCOS).The study aims were 1) to determine whether any of four SHBG SNPs (rs1779941, rs6297, rs6259, and rs727428) are associated with PCOS and 2) to determine whether SNP genotype

Full Text available with Trip Pro

2011 Journal of Clinical Endocrinology and Metabolism

199. Sex hormone-binding globulin and type 2 diabetes mellitus. (PubMed)

Sex hormone-binding globulin and type 2 diabetes mellitus. Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence

Full Text available with Trip Pro

2011 Trends in Endocrinology and Metabolism

200. Sex Hormone-Binding Globulin, But Not Testosterone, Is Associated Prospectively and Independently With Incident Metabolic Syndrome in Men: The Framingham Heart Study. (PubMed)

Sex Hormone-Binding Globulin, But Not Testosterone, Is Associated Prospectively and Independently With Incident Metabolic Syndrome in Men: The Framingham Heart Study. The association between total testosterone and metabolic syndrome has prompted speculation that low testosterone contributes to the pathophysiology of metabolic syndrome in men. We determined whether testosterone or sex hormone-binding globulin (SHBG) is independently associated with the risk of metabolic syndrome.Cross-sectional

Full Text available with Trip Pro

2011 Diabetes Care

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>