How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

205 results for

Thyroxine-Binding Globulin

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Effect of four different oral contraceptives on various sex hormones and serum-binding globulins. (Abstract)

%), while the effect of 20EE/DNG and EE/EV/DNG was similar (+270%). The thyroxine-binding globulin (TBG) levels increased significantly, by 50-60%, during treatment with the DNG-containing formulations, while the effect of EE/LNG was less significant (+30%). The rise in corticosteroid-binding globulin (CBG), which occurred in all groups, was most pronounced in women treated with 30EE/DNG (+90%) and least with EE/EV/DNG (+55%), indicating a strong influence of EE and no effect of the progestogen (...) Effect of four different oral contraceptives on various sex hormones and serum-binding globulins. In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on various hormone parameters and serum-binding globulins was investigated. Four groups with 25 volunteers each (18-35 years of age) were treated for six cycles with monophasic combinations containing 21 tablets with either 30 microg ethinylestradiol (EE) + 2 mg dienogest (DNG

2003 Contraception Controlled trial quality: uncertain

182. Quantifying spurious free T4 results attributable to thyroxine-binding proteins in serum dialysates and ultrafiltrates. Full Text available with Trip Pro

that detects and quantifies dialyzable and ultrafilterable serum free T(4) to detect T(4)-binding serum proteins. Two equilibrium dialysis devices and 3 ultrafiltration devices were used to illustrate this application. Displacements of [(125)I]T(4) from anti-T(4) by various concentrations of T(4)-depleted thyroxine-binding globulin, albumin, and serum total protein were compared to displacements by various concentrations of free T(4).Both dialysis devices excluded detectable T(4)-binding serum proteins (...) Quantifying spurious free T4 results attributable to thyroxine-binding proteins in serum dialysates and ultrafiltrates. Direct equilibrium dialysis and direct ultrafiltration free thyroxine (T(4)) assays rely on semipermeable membranes to exclude T(4)-binding serum proteins from dialysates and ultrafiltrates. The presence of these proteins in dialysates or ultrafiltrates will yield spuriously high free T(4) values when free T(4) is quantified by RIA.We used a nonanalog free T(4) RIA

2007 Clinical Chemistry

183. Underestimates and overestimates of total thyroxine concentrations caused by unwanted thyroxine-binding protein effects. (Abstract)

applied to solutions that contained either free T4 without binding protein, a T4-binding protein without T4, or protein-bound T4. When total T4 concentrations were 3-12 microg/dL, the assays reported total T4 determinations that ranged from none detected to 23 microg/dL. These T4 determinations reflected the protein to which T4 was bound, in addition to the level of T4. Total T4 was underrepresented when T4 was unbound, or thyroxine-binding globulin (TBG) bound. Total T4 was overrepresented when T4 (...) Underestimates and overestimates of total thyroxine concentrations caused by unwanted thyroxine-binding protein effects. The first evidence of unwanted serum protein effects on analogue-based total thyroxine (T4) determinations came from a study that varied serum protein concentrations while total T4 concentrations were constant. The present study approached this issue by varying total T4 concentrations while protein concentrations were constant. Four analogue-based total T4 immunoassays were

2005 Thyroid

184. Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation. Full Text available with Trip Pro

Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation. A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodothyronine concentrations were normal (...) . Problems encountered in the recognition of this thyroxine binding protein disorder are discussed. Clinicians and clinical biochemists should be aware of these pitfalls and thus avoid further incorrect treatment on the basis of biochemical findings, even though free hormone estimations are now becoming readily available.

1985 Journal of Clinical Pathology

185. Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins. Full Text available with Trip Pro

Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins. Rates of hepatic uptake of thyroxine (T4) from dilute solutions of five different plasma T4-binding proteins were measured in the isolated perfused rat liver using an indicator dilution method. For each protein, this rate was compared with the rate of spontaneous dissociation of the T4-protein complex measured in vitro. Proteins studied were human T4-binding globulin (TBG), human

1990 Journal of Clinical Investigation

186. Partial deficiency of thyroxine-binding globulin-Allentown is due to a mutation in the signal peptide. Full Text available with Trip Pro

Partial deficiency of thyroxine-binding globulin-Allentown is due to a mutation in the signal peptide. We present an unusual variant of T(4)-binding globulin (TBG) found in a family from Allentown, Pennsylvania (TBG-AT). The heterozygous proposita presented serum total T(4) and TBG levels ranging from low to normal. TBG gene sequencing revealed a C-to-T substitution in codon -2 (CAC to TAC) leading to the substitution of the normal histidine by a tyrosine within the signal peptide. No mutation

2004 Journal of Clinical Endocrinology and Metabolism

187. Neonatal screening for congenital hypothyroidism based on thyroxine, thyrotropin, and thyroxine-binding globulin measurement: potentials and pitfalls. Full Text available with Trip Pro

Neonatal screening for congenital hypothyroidism based on thyroxine, thyrotropin, and thyroxine-binding globulin measurement: potentials and pitfalls. The Dutch T(4)-TSH-TBG-based neonatal screening program detects patients with congenital hypothyroidism (CH) of thyroidal (CH-T) as well as central (CH-C) origin. The numbers and characteristics of true-positive and false-positive referrals will differ from other, predominantly TSH-based, screening methods.The present study describes

2006 Journal of Clinical Endocrinology and Metabolism

188. C-terminal amino acid alteration rather than late termination causes complete deficiency of thyroxine-binding globulin CD-NeuIsenburg. Full Text available with Trip Pro

C-terminal amino acid alteration rather than late termination causes complete deficiency of thyroxine-binding globulin CD-NeuIsenburg. T(4)-binding globulin (TBG) is the main transport protein for T(4) in blood and a member of the superfamily of serine proteinase inhibitors. So far, 14 mutations leading to familial complete TBG deficiency have been reported. Eleven of these are caused by mutations leading to truncation of the molecule, and three are caused by single amino acid substitutions.We

2006 Journal of Clinical Endocrinology and Metabolism

189. Characterization of a major development-regulated serum thyroxine-binding globulin in the euthyroid mouse. Full Text available with Trip Pro

Characterization of a major development-regulated serum thyroxine-binding globulin in the euthyroid mouse. We confirm our finding of a major development-regulated thyroxine-binding globulin (TBG) in the serum of the euthyroid mouse and investigate a number of its binding, structural and regulatory properties. Between 16 days foetal and 60 days postnatal life, the thyroxine (T4)- and tri-iodothyronine (T3)-binding activities of the sera show a striking ontogenic pattern: the binding is 2-3 times (...) higher in foetuses than in mothers, then further increases after birth, reaching between 3 and 5 days maximum values which are 7-8 times higher than the adult ones. This pattern is not correlated with the ontogenesis of the acknowledged specific (transthyretin, TTR) and non-specific (albumin, alpha 1-foetoprotein) thyroid-hormone carriers of the mouse sera. PAGE studies demonstrate that the protein responsible for the elevated binding of the perinatal period is an alpha 1-globulin, with a migration

1990 Biochemical Journal

190. Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Full Text available with Trip Pro

Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Antibodies directed against thyroxine-binding globulin (TBG) have been used to screen a human liver lambda gt11 expression library. A 1.46-kilobase clone was identified which encodes nearly the complete amino acid sequence, beginning at amino acid 17 of the mature protein. To complete the protein sequence, the cDNA clone was used to identify a genomic clone (...) thyroxine-binding protein of human plasma.

1986 Proceedings of the National Academy of Sciences of the United States of America

191. Congenital hypothyroidism with raised thyroxine binding globulin. Full Text available with Trip Pro

Congenital hypothyroidism with raised thyroxine binding globulin. 3146637 1989 03 23 2018 11 13 0141-0768 81 12 1988 Dec Journal of the Royal Society of Medicine J R Soc Med Congenital hypothyroidism with raised thyroxine binding globulin. 736-7 Menon G G Department of Paediatrics, Peterborough District Hospital. eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 0 Thyroxine-Binding Proteins 06LU7C9H1V Triiodothyronine Q51BO43MG4 Thyroxine IM Adolescent Congenital (...) Hypothyroidism Humans Hypothyroidism blood therapy Male Thyroxine therapeutic use Thyroxine-Binding Proteins blood Triiodothyronine therapeutic use 1988 12 1 1988 12 1 0 1 1988 12 1 0 0 ppublish 3146637 PMC1291893 10.1177/014107688808101221 J Clin Invest. 1972 Apr;51(4):848-67 4111366 Q J Med. 1980;49(195):295-313 6162169 Acta Paediatr Scand. 1986 Sep;75(5):872-4 3105238 Clin Chem. 1986 Apr;32(4):687-9 3082534 Arch Dis Child. 1985 Aug;60(8):766-8 3929699

1988 Journal of the Royal Society of Medicine

192. Structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. Full Text available with Trip Pro

Structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. Thyroxine-binding globulin (TBG), the major carrier of thyroid hormones in human and murine sera, is in the rat a developmentally regulated protein, showing a large surge during post-natal growth followed by virtual disappearance in adults. Here we study as a function of age, from the 19-day embryo to 60 days after birth, the structural and binding characteristics of rat TBG microheterogeneity

1992 Biochemical Journal

193. The influence of growth hormone monotherapy and growth hormone in combination with oxandrolone or testosterone on thyroxid hormone parameters and thyroxine binding globulin in patients with Ullrich-Turner syndrome. (Abstract)

The influence of growth hormone monotherapy and growth hormone in combination with oxandrolone or testosterone on thyroxid hormone parameters and thyroxine binding globulin in patients with Ullrich-Turner syndrome. Administration of human growth hormone (GH) has yielded conflicting results concerning its role on thyroid function in patients with Ullrich-Turner syndrome. Therefore, we investigated the course of thyroid hormone parameters and thyroxin binding globulin in relation to GH therapy

1997 European journal of pediatrics Controlled trial quality: uncertain

194. Genetic polymorphism of thyroxin-binding globulin (TBG) in the Pacific area. Full Text available with Trip Pro

Genetic polymorphism of thyroxin-binding globulin (TBG) in the Pacific area. Human plasma samples, radiolabeled with [125I]thyroxin, from the Asian, Pacific, and Australian area have been subjected to isoelectric focusing to reveal genetic variation in thyroxin-binding globulin (TBG). A genetically determined electrophoretic slow variant, TBG S, indistinguishable from the variant found in black Africans, has been observed with a frequency of 1%-10% in all Melanesian and Polynesian populations

1984 American Journal of Human Genetics

195. Congenital hypothyroidism with hereditary, raised thyroxine binding globulin. Full Text available with Trip Pro

Congenital hypothyroidism with hereditary, raised thyroxine binding globulin. A boy with congenital hypothyroidism and hereditary raised thyroxine binding globulin is described. This hitherto unreported combination resulted in under treatment of the thyroid deficiency until serum thyroid stimulating hormone measurement became routinely available. Inadequate L-thyroxine replacement treatment between 2 and 7 years of age caused retarded bone maturation, poor growth velocity, and probably added

1985 Archives of Disease in Childhood

196. Localization of the human thyroxine-binding globulin gene to the long arm of the X chromosome (Xq21-22). Full Text available with Trip Pro

Localization of the human thyroxine-binding globulin gene to the long arm of the X chromosome (Xq21-22). Thyroxine-binding globulin (TBG) is the major thyroid-hormone transport protein in the plasma of most vertebrate species. A recombinant phage (lambda cTBG8) containing a cDNA insert of human TBG recently has been described. With the cDNA insert from lambda cTBG8 used as a radiolabeled probe, DNA from a series of somatic-cell hybrids containing deletions of the X chromosome was analyzed

1987 American Journal of Human Genetics

197. Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. Full Text available with Trip Pro

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine (T3) were carried out in eight subjects with familial dysalbuminemic hyperthyroxinemia

1987 Journal of Clinical Investigation

198. Two new inherited defects of the thyroxine-binding globulin (TBG) molecule presenting as partial TBG deficiency. Full Text available with Trip Pro

Two new inherited defects of the thyroxine-binding globulin (TBG) molecule presenting as partial TBG deficiency. Serum-denatured TBG (dnTBG) measured in 32 families deficient in native TBG (nTBG) was undetectable in all subjects with complete nTBG deficiency and was high in 2 of 16 families with partial nTBG deficiency. nTBG (in mean micrograms per decaliter +/- SD) in members of the Quebec and Montreal families, respectively were: 258 +/- 54 and 230 in affected men, 747 +/- 190 and 927 +/- 90

1987 Journal of Clinical Investigation

199. Detection of genetic variation with radioactive ligands. IV. X-linked, polymorphic genetic variation of thyroxin-binding globulin (TBG). Full Text available with Trip Pro

Detection of genetic variation with radioactive ligands. IV. X-linked, polymorphic genetic variation of thyroxin-binding globulin (TBG). A genetically determined, polymorphic electrophoretic variant of thyroxin-binding alpha-globulin (TBG) is found in sera from populations of African and Oceania origin, although not in Caucasians nor Orientals. The TBG polymorphism is inherited in X-linked fashion, based on data from American blacks, and thus provides an X-chromosome marker with a relatively

1981 American Journal of Human Genetics

200. Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. Full Text available with Trip Pro

Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. Thyroxine-binding globulin (TBG) is a liver glycoprotein that transports thyroid hormone in serum. In 1987 a variant TBG was discovered in an infant born in Quebec, following an investigation prompted by the finding of low blood thyroxine (T4) level on screening for neonatal hypothyroidism. This variant, TBG-Quebec, has cathodal shift on isoelectric focusing, reduced affinity for thyroxine

1991 American Journal of Human Genetics

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>