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Thyroxine-Binding Globulin

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1. A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families Full Text available with Trip Pro

A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families Thyroxine-binding globulin (TBG) is the major thyroid hormone transport protein in serum. Located on the long arm of the X chromosome, TBG (SERPINA7) gene mutations most commonly produce inherited partial TBG deficiency (TBG-PD).We report a novel TBG variant associated with TBG-PD identified in 2 different families of Ashkenazi origin residing in greater Chicago.Family 1

2017 European thyroid journal

2. Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease Full Text available with Trip Pro

Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease Biomarkers for the management of chronic obstructive pulmonary disease (COPD) are limited. The aim of this study was to explore new plasma biomarkers in patients with COPD. Thyroxine-binding globulin (THBG) was initially identified by proteomics in a discovery panel and subsequently verified by enzyme-linked immunosorbent assay in another verification panel with a 1-year follow-up

2017 International journal of chronic obstructive pulmonary disease

3. Thyroxine-Binding Globulin

Thyroxine-Binding Globulin Thyroxine-Binding Globulin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thyroxine-Binding Globulin (...) Thyroxine-Binding Globulin Aka: Thyroxine-Binding Globulin , Thyroxine Binding Globulin , Thyroid Binding Globulin , TBG II. Physiology Radioimmunoassay of major storage of hormone TBG binds hormone in circulation (T4) is 99.97% protein bound (T3) is 99.7% protein bound III. Interpretation: General TBG effects measurement of total T4 and T3 Increased TBG increases total T4 and T3 measurements Decreased percent and T3 No change in and Decreased TBG decreases total T4 and T3 measurements Increased percent

2018 FP Notebook

4. Thyroxine binding globulin excess detected by neonatal screening Full Text available with Trip Pro

Thyroxine binding globulin excess detected by neonatal screening Inherited thyroxine binding globulin (TBG) disorder can be identified incidentally or through neonatal screening test. TBG excess is characterized by high levels of thyroxine (T4) but normal level of free T4 (fT4), while TBG deficiency presents with low T4 levels and normal fT4 levels. A 27-day-old newborn was brought to the hospital because of hyperthyroxinemia detected by neonatal screening. His T4 level was 18.83 µg/dL (normal

2016 Annals of pediatric endocrinology & metabolism

5. First report of inherited thyroxine-binding globulin deficiency in Iran caused by a known de novo mutation in SERPINA7 Full Text available with Trip Pro

First report of inherited thyroxine-binding globulin deficiency in Iran caused by a known de novo mutation in SERPINA7 Thyroxine-binding globulin (TBG) is the main transporter of thyroid hormones in human serum, encoded by the gene TBG (SERPINA7), located in long arm of X-chromosome (Xq21-q22). Deficiency of SERPINA7 (serum protease inhibitor, clade A [alpha-1 antiproteinase, antitrypsin], member 7) leads to inherited TBG deficiency. Several mutations have been reported in the coding

2016 Molecular genetics and metabolism reports

6. Metabolism of thyroxine-binding globulin in man. Abnormal rate of synthesis in inherited thyroxine-binding globulin deficiency and excess. Full Text available with Trip Pro

Metabolism of thyroxine-binding globulin in man. Abnormal rate of synthesis in inherited thyroxine-binding globulin deficiency and excess. It has been previously suggested that inherited thyroxine-binding globulin (TBG) abnormalities in man may be due to mutations at a single X-chromosome-linked locus controlling TBG synthesis. However, abnormalities in TBG degradation have not been excluded. The availability of purified human TBG and its successful labeling with radioiodide allowed us

1976 Journal of Clinical Investigation

7. Studies on Human Thyroxine-Binding Globulin: VI. THE NATURE OF SLOW THYROXINE-BINDING GLOBULIN Full Text available with Trip Pro

Studies on Human Thyroxine-Binding Globulin: VI. THE NATURE OF SLOW THYROXINE-BINDING GLOBULIN A model system utilizing a highly purified partially desialylated thyroxine-(T(4)) binding protein (STBG) was studied. STBG was prepared by the same affinity chromatographic method we have reported for preparation of highly purified T(4)-binding globulin (TBG). The necessary prerequisite for preparation of STBG was the use of T(4)-substituted Sepharose which had been repeatedly exposed to large

1972 Journal of Clinical Investigation

8. Salicylate-induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin Full Text available with Trip Pro

Salicylate-induced increases in free triiodothyronine in human serum: Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin Addition of sodium salicylate to human serum at concentrations often obtained during aspirin therapy causes 100-200% increases in free triiodothyronine (T(3)) and free thyroxine (T(4)) as estimated by ultrafiltration. The increase in free T(3) was unexpected since previous data had suggested that salicylate (...) to thyroxine-binding globulin (TBG). Using a competitive-binding protein displacement technique, it has been shown that sodium salicylate, like diphenylhydantoin (DPH), inhibits the binding of T(3) and T(4) to TBG. The magnitude of the increase in free T(3) and free T(4) induced by salicylates suggests that interference with TBG binding is its major effect. Aspirin was administered orally to two normal subjects in quantities sufficient to obtain serum salicylate levels of 20-25 mg/100 ml. This resulted

1972 Journal of Clinical Investigation

9. Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates Full Text available with Trip Pro

Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates 1. A simple method is described for estimating the rate of thyroxine dissociation from binding sites in plasma.2. At tracer concentrations in human plasma thyroxine dissociates at two distinct exponential rates. These are due to the two thyroxine-binding proteins present in human plasma.3. The t((1/2)) for thyroxine dissociation from thyroxine-binding globulin is 8.1 +/- 0.7 (S.E.) min at room temperature (...) and 38.6 +/- 2.1 sec at 37 degrees C.4. The t((1/2)) for thyroxine dissociation from thyroxine-binding pre-albumin is 53 +/- 5.0 sec at room temperature and 7.9 +/- 0.3 sec at 37 degrees C.5. Dissociation of thyroxine from both proteins is a single exponential process, suggesting that each protein has only one type of specific binding site.6. These results indicate that the minute pool of free thyroxine in plasma is turning over about 100 times each second, with about two thirds of this flux being due

1971 The Journal of physiology

10. Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine-Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE-BINDING PREALBUMIN Full Text available with Trip Pro

Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine-Binding Globulin: OBSERVATIONS ON THE PHYSIOLOGICAL ROLE OF THYROXINE-BINDING PREALBUMIN Studies of the effect of norethandrolone on the transport and peripheral metabolism of thyroxine were carried out in four patients lacking thyroxine-binding globulin. Before norethandrolone administration, values for serum protein-bound iodine (PBI) were decreased (1.8 +/-0.5 mug/100 ml (...) increased slightly. As a result, thyroxine-clearance rate decreased in all patients. Owing to the reciprocal changes in clearance rate and PBI, no significant change in total daily thyroxine disposal was observed. The present studies reveal that when the thyroxine-binding prealbumin is increased in patients lacking thyroxine-binding globulin, several indices of peripheral thyroxine transport and metabolism are altered. However, these changes were small, even in the absence of thyroxine-binding globulin

1971 Journal of Clinical Investigation

11. DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE-BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN. STERIC ASPECTS OF THE THYROXINE-BINDING SITE Full Text available with Trip Pro

DISPLACEMENT OF THYROXINE FROM HUMAN THYROXINE-BINDING GLOBULIN BY ANALOGUES OF HYDANTOIN. STERIC ASPECTS OF THE THYROXINE-BINDING SITE 13940236 1998 11 01 2018 12 01 0021-9738 41 1962 Dec The Journal of clinical investigation J. Clin. Invest. Displacement of thyroxine from human thyroxine-binding globulin by analogues of hydantoin. Steric aspects of the thyroxinebinding site. 2213-20 OPPENHEIMER J H JH TAVERNETTI R R RR eng Journal Article United States J Clin Invest 7802877 0021-9738 0 (...) Anticonvulsants 0 Hydantoins 0 Imidazoles 0 SERPINA7 protein, human 0 Serum Globulins 0 Thyroxine-Binding Globulin 6158TKW0C5 Phenytoin 7GBN705NH1 imidazole Q51BO43MG4 Thyroxine OM Anticonvulsants Humans Hydantoins Imidazoles Phenytoin Serum Globulins Thyroxine Thyroxine-Binding Globulin DIPHENYLHYDANTOIN HYDANTOINS SERUM GLOBULIN THYROXIN 1962 12 1 1962 12 1 0 1 1962 12 1 0 0 ppublish 13940236 10.1172/JCI104680 PMC291156 J Clin Endocrinol Metab. 1961 Mar;21:252-62 13731058 Endocrinology. 1955 Jun;56(6):737

1962 Journal of Clinical Investigation

12. Thyroxine-Binding Globulin Deficiency (Follow-up)

Thyroxine-Binding Globulin Deficiency (Follow-up) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

13. Thyroxine-Binding Globulin Deficiency (Diagnosis)

Thyroxine-Binding Globulin Deficiency (Diagnosis) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

14. Thyroxine-Binding Globulin Deficiency (Treatment)

Thyroxine-Binding Globulin Deficiency (Treatment) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

15. Thyroxine-Binding Globulin Deficiency (Overview)

Thyroxine-Binding Globulin Deficiency (Overview) Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI1NzY0LW92ZXJ2aWV3 processing (...) > Thyroxine-Binding Globulin Deficiency Updated: Sep 14, 2017 Author: Nicholas J Sarlis, MD, PhD, FACP; Chief Editor: George T Griffing, MD Share Email Print Feedback Close Sections Sections Thyroxine-Binding Globulin Deficiency Overview Overview Thyroxine-binding globulin (TBG) deficiency is a nonharmful condition that is either acquired or inherited. The only known complications associated with TBG deficiency are those stemming from the primary disorders that cause the acquired form of this condition

2014 eMedicine.com

16. Thyroxine-Binding Globulin

Thyroxine-Binding Globulin Thyroxine-Binding Globulin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thyroxine-Binding Globulin (...) Thyroxine-Binding Globulin Aka: Thyroxine-Binding Globulin , Thyroxine Binding Globulin , Thyroid Binding Globulin , TBG II. Physiology Radioimmunoassay of major storage of hormone TBG binds hormone in circulation (T4) is 99.97% protein bound (T3) is 99.7% protein bound III. Interpretation: General TBG effects measurement of total T4 and T3 Increased TBG increases total T4 and T3 measurements Decreased percent and T3 No change in and Decreased TBG decreases total T4 and T3 measurements Increased percent

2015 FP Notebook

17. THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS Full Text available with Trip Pro

THYROXINE BINDING CAPACITY OF SERUM ALPHA GLOBULIN IN HYPOTHYROID, EUTHYROID, AND HYPERTHYROID SUBJECTS 13221653 2003 05 01 2018 12 01 0021-9738 34 1 1955 Jan The Journal of clinical investigation J. Clin. Invest. Thyroxine binding capacity of serum alpha globulin in hypothyroid, euthyroid, and hyperthyroid subjects. 44-7 ALBRIGHT E C EC LARSON F C FC DEISS W P WP eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Alpha-Globulins 0 Serum Globulins Q51BO43MG4 Thyroxine OM Alpha (...) -Globulins Humans Hyperthyroidism blood Hypothyroidism blood Serum Globulins Thyroxine 5527:33585:230:232:417:459 HYPERTHYROIDISM/blood in HYPOTHYROIDISM/blood in SERUM GLOBULIN THYROXIN 1955 1 1 1955 1 1 0 1 1955 1 1 0 0 ppublish 13221653 10.1172/JCI103061 PMC438579 Nature. 1952 Jan 5;169(4288):19-20 14910673 Science. 1952 Jun 6;115(2997):626-7 17841620 Proc Soc Exp Biol Med. 1953 Nov;84(2):513-6 13121091 J Clin Invest. 1954 Feb;33(2):230-4 13130690 Klin Wochenschr. 1953 Jan 1;31(1-2):13-7 13062550 J

1955 Journal of Clinical Investigation

18. FAMILIAL INCREASE IN THE THYROXINE-BINDING SITES IN SERUM ALPHA GLOBULIN Full Text available with Trip Pro

FAMILIAL INCREASE IN THE THYROXINE-BINDING SITES IN SERUM ALPHA GLOBULIN 13798328 1998 11 01 2018 12 01 0021-9738 38 1959 Oct The Journal of clinical investigation J. Clin. Invest. Familial increase in the thyroxine-binding sites in serum alpha globulin. 1683-8 BEIERWALTES W H WH ROBBINS J J eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Alpha-Globulins 0 Serum Globulins Q51BO43MG4 Thyroxine OM Alpha-Globulins Binding Sites Humans Serum Globulins chemistry Thyroxine blood (...) Transcription, Genetic SERUM GLOBULIN/chemistry THYROXIN/blood 1959 10 1 1959 10 1 0 1 1959 10 1 0 0 ppublish 13798328 10.1172/JCI103946 PMC444135 J Biol Chem. 1950 Nov;187(1):97-106 14794694 J Clin Invest. 1958 Feb;37(2):153-9 13513745 Nature. 1952 Jan 5;169(4288):19-20 14910673 Ann Intern Med. 1956 Jan;44(1):40-51 13275849 J Clin Invest. 1937 Sep;16(5):695-703 16694514 J Clin Endocrinol Metab. 1957 Jan;17(1):33-43 13385316 J Clin Invest. 1958 Jul;37(7):1024-30 13563631 Endocrinology. 1958 Aug;63(2):256-9

1959 Journal of Clinical Investigation

19. Studies on human thyroxine-binding globulin (TBG). IX. Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG. Full Text available with Trip Pro

Studies on human thyroxine-binding globulin (TBG). IX. Some physical, chemical, and biological properties of radioiodinated TBG and partially desialylated TBG. Thyroxine-binding globulin (TBG) and partially desialylated or slow TBG (STBG) were purified from human serum by affinity chromatography. Purified TBG was identical to TBG present in serum by the criteria of electrophoretic mobility, affinity for thyroxine (T4), and heat-inactivation response. Purified STBG had slower electrophoretic

1975 Journal of Clinical Investigation

20. Preparation of 125-I-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. Full Text available with Trip Pro

Preparation of 125-I-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. A protein with the electrophoretic, immunologic, and hormone-binding properties of thyroxine-binding globulin (TBG) has been prepared from human plasma and labeled with radioiodine (125-I) by an enzymatic method of iodination. The [125-I]TBG retained the electrophoretic and immunologic characteristics of unlabeled TBG but exhibited a partial loss of thyroxine-binding activity

1975 Journal of Clinical Investigation

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