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of Harbin Medical University Information provided by (Responsible Party): First Affiliated Hospital of Harbin Medical University Study Details Study Description Go to Brief Summary: Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis (...) thyroidfunction changed [ Time Frame: Baseline, 3 months, 6 months, 9 months, 12 months ] Serum thyroidfunction measured by Immunohistochemistry Other Outcome Measures: Serum thyroid related antibodies changed [ Time Frame: Baseline, 3 months, 6 months, 9 months, 12 months ] Serum thyroid related antibodies measured by Immunohistochemistry Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your
Sponsor: Huijing Ye Information provided by (Responsible Party): Huijing Ye, Sun Yat-sen University Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the psychological status of Thyroid Related Eye Disease. Condition or disease Intervention/treatment Thyroid Related Eye Disease Behavioral: psychological condition Detailed Description: The purpose of this study is to evaluate the psychological status of patients of Thyroid Related Eye Disease over 16 years (...) ) Outcome Measures Go to Primary Outcome Measures : Quality of life questionnaire of patients of Thyroid Related Eye Disease [ Time Frame: immediately ] Graves ́ ophthalmopathy quality of life questionnaire (GO-QoL) , The GO-QoL contains 8 questions on visual functioning and 8 questions on appearance; answers on each subscale are transformed to scores ranging from 0 (worst) to 100 (best). Secondary Outcome Measures : Symptom checklist 90(SLC-90) [ Time Frame: immediately ] It consists of 90 items
: February 14, 2018 See Sponsor: Seoul National University Hospital Information provided by (Responsible Party): Ji-hoon Kim, Seoul National University Hospital Study Details Study Description Go to Brief Summary: This is a single center prospective clinical trial with regard to efficacy and safety of radiofrequency ablation of papillary thyroid microcarcinoma. Condition or disease Intervention/treatment Phase Papillary Thyroid Microcarcinoma Thyroid Cancer Procedure: RFA for PTMC Not Applicable Detailed (...) and hydrodissection, if indicated, will be used. After RFA, follow-up will be performed using ultrasonography, serum thyroidfunction test, and questionnaire for quality of life by face-to-face interview at 2 months, 6, 12, 18, 24 months during the first 2 years after RFA, and yearly afterwards. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary
Posted : December 3, 2018 Last Update Posted : December 3, 2018 See Sponsor: Rongrong Li Information provided by (Responsible Party): Rongrong Li, Peking Union Medical College Hospital Study Details Study Description Go to Brief Summary: Two hundred and ninety pregnant women with gestational age less than 20 weeks will be recruited in this study. Selenium and iodine conditions, and risk of thyroid disease will be monitored until termination of pregnancy, with pregnancy outcomes recorded. Condition (...) concentrations, serum selenium concentrations, etc). The nutritional status of iodine and selenium will be monitored and followed up for all the included subjects throughout the pregnancy. The information of thyroidfunction and level of anti-TPO and anti-TG will be collected. And all the complications (especially thyroid disease) in pregnancy will also be recorded. All pregnant women will be followed up until the termination of pregnancy, with pregnancy outcomes recorded. Study Design Go to Layout table
Identifier: NCT03757637 Recruitment Status : Not yet recruiting First Posted : November 29, 2018 Last Update Posted : November 29, 2018 See Sponsor: National Taiwan University Hospital Information provided by (Responsible Party): National Taiwan University Hospital Study Details Study Description Go to Brief Summary: Background: Despite the good prognosis of patients with differentiated thyroid carcinomas (DTC), the diagnosis of cancer, fear of cancer recurrence and its side effects might still bring (...) help us better understanding DTC patients' impacts and care needs. The comparison of three groups of intervention will also help us to identify the best model to decrease distress and enhance life function for them. Condition or disease Intervention/treatment Phase Differentiated Thyroid Cancer Other: NLSCP Other: ICT supported HAP Not Applicable Detailed Description: Phase I is a cross-sectional survey study (first year) with the specific aims to examine the current status of physical distress
with thyroid cancer 61 15 Thyroid cancer in childhood 64 16 Pathology reporting, grading and staging of thyroid cancers 16.1 General principles 65 16.2 Pathology report 65 16.3 Pathological staging 65 16.4 Staging protocol 65 16.5 Summary of thyroid cancer types 65 17 Medullary thyroid cancer 17.1 Presentation 69 17.2 Initial investigations of patients with suspected or con? rmed MTC 70 17.3 Treatment 70 17.4 Adjuvant therapies 71 17.5 Pathology 72 17.6 Follow-up for MTC 73 17.7 Investigation of persistent (...) 21.3 Screening 86 21.4 Diagnosis and referral 86 21.5 Summary of treatment of thyroid cancer 87 21.6 Follow-up 88 Appendices 1. Assay methodology 89 2. Recognition of MEN3 (MEN2B) 94 3. Search methodology 95 4. Patient information 97 Patient support groups 97 Websites with useful information for patients 97 Lea? ets for patients 1. The thyroid gland and thyroid cancer – tests and treatment 99 2. Information for patients being investigated for thyroid lumps 102 3. Surgery for thyroid Cancer 104 4
signs or symptoms, including a history of severe or persistent headaches; persistent vomiting that is not self-induced; changes in vision, thirst or urination not attributable to other causes; neurological signs suggesting a central nervous system abnormality; or other clinical signs or test results that suggest pituitary hormone deficiency or excess. Summary of Recommendations 1.1 We suggest that clinicians only make the diagnosis of functional hypothalamic amenorrhea (FHA) after excluding (...) Functional Hypothalamic Amenorrhea '); '); Hypothalamic Amenorrhea Guideline Resources | Endocrine Society Hormone Science to Health / › › › Guidelines and Clinical Practice Section + Hypothalamic Amenorrhea Guideline Resources Full Guideline: JCEM | March 2017 Catherine M. Gordon (chair), Kathryn E. Ackerman, Sarah L. Berga, Jay R. Kaplan, George Mastorakos, Madhusmita Misra, M. Hassan Murad, Nanette F. Santoro, and Michelle P. Warren The 2017 guideline addresses: Diagnosing functional
of thyroid surgery remain: complete removal of the abnormal thyroid and any involved lymph nodes, preservation of parathyroid gland function, and maintenance or improvement of voice and swallowing. Reduction in quality of life (QOL) after thyroid surgery is multifactorial and may include need for lifelong medication, thyroid suppression, radioactive scanning/treatment, temporary and permanent hypoparathyroidism, temporary or permanent dysphonia postoperatively, and dysphagia. - Voice disturbance may (...) , there is no evidence-based, multidisciplinary CPG that specifically deals with improving voice outcomes. This guideline is warranted because of known practice variations in the care of patients who undergo thyroid surgery and the large impact resulting voice impairment can have on a patient’s QOL and functional health status. Health Care Burden Thyroid nodules are a major reason for thyroid surgery and are present in 50% of adults in the United States when assessed by ultrasound. In addition, thyroid cancer rates
; Francis Worden, MD 12 ; Anamaria Reyna Yeung, MD. 13 Summary of Literature Review Introduction/Background Thyroid cancer is the most common endocrine malignancy in the United States, where the annual incidence is approximately 37,000 and increasing due to the more frequent diagnosis of early well-differentiated thyroid carcinoma (WDTC) . Annually, approximately 1,600 people die from thyroid malignancies . Women represent approximately 75% of newly diagnosed thyroid carcinoma cases. Risk factors (...) , such as systemic therapy options, are being actively investigated. The tyrosine kinase inhibitor axitinib has shown a 30% overall response rate in incurable thyroid cancer of any histology , and thalidomide has shown activity in rapidly progressive metastatic thyroid cancer . Patients with metastatic thyroid cancer that is not iodine avid should be encouraged to enroll in clinical trials that further explore novel systemic agents. (See Variant 7 and Variant 8.) Summary ? For WDTC, surgery and often
The association of maternal thyroidfunction and thyroid autoimmunity with offspring birth-weight Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model
Thyroid disease patient reacts to ‘insulting’ Women’s Health magazine piece Thyroid disease patient reacts to 'insulting' Women's Health magazine piece - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your critical (...) thinking about health care interventions. And those will be still be alive on the site for a couple of years. 6093 Posts Menu May 7, 2018 Thyroid disease patient reacts to ‘insulting’ Women’s Health magazine piece Posted By Categories Tags Gary Schwitzer is the founder & publisher of HealthNewsReview.org. He estimates he’s been telling stories of patient harm from misleading media for more than 30 years. He tweets as @garyschwitzer. This is just one little story about one woman reacting to one magazine
table for eligibility information Ages Eligible for Study: 18 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 30Kg/m2 ≥ BMI > 18Kg/m2; undergoing general anesthesia; ASA physical status I and II undergoing elective thyroid surgery. Exclusion Criteria: hyperthyroidism; preoperative bradycardia; liver function impairment; renal function impairment; heart function failure; history of asthma or COPD; history of diabetes (...) Efficacy of Dexmedetomidine for Cough Suppression in Patients Undergoing Thyroid Surgery Efficacy of Dexmedetomidine for Cough Suppression in Patients Undergoing Thyroid Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies
): Stanislav Emelianov, Emory University Study Details Study Description Go to Brief Summary: In this study the researchers will scan the thyroid nodules of patients scheduled for surgical removal of these nodules. During their preadmission testing, but prior to their surgery, the researchers will perform standard ultrasound and shear wave elasticity imaging (SWEI) scans of the thyroid nodules in these patients. Both images can be generated by the same ultrasound scanner and within the same imaging session (...) Thyroid Ultrasound Elasticity (TrUE) Imaging Thyroid Ultrasound Elasticity (TrUE) Imaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thyroid Ultrasound Elasticity (TrUE) Imaging The safety
Predictors of a follicular nodule (Thy3) outcome of thyroid fine needle aspiration cytology among Saudi patients A retrospective study was performed to evaluate predictors of thyroid fine needle aspiration cytology (FNAC) outcomes among Saudis with a thyroid nodule. Socio-demographic data, thyroidfunction status, thyroid parameters, ultrasound and cytology results were collected from 269 files of patients with thyroid nodules.The patients' age was 40 ± 1.4 years (mean ± SD), and the mean body (...) = 0.039), respectively]. In summary, younger age, multinodular goitre, the absence of an irradiation history and cervical lymphadenopathy were protective against Thy3 in a thyroid nodule.
showed significantly lower scores than those of the control group in 7 domains of the HRQoL: role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role-emotional (RE), and mental health (MH). PTC was a risk factor for a low Physical Component Summary (PCS) score and a low Mental Component Summary (MCS) score (all P values were less than .05). Significant reductions in the scores of all 8 domains were observed at 1 month after the operation, and obvious (...) Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma: A single-center analysis from Mainland China. Even with a favorable prognosis, the health-related quality of life (HRQoL) of papillary thyroid carcinoma (PTC) patients remains unclear and conflicting. Thus, in the present study, we compared the HRQoL of PTC patients with that of the general population (GP).The study was performed in our thyroid and parathyroid surgery department, and 186 PTC
of Harbin Medical University Information provided by (Responsible Party): First Affiliated Hospital of Harbin Medical University Study Details Study Description Go to Brief Summary: Autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Grave's disease (GD), are the most common organ-specific autoimmune diseases and affect more women than men, with a female-to-male ratio from 5 to 10. Many studies have indicated that alterations in the gut microbiota are important (...) with Methimazole Pill according to the guidelines Other Name: Methimazole Outcome Measures Go to Primary Outcome Measures : 16S rRNAgene sequencing was used to measure the diversity of gut microbiota [ Time Frame: HC, treatment_naive HT and treatment_naive GD patients samples were collected at the enroll. Treated GD patients were collected until thyroidfunction resumed to the normal for at least 3 months of methimazole withdrawal ] Intestinal microbes are different in different groups Secondary Outcome
and development. One of the best-described lncRNAs, HOX transcript antisense RNA (HOTAIR), functions as a regulatory molecule in a wide variety of biological processes, and represses gene expression through recruitment of the chromatin modifying complex. However, the function of HOTAIR in TC remains unclear. In the current study, the expression of HOTAIR is elevated in TC and correlates with metastasis and poor prognosis. Furthermore, the expression of HOTAIR is significantly upregulated in human thyroid (...) carcinoma cells compared with normal human thyroid cells. Furthermore, knockdown of HOTAIR significantly inhibited cell growth and invasion in TPC-1 and SW579 human thyroid carcinoma. In summary, HOTAIR is a promising novel biomarker in patients with TC.
and hereby, parental informed consent was already obtained. TH function is assessed in preterm infants ≤ 34 weeks as part of the clinical care protocol. No additional blood samples were taken. Quantitative EEG measures will be compared between the preterm infants with THOP (circulating thyroxine levels< P10) and without THOP. Logisitic regression will be performed to determine the effect of thyroidfunction as well as other clinical and demographic variables, on functional brain development at term (...) Ages Eligible for Study: 24 Weeks to 27 Weeks (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Probability Sample Study Population Preterm infants who had EEG recordings in the framework of the Resilience study and gestational age < 28 weeks. Criteria Inclusion Criteria: gestational age < 28 weeks serial EEG recordings available thyroidfunction test on the first day of life and at the end of the first week of life available Exclusion Criteria: Presence
First Posted : January 2, 2018 Last Update Posted : January 3, 2018 See Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Information provided by (Responsible Party): CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Study Details Study Description Go to Brief Summary: This is a prospective, multicenter, open label Phase II Clinical Trial. 30 advanced poorly differentiated thyroid carcinoma patients who were histopathologically confirmed inoperable were enrolled in this study. Condition (...) in the treatment. [ Time Frame: A summary of adverse events of each cycle,from date of administration of drugs until 30 days after the last chemotherapy or progression,whichever came first,assessed up to 18 months. ] Evaluate the adverse reaction rate of drugs assessed by number and severity of adverse events in the treatment of advanced thyroid poorly differentiated carcinoma. quality of life assessment [ Time Frame: It will be assessed before the administration of drugs at each first day of the chemotherapy