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Thyroid Function Summary

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7641. Swallowing Function Before and After Surgery for Thyroid Goiter

Swallowing Function Before and After Surgery for Thyroid Goiter Swallowing Function Before and After Surgery for Thyroid Goiter - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Swallowing Function Before (...) by (Responsible Party): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: To date, there have been no comprehensive studies on swallowing function in patients undergoing surgery for multinodular goiter. We hypothesize that 1. Multinodular goiter has significant effect on swallowing function in symptomatic and asymptomatic patients, which can be demonstrated by a standardized questionnaire and a formal swallowing evaluation and 2. Surgery will improve swallowing function

2005 Clinical Trials

7642. Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)

Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764) Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting (...) registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764) The safety and scientific validity of this study is the responsibility of the study

2007 Clinical Trials

7643. Cardiac expression and function of thyroid hormone receptor beta and its PV mutant. (PubMed)

Cardiac expression and function of thyroid hormone receptor beta and its PV mutant. Thyroid hormone (T3) influences cardiac function, and mice with deletion of thyroid hormone receptor (TR)alpha have diminished cardiac function. TR alpha 1 represents 70% and TR beta 1 represents the remaining 30% of TR in ventricular myocytes, and its role in cardiac function is not well established. To determine the role of TR beta 1 in detail, we compared contractility in isolated perfused hearts from wild (...) and TR beta 1 mRNA in sinoatrial node, which showed that TR beta 1 mRNA represents 27.5 +/- 1.6% of the ligand-binding isoforms of the TR. In summary, although TR beta is expressed at much lower levels in all regions of the heart than TR alpha 1, expression of the strong dominant negative TR beta PV mutant results in decreased contractile function and heart rate.

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2003 Endocrinology

7644. Thyroid function test abnormalities in patients with metastatic renal cell carcinoma treated with sorafenib. (PubMed)

Thyroid function test abnormalities in patients with metastatic renal cell carcinoma treated with sorafenib. Sorafenib is an orally bioavailable vascular endothelial growth factor receptor (VEGFR) inhibitor with antitumor activity in metastatic renal cell carcinoma (RCC). Sunitinib, also a VEGFR inhibitor, induces biochemical hypothyroidism in 85% of metastatic RCC patients, the majority of whom have signs or symptoms of hypothyroidism. Hence, the incidence of thyroid function test (TFT (...) to thyroid dysfunction and received thyroid hormone replacement.In summary, clinically significant TFT abnormalities were not common in patients treated with sorafenib, and replacement therapy was rarely indicated. TFTs should be measured before sorafenib therapy in RCC patients and subsequently only if clinically indicated.

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2007 Annals of Oncology

7645. Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. (PubMed)

Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. Retinoid X receptor (RXR)-selective retinoids (rexinoids) can cause central hypothyroidism in humans, and this effect has been confirmed in rodent models. In this report, we characterized the effect of rexinoids on the hypothalamic-pituitary-thyroid axis in mice and TSH regulation in a thyrotrope-derived cell line. The synthetic rexinoid (LG 268) suppressed TSH and T4 levels in mice. Hypothalamic TRH mRNA (...) TSHbeta promoter activity by 42% and the -200 to -149 region accounted for a majority of the LG 268-mediated suppression of promoter activity. The RXRgamma isotype is expressed in thyrotropes. In vitro transfection and in vivo transgenic studies indicate that any RXR isotype can mediate TSH suppression by rexinoids, but the RXRgamma isotype is most efficient at mediating this response. RXRgamma-deficient mice lacked pituitary D2 mRNA suppression by LG 268, but D2 activity remained intact. In summary

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2006 Endocrinology

7646. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. (PubMed)

Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Subclinical thyroid dysfunction is a risk factor for developing symptomatic thyroid disease. Advocates of screening argue that early treatment can prevent serious morbidity in individuals who are found to have laboratory evidence of subclinical thyroid dysfunction.This article focuses on whether it is useful to order a thyroid function test for patients who (...) have no history of thyroid disease and have few or no signs or symptoms of thyroid dysfunction.A MEDLINE search, supplemented by searches of EMBASE and the Cochrane Library, reference lists, and a local database of thyroid-related articles.Controlled treatment studies that used thyroid-stimulating hormone (TSH) levels as an inclusion criterion and reported quality of life, symptoms, or lipid level outcomes were selected. Observational studies of the prevalence, progression, and consequences

2004 Annals of Internal Medicine

7647. Internal Medicine: Thyroid Function Tests—The Next Generation (PubMed)

Internal Medicine: Thyroid Function Tests—The Next Generation The Council on Scientific Affairs of the California Medical Association presents the following inventory of items of progress in internal medicine. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself (...) Medical Association, and the summaries were prepared under its direction.

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1994 Western Journal of Medicine

7648. Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer

: Lucille P. Markey Cancer Center at University of Kentucky Collaborator: National Cancer Institute (NCI) Information provided by: National Cancer Institute (NCI) Study Details Study Description Go to Brief Summary: RATIONALE: Azacitidine may help thyroid cancer cells regain the ability to take up iodine. This would allow the cancer to be detected and treated by radioactive iodine. PURPOSE: Phase I trial to study the effectiveness of azacitidine to restore thyroid function in treating patients who have (...) Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

1999 Clinical Trials

7649. 2004 where do we go from here?--Summary of working group discussions on thyroid function and gestational outcomes. (PubMed)

2004 where do we go from here?--Summary of working group discussions on thyroid function and gestational outcomes. A workshop entitled, "The Impact of Maternal Thyroid Diseases on the Developing Fetus: Implications for Diagnosis, Treatment, and Screening," was held in Atlanta, Georgia, January 12-13, 2004. This paper reports points of agreement among the attendees based on the scientific rigor of material presented. At the end of the workshop, participants were divided into four smaller groups (...) to discuss and determine areas of agreement on issues associated with thyroid insufficiency, identify research needs and gaps, and recommend research strategies and policy needs. Discussion included: problems for the mother and the pregnancy; neuropsychological/developmental performance in offspring of women with thyroid deficiency; issues of diagnosis and treatment for the pregnant women with overt and subclinical hypothyroidism; the issues involved with screening women who are pregnant or who

2005 Thyroid

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