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Thyroid Function Summary

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181. Effect of Secretin in Functional Dyspepsia and Healthy Subjects

Information provided by (Responsible Party): Michael Camilleri, MD, Mayo Clinic Study Details Study Description Go to Brief Summary: Insights into the pathophysiology of functional dyspepsia, with recent demonstration of inflammation with eosinophilia and mastocytosis in the duodenum (3, 6, 7), providing a possible lead toward reduced secretion of a potential mediator of post-prandial gastric accommodation, the gastrointestinal peptide hormone secretin. The dominant site of synthesis and secretion (...) medications 48 hours prior to the baseline period and throughout the study: Medications that alter GI transit or motor function including laxatives, magnesium and aluminum containing antacids, prokinetics, erythromycin, buspirone, clonidine, tricyclic antidepressants, and secretin-norepinephrine reuptake inhibitors Analgesic drugs including NSAIDs and COX-2 inhibitors NOTE: Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardio-protection, low stable dose antidepressants

2018 Clinical Trials

182. Hypoglycemia and Autonomic Nervous System Function- B2

function. Such illnesses include congestive heart failure, renal, pulmonary, hepatic disease, anemia, malignancies, untreated thyroid disease, and alcoholism. Current major depressive illness In all subjects, any individuals on oral, injected, inhaled or topical corticosteroids within the last year or oral contraceptives within the past 3 months will be excluded. Known hypersensitivity to nitroglycerin, nitroprusside and/or phenylephrine. Blood pressure > 160/100 mmHg (applies to participants with T2 (...) Hypoglycemia and Autonomic Nervous System Function- B2 Hypoglycemia and Autonomic Nervous System Function- B2 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hypoglycemia and Autonomic Nervous System

2018 Clinical Trials

183. Hypoglycemia and Autonomic Nervous System Function-B

Collaborators: Beth Israel Deaconess Medical Center National Heart, Lung, and Blood Institute (NHLBI) Information provided by (Responsible Party): Gail Kurr Adler, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: This study tests the hypothesis that, compared to prior normal blood sugar, prior low blood sugar impairs cardiovascular autonomic function. The proposed studies will also test the hypothesis that the effects of prior low blood sugar on cardiovascular autonomic (...) Hypoglycemia and Autonomic Nervous System Function-B Hypoglycemia and Autonomic Nervous System Function-B - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hypoglycemia and Autonomic Nervous System Function-B

2018 Clinical Trials

184. The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes

detected on physical examination that has not been fully evaluated Thyroid hormone therapy that has not been stable for ≥6 weeks prior to Screening Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN-2) History of acute or chronic pancreatitis Subjects taking medications that are known to affect autonomic function need to be at a stable dose of those medications ≥ 3 months prior to inclusion in the study Other clinically significant, active (over (...) The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

185. Myocardial Function and Vitamin D Supplementation in Diabetes.

: University of Avignon Information provided by (Responsible Party): University of Avignon Study Details Study Description Go to Brief Summary: Vitamin D deficiency is recognized as a cardiovascular risk factor. Diabetic patients are of major risk for cardiovascular diseases and typically present with Vitamin D deficiencies. Myocardial function is altered in both type I and II diabetic patients but no data is today available on the effect of Vitamin D supplementation. The aim of the study (...) Myocardial Function and Vitamin D Supplementation in Diabetes. Myocardial Function and Vitamin D Supplementation in Diabetes. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Myocardial Function and Vitamin

2018 Clinical Trials

186. The Effects of Different Doses of Exercise on Pancreatic β-cell Function in Patients With Newly Diagnosed Type 2 Diabetes

The Effects of Different Doses of Exercise on Pancreatic β-cell Function in Patients With Newly Diagnosed Type 2 Diabetes The Effects of Different Doses of Exercise on Pancreatic β-cell Function in Patients With Newly Diagnosed Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects of Different Doses of Exercise on Pancreatic β-cell Function in Patients With Newly Diagnosed Type 2 Diabetes (DOSE-EX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read

2018 Clinical Trials

187. The Effects of Abdominal Massage on Functional (Primary) Chronic Constipation

: February 21, 2019 See Sponsor: Hacettepe University Information provided by (Responsible Party): Ceren Orhan, Hacettepe University Study Details Study Description Go to Brief Summary: The aim of the present study is to investigate the efficacy of abdominal massage in patients with functional (primary) chronic constipation. The present study is designed as a randomized placebo controlled. Since the placebo group is included in the research design, if there is a greater improvement of symptoms (...) The Effects of Abdominal Massage on Functional (Primary) Chronic Constipation The Effects of Abdominal Massage on Functional (Primary) Chronic Constipation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

188. Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer

Posted : May 14, 2014 Last Update Posted : August 3, 2018 See Sponsor: University of Wisconsin, Madison Collaborators: National Cancer Institute (NCI) National Institutes of Health (NIH) Information provided by (Responsible Party): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: This phase II trial studies how well thyroid gland removal with or without central lymph node dissection works in treating patients with thyroid cancer or suspected thyroid cancer (...) Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2014 Clinical Trials

189. Evaluation and Treatment of Functional Constipation in Infants and Children: Evidence-Based Recommendations from ESPGHAN and NASPGHAN

No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No No Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes Yes Y es Yes FIGURE 2. Algorithm for the evaluation and treatment of infants 6 months of age. ACE¼antegrade continence enema; MRI¼magnetic resonance imaging; SNS¼sacral nerve stimulation; TENS¼transcutaneous electric nerve stimulation; TSH¼thyroid-stimulating hormone. TABLE 2. Rome III diagnostic criteria for functional (...) Evaluation and Treatment of Functional Constipation in Infants and Children: Evidence-Based Recommendations from ESPGHAN and NASPGHAN Copyright 2014 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited. Evaluation and Treatment of Functional Constipation in Infants and Children: Evidence-Based Recommendations From ESPGHAN and NASPGHAN M.M. Tabbers, C. DiLorenzo, M.Y. Berger, C. Faure, M.W. Langendam, S. Nurko, A. Staiano, Y. Vandenplas, and M.A. Benninga ABSTRACT

2014 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

190. Nerve integrity monitoring (NIM) systems (Medtronic Inc.) for intraoperative monitoring of motor nerve function during thyroidectomy

. No evaluation of the quality of this assessment has been made for the HTA database. Citation Nerve integrity monitoring (NIM) systems (Medtronic Inc.) for intraoperative monitoring of motor nerve function during thyroidectomy. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2012 Authors' conclusions Abnormalities of the thyroid are extremely common, affecting approximately 12% of the general population and resulting in over 61,000 thyroidectomies in the United States annually. Injury (...) to the recurrent laryngeal nerve (RLN) resulting in vocal cord paralysis occurs in approximately 1.4% of cases and ranks among the leading causes for medicolegal litigation following thyroid surgery. Additionally, trauma to the RLN can lead to persistent airway obstruction and difficulty in swallowing, which can greatly impair quality of life and functioning. Although visual nerve identification via meticulous surgical technique is the standard of care for protecting the RLN, traditional methods are often

2012 Health Technology Assessment (HTA) Database.

191. Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal Full Text available with Trip Pro

by co-binding to the promoter region of BMI1 gene. In summary, our study uncovers a novel function of TH signaling in regulating the CSCs of HCC, and these findings might be useful for developing novel therapies by targeting TH function in HCC cells. (...) Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and promotes drug resistance of HCC cells. By analyzing primary

2016 Scientific reports

192. Osteopontin-a splice variant is overexpressed in papillary thyroid carcinoma and modulates invasive behavior Full Text available with Trip Pro

with clinicopathological, molecular features and their functional roles. We showed that tOPN and OPNa are overexpressed in classic papillary thyroid carcinoma (cPTC) in relation to adjacent thyroid, adenoma and follicular variant of papillary thyroid carcinoma (fvPTC) tissues. In cPTC, OPNa overexpression is associated with larger tumor size, vascular invasion, extrathyroid extension and BRAFV600E mutation. We found that TC cell lines overexpressing OPNa exhibited increased proliferation, migration, motility (...) Osteopontin-a splice variant is overexpressed in papillary thyroid carcinoma and modulates invasive behavior Osteopontin (OPN) is a matricellular protein overexpressed in cancer cells and modulates tumorigenesis and metastasis, including in thyroid cancer (TC). The contribution of each OPN splice variant (OPN-SV), named OPNa, OPNb and OPNc, in TC is currently unknown. This study evaluates the expression of total OPN (tOPN) and OPN-SV in TC tissues and cell lines, their correlation

2016 Oncotarget

193. Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin Full Text available with Trip Pro

Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin Obesity results in increased secretion of cytokines from adipose tissue and is a risk factor for various cancers. Leptin is largely produced by adipose tissue and cancer cells. It induces cell proliferation and may serve to induce various cancers. OB3-leptin peptide (OB3) is a new class of functional leptin peptide. However, its mitogenic effect has not been determined. In the present study (...) in the mouse showed that leptin, but not OB3, significantly increased circulating levels of thyrotropin (TSH), a growth factor for thyroid cancer. In summary, OB3 is a derivative of leptin that importantly lacks the mitogenic effects of leptin on thyroid cancer cells.

2016 Oncotarget

194. Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness Full Text available with Trip Pro

node metastasis (P=2.64E-05). In summary, BRAF V600E-activated MAP kinase pathway causes hypomethylation and overexpression of WIPF1; WIPF1 then functions like an oncoprotein to robustly promote aggressive cellular and tumor behaviors of PTC. This represents a novel mechanism in BRAF V600E-promoted PTC aggressiveness and identifies WIPF1 as a novel therapeutic target for thyroid cancer. (...) Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness How the BRAF V600E mutation promotes the pathogenesis and aggressiveness of papillary thyroid cancer (PTC) is not completely understood. Here we explored a novel mechanism involving WASP interacting protein family member 1 (WIPF1). In PTC tumors, compared with the wild-type BRAF, BRAF V600E was associated with over-expression and hypomethylation of the WIPF1 gene. In thyroid cancer

2016 Oncotarget

195. Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells Full Text available with Trip Pro

studies indicated that mechanisms involved in T4- and E2-induced nuclear co-localization of phosphorylated ERα and integrin αv are dissimilar. Chromatin immunoprecipitation results showed that T4-induced binding of integrin αv monomer to ERα promoter and this was reduced by ICI. In summary, thyroid hormone stimulates proliferation of ovarian cancer cells via crosstalk between integrin αv and ERα, mimicking functions of E2. (...) Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells Ovarian cancer is the leading cause of death in gynecological diseases. Thyroid hormone promotes proliferation of ovarian cancer cells via cell surface receptor integrin αvβ3 that activates extracellular regulated kinase (ERK1/2). However, the mechanisms are still not fully understood. Thyroxine (T4) at a physiologic total hormone concentration (10-7 M) significantly increased

2016 Oncotarget

196. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research Full Text available with Trip Pro

of thyrotropic pituitary function, supplemented by a recently published algorithm for reconstructing the personal set point of thyroid homeostasis. In addition, a family of integrated models (University of California-Los Angeles platform) provides advanced methods for bioequivalence studies. This perspective article delivers an overview of current clinical research on the basis of mathematical thyroid models. In addition to a summary of large clinical trials, it provides previously unpublished results (...) Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research Although technical problems of thyroid testing have largely been resolved by modern assay technology, biological variation remains a challenge. This applies to subclinical thyroid disease, non-thyroidal illness syndrome, and those 10% of hypothyroid patients, who report impaired quality of life, despite normal thyrotropin (TSH) concentrations under levothyroxine (L-T4) replacement

2016 Frontiers in endocrinology

197. Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas Full Text available with Trip Pro

histone H3 trimethylation and increased proliferation of thyroid cells. In summary, this study revealed that a hot-spot mutation in EZH1 is the second most frequent genetic alteration in ATAs. The association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells. (...) Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs. The involvement of other genes and the pathogenesis of the remaining cases are presently unknown. Here, we performed whole-exome sequencing in 19 ATAs that were paired with normal DNA samples and identified a recurrent

2016 The Journal of clinical investigation

198. The Establish of Specific Reference Ranges for Thyroid Tests in Pregnant Women

, 2016 Last Update Posted : November 22, 2016 Sponsor: Xiaomei Zhang Information provided by (Responsible Party): Xiaomei Zhang, Peking University International Hospital Study Details Study Description Go to Brief Summary: A descriptive analysis involving 300 healthy pregnant women to the establish of trimester-specific reference ranges for thyroid tests in pregnant women. 700 cases were selected as the normal pregnant population to establish a self-sequential longitudinal reference range. Condition (...) or disease Diseases Pregnancy Thyroid Detailed Description: A descriptive analysis involving 300 healthy pregnant women according NACB to the establish of trimester-specific reference ranges for thyroid tests in pregnant women. According to the selection criteria, 700 cases were selected as the normal pregnant population to establish a self-sequential longitudinal reference range. The aim of this study to monitor the change of thyroid function and antibody during the course of pregnancy in those who

2016 Clinical Trials

199. A Trial of Lenvatinib (E7080) in Radioiodine (131 I)-Refractory Differentiated Thyroid Cancer in China

: February 27, 2019 Sponsor: Eisai Co., Ltd. Information provided by (Responsible Party): Eisai Inc. ( Eisai Co., Ltd. ) Study Details Study Description Go to Brief Summary: The primary purpose of this study is to compare the progression-free survival (PFS) of participants with radioiodine (131 I)-refractory differentiated thyroid cancer (DTC) and radiographic evidence of disease progression within the prior 12 months treated with lenvatinib 24 mg by continuous once daily (QD) oral dosing versus placebo (...) A Trial of Lenvatinib (E7080) in Radioiodine (131 I)-Refractory Differentiated Thyroid Cancer in China A Trial of Lenvatinib (E7080) in Radioiodine (131 I)-Refractory Differentiated Thyroid Cancer in China - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2016 Clinical Trials

200. Celecoxib for Thyroid Eye Disease

Description Go to Brief Summary: Thyroid eye disease (TED) is an autoimmune disorder in which the immune system attacks orbital tissues, resulting in characteristic changes in eyelid position, globe position in the orbit, extraocular muscle balance, and optic nerve function. TED is a potentially blinding disease, and current treatments largely consist of nonspecific reduction of inflammation using corticosteroids or radiation therapy. Regardless of treatment, once TED progresses from its inflammatory (...) Celecoxib for Thyroid Eye Disease Celecoxib for Thyroid Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Celecoxib for Thyroid Eye Disease The safety and scientific validity of this study

2016 Clinical Trials

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