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Thyroid Function Summary

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1. Thyroid function testing

Thyroid function testing Thyroid function testing - Medical information | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Thyroid function testing Last reviewed: February 2019 Last updated: February 2018 Summary Thyroid hormones thyroxine (T4) and tri-iodothyronine (T3) are produced, stored, and secreted by the thyroid gland. These hormones, particularly T3, play a major role in multiple biological and metabolic processes. They act by binding to thyroid (...) receptors that are distributed in almost every organ. Typically, this process regulates gene transcription and the subsequent production of various proteins that are involved in development, growth, and cellular metabolism. Kronenberg HM, Melmed S, Polonsky KS, et al, eds. Williams textbook of endocrinology. 12th ed. Philadelphia, PA: Saunders/Elsevier; 2011. Thyroid function tests (TFTs) are the most commonly used endocrine test. Details Thyroid hormone production Thyroid hormone-binding proteins

2018 BMJ Best Practice

2. Abnormal thyroid function caused by COH and how does COH effect thyroid function? A meta-analysis and systematic review

Abnormal thyroid function caused by COH and how does COH effect thyroid function? A meta-analysis and systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

3. Thyroid Function Summary

Thyroid Function Summary Thyroid Function Summary Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thyroid Function Summary Thyroid (...) Function Summary Aka: Thyroid Function Summary II. Findings: Hyperthyroidism Increased (T4) and (T3) (fT4) and (fT3) ( ) and (FTI) (rT3) Decreased (TSH) (TRH) III. Findings: Hypothyroidism Increased (TSH) (TRH) Decreased (T4) and (T3) (fT4) and (fT3) ( ) and (FTI) (rT3) IV. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Thyroid Function Summary." Click on the image (or right click) to open the source website in a new

2018 FP Notebook

4. Thyroid Ultrasound to Evaluate Thyroid Function

, and meta-analyses are presented first. These are followed by randomized controlled trials and evidence-based guidelines. No relevant health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, or evidence-based guidelines were identified regarding the use of thyroid ultrasound to evaluate thyroid function in patients with no palpable abnormality of the thyroid gland. References of potential interest are provided in the appendix. OVERALL SUMMARY OF FINDINGS (...) No relevant literature was identified regarding the use of thyroid ultrasound to evaluate thyroid function in patients with no palpable abnormality of the thyroid gland; therefore, no summary can be provided. Thyroid Ultrasound to Evaluate Thyroid Function 3 REFERENCES SUMMARIZED Health Technology Assessments No literature identified. Systematic Reviews and Meta-analyses No literature identified. Randomized Controlled Trials No literature identified. Guidelines and Recommendations No literature identified

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. The association of gestational thyroid function and thyroid autoimmunity with gestational hypertension and preeclampsia

The association of gestational thyroid function and thyroid autoimmunity with gestational hypertension and preeclampsia Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

6. CAR T-cell therapy: a summary of evidence

CAR T-cell therapy: a summary of evidence CAR T-cell therapy: a summary of evidence An Evidence Check rapid review brokered by the Sax Institute for the NSW Ministry of Health. November 2018. An Evidence Check rapid review brokered by the Sax Institute for the NSW Ministry of Health. November 2018. This report was prepared by: Kayleigh M Kew, Korin Knight, Charlotta Karner and Steven J Edwards. November 2018. © Sax Institute 2018 This work is copyright. It may be reproduced in whole or in part (...) S J. CAR T-cell therapy: a summary of evidence: an Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the NSW Ministry of Health, 2018. Disclaimer: This Evidence Check Review was produced using the Evidence Check methodology in response to specific questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily at the time

2018 Sax Institute Evidence Check

7. Thyroid disease: assessment and management

with thyroid disease, their families and carers 6 1.2 Investigating suspected thyroid dysfunction or thyroid enlargement 8 1.3 Managing primary hypothyroidism 10 1.4 Follow-up and monitoring of primary hypothyroidism 11 1.5 Managing and monitoring subclinical hypothyroidism 13 1.6 Managing thyrotoxicosis 15 1.7 Follow-up and monitoring of hyperthyroidism 20 1.8 Managing and monitoring subclinical hyperthyroidism 22 1.9 Diagnosing, managing and monitoring thyroid enlargement with normal thyroid function 23 (...) with Graves' disease or toxic nodular goitre 42 Antithyroid drugs for people with hyperthyroidism 43 Follow-up and monitoring of hyperthyroidism 45 Managing and monitoring subclinical hyperthyroidism 46 Investigating non-malignant thyroid enlargement with normal thyroid function 47 Managing non-malignant thyroid enlargement 49 Context 51 Key facts and figures 51 Current practice 52 Finding more information and resources 53 Thyroid disease: assessment and management (NG145) © NICE 2019. All rights reserved

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

8. Thyroid hormone treatment does not help adults with mildly abnormal thyroid tests

enough hormones. Symptoms can vary, and a blood test measuring your hormone levels is the only accurate way to find out whether there's a problem. Thyroid function tests look at levels of thyroid-stimulating hormone (TSH) and thyroxine (T4) in the blood. Levels are compared to what's normal for a healthy person, in summary: A high level of TSH and a low level of T4 in the blood could mean you have an underactive thyroid. A low level of TSH and high levels of T3 and/or T4 usually means you have (...) are drawn from the British Thyroid Association’s 2006 guideline for the use of thyroid function tests in the UK. The British Thyroid Association recommends levothyroxine if TSH is greater than 10mU/L. If TSH is higher than normal but below 10mU/L, treatment is not routinely recommended except in certain circumstances, such as patients with goitre (swelling of the thyroid gland) or women who are planning pregnancy. What are the implications? This review does not support the routine treatment

2019 NIHR Dissemination Centre

9. Thyroid (dys)function in neonates born after exposure to iodinated contrast media

Thyroid (dys)function in neonates born after exposure to iodinated contrast media Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) : secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify

2019 PROSPERO

10. Circulating irisin level in patients with abnormal thyroid function: a systematic review and meta-analysis

Circulating irisin level in patients with abnormal thyroid function: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

11. Thyroid function and the risk of fibrosis of the liver, heart and lung in humans: a systematic review and meta-analysis

Thyroid function and the risk of fibrosis of the liver, heart and lung in humans: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A meta‐analysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If meta‐analysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

12. Comprehensive Systematic Review Summary: Disease-modifying Therapies for Adults with Multiple Sclerosis

Comprehensive Systematic Review Summary: Disease-modifying Therapies for Adults with Multiple Sclerosis 1 Practice guideline: Disease-modifying therapies for adults with multiple sclerosis Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology Alexander Rae-Grant, MD 1 ; Gregory S. Day, MD, MSc 2 ; Ruth Ann Marrie, MD, PhD 3 ; Alejandro Rabinstein, MD 4 ; Bruce A.C. Cree, MD, PhD, MAS 5 ; Gary S. Gronseth, MD 6 ; Michael Haboubi (...) and an additional 73 full-text articles were selected for data extraction through an updated systematic review, completed in November 2016. In people with RRMS, many DMTs are superior to placebo as measured by annualized relapses rates (ARRs), new disease activity as measured by new MRI T2 lesion burden, and in-study disease progression (see summary and full-text publications). For people with RRMS who experienced a relapse while using interferon beta or glatiramer acetate, alemtuzumab is more effective than

2018 American Academy of Neurology

13. Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function (PubMed)

-/- mice, display mild hypothyroidism. In summary, our data suggest the roles of Rtfc in in vitro thyroid differentiation of embryonic stem cells, and in vivo thyroid function. (...) Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function Thyroid is a one of the most important endocrine organs. Understanding the molecular mechanism underlying thyroid development and function, as well as thyroid diseases, is beneficial for the clinical treatment of thyroid diseases and tumors. Through genetic linkage analysis and exome sequencing, we previously identified an uncharacterized gene C14orf93 (RTFC, mouse homolog: 4931414P19Rik) as a novel

Full Text available with Trip Pro

2017 Scientific reports

14. Thyroid hormones treatment for subclinical hypothyroidism

Thyroid hormones treatment for subclinical hypothyroidism Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline | The BMJ Intended for healthcare professionals Username * Password * Edition: Search form Search Search Thyroid hormones... Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline (Published 14 May 2019) Cite this as: BMJ 2019;365:l2006 Visual summary of recommendation or No thyroid hormones Thyroid hormones (...) ) After 1.5 years No important difference Cognitive function High More 27.1 28.1 Risk of Bias No serious concerns Imprecision No serious concerns Indirectness No serious concerns Inconsistency No serious concerns Publication bias No serious concerns Thyroid hormone has little or no effect on cognitive function High GRADE score, because of: GRADE certainty ratings The authors have a lot of confidence that the true effect is similar to the estimated effect The authors believe that the true effect

2019 BMJ Rapid Recommendations

15. The <i>in vitro</i> functional impairment of thyroid hormone receptor alpha 1 isoform mutants is mainly dictated by reduced ligand-sensitivity. (PubMed)

The <i>in vitro</i> functional impairment of thyroid hormone receptor alpha 1 isoform mutants is mainly dictated by reduced ligand-sensitivity. Thyroid hormone (TH) acts on TH receptors (TRs) and regulates gene transcription by binding of TRs to TH response elements (TREs) in target gene promoters. The transcriptional activity of TRs is modulated by interactions with TR-coregulatory proteins. Mutations in TRα cause resistance to thyroid hormone alpha (RTHα). In this study, we (...) with coregulatory proteins (NCoR1 and SRC1) were also determined.We found that the affinity for T3 was significantly reduced for all mutants, except for TRα1-T223A. The reduction in the T3 sensitivity of the transcriptional activity on three TREs, the dissociation of the corepressor NCoR1, and the association of the coactivator SRC1 recruitment for each mutant correlated with the reduced affinity for T3. We did not observe mutation-specific alterations in interactions with cofactors or TREs.In summary

2019 Thyroid

16. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Gui

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Gui 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search (...) March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary A Report of the American

2017 American Heart Association

17. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines | Hypertension Search Hello Guest (...) ! Login to your account Email Password Keep me logged in Search April 2019 March 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart

2017 American Heart Association

18. Toxic thyroid adenoma

Toxic thyroid adenoma Toxic thyroid adenoma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Toxic thyroid adenoma Last reviewed: February 2019 Last updated: February 2019 Summary Typically a single large thyroid nodule accompanied by clinical and biochemical hyperthyroidism. Diagnosis confirmed by thyroid scan demonstrating a hot area and suppression of extranodular thyroid tissue. Hyperthyroidism caused by toxic (...) adenomas generally does not remit. Definitive treatment, such as radioactive iodine therapy, is usually required. Complications of untreated toxic adenomas may include sequelae of hyperthyroidism such as cardiac dysfunction or bone loss, or tracheal compression by large nodules. Definition A toxic adenoma is an autonomously functioning thyroid nodule that causes hyperthyroidism. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management

2019 BMJ Best Practice

19. Lenvatinib (thyroid carcinoma) - Benefit assessment according to §35a Social Code Book V

, NCT01321554, NCT00984282 Extract of dossier assessment A19-19 Version 1.0 Lenvatinib (thyroid carcinoma) 13 May 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - iii - Table of contents Page List of tables iv List of figures v List of abbreviations vi 2 Benefit assessment 1 2.1 Executive summary of the benefit assessment 1 2.2 Research question 6 2.3 Information retrieval and study pool 6 2.3.1 Studies included 7 2.3.2 Study characteristics 8 2.3.3 Similarity of the studies (...) controlled trial rhTSH recombinant human TSH RR relative risk SAE serious adverse event SGB Sozialgesetzbuch (Social Code Book) SPC Summary of Product Characteristics TSH thyroid stimulating hormone VAS visual analogue scale VEGF vascular endothelial growth factor VEGFR VEGF receptor Extract of dossier assessment A19-19 Version 1.0 Lenvatinib (thyroid carcinoma) 13 May 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - 1 - 2 Benefit assessment 2.1 Executive summary of the benefit

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

20. Overview of thyroid dysfunction

Overview of thyroid dysfunction Overview of thyroid dysfunction - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of thyroid dysfunction Last reviewed: February 2019 Last updated: October 2018 Introduction The thyroid gland produces, stores, and secretes thyroxine (T4) and triiodothyronine (T3) through a negative feedback process involving the hypothalamus and pituitary gland. Thyroid dysfunction can result when (...) is diagnostic of Graves' disease. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. https://www.liebertpub.com/doi/full/10.1089/thy.2016.0229 http://www.ncbi.nlm.nih.gov/pubmed/27521067?tool=bestpractice.com In questionable cases, measurement of TRAb is used as a diagnostic test. A toxic multinodular goitre (MNG) contains multiple autonomously functioning

2018 BMJ Best Practice

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