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Thromboembolic Disease in Pregnancy

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141. Migraine, cardiovascular disease, and stroke during pregnancy: systematic review of the literature. (Abstract)

, there is an association between an increased risk of ischemic stroke in pregnancy (OR range 7.9 to 30.7), particularly with active migraine. There is also an association between migraine and increased risk of acute myocardial infarction and heart disease (OR 4.9; 95% CI 1.7, 14.2), and thromboembolic events during pregnancy (deep venous thrombosis OR 2.4; 95% CI 1.3, 4.2 and pulmonary embolus OR 3.1; 95% CI 1.7, 5.6).In this review, we summarized the association between migraine and risk of vascular disease during (...) Migraine, cardiovascular disease, and stroke during pregnancy: systematic review of the literature. The objective of this article is to review the literature relating migraine, cardiovascular disease, and stroke during pregnancy in order to better define the relationship between migraines and vascular disease.We conducted a systematic review of the literature using Medline and Cochrane Review with the following search terms: migraine AND pregnancy and vascular disease OR myocardial infarction

2015 Cephalalgia : an international journal of headache

142. Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score

associated with thrombophilia could be more useful in the prediction for RPL than FVL and PT alone. Condition or disease Miscarriage, Recurrent Detailed Description: Recurrent pregnancy loss can affect up to 5% of women in child-bearing age and is considered one of the most common causes of female sterility. In recent years, the association between thrombophilia and pregnancy failure has been observed in a number of studies, varying according to the nature of the thrombophilia (for example (...) the antiphospholipid syndrome as opposed to the hereditary forms) or the type of pregnancy loss (either isolated or recurrent, or early or late). It has therefore been accepted that thrombophilia is detected in a significant number of idiopathic pregnancy losses, reaching 66% of the cases in some series. Since the 1990's, a number of studies have associated recurrent pregnancy loss with FVL mutations (most frequently) and G20210 PT. In a systematic review, it was confirmed that women with thrombophilia have

2017 Clinical Trials

143. Impact of maternal obesity on the incidence of pregnancy complications in France and Canada Full Text available with Trip Pro

. Outcomes studied included, hypertensive disorders of pregnancy (HDP), venous thromboembolism, stillbirth, caesarean delivery and macrosomia. The impact of obesity across both cohorts was studied using univariate and multivariate logistic regression analyses, adjusting for relevant confounders. The French and Canadian databases included 26,973 and 22,046 deliveries respectively, with obesity rates of 9.1% and 16% respectively (p < 0.001). In both cohorts, obesity was significantly associated (...) Impact of maternal obesity on the incidence of pregnancy complications in France and Canada The aim of our study was to compare the impact of maternal obesity on the incidence of medical complications of pregnancy in France and Canada. We performed a prospective comparative cohort study using French data, retrieved from a prospective cohort of singleton deliveries, and Canadian data retrieved from QUARISMA, a cluster-randomized controlled trial conducted in Quebec, both between 2009 and 2011

2017 Scientific reports

144. Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature Full Text available with Trip Pro

Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature Mesenteric cyst is a rare clinical entity especially in pregnancy; therefore, few cases have been reported in the literature. The standard method of their treatment is surgical excision either with laparotomy or laparoscopy. In addition, mesenteric vein thrombosis is a rare and life-threatening condition in pregnancy and needs (...) of a simultaneous mesenteric cyst and mesenteric vein thrombosis in pregnancy. It is known that pregnancy is a state of hypercoagulation and clinicians should bear in mind this rare clinical condition in their diagnostic algorithm for acute abdominal pain.

2017 Journal of medical case reports

145. Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report Full Text available with Trip Pro

Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report Polymyositis is a rare medical disorder complicating pregnancy. Ventilatory muscle weakness leading to respiratory failure is an uncommon manifestation of this autoimmune disease. We report a case of life-threatening hypercapnic respiratory failure due to polymyositis-related respiratory muscle weakness in a pregnant woman.A 31-year-old, African woman in her second trimester (...) of pregnancy presented to the emergency department with fever, shortness of breath and muscle weakness. Initial investigations excluded pulmonary infection, thromboembolism, and cardiac dysfunction as the underlying cause of her symptoms. She developed deterioration in her level of consciousness due to carbon dioxide narcosis requiring invasive mechanical ventilation. Further workup revealed markedly elevated serum creatine kinase, abnormal electromyography and edema of her thigh muscles on magnetic

2017 Journal of medical case reports

146. Physical Activity in Pregnancy

of hypertensive disorders in pregnancy). Condition or disease Pregnancy, Physical Activity Detailed Description: Pregnancy is a natural state of low grade inflammation in the mother and the feto-placental unit. The severity of this inflammation increases with higher pregravid Body Mass Index (BMI). This is reflected by an increase in pro-inflammatory cytokines in the maternal circulation and in the placenta. It has been proposed that the pro-inflammatory maternal and fetal environment plays a role (...) ) Inactive pregnant women who are physically inactive (spend less than 150min/week with moderate to vigorous physical activity) risk for hypertensive disorders pregnant women with a history of preeclampsia or positive history for metabolic conditions increasing the risk of hypertensive disorders in pregnancy Outcome Measures Go to Primary Outcome Measures : low grade inflammation (in maternal and cord blood) [ Time Frame: 1 year ] clinical inflammation markers: C-reactive protein, cytokines and chemokine

2017 Clinical Trials

147. Autoimmune hepatitis and pregnancy: report of two cases with different maternal outcomes Full Text available with Trip Pro

Autoimmune hepatitis and pregnancy: report of two cases with different maternal outcomes Women of childbearing age with autoimmune hepatitis (AIH) are now able to get pregnant. The progress of the disease during pregnancy is not well clarified yet. The first pregnant woman had cirrhosis secondary to AIH, and she delivered by cesarean section. The patient had severe thrombocytopenia at the time of hospitalization. Unfortunately, she died due to massive thromboembolism at the 24th hour after (...) delivery. The other patient had three recurrent abortions with a diagnosis of AIH. Low-dose low molecular weight heparin and low-dose acetylsalicylic acid along with low-dose prednisolone were administered during the course of the following pregnancies. The following pregnancies ended up with a living child. There is a high morbidity and mortality risk for both fetus and mother. Hepatic performance of the patients, thrombotic events, inflammatory disorders and autoimmune system activation must

2017 Clinical and Experimental Hepatology

148. The Role of Prothrombin Gene Polymorphism as a Risk Factor for Recurrent Pregnancy Loss

Committee issued a statement that defined recurrent pregnancy loss as a disease distinct from infertility defined by two or more failed consecutive pregnancies. Condition or disease Intervention/treatment Recurrent Pregnancy Loss Diagnostic Test: polymerase chain reaction Detailed Description: Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full (...) reproductive period) . In 2012, the American Society for Reproductive Medicine Practice Committee issued a statement that defined recurrent pregnancy loss as a disease distinct from infertility defined by two or more failed consecutive pregnancies. Thrombophilia is the tendency to develop thromboses due to inherited defects in the coagulation system. Thrombophilia was identified as a major cause of recurrent pregnancy loss , Because pregnancy is a hypercoagulable state, thromboembolism is the leading cause

2017 Clinical Trials

149. Pregnancy and reproductive aspects of systemic lupus erythematosus. (Abstract)

Pregnancy and reproductive aspects of systemic lupus erythematosus. To discuss pregnancy and reproductive aspects in women with systemic lupus erythematosus (SLE) with particular focus on preconception counselling, maternal and foetal outcomes, safety and beneficial effects of drugs during pregnancy as well as contraception methods, assisted reproduction techniques and strategies for thromboembolism prophylaxis in patients with positive antiphospholipid antibodies.Evidence-based recommendations (...) and risk stratification (based on disease activity and serological profile) are key points for having successful pregnancies thanks to individualized treatments and close monitoring for maternal and foetal complications. Contraception and assisted reproduction techniques are feasible in women with SLE, provided that potential risks are minimized by individualized management and appropriate prophylaxis.

2017 Current Opinion in Rheumatology

150. Obstetrical history of women with cerebral vein thrombosis: outcome of the pregnancies before and after the thrombotic event. (Abstract)

Obstetrical history of women with cerebral vein thrombosis: outcome of the pregnancies before and after the thrombotic event. Cerebral vein thrombosis (CVT) is a rare disease usually affecting young people, especially women, with a high prevalence of thrombophilic defects. It is known that thrombophilia is associated with pregnancy complications; therefore, a high rate of complications could be expected in women with the previous CVT who become pregnant. This study examined the whole obstetric (...) at prophylactic dosage during pregnancy. No recurrent CVT, venous thromboembolic events, or death was recorded during the observed pregnancies. Ten miscarriages were recorded (rate 8.1%), with a rate similar to that expected in the general population. We confirm the favorable outcome of pregnancies in women who suffered from CVT during their entire lifespan, whether they have occurred before and after or in relation to CVT.

2017 Internal and emergency medicine

151. Thromboprophylaxis reduces venous thromboembolism rate in ambulatory patients immobilised in above knee plaster cast.

and Critical Care Institution: Lancashire Teaching Hospitals NHS Trust Date Submitted: 5th July 2011 Date Completed: 13th June 2012 Last Modified: 13th June 2012 Status: Green (complete) Three Part Question In [patients with lower extremity injury requiring temporary immobilisation with above knee plaster of paris] does [prophylactic anticoagulation with LMWH] reduce the risk of [venous thromboembolic disease within the next three months] Clinical Scenario You see a 27 year old male who has ruptured his (...) Thromboprophylaxis reduces venous thromboembolism rate in ambulatory patients immobilised in above knee plaster cast. BestBets: Thromboprophylaxis reduces venous thromboembolism rate in ambulatory patients immobilised in above knee plaster cast. Thromboprophylaxis reduces venous thromboembolism rate in ambulatory patients immobilised in above knee plaster cast. Report By: Catherine Roberts - SpR in Emergency Medicine & Critical Care Search checked by Daniel Horner - StR in Emergency Medicine

2012 BestBETS

152. Risk of Venous Thromboembolism Among Users of Drospirenone-Containing Oral Contraceptive Pills

, this risk is still very low and is much lower than the risk of venous thromboembolism during pregnancy and the immediate postpartum period. When prescribing any oral contraceptive, clinicians should consider a woman’s risk factors for venous thromboembolism and refer to the U.S. Medical Eligibility Criteria for Contraceptive Use issued by the Centers for Disease Control and Prevention. Patient education materials, including product labeling, should place information regarding oral contraceptive use (...) to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Risk of Venous Thromboembolism Among Users of Drospirenone-Containing Oral Contraceptive Pills ABSTRACT: Although the risk of venous thromboembolism is increased among oral contraceptive users compared with nonusers who are not pregnant and not taking hormones, and some data have suggested that use of drospirenone-containing pills has a higher risk of venous thromboembolism

2012 American College of Obstetricians and Gynecologists

153. Haemorrhages and Thromboembolic Venous Disease of the Postpartum

Thromboembolism Venous Thromboembolism Postpartum Hemorrhage Pathologic Processes Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Obstetric Labor Complications Pregnancy Complications Puerperal Disorders Uterine Hemorrhage (...) : University Hospital, Brest Information provided by (Responsible Party): University Hospital, Brest Study Details Study Description Go to Brief Summary: The aim of this study is to evaluate the frequencey and the determinants of postpartum major complications (hemorrhage and thrombosis) up to 3 months after delivery in the maternity hospitals of Finistère (Bretagne - France) Condition or disease Postpartum Hemorrhage Venous Thromboembolism Detailed Description: This is an analytical observational

2015 Clinical Trials

154. A meta-analysis of the risk of venous thromboembolism in inflammatory rheumatic diseases. Full Text available with Trip Pro

A meta-analysis of the risk of venous thromboembolism in inflammatory rheumatic diseases. We performed a meta-analysis to investigate the risk of deep vein thrombosis (DVT) and/or pulmonary embolisms (PEs) in patients with inflammatory arthritis, vasculitis and connective tissue diseases (CTDs) (systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammatory myositis and systemic sclerosis (SSc)).PubMed, Embase, the Cochrane databases and MEDLINE were searched to identify full-text English (...) -language publications about adult patients with rheumatologic inflammatory diseases and venous thromboembolisms (VTEs). Data regarding rates of DVTs and PEs were extracted. Using random-effects models, pooled estimates for VTEs in individual and pooled diseases were compared with matched populations where possible. Studies were excluded if VTEs were described in the setting of pregnancy, postoperative outcomes or solely antiphospholipid antibody syndrome.Most of the 5,206 studies were excluded because

2015 Arthritis research & therapy

155. Epidemiology of venous thromboembolism in Africa: a systematic review. Full Text available with Trip Pro

Epidemiology of venous thromboembolism in Africa: a systematic review. Essentials Venous thromboembolism (VTE) is among the three main causes of cardiovascular disease worldwide. This review is the first to summarize the epidemiology of VTE in African populations. The prevalence of VTE in Africa is high following surgery, in pregnancy and post-partum. At least one quarter of patients at risk of VTE in Africa are not receiving prophylaxis.Background Venous thromboembolism (VTE) is among (...) the three leading causes of cardiovascular disease worldwide. Despite its high burden, there has been no previous study summarizing the epidemiology of VTE in African populations. Hence, we conducted this systematic review to determine the prevalence, incidence and mortality associated with VTE, and to evaluate the use of VTE prophylaxis in Africa. Methods We searched PubMed, Scopus and African Journals Online to identify articles published on VTE in Africa from inception to November 19, 2016, without

2017 Journal of thrombosis and haemostasis : JTH

156. Is Infection an Independent Risk Factor for Venous Thromboembolism? a Population-Based Case-Control Study. Full Text available with Trip Pro

Olmsted County, Minnesota, residents with objectively diagnosed incident deep vein thrombosis or pulmonary embolism over the 13-year period 1988 to 2000 (cases; n = 1303) and 1 to 2 residents without venous thromboembolism matched to each case on age, sex, and incident venous thromboembolism date (controls; n = 1494). Using conditional logistic regression, we tested recent infection and infection site(s) for an association with venous thromboembolism, adjusting for body mass index, smoking, current (...) /recent hospitalization with/without surgery, nursing home confinement, active cancer, trauma/fracture, leg paresis, prior superficial vein thrombosis, transvenous catheter/pacemaker, ischemic heart disease, congestive heart failure, chronic lung or renal disease, serious liver disease, asthma, diabetes mellitus, hormone therapy, and pregnancy/postpartum.A total of 513 cases (39.4%) and 189 controls (12.7%) had an infection in the previous 92 days (odds ratio, 4.5; 95% confidence interval, 3.6-5.5; P

2017 American Journal of Medicine

157. Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region

: Recruiting First Posted : November 21, 2017 Last Update Posted : November 21, 2017 See Sponsor: Novosibirsk Scientific Research Institute for Circulatory Pathology Information provided by (Responsible Party): Novosibirsk Scientific Research Institute for Circulatory Pathology Study Details Study Description Go to Brief Summary: There will be assessment of patients after acute pulmonary embolism for the development of CTEPH Condition or disease Intervention/treatment Chronic Thromboembolic Pulmonary (...) Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

158. A Study of Dabigatran Etexilate as Primary Treatment of Malignancy Associated Venous Thromboembolism

dose of dabigatran will be given within 2 hours before the time that the next dose of tinzaparin would have been due. Anticoagulation will be continued as long as malignancy is active. If patients achieve a complete remission of their underlying malignancies, dabigatran will be continued for 6 months further. Condition or disease Intervention/treatment Phase Venous Thromboembolism Deep Vein Thrombosis Pulmonary Embolism Drug: Dabigatran etexilate Drug: Tinzaparin Phase 3 Detailed Description (...) Verified: October 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Thrombosis Thromboembolism Embolism Venous Thromboembolism Pulmonary Embolism Venous Thrombosis Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases

2017 Clinical Trials

159. Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology

. Data comparing these two methods of VTE prophylaxis in patients undergoing pelvic/lower extremity orthopaedic surgery for malignancy are lacking, however, as compared to the data and guidelines present for VTE chemoprophylaxis after joint arthroplasty and hip fracture surgery. In this clinical trial, our specific aim is to compare the post operative incidence of VTE between patients receiving aspirin and LMWH after pelvic/lower extremity orthopaedic oncology procedures. Condition or disease (...) : 1) soft tissue sarcoma; 2) primary bone sarcoma; 3) metastatic bone disease. Within each of these groups, patients will be randomized to either aspirin or low molecular weight heparin (enoxaparin) for venous thromboembolism prophylaxis post operatively. Masking: None (Open Label) Primary Purpose: Prevention Official Title: Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology Actual Study Start Date : February 16, 2018 Estimated Primary

2017 Clinical Trials

160. REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism.

, a reduced dose of DOAC will be non-inferior to a full dose of DOAC in terms of recurrent VTE during extended anticoagulation phase. Condition or disease Intervention/treatment Phase Venous Thromboembolism Drug: Reduced dose of DOAC Drug: Full dose of DOAC Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 2200 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: The trial (...) Chronic liver disease or chronic hepatitis Patient considered at high risk of bleeding (eg: previous gastro-intestinal tract bleeding in the past three months, uncontrolled hypertension, etc.) Renal insufficiency with creatinine <25 ml / min on Cockcroft and Gault formula Antiphospholipid syndrome Dual anti-platelet therapy or aspirin at dosage >100 mg per day Concomitant use of a strong inhibitor of cytochrome P-450 3A4 (CYP3A4) (e.g., a protease inhibitor for human immunodeficiency virus infection

2017 Clinical Trials

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