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Thromboembolic Disease in Pregnancy

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121. Risk of Pulmonary and Venous Thromboembolism in Pregnancies After in Vitro Fertilization

concerning pulmonary embolism (PE). The aim is to estimate and compare the risk of both PE and VTE during the the different phases of pregnancy after IVF to that in age and period matched control women. The investigators will use the Swedish National Health Registers to estimate the risk. Condition or disease Pulmonary Embolism Venous Thromboembolism Detailed Description: Background: Occurrence of venous thromboembolism (VTE) during IVF pregnancies has been reported in numerous case reports and in two (...) Posted: February 2, 2012 Last Verified: January 2012 Keywords provided by Professor Peter Henriksson, Danderyd Hospital: Assisted Reproductive Techniques Pregnancy Pulmonary Embolism Venous Thromboembolism Additional relevant MeSH terms: Layout table for MeSH terms Thromboembolism Embolism Venous Thromboembolism Pulmonary Embolism Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases

2012 Clinical Trials

122. Adults With Congenital Heart Disease

. Echocardiography 27 3.4.4. CMR Imaging 28 3.4.5. Cardiac Computed Tomography 29 3.4.6. Cardiac Catheterization 30 3.4.7. Exercise Testing 31 3.5. Transition Education 31 3.6. Exercise and Sports 32 3.7. Mental Health and Neurodevelopmental Issues 34 3.8. Endocarditis Prevention 34 3.9. Concomitant Syndromes 35 3.10. Acquired Cardiovascular Disease 36 3.11. Noncardiac Medical Issues 37 3.12. Noncardiac Surgery 37 3.13. Pregnancy, Reproduction, and Sexual Health 39 3.13.1. Pregnancy 39 3.13.2. Contraception 41 (...) Adults With Congenital Heart Disease Accepted Manuscript 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease Karen K. Stout, MD, FACC, Chair, Writing Committee, Curt J. Daniels, MD, Vice Chair, Writing Committee, Jamil A. Aboulhosn, MD, FACC, FSCAI, Writing Committee Member, Biykem Bozkurt, MD, PhD, FACC, FAHA, Writing Committee Member, Craig S. Broberg, MD, FACC, Writing Committee Member, Jack M. Colman, MD, FACC, Writing Committee Member, Stephen R. Crumb, DNP

2018 American College of Cardiology

123. Fistulizing Crohn's Disease

Fistulizing Crohn's Disease 1 © The Author(s) 2018. Published by Oxford University Press on behalf of the Canadian Association of Gastroenterology. Clinical Review Article Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn’s Disease: The T oronto Consensus A. Hillary Steinhart, MD, 1 Remo Panaccione, MD, 2 Laura T argownik, MD, 3 Brian Bressler, MD, 4 Reena Khanna, MD, 5 John K. Marshall, MD, 6 Waqqas Afif , MD, 7 Charles N. Bernstein, MD, 3 Alain Bitton , MD (...) Division of Gastroenterology, University of Ottawa, Ottawa, Ontario, Canada; 15 Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada; 16 Division of Gastroenterology, Pacific Gastroenterology Associates, V ancouver, British Columbia, Canada; 17 Inflammatory Bowel Disease Center, V anderbilt University, Nashville, T ennessee, USA; 18 Departments of Medicine & Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; 19 Division of Digestive Care & Endoscopy

2018 Canadian Association of Gastroenterology

124. Antenatal care - uncomplicated pregnancy

are unsure about the safety of a medication during pregnancy, contact the on 0344 892 0909 for a patient-specific risk assessment. Assess and document the risk factors for venous thromboembolism including: History of thromboembolism. Thrombophilia (such as Factor V Leiden deficiency, Antiphospholipid syndrome, Prothrombin 20210, Protein C, protein S or antithrombin deficiencies). Other medical conditions (such as heart disease, sickle cell disease, systemic lupus erythematosus, obesity, anaemia, diabetes (...) ). Seven appointments are sufficient for a parous woman (having borne at least one viable offspring — usually after 24 weeks). Two ultrasound scans are usually offered during the course of an uncomplicated pregnancy: A dating scan (10–13 weeks). A fetal anomaly scan (18–20 weeks). Women with an uncomplicated pregnancy are usually offered screening for: Gestational diabetes. Hypertension in pregnancy and pre-eclampsia. Anaemia. Down's syndrome. Haemoglobinopathies (sickle cell disease and thalassaemia

2016 NICE Clinical Knowledge Summaries

125. Maternal Collapse in Pregnancy and the Puerperium

, Placenta Praevia Accreta and Vasa Praevia: Diagnosis and Management. 67 4.6.2 Venous thromboembolism The specific management of massive pulmonary embolism is covered in the RCOG Green-top Guideline No. 28: Thromboembolic Disease in Pregnancy and the Puerperium: Acute Management. 68 4.6.3 Amniotic fluid embolism The management of AFE is supportive rather than specific, as there is no proven effective therapy. 2 12 of 24 RCOG Green-top Guideline No. 56 © Royal College of Obstetricians and Gynaecologists (...) The incidence of primary cardiac arrest in pregnancy is much rarer at around 1/30 000 maternities, and most cardiac events have preceding signs and symptoms. Aortic root dissection can present in otherwise healthy women, and signs and symptoms such as central chest or interscapular pain, a wide pulse pressure, mainly secondary to systolic hypertension, and a new cardiac murmur must prompt referral to a cardiologist and appropriate imaging. The incidence of congenital and rheumatic heart disease in pregnancy

2011 Royal College of Obstetricians and Gynaecologists

126. Migraine, cardiovascular disease, and stroke during pregnancy: systematic review of the literature. (PubMed)

, there is an association between an increased risk of ischemic stroke in pregnancy (OR range 7.9 to 30.7), particularly with active migraine. There is also an association between migraine and increased risk of acute myocardial infarction and heart disease (OR 4.9; 95% CI 1.7, 14.2), and thromboembolic events during pregnancy (deep venous thrombosis OR 2.4; 95% CI 1.3, 4.2 and pulmonary embolus OR 3.1; 95% CI 1.7, 5.6).In this review, we summarized the association between migraine and risk of vascular disease during (...) Migraine, cardiovascular disease, and stroke during pregnancy: systematic review of the literature. The objective of this article is to review the literature relating migraine, cardiovascular disease, and stroke during pregnancy in order to better define the relationship between migraines and vascular disease.We conducted a systematic review of the literature using Medline and Cochrane Review with the following search terms: migraine AND pregnancy and vascular disease OR myocardial infarction

2015 Cephalalgia : an international journal of headache

127. Weight management before, during and after pregnancy

birth are related to socioeconomic deprivation (Heslehurst et al. 2010). Health risks for obese women and their babies Women who are obese when they become pregnant face an increased risk of complications during pregnancy and childbirth. These include the risk of impaired glucose tolerance and gestational diabetes, miscarriage, pre-eclampsia, thromboembolism and maternal death (Centre for Maternal and Child Enquiries and the Royal College of Obstetricians and Gynaecologists 2010). Even a relatively (...) be restrictions on home births, the use of birthing pools and types of pain relief that can be given. Obese women who are pregnant are likely to spend longer in hospital than those with a healthy weight because of morbidity during pregnancy and labour related to their weight (Chu et al. 2008). In the longer term, weight control after pregnancy may reduce the woman's risk of obesity, coronary heart disease, some cancers and type 2 diabetes. Weight management before, during and after pregnancy (PH27) © NICE

2010 National Institute for Health and Clinical Excellence - Clinical Guidelines

128. Pregnancy and reproductive aspects of systemic lupus erythematosus. (PubMed)

Pregnancy and reproductive aspects of systemic lupus erythematosus. To discuss pregnancy and reproductive aspects in women with systemic lupus erythematosus (SLE) with particular focus on preconception counselling, maternal and foetal outcomes, safety and beneficial effects of drugs during pregnancy as well as contraception methods, assisted reproduction techniques and strategies for thromboembolism prophylaxis in patients with positive antiphospholipid antibodies.Evidence-based recommendations (...) and risk stratification (based on disease activity and serological profile) are key points for having successful pregnancies thanks to individualized treatments and close monitoring for maternal and foetal complications. Contraception and assisted reproduction techniques are feasible in women with SLE, provided that potential risks are minimized by individualized management and appropriate prophylaxis.

2017 Current Opinion in Rheumatology

129. Obstetrical history of women with cerebral vein thrombosis: outcome of the pregnancies before and after the thrombotic event. (PubMed)

Obstetrical history of women with cerebral vein thrombosis: outcome of the pregnancies before and after the thrombotic event. Cerebral vein thrombosis (CVT) is a rare disease usually affecting young people, especially women, with a high prevalence of thrombophilic defects. It is known that thrombophilia is associated with pregnancy complications; therefore, a high rate of complications could be expected in women with the previous CVT who become pregnant. This study examined the whole obstetric (...) at prophylactic dosage during pregnancy. No recurrent CVT, venous thromboembolic events, or death was recorded during the observed pregnancies. Ten miscarriages were recorded (rate 8.1%), with a rate similar to that expected in the general population. We confirm the favorable outcome of pregnancies in women who suffered from CVT during their entire lifespan, whether they have occurred before and after or in relation to CVT.

2017 Internal and emergency medicine

130. Complications of pregnancy and labor in women with Klippel-Trenaunay syndrome: a nationwide cross-sectional study. (PubMed)

their obstetric history. Reference data on pregnancy outcomes and complications of non-diseased women were collected from population-based cohorts from the literature.Prevalence of complications, specifically venous thromboembolism and postpartum haemorrhage.Sixty women completed the survey. Seventeen patients did not conceive, of whom three refrained from pregnancy because of KTS. A total of 97 pregnancies and 86 deliveries were reported in 43 patients. KTS-related symptoms were aggravated during pregnancy (...) Complications of pregnancy and labor in women with Klippel-Trenaunay syndrome: a nationwide cross-sectional study. To evaluate complications of pregnancy, including thromboembolism, in women with extensive vascular malformations associated with Klippel-Trénaunay syndrome (KTS).Nationwide cross-sectional study.Two tertiary expert centres and the Dutch Klippel-Trénaunay patient organisation.Adult women with KTS.Patients with KTS were invited to participate in a comprehensive online survey about

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2017 BJOG

131. Physical Activity in Pregnancy

of hypertensive disorders in pregnancy). Condition or disease Pregnancy, Physical Activity Detailed Description: Pregnancy is a natural state of low grade inflammation in the mother and the feto-placental unit. The severity of this inflammation increases with higher pregravid Body Mass Index (BMI). This is reflected by an increase in pro-inflammatory cytokines in the maternal circulation and in the placenta. It has been proposed that the pro-inflammatory maternal and fetal environment plays a role (...) of women who are not physically active, and Group3 consists of women with a risk of hypertensive disorders or metabolic diseases (not diabetes). PA before and in early pregnancy will be assessed with a screening questionnaire. Women reporting a minimum of 150 mins of moderate to vigorous PA per week will be classified as active, women with less PA will be classified as inactive. 20 women each group will be recruited not later than 14 weeks of gestation. Women will be recruited at the outpatient clinic

2017 Clinical Trials

132. The Role of Prothrombin Gene Polymorphism as a Risk Factor for Recurrent Pregnancy Loss

reproductive period) . In 2012, the American Society for Reproductive Medicine Practice Committee issued a statement that defined recurrent pregnancy loss as a disease distinct from infertility defined by two or more failed consecutive pregnancies. Thrombophilia is the tendency to develop thromboses due to inherited defects in the coagulation system. Thrombophilia was identified as a major cause of recurrent pregnancy loss , Because pregnancy is a hypercoagulable state, thromboembolism is the leading cause (...) Committee issued a statement that defined recurrent pregnancy loss as a disease distinct from infertility defined by two or more failed consecutive pregnancies. Condition or disease Intervention/treatment Recurrent Pregnancy Loss Diagnostic Test: polymerase chain reaction Detailed Description: Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full

2017 Clinical Trials

133. Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score

associated with thrombophilia could be more useful in the prediction for RPL than FVL and PT alone. Condition or disease Miscarriage, Recurrent Detailed Description: Recurrent pregnancy loss can affect up to 5% of women in child-bearing age and is considered one of the most common causes of female sterility. In recent years, the association between thrombophilia and pregnancy failure has been observed in a number of studies, varying according to the nature of the thrombophilia (for example (...) a higher risk of developing thromboembolism and complications in pregnancy. Another recent meta-analysis of prospective cohort studies concluded that women who were carriers of FVL had a higher risk of late pregnancy loss, at 52%, as opposed to non-carriers (OR=1.52), though the differences in absolute risk were discreet (4.2% and 3.2%, respectively). However, the analysis of these 2 single nucleotide polymorphisms (SNPs) showed low discriminative capacity and diagnostic sensitivity. This study

2017 Clinical Trials

134. Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report (PubMed)

Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report Polymyositis is a rare medical disorder complicating pregnancy. Ventilatory muscle weakness leading to respiratory failure is an uncommon manifestation of this autoimmune disease. We report a case of life-threatening hypercapnic respiratory failure due to polymyositis-related respiratory muscle weakness in a pregnant woman.A 31-year-old, African woman in her second trimester (...) of pregnancy presented to the emergency department with fever, shortness of breath and muscle weakness. Initial investigations excluded pulmonary infection, thromboembolism, and cardiac dysfunction as the underlying cause of her symptoms. She developed deterioration in her level of consciousness due to carbon dioxide narcosis requiring invasive mechanical ventilation. Further workup revealed markedly elevated serum creatine kinase, abnormal electromyography and edema of her thigh muscles on magnetic

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2017 Journal of medical case reports

135. Autoimmune hepatitis and pregnancy: report of two cases with different maternal outcomes (PubMed)

Autoimmune hepatitis and pregnancy: report of two cases with different maternal outcomes Women of childbearing age with autoimmune hepatitis (AIH) are now able to get pregnant. The progress of the disease during pregnancy is not well clarified yet. The first pregnant woman had cirrhosis secondary to AIH, and she delivered by cesarean section. The patient had severe thrombocytopenia at the time of hospitalization. Unfortunately, she died due to massive thromboembolism at the 24th hour after (...) delivery. The other patient had three recurrent abortions with a diagnosis of AIH. Low-dose low molecular weight heparin and low-dose acetylsalicylic acid along with low-dose prednisolone were administered during the course of the following pregnancies. The following pregnancies ended up with a living child. There is a high morbidity and mortality risk for both fetus and mother. Hepatic performance of the patients, thrombotic events, inflammatory disorders and autoimmune system activation must

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2017 Clinical and Experimental Hepatology

136. CRACKCast E087 – Peripheral Arteriovascular Disease

, MSK shoulder disease, peripheral neuropathies, MS, ETOH abuse, diabetes, and many others! Management depends on the severity and type: Nerve compression only = physio, shoulder rehab, then maybe surgery Arterial compression is a BIG deal: Risk for thrombosis, thromboembolism, acute ischemia, rupture, etc. Acute thrombosis = see the first few questions above. 17) List four anatomic abnormalities associated with thoracic outlet syndrome. See Rosen’s Fig 87-3. Think muscle, ligament, and bone (...) CRACKCast E087 – Peripheral Arteriovascular Disease CRACKCast E087 - Peripheral Arteriovascular Disease - CanadiEM CRACKCast E087 – Peripheral Arteriovascular Disease In , , by Chris Lipp June 26, 2017 This episode of CRACKCast covers Rosen’s Chapter 87, Peripheral Arteriovascular Disease. This episode covers the diagnosis and management of acute and chronic arterial insufficiency, differentiating between thrombotic and embolic insufficiency, as well as aneurysms, AV fistulae, and thoracic

2017 CandiEM

137. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

, Yao X, Shah ND, Gersh BJ? Comparative effective- ness and safety of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease? Int J Cardiol? 2016;209:181–3? 36? Avezum A, Lopes RD, Schulte PJ, et al? Apixaban in comparison with warfarin in patients with atrial fibrillation and valvular heart disease: findings from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial (...) 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines CLINICAL STATEMENTS AND GUIDELINES Circulation. 2017;135:e1159–e1195. DOI: 10.1161/CIR.0000000000000503 June 20/27, 2017 e1159 WRITING GROUP MEMBERS* Rick A. Nishimura, MD, MACC, FAHA, Co-Chair Catherine M. Otto, MD, FACC, FAHA, Co-Chair Robert O. Bonow, MD, MACC

2017 American Heart Association

138. 2017 Antithrombotic Therapy in Atrial Fibrillation Associated with Valvular Heart Disease: A Joint Consensus Document from EHRA and ESC Working Group on Thrombosis

‘valvular AF’ and refer simply to ‘AF related to hemodynamically significant mitral stenosis or prosthetic mechanical heart valves’. AF clearly leads to an incremental risk for thromboembolism in patients with mitral valve stenosis, but there are limited data for other valvular diseases. Another proposal is to use the acronym MARM-AF as a simple acronym to designate ‘Mechanical and Rheumatic Mitral AF’ as an alternative to term ‘valvular AF’ to designate the clinical scenarios for which at the non (...) valves 3.5 High Lillehei-Kaster, Omniscience, Starr-Edwards, Bjork-Shiley and other tilting-disc valves 4.0 * Risk factors: previous thromboembolism; AF; mitral stenosis of any degree; left ventricular ejection fraction < 35%. Reproduced from reference. The duration of antithrombotic therapy also varies according to a number of factors. Lifelong anticoagulant treatment is indicated for all patients with mechanical valves and those with bioprosthetic valves or native valve disease with ≥1 additional

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2017 Heart Rhythm Society

139. Heart Disease and Stroke Statistics 2017 Update: A Report From the American Heart Association

Cardiac Arrest . . . . . . . . . . . . . . e468 19. Subclinical Atherosclerosis . . . . . . . . . . . . e487 20. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pectoris. . . . . . . . . . e505 21. Cardiomyopathy and Heart Failure . . . . . . . . e523 22. Valvular Diseases . . . . . . . . . . . . . . . . e539 23. Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism), Chronic Venous Insufficiency, Pulmonary Hypertension. . . e548 24. Peripheral Artery Disease and Aortic (...) , which occurs among 1.0% to 8.8% of those with pulmo- nary embolism. • Assuming 375 000 to 425 000 new cases of venous thromboembolism annually, the overall cost of venous thromboembolism was estimated at $7 billion to $10 billion annually. New Section on Chronic Venous Insufficiency • Varicose veins affect 25 million US adults. More severe venous disease affects 6 million. • Venous ulcer is a substantial morbidity of chronic venous insufficiency. Estimated prevalence in adults is ˜0.3

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2017 American Heart Association

140. Pulmonary hypertensive vascular changes in lungs of patients with sudden unexpected death. Emphasis on congenital heart disease, Eisenmenger syndrome, postoperative deaths and death during pregnancy and postpartum. (PubMed)

Pulmonary hypertensive vascular changes in lungs of patients with sudden unexpected death. Emphasis on congenital heart disease, Eisenmenger syndrome, postoperative deaths and death during pregnancy and postpartum. Pulmonary hypertension (PH) in asymptomatic patients is a rare cause of sudden death. This study aims to determine the incidence of this entity and raise awareness among pathologists.We retrospectively investigated 44 cases of sudden unexpected death in relation to PH in patients (...) heart disease. The cause of PH was recognised as congenital heart disease in 27 patients (61.36%), 14 of whom had simple congenital heart disease, such as atrial or ventricular septal defect,and 13 had complex congenital heart disease with associated atrial septal defect or ventricular septal defect. The remaining 17 patients (29.55%) suffered from primary PH due to plexiform arteriopathy, veno-occlusive disease and thromboembolic disease. Extensive sampling of the lungs is required to detect

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2014 Journal of Clinical Pathology

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