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Thromboembolic Disease in Pregnancy

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121. Combined hormonal contraceptives and venous thromboembolism: review confirms risk is small

Leaflet) Our recent letter includes the following tools to help prescribers and women jointly make informed choices: Prescribing checklist A prescribing checklist that may be used during a CHC consultation has also been made available (annex 2 of the ). The checklist: specifies the conditions that contraindicate the use of a CHC lists the factors that increase a woman’s risk (such as older age, obesity, prolonged immobilisation, surgery, personal history of thromboembolism, smoking etc) reminds (...) Combined hormonal contraceptives and venous thromboembolism: review confirms risk is small Combined hormonal contraceptives and venous thromboembolism: review confirms risk is small - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Combined hormonal contraceptives and venous thromboembolism: review confirms risk is small A review of the latest evidence on the risk of thromboembolism advises to consider risk factors and remain vigilant for signs and symptoms. - the risk of blood

2014 MHRA Drug Safety Update

122. Guillain-Barré Syndrome in Pregnancy. (Abstract)

Guillain-Barré Syndrome in Pregnancy. Guillain-Barré syndrome has been reported in pregnancy and is a potentially lethal condition. It affects the nervous system with acute onset of symmetric ascending weakness and may result in frank respiratory failure and autonomic dysfunction. Most patients recall symptoms of a respiratory or gastrointestinal illness in the weeks preceding the onset of weakness. Recent evidence suggests a potential role of the Zika virus as a trigger for the syndrome (...) . The diagnosis of Guillain-Barré is clinical. Supportive measures include venous thromboembolism prophylaxis, aggressive physical therapy, pressure ulcer prevention, enteral nutrition, and respiratory support. The mainstay of management comprises plasmapheresis or administration of intravenous immunoglobulins. Affected patients must be closely monitored for development of respiratory failure and autonomic dysfunction. Treatment during pregnancy should follow the same principles as for nonpregnant individuals.

2016 Obstetrics and Gynecology

123. Maternal and neonatal outcomes of pregnancies in women with Addison's disease: a population-based cohort study on 7.7 million births. Full Text available with Trip Pro

Maternal and neonatal outcomes of pregnancies in women with Addison's disease: a population-based cohort study on 7.7 million births. To assess if pregnancies among women with Addison's disease (AD) are at higher risk of adverse maternal and neonatal outcomes.Population-based retrospective cohort study.All births in the United States' Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from 2003 to 2011.Baseline characteristics were compared between women with AD and those (...) -for-gestational age infants (OR 1.78, 95% CI 1.15-2.75) were more likely in these pregnancies.Addison's disease significantly increases the risk of severe adverse maternal and neonatal outcomes, so pregnant women with AD are best managed in tertiary-care centres.Pregnancies complicated by Addison's disease have an increased risk of adverse maternal and neonatal outcomes.© 2016 Royal College of Obstetricians and Gynaecologists.

2016 BJOG

124. Systematic review: Prophylactic dose fondaparinux for 6?weeks in superficial thrombophlebitis of the legs reduces the risk for symptomatic thromboembolic complications

-thrombotic disorder in a superficial vein, is relatively common and estimated to occur in 1 per 1000 persons. 1 The classic symptoms include pain, oedema, erythema and occasionally a palpable cord in the area of the thrombosed vein. Risk factors for ST include surgery, pregnancy and puerperium, female hormones, malignancy, infection, varicose veins, autoimmune disorders and thrombophilia. 2 ST is a risk factor for deep venous thrombosis (DVT); 12–44% of patients with ST develop a DVT. 3 The treatment (...) Systematic review: Prophylactic dose fondaparinux for 6?weeks in superficial thrombophlebitis of the legs reduces the risk for symptomatic thromboembolic complications Prophylactic dose fondaparinux for 6 weeks in superficial thrombophlebitis of the legs reduces the risk for symptomatic thromboembolic complications | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time

2013 Evidence-Based Medicine

125. ABO Blood Group and Risk of Thromboembolic and Arterial Disease: A Study of 1.5 Million Blood Donors. Full Text available with Trip Pro

ABO Blood Group and Risk of Thromboembolic and Arterial Disease: A Study of 1.5 Million Blood Donors. ABO blood groups have been shown to be associated with increased risks of venous thromboembolic and arterial disease. However, the reported magnitude of this association is inconsistent and is based on evidence from small-scale studies.We used the SCANDAT2 (Scandinavian Donations and Transfusions) database of blood donors linked with other nationwide health data registers to investigate (...) , non-O blood groups were associated with higher incidence of both venous and arterial thromboembolic events. The highest rate ratios were observed for pregnancy-related venous thromboembolism (incidence rate ratio, 2.22; 95% confidence interval, 1.77-2.79), deep vein thrombosis (incidence rate ratio, 1.92; 95% confidence interval, 1.80-2.05), and pulmonary embolism (incidence rate ratio, 1.80; 95% confidence interval, 1.71-1.88).In this healthy population of blood donors, non-O blood groups explain

2016 Circulation

126. The Birth Control Pill, Thromboembolic Disease, Science and the Media: A Historical Review of the Relationship. (Abstract)

The Birth Control Pill, Thromboembolic Disease, Science and the Media: A Historical Review of the Relationship. The introduction of the birth control pill (the Pill) in 1960 revolutionized the options for contraception, sparking vibrant discussion in the scientific and social science literature and in the media. Much attention focused on issues of women's rights, including ethics and personal choice. But the Pill also introduced new questions about risk. Shortly after its introduction, the risk (...) of thromboembolic disease was recognized [1]. After more than half a century, controversies about the relationship between the Pill and thromboembolic disease have persisted. The scientific and media communities have been active in the discussion, debate and delivery of information about this risk. Scientific and public attention to thromboembolism and the Pill has had dramatic consequences, both good and bad. The spotlight on risk has helped to change norms regarding the public's right to know and assess

2016 Contraception

127. Effect of Intravenous Continuous Infusion Heparin on Rates of Venous Thromboembolism in High-Risk, Critically Ill Patients

as compared with guideline recommended subcutaneous heparin. Antifactor Xa assay, a laboratory test to measure the anticoagulant activity of heparin, or the ability of heparin to thin the blood, will be used to demonstrate that Intravenous administration is more effective. Condition or disease Intervention/treatment Phase Venous Thromboembolism Drug: intravenous continuous infusion of heparin (IV UFH) Drug: Subcutaneous Heparin Not Applicable Study Design Go to Layout table for study information Study (...) information Responsible Party: New York University School of Medicine ClinicalTrials.gov Identifier: Other Study ID Numbers: 15-01051 First Posted: March 14, 2016 Last Update Posted: April 27, 2017 Last Verified: April 2017 Keywords provided by New York University School of Medicine: heparin Additional relevant MeSH terms: Layout table for MeSH terms Critical Illness Thromboembolism Venous Thromboembolism Disease Attributes Pathologic Processes Embolism and Thrombosis Vascular Diseases Cardiovascular

2016 Clinical Trials

128. Prospective and Monocentric Study of the Incidence of Venous Thromboembolic Disease (VTE) in Spinal Cord Injury (SCI) Patient Between 3 and 12 Months After SCI

Prospective and Monocentric Study of the Incidence of Venous Thromboembolic Disease (VTE) in Spinal Cord Injury (SCI) Patient Between 3 and 12 Months After SCI Prospective and Monocentric Study of the Incidence of Venous Thromboembolic Disease (VTE) in Spinal Cord Injury (SCI) Patient Between 3 and 12 Months After SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prospective and Monocentric Study of the Incidence of Venous Thromboembolic Disease (VTE) in Spinal Cord Injury (SCI) Patient Between 3 and 12 Months After SCI (IMATEM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2016 Clinical Trials

129. Cancer-related Thromboembolic Disease

(Visit 4) and 12-month (or at the end of trial - Visit 5) visits. Patients eventually undergoing second-line chemotherapy during the course of the follow-up will remain on study. The study will document all cases of symptomatic thromboembolic events together with the relevant diagnostic work-up. Condition or disease Intervention/treatment Phase Adenocarcinoma Other: Thrombin Generation Assay Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical (...) Cancer-related Thromboembolic Disease Cancer-related Thromboembolic Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cancer-related Thromboembolic Disease (PROSPECT) The safety and scientific

2016 Clinical Trials

130. Ionizing Radiation in Pregnant Women

June 2015 CONTEXT AND POLICY ISSUES During pregnancy it is possible that a disease condition may develop or a pre-existing condition may worsen. The incidence of cancer, is estimated to be in 1 in 1000 pregnancies. 1 There is a tendency for periodontal disease to develop or deteriorate possibly as a result of hormone fluctuations during pregnancy. 2 Cholesdocholithiasis is estimated to occur in up to 12% of pregnant women and may be associated with cholangitis and/or gallstones, both of which may (...) on thromboembolic disease in pregnancy and puerperium was published in 2015 by the Royal College of Obstetricians and Gynaecologists (RCOG), UK and the older version 21 was published in 2007. One guideline 19 on Hodgkin lymphoma was published in 2014 by the British Committee for Standards in Hematology. One guideline 23 on common breast problems was published in 2013 by the University of Michigan Health System, USA. Two guidelines 17,24 on endoscopy were published in 2012 with one guideline 24 published

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

131. Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy

Details Study Description Go to Brief Summary: This is a randomized-controlled open-label trial comparing two different doses of low-molecular-weight heparin (LMWH) in pregnant patients with a history of previous venous thromboembolism (VTE). Both doses are recommended doses in the 2012 guidelines of the American College of Chest Physicians (ACCP), but it is not known which dose is more efficacious in preventing recurrent venous thromboembolism in pregnancy. Patients enter the study (...) and will be randomized as soon as a home test confirms pregnancy. LMWH will be administered until 6 weeks postpartum. Follow-up will continue until 3 months postpartum. Patients will be recruited by their treating physician, either an obstetrician or internist. Condition or disease Intervention/treatment Phase Deep Venous Thrombosis Pulmonary Embolism Drug: Low dose nadroparin Drug: Intermediate dose nadroparin Drug: Low dose enoxaparin Drug: Intermediate dose enoxaparin Drug: Low dose dalteparin Drug: Intermediate

2013 Clinical Trials

132. Trends in Venous Thromboembolism among Pregnancy-Related Hospitalizations, United States, 1994-2009. Full Text available with Trip Pro

Trends in Venous Thromboembolism among Pregnancy-Related Hospitalizations, United States, 1994-2009. The purpose of this study was to evaluate national trends in the rate of pregnancy-related hospitalizations for venous thromboembolism (VTE) from 1994-2009 and to estimate the prevalence of comorbid conditions among these hospitalizations.An estimated 64,413,973 pregnancy-related hospitalizations among women 15-44 years old were identified in the 1994-2009 Nationwide Inpatient Sample. Trends (...) from 2006-2009 when compared with 1994-1997 (adjusted odds ratio, 1.62; 95% confidence interval, 1.48-1.78).There has been an upward trend in VTE-associated pregnancy hospitalizations from 1994-2009 with concomitant increases in comorbid conditions. Clinicians should have a heightened awareness of the risk of VTE among pregnant women, particularly among those with comorbid conditions, and should have a low threshold for evaluation in women with symptoms or signs of VTE.Copyright © 2013 Mosby, Inc

2013 American Journal of Obstetrics and Gynecology

133. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Full Text available with Trip Pro

Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Knowledge of the absolute risk (AR) for venous thromboembolism (VTE) in women around pregnancy and how potential risk factors modify this risk is crucial in identifying women who would benefit most from thromboprophylaxis. We examined a large primary care database containing 376 154 pregnancies ending in live birth or stillbirth from women aged 15 to 44 years between 1995 (...) and 2009 and assessed the effect of risk factors on the incidence of antepartum and postpartum VTE in terms of ARs and incidence rate ratios (IRR), using Poisson regression. During antepartum, varicose veins, inflammatory bowel disease (IBD), urinary tract infection, and preexisting diabetes were associated with an increased risk for VTE (ARs, ≥139/100 000 person-years; IRRs, ≥1.8/100 000 person-years). Postpartum, the strongest risk factor was stillbirth (AR, 2444/100 000 person-years; IRR, 6.2/100

2013 Blood

134. Cardiovascular Disease: Tailored Pharmacy-based Interventions to Improve Medication Adherence

ischemia" or "heart diseases" or "myocardial infarction" or "stroke" or "cerebrovascular disorders" or "basal ganglia cerebrovascular disease").mp. 35. (angina pectoris or cardiomyopathy or heart arrhythmia or irregular heartbeat or congenital heart disease or valvular heart disease or valve heart disease or peripheral artery disease).mp. 36. (thromboembolic disease or congestive heart failure or atherosclerosis).mp. 37. or/28-36 38. 8 and 21 and 22 and 27 39. 7 and 21 and 22 and 27 and 37 40. limit 38 (...) or cerebrovascular disorders or basal ganglia cerebrovascular disease or angina pectoris or cardiomyopathy OR heart arrhythmia or irregular heartbeat OR congenital heart disease OR valvular heart disease or valve heart disease OR peripheral artery disease OR thromboembolic disease OR congestive heart failure OR atherosclerosis):ti,ab #7 #1 AND #2 AND #3 AND #4 AND #5 #8 #1 AND #2 AND #3 AND #5 AND #6 #9 #7 or #8 Limit to English Database: ERIC (ProQuest) 1 pharmacist or pharmacists or "pharmacy services

2020 Community Preventive Services Task Force

135. Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period

diseases during pregnancy , European Heart Journal , 10.1093/eurheartj/ehy340 , 39 , 34 , (3165-3241) , (2018) . Roza Chaireti and Katarina Bremme , Risk Factors, Treatment and Prevention of Venous Thromboembolism During Pregnancy and Postpartum , Embolic Diseases - Unusual Therapies and Challenges , 10.5772/67709 , (2017) . Antonin Zoubian, Laurent Bertoletti and Paul Frappé , After deep vein thrombosis, which patients refer to vascular specialist for anticoagulant withdrawal? A Delphi study results (...) thrombosis and pulmonary embolism in pregnancy and the postpartum period National Women’s Health, Auckland City Hospital, Grafton, Auckland, New Zealand Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales Clinical Haematology Department, Monash Medical Centre, Clayton Australian Centre for Blood Diseases, Monash University, Prahran, Victoria Discipline of Obstetrics and Gynaecology, University of Adelaide, Lyell McEwin Hospital Department of Obstetrics and Gynaecology, Women’s

2012 Clinical Practice Guidelines Portal

136. Phlegmasia Cerulea Dolens and May–Thurner Syndrome in the first trimester of Pregnancy Full Text available with Trip Pro

Phlegmasia Cerulea Dolens and May–Thurner Syndrome in the first trimester of Pregnancy Background Venous thromboembolism in pregnancy remains one of the leading causes of morbidity and mortality. Case A young, gravid patient presented with a cyanotic, edematous left lower extremity with no distal pulses palpable. She was emergently taken to the operating room and was found to have extensive iliofemoral thrombosis requiring femoral angioplasty and embolectomy with 43.7-rad intraoperative (...) radiation exposure. Phlegmasia cerulea dolens and May-Thurner syndrome were diagnosed. Conclusion Timely diagnosis and prompt surgical management are necessary due to the limb-threatening nature of this condition. Despite maternal radiation exposure, the nature and extent of fetal effects depends upon radiation dose and gestational age.

2015 AJP Reports

137. Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score

associated with thrombophilia could be more useful in the prediction for RPL than FVL and PT alone. Condition or disease Miscarriage, Recurrent Detailed Description: Recurrent pregnancy loss can affect up to 5% of women in child-bearing age and is considered one of the most common causes of female sterility. In recent years, the association between thrombophilia and pregnancy failure has been observed in a number of studies, varying according to the nature of the thrombophilia (for example (...) the antiphospholipid syndrome as opposed to the hereditary forms) or the type of pregnancy loss (either isolated or recurrent, or early or late). It has therefore been accepted that thrombophilia is detected in a significant number of idiopathic pregnancy losses, reaching 66% of the cases in some series. Since the 1990's, a number of studies have associated recurrent pregnancy loss with FVL mutations (most frequently) and G20210 PT. In a systematic review, it was confirmed that women with thrombophilia have

2017 Clinical Trials

138. Impact of maternal obesity on the incidence of pregnancy complications in France and Canada Full Text available with Trip Pro

. Outcomes studied included, hypertensive disorders of pregnancy (HDP), venous thromboembolism, stillbirth, caesarean delivery and macrosomia. The impact of obesity across both cohorts was studied using univariate and multivariate logistic regression analyses, adjusting for relevant confounders. The French and Canadian databases included 26,973 and 22,046 deliveries respectively, with obesity rates of 9.1% and 16% respectively (p < 0.001). In both cohorts, obesity was significantly associated (...) Impact of maternal obesity on the incidence of pregnancy complications in France and Canada The aim of our study was to compare the impact of maternal obesity on the incidence of medical complications of pregnancy in France and Canada. We performed a prospective comparative cohort study using French data, retrieved from a prospective cohort of singleton deliveries, and Canadian data retrieved from QUARISMA, a cluster-randomized controlled trial conducted in Quebec, both between 2009 and 2011

2017 Scientific reports

139. Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature Full Text available with Trip Pro

Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature Mesenteric cyst is a rare clinical entity especially in pregnancy; therefore, few cases have been reported in the literature. The standard method of their treatment is surgical excision either with laparotomy or laparoscopy. In addition, mesenteric vein thrombosis is a rare and life-threatening condition in pregnancy and needs (...) of a simultaneous mesenteric cyst and mesenteric vein thrombosis in pregnancy. It is known that pregnancy is a state of hypercoagulation and clinicians should bear in mind this rare clinical condition in their diagnostic algorithm for acute abdominal pain.

2017 Journal of medical case reports

140. Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report Full Text available with Trip Pro

Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report Polymyositis is a rare medical disorder complicating pregnancy. Ventilatory muscle weakness leading to respiratory failure is an uncommon manifestation of this autoimmune disease. We report a case of life-threatening hypercapnic respiratory failure due to polymyositis-related respiratory muscle weakness in a pregnant woman.A 31-year-old, African woman in her second trimester (...) of pregnancy presented to the emergency department with fever, shortness of breath and muscle weakness. Initial investigations excluded pulmonary infection, thromboembolism, and cardiac dysfunction as the underlying cause of her symptoms. She developed deterioration in her level of consciousness due to carbon dioxide narcosis requiring invasive mechanical ventilation. Further workup revealed markedly elevated serum creatine kinase, abnormal electromyography and edema of her thigh muscles on magnetic

2017 Journal of medical case reports

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