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Thromboembolic Disease in Pregnancy

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101. The epidemiology of venous thromboembolism (PubMed)

The epidemiology of venous thromboembolism Venous thromboembolism (VTE) is categorized by the U.S. Surgeon General as a major public health problem. VTE is relatively common and associated with reduced survival and substantial health-care costs, and recurs frequently. VTE is a complex (multifactorial) disease, involving interactions between acquired or inherited predispositions to thrombosis and VTE risk factors, including increasing patient age and obesity, hospitalization for surgery or acute (...) illness, nursing-home confinement, active cancer, trauma or fracture, immobility or leg paresis, superficial vein thrombosis, and, in women, pregnancy and puerperium, oral contraception, and hormone therapy. Although independent VTE risk factors and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be relatively constant, or even increasing.

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2016 Journal of thrombosis and thrombolysis

102. Pregnancy outcome in patients with sickle cell disease in the UK--a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease. (PubMed)

Pregnancy outcome in patients with sickle cell disease in the UK--a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease. We describe the findings from a national study of maternal and fetal outcomes of pregnancy in women with sickle cell disease (SCD). Data were collected via the United Kingdom Obstetric Surveillance System between 1 February 2010 and 31 January 2011 from 109 women, of whom 51 (46·8%) had HbSS and 44 (40·4%) had HbSC. Data included antenatal, maternal (...) and fetal outcomes. Comparisons were made between women with HbSS and HbSC. Incidence of complications were acute pain (57%), blood transfusion (26%), urinary tract infection (UTI; 12%) and critical care unit admission (23%) and these were all more common in women with HbSS than HbSC. There was no difference in the incidence of acute chest syndrome, hypertension and venous thromboembolism between HbSS and HbSC. Women with HbSS were more likely to deliver at <37 weeks gestation (P = 0·01

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2015 British journal of haematology

103. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. (PubMed)

Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Knowledge of the absolute risk (AR) for venous thromboembolism (VTE) in women around pregnancy and how potential risk factors modify this risk is crucial in identifying women who would benefit most from thromboprophylaxis. We examined a large primary care database containing 376 154 pregnancies ending in live birth or stillbirth from women aged 15 to 44 years between 1995 (...) and 2009 and assessed the effect of risk factors on the incidence of antepartum and postpartum VTE in terms of ARs and incidence rate ratios (IRR), using Poisson regression. During antepartum, varicose veins, inflammatory bowel disease (IBD), urinary tract infection, and preexisting diabetes were associated with an increased risk for VTE (ARs, ≥139/100 000 person-years; IRRs, ≥1.8/100 000 person-years). Postpartum, the strongest risk factor was stillbirth (AR, 2444/100 000 person-years; IRR, 6.2/100

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2013 Blood

104. Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy

. Middeldorp, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA): Low-molecular-weight heparin Pregnancy Venous thrombosis Additional relevant MeSH terms: Layout table for MeSH terms Thrombosis Embolism Venous Thromboembolism Pulmonary Embolism Venous Thrombosis Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Thromboembolism Lung Diseases Respiratory Tract Diseases Heparin Calcium heparin Heparin, Low-Molecular-Weight Dalteparin Tinzaparin Nadroparin Enoxaparin (...) Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2013 Clinical Trials

105. Trends in Venous Thromboembolism among Pregnancy-Related Hospitalizations, United States, 1994-2009. (PubMed)

Trends in Venous Thromboembolism among Pregnancy-Related Hospitalizations, United States, 1994-2009. The purpose of this study was to evaluate national trends in the rate of pregnancy-related hospitalizations for venous thromboembolism (VTE) from 1994-2009 and to estimate the prevalence of comorbid conditions among these hospitalizations.An estimated 64,413,973 pregnancy-related hospitalizations among women 15-44 years old were identified in the 1994-2009 Nationwide Inpatient Sample. Trends (...) , there was a 14% increase in the rate of overall VTE-associated pregnancy hospitalizations; antepartum and postpartum hospitalizations with VTE increased by 17% and 47%, respectively. Between 1994-1997 and 2006-2009, the prevalence of hypertension and obesity doubled among all VTE-associated pregnancy hospitalizations; significant increases in diabetes mellitus and heart disease were also noted. A temporal increase in the likelihood of a VTE diagnosis in pregnancy was observed for antepartum hospitalizations

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2013 American Journal of Obstetrics and Gynecology

106. Management of AML in Pregnancy

pregnancy should be managed jointly by consultant haematologists, obstetricians, anaesthetists and neonatologists. Consideration should be given to the health of both mother and baby and the informed wishes of the mother. The woman should be fully informed about the diagnosis, treatment of the disease and possible complications during pregnancy. Treatment delays may compromise maternal outcome without improving the outcome for the foetus (Greenlund et al , ). Without treatment, maternal death can occur (...) . & Chapman, S.W. ( 1998 ) Antifungal therapy during pregnancy . Clinical Infectious Diseases , 27 , 1151 – 1160 . Lynch, C.M. , Sinnott, J.T. , Holt, D.A. & Herold, A.H. ( 1991 ) Use of antibiotics during pregnancy . American Family Physician , 43 , 1365 – 1368 . Meyer‐Wittkopf, M. , Barth, H. , Emons, G. & Schmidt, S. ( 2001 ) Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literature . Ultrasound in Obstetrics & Gynecology , 18

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2015 British Committee for Standards in Haematology

107. Obesity in pregnancy

(Gestational diabetes mellitus and Diabetes in Pregnancy ) 14 • Preeclampsia 14 • Obstructive sleep apnoea—may be related to adverse fetal outcomes 14 • Thromboembolic disease 14 • Cholecystitis 14 • Depression 4 • Difficulties with abdominal palpitation and obtaining adequate auscultation of fetal heart and cardiotocograph (CTG) • Suboptimal ultrasonography 5 • Diagnosis of congenital abnormality 17 • Preterm birth (PTB)—mostly associated with comorbidities 14,18 • Increased odds of dizygous twinning 19 (...) • Haemorrhage 14 • Chest, genital tract, wound and urinary infections 14 • Reduced rate of breastfeeding 14 • Postnatal depression 27 • Thromboembolic disease Neonatal/ childhood • Admission to neonatal intensive care units 14 • Macrosomia 14 • Congenital malformations 17 • Obesity 14 and metabolic syndrome 28 • Neurodevelopmental disorders (e.g. autism, developmental delays) 29 • Asthma 30 Queensland Clinical Guideline: Obesity in pregnancy Refer to online version, destroy printed copies after use Page 10

2015 Queensland Health

108. Heart Disease and Stroke Statistics

Cardiac Arrest, Ventricular Arrhythmias, and Inherited Channelopathies e377 18. Subclinical Atherosclerosis e401 19. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pectoris e415 20. Cardiomyopathy and Heart Failure e438 21. Valvular Diseases e455 22. Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism), Chronic Venous Insufficiency, Pulmonary Hypertension e472 23. Peripheral Artery Disease and Aortic Diseases e481 Outcomes 24. Quality of Care e497 25. Medical Procedures (...) disease. Admissions for endocarditis related to injection drug use have risen in recent years in parallel with the opioid drug crisis. The prevalence of documented intravenous drug use among people admitted to a hospital because of endocarditis in the National (Nationwide) Inpatient Sample rose from 4.3% in 2008 to 10% in 2014. Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism), Chronic Venous Insufficiency, Pulmonary Hypertension (Chapter 22) Traditional atherosclerotic risk factors

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2019 American Heart Association

109. BSG consensus guidelines on the management of inflammatory bowel disease in adults

BSG consensus guidelines on the management of inflammatory bowel disease in adults 1 Version accepted by Gut 10 th June 2019 British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults Authors Christopher A. Lamb 1,2 *, Nicholas A. Kennedy 3,4 , Tim Raine 5 , Philip Hendy 6,7 , Philip J. Smith 8 , Jimmy K. Limdi 9,10 , Bu’Hussain Hayee 11,12 , Miranda Lomer 12,13 , Gareth C. Parkes 14,15 , Christian P. Selinger 16,17 , Kevin J. Barrett 18 (...) Trust, Wolverhampton, WV10 0QP, UK 39. University of Wolverhampton, Wolverhampton, WV1 1LY, UK 40. University Hospital of Wales, Cardiff, CF14 4XW, UK See Supplementary Table 1 for affiliations of the IBD guidelines eDelphi consensus group Accepted manuscript 4 Version accepted by Gut 10 th June 2019 Keywords Ulcerative colitis, UC, colitis, Crohn’s disease, CD, ileitis, granuloma, fistula, stricture, perianal, inflammatory bowel disease, IBD, pouch, pouchitis, guideline, classification, diagnosis

2019 British Society of Gastroenterology

110. Prevention and management of venous thromboembolism

thromboembolism 4 2.2 Thromboprophylaxis in surgical patients 4 2.3 Thromboprophylaxis in medical patients 4 2.4 Pregnancy and the puerperium 4 2.5 Diagnosis of venous thromboembolism 5 2.6 Preliminary assessment 5 2.7 Initial management of venous thromboembolism 5 2.8 Further management of venous thromboembolism 5 2.9 Adverse effects of venous thromboembolism prophylaxis and treatment 6 3 a ssessment of risk for venous thromboembolism 7 3.1 Introduction 7 3.2 Clinical assessment of venous thrombosis risk 7 (...) Cerebral vein thrombosis 47 11.6 Splanchnic vein thrombosis 47 r evised n ov. 2011 Prevention and management of venous thromboembolism11.7 Incidental VTE 48 11.8 Pregnancy 48 12 f urther management of venous thromboembolism 49 12.1 Choice of anticoagulant 49 12.2 Graduated elastic compression stockings 51 13 monitoring the anticoagulant effect 52 13.1 Unfractionated heparin 52 13.2 Low molecular weight heparin 52 13.3 Warfarin 52 14 o utpatient management of acute vte 54 14.1 Deep vein thrombosis 54

2010 SIGN

111. Clinical practice guideline for care in pregnancy and puerperium

disease requiring medication • Liver disease with failure • Thromboembolic disease • Neoplastic disease • HIV infection or hepatitis B virus infection • Cystic Fibrosis • Other serious medical and surgical conditions • Family history of genetic diseases • Physical or mental disability38 CLINICAL PRACTICE GUIDELINES IN THE SNS Obstetrical pathology during pregnancy and the puerperium: • Pregnancy-induced hypertension • Severe anaemia • Gestational Diabetes • Recurrent urinary tract infection (...) creatinine level in a biochemical test? 8. What is the purpose of determining the plasma uric acid level in a biochemical test? 9. What is the purpose of universal screening for syphilis in pregnant women and at what stage of pregnancy should it be done? 10. What is the purpose of universal screening for Chagas disease in pregnant women and at what stage of pregnancy should it be done? 11. What is the purpose of universal screening for chlamydia in pregnant women and at what stage of pregnancy should

2014 GuiaSalud

112. Air Travel and Pregnancy

–security–scanner]. Scientific Impact Paper 1 © Royal College of Obstetricians and Gynaecologists 5of 67. Centers for Disease Control and Prevention. Travelling While Pregnant. [http://wwwnc.cdc.gov/ travel/yellowbook/2012/chapter–8–advising–travelers–with–specific–needs/pregnant–travelers.htm]. 8. Hezelgrave NL, Whitty CJ, Shennan AH, Chappell LC. Advising on travel during pregnancy. BMJ 2011;342:d2506. 9. Civil Aviation Authority. Guidance for Health Professionals Information on assessing fitness (...) Air Travel and Pregnancy Air Travel and Pregnancy Scientific Impact Paper No. 1 May 2013Air Travel and Pregnancy This is the third edition of this paper, which was published in 2001 and 2005 under the title ‘Advice on Preventing Deep Vein Thrombosis (DVT) for Pregnant Women Travelling by Air’. 1. Background Obstetricians are commonly asked to give advice on whether it is suitable for women who are pregnant to fly during pregnancy. Such advice is sought because of the physiological

2013 Royal College of Obstetricians and Gynaecologists

113. A single-center experience with 12 consecutive cases of pregnancy among patients with membranous ventricular septal aneurysm. (PubMed)

A single-center experience with 12 consecutive cases of pregnancy among patients with membranous ventricular septal aneurysm. Membranous ventricular septal aneurysm (MVSA) is a rare cardiac anomaly that can occur as an isolated entity or being associated with other cardiac malformations. Complications of MVSA include thromboembolism, arrhythmia, rupture, bacterial endocarditis, right ventricular outflow tract obstruction, and atrioventricular valve diseases.The success rate of pregnancy (...) delivery. One patient terminated pregnancy in the second trimester- necessitated by cardiogenic shock. The other mothers had varying degrees of cardiac morbidity, but survived. Ten of thirteen newborns survived. Congenital heart disease and small-for-gestational-age (SGA) of newborn occurred in two cases (one twin and one single gestation). Two of these babies expired.Maternal and neonatal risk appeared associated with heart functional classifications, pulmonary hypertension and histories of cardiac

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2018 BMC Pregnancy and Childbirth

114. Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy (PubMed)

and microangiopathic diseases. Because of the high associated mortality rate, prompt recognition and treatment are paramount.A twenty-five-year-old G3P0111 with a history of multiple thromboembolisms presented at 21 weeks and 3 days of gestation with complaints of right upper quadrant pain, visual disturbances, headache, and syncopal episodes. Laboratory evaluation demonstrated microangiopathic disease with hemolysis (confirmed on peripheral smear), elevated liver enzymes, and abnormal 24-hour urine protein (...) Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnostic challenges as a result of its broad range of clinical presentations and its overlap with other obstetric complications

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2018 Case reports in obstetrics and gynecology

115. Tranexamic Acid in Pregnancies With Vaginal Bleeding

Description Go to Brief Summary: Tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage. Condition or disease Intervention/treatment Phase Vaginal Bleeding During Pregnancy Drug: Tranexamic Acid Not Applicable Detailed Description: Bleeding during pregnancy is associated with a three- to fourfold increase in perinatal mortality. Hemorrhage in pregnancy is characterized by activation of the fibrinolytic system. Tranexamic acid is a potent (...) pharmaceutical agent that suppresses fibrinolysis, and thus can be used for managing hemorrhage in pregnancy. The FDA's pregnancy category for tranexamic acid is Category B. It crosses the placenta however; its lack of effect on plasminogen activator activity in the vascular cell wall protects the fetus and newborn from potential thromboembolic complications. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 79 participants Intervention

2018 Clinical Trials

116. Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy. Condition or disease Intervention/treatment Phase Obstructive Sleep Apnea of Adult Preeclampsia Obstetrical Complications Device: Continuous Positive Airway Pressure Other: Sleep Hygiene Control Not Applicable Detailed Description: Emerging data support a link between sleep disordered breathing (SDB) and adverse pregnancy outcomes. In particular, women with obstructive sleep apnea (OSA (...) such as: Active liver disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes) Thrombocytopenia with platelet count <100,000 because of the difficulty in assessing the primary outcome. Active vaginal bleeding (more than spotting) at the time of randomization. Known chromosomal, genetic, major malformations or fetal demise, or planned termination of pregnancy because inclusion would compromise evaluation of secondary neonatal outcomes. Known major uterine malformations

2018 Clinical Trials

117. Recombinant Human Thrombopoietin(rhTPO) in Pregnancy With Immune Thrombocytopenia

reactions of rhTPO in the treatment of pregnancy-induced thrombocytopenia. Condition or disease Intervention/treatment Phase Immune Thrombocytopenia Drug: recombinant human thrombopoietin Drug: Platelet Concentrate Phase 3 Detailed Description: The project is undertaken by Qilu Hospital of Shandong University and other 6 well-known hospitals in China. The investigators anticipate to undertaking a concurrent control, multicentre trial including 60 pregnancy associated ITP adult patients which (...) of the serum urea nitrogen, creatinine, serum transaminase and bilirubin ); No severe cardiac and pulmonary dysfunction; No history of mental illness; Voluntarily signed written informed consent. Exclusion Criteria: A history of serious allergies to biologics; The history of thrombosis; Thromboembolic or hemorrhagic disease; Patients who are deemed unsuitable for the study by the investigator. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you

2018 Clinical Trials

118. Antiphospholipid syndrome: An update on risk factors for pregnancy outcome. (PubMed)

and/or other autoimmune diseases are well known history-based predictive factors for obstetrical complications, such as miscarriage, maternal venous thromboembolism, intrauterine foetal demise, preeclampsia, and neonatal death. Moreover, laboratory findings associated with poor pregnancy outcome are:triple antiphospholipid antibodies aPL positivity, double aPL positivity, single aPL positivity, false-positive IgM for CMV, and hypocomplementemia. Triple positivity is confirmed as the most significant risk (...) Antiphospholipid syndrome: An update on risk factors for pregnancy outcome. The optimal treatment of women with primary antiphospholipid syndrome (APS) is still debated. About 20-30% of women with APS remain unable to give birth to healthy neonates despite conventional treatment, consisting of prophylactic-dose heparin and low-dose aspirin. These cases are defined "refractory obstetric APS". The early identification of risk factors associated with poor pregnancy outcome could be the optimal

2018 Autoimmunity reviews

119. Guidelines on autopsy practice: Autopsy in sickle cell disease and persons with sickle trait

· deep vein thrombosis and pulmonary thromboembolism · dural venous sinus thrombosis and brain haemorrhage · aplastic marrow crisis from parvovirus B19 infection (in children and less commonly in adults). Common pathologies that are less often the direct cause of death: · left ventricular hypertrophy 16 · bone marrow necrosis from painful bony sickle crisis. CEff 050417 7 V4 Final Less common pathologies and scenarios: · posterior reversible encephalopathy syndrome (PRES) 17 · ischaemic heart disease (...) 16 · pregnancy-related with multi-organ failure and ACS, and sepsis · hyperhaemolysis (post-transfusion) syndrome in adults 18 · multi-organ haemosiderosis related to therapeutic/prophylactic blood transfusions; this mainly affects heart, liver, kidney and pancreas · biliary stone diseases: obstructive jaundice, cholecystitis and pancreatitis · overdose of opiate pain-killers: morphine/heroin, pethidine (which also causes seizures), fentanyl patches 19 · gut ulceration and perforation from NSAID

2017 Royal College of Pathologists

120. Management of Valvular Heart Disease

Aortic stenosis 2778 12.2.2 Mitral stenosis 2778 12.2.3 Aortic and mitral regurgitation 2778 12.3 Perioperative monitoring 2779 13. Management during pregnancy 2779 13.1 Native valve disease 2779 13.2 Prosthetic valves 2779 14. To do and not to do messages from the Guidelines 2780 15. What is new in the 2017 Valvular Heart Disease Guidelines? 2782 16. Appendix 2784 17. References 2785 Abbreviations and acronyms ΔPm Mean transvalvular pressure gradient 2D Two-dimensional 3D Three-dimensional ABC Age (...) Management of Valvular Heart Disease We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. 2017 ESC/EACTS Guidelines for the management of valvular heart disease | European Heart Journal | Oxford Academic Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article

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2017 European Society of Cardiology

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